Clinical trials: Precision Screening
Coronary Heart Disease (CHD)
Proteomic and Inflammatory Omics Changes With Colchicine Therapy in Coronary Heart Disease
The goal of this exploratory clinical trial is to investigate the proteomic changes induced by low-dose colchicine anti-inflammatory therapy in coronary heart disease (CHD) patients, with the aim of identifying novel biomarkers…
- Trial name
- PIC-CHD (NCT07462325)
- Testing
- colchicine
- Volunteers
- 176 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Pulmonary Disease, Chronic Obstructive Pulmonary Disease
Quantitative Lung Cancer Screening
The purpose of this project is to validate quantitative lung structure assessment using an automated analysis software (VIDA), for application to low dose computed tomography (LDCT) acquired for lung cancer screening.
- Conditions
- Pulmonary Disease, Chronic Obstructive Pulmonary Disease, Cancer, Lung
- Trial name
- NCT03622528
- Testing
- Chest CT scan
- Sponsor
- Jessica Sieren
Recurrent High Grade Glioma
PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas
This trial is an open-label, single-arm, phase 0/1 study of high-grade glioma that aims to evaluate the feasibility, preliminary efficacy and safety of the precision treatment strategy.
- Trial name
- NCT05473923
- Testing
- Receiving chemotherapeutic or targeted drugs recommended by molecular tumor board.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
Breast Cancer
Using AI to Select Women for Supplemental MRI in Breast Cancer Screening
This is a prospective clinical trial aiming to determine the ability of an AI pipeline to identify women who would benefit from supplemental MRI in terms of decreasing the number of cancers having a significantly delayed detection
- Trial name
- ScreenTrustMRI (NCT04832594)
- Testing
- AI selection for supplemental breast MRI
- Where
- Sweden
- Volunteers
- 2,500 people
- Sponsor
- Karolinska University Hospital
Mechanical Ventilation Weaning, Chronic Disease
Phenotype-Guided Weaning in Mechanically Ventilated Patients With Chronic Comorbidities
The goal of this clinical trial is to learn whether a phenotype-guided weaning strategy can help adults with chronic comorbidities be liberated from invasive mechanical ventilation earlier.
- Trial name
- NCT07594418
- Testing
- Phenotype-Guided Weaning Strategy, Standard Care
- Volunteers
- 1,380 people
- Sponsor
- Southeast University, China
Esophageal Cancer, Gastric Cancer
Effectiveness of Risk-based Sequential Screening for Esophageal and Gastric Cancer
To evaluate the feasibility, applicability, effectiveness, and health-economic value of the risk-based sequential screening modality for esophageal and gastric cancers, the investigators aim to initiate a community-based…
- Conditions
- Esophageal Cancer, Gastric Cancer, Precision Screening, Sequential Screening
- Trial name
- ERSS-EGC (NCT06306755)
- Testing
- Risk Assessment and Individualized Surveillance, Universal screening
- Where
- China
- Volunteers
- 21,000 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Monogenic Diabetes
Screening and Molecular Diagnosis-based Individualized Precision Management of Monogenic Diabetes
The goal of this observational study is to establish a registry, screening, and individualized management platform for patients with monogenic diabetes mellitus(MDM) using internet-based and mobile application software.
- Trial name
- NCT06746610
- Testing
- Genetic Screening for Monogenic Diabetes
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tianjin Medical University General Hospital
Dietary Behavior; Metabolic Health; Obesity; Lifestyle Modification; Metabolic Syndrome Risk
Agentic AI Personalized Dietary Management Study
This randomized controlled trial aims to evaluate the effectiveness of an Agentic AI-based personalized dietary management algorithm among adults undergoing health screening.
- Trial name
- AIDiet (NCT07638241)
- Testing
- Static AI-based personalized dietary goal setting, Adaptive AI-based personalized dietary management
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
the National Colorectal Cancer Cohort (NCRCC) Study: National Colorectal Cancer Research Consortium
NCRCC study is a national prospective cohort study including colorectal cancer screening population and stage Ⅰ-Ⅳ colorectal cancer patients.
- Trial name
- NCT04074538
- Where
- 5 sites in China
- Volunteers
- 55,000 people
- Sponsor
- Ding Ke-Feng
Colorectal Cancer, Advanced Neoplasia
Development and Validation of a Colorectal Cancer Diagnostic Model
This is a multicenter, observational study designed to develop and validate a diagnostic model for colorectal cancer and advanced colorectal neoplasia among adults undergoing routine-care colonoscopy in the Chinese population.
- Conditions
- Colorectal Cancer, Advanced Neoplasia, Prediction Models, Risk Stratification
- Trial name
- NCT07692555
- Where
- 4 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Cancer Screening
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)
This research study aims to investigate methods for enhancing lung cancer screening. The study will investigate whether an artificial intelligence (AI) tool, known as Sybil, can aid in predicting the risk of lung cancer.
- Trial name
- NCT07408531
- Testing
- Sybil Artificial Intelligence (AI) screening
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Haematological Malignancy, Solid Tumour
DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol
DETERMINE is an open-label phase II/III trial. It will look at targeted treatments in rare cancers or common cancers with rare genetic change (mutation). Patients must have a cancer with an identified mutation.
- Trial name
- DETERMINE (NCT05722886)
- Testing
- Alectinib, Atezolizumab, Entrectinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 825 people
- Sponsor
- Cancer Research UK
Smoking, Smoking Cessation
Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment
This trial tests the effects of two versions of RiskProfile, a clinically-informed and a genetically-informed version of a patient-specific risk feedback tool, in comparison to usual care, on lung cancer screening and tobacco…
- Conditions
- Smoking, Smoking Cessation, Tobacco Use Cessation
- Trial name
- PRECISE (NCT05627674)
- Testing
- Usual Care, RiskProfile-Clin, RiskProfile-Gen
- Where
- United States
- Volunteers
- 915 people
- Sponsor
- Washington University School of Medicine
Obese Adults, BMI/Body Composition
Precision Lifestyle Medicine Program for IFHAS Participants
The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who…
- Conditions
- Obese Adults, BMI/Body Composition, Cardiometabolic Risk, Cardiovascular Disease Risk
- Trial name
- NCT07742917
- Testing
- Precision Lifestyle Medicine Program, Standard IFHAS Care
- Where
- United Arab Emirates
- Volunteers
- 150 people
- Sponsor
- Institute for Healthier Living Abu Dhabi