Clinical trials: Precision Treatment
PTSD, PTSD - Post Traumatic Stress Disorder
Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies
PRE-EMPT will assemble a cohort of 150 participants from three populations (low risk, intermediate risk, and high risk for self-harm).
- Conditions
- PTSD, PTSD - Post Traumatic Stress Disorder, Major Depression, Suicidality
- Trial name
- PRE-EMPT (NCT07745569)
- Testing
- Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback
- Volunteers
- 150 people
- Sponsor
- University of New Mexico
Metastatic Neoplasm, Recurrent Neoplasm
Genomic Sequencing in Determining Treatment in Patients With Metastatic Cancer or Cancer That Cannot Be Removed by Surgery
This pilot clinical trial studies patients' genomic sequencing in determining specific treatments, also called Precision Medicine, in patients with cancer that has spread to other parts of the body (metastatic) and/or cannot be…
- Conditions
- Metastatic Neoplasm, Recurrent Neoplasm, Recurrent Non-Small Cell Lung Carcinoma, Stage IIIA Non-Small Cell Lung Cancer
- Trial name
- NCT02566421
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Targeted Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Wake Forest University Health Sciences
Biliary Tract Cancer (BTC)
Investigating Precision Medicine in the Adjuvant Setting in Biliary Tract Cancer
The objective of SAFIR-IMPACT BTC is to see whether, combining or replacing the standard adjuvant chemotherapy with a targeted therapy matched to the person's cancer, is better than the standard treatment alone in delaying or…
- Trial name
- SAFIR-IMPACT (NCT07745296)
- Testing
- Futibatinib, Ivosidenib + Capecitabine, Zanidatamab + Capecitabine
- Volunteers
- 990 people
- Sponsor
- UNICANCER
Systemic Sclerosis, Scleroderma
Evaluating Gut Imaging and Stool Biomarkers in Patients With Scleroderma-associated Gastrointestinal Disease
Systemic sclerosis (SSc) is characterized by autoimmunity and vasculopathy resulting in fibrosis of the skin and internal organs including the Gastrointestinal (GI) tract.
- Trial name
- Pre Med SSc GI (NCT04630782)
- Testing
- PET-MRI scan
- Where
- 5 sites in Singapore
- Volunteers
- 70 people
- Sponsor
- Singapore General Hospital
Type 2 Diabetes (T2DM)
Impact of a Nutritional Intervention Based on Moroccan Dietary Habits on the Glycemic Control of Type 2 Diabetics
The goal of this study is to learn if a nutritional intervention adapted to Moroccan dietary habits can improve blood sugar control in adults with Type 2 Diabetes.
- Trial name
- NCT07404280
- Testing
- Moroccan-Adapted Nutritional Plan
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Bladder Cancer, Prostate Cancer
Associations Between Chemotherapy-Induced Nausea in Patients With Genitourinary, Sarcoma or Melanoma Cancers and Changes in Gut Microbiome: Potential for Precision Therapeutics
The objective of this pilot cohort study is to investigate associations between CIN and changes in gut microbiome composition profiles.
- Conditions
- Bladder Cancer, Prostate Cancer, Testicular Cancer, Bladder Carcinoma
- Trial name
- NCT05819827
- Testing
- Blood and Tissue
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Knee Arthritis Osteoarthritis
Comparing Treatment of Knee Osteoarthritis With Triamcinolone Injections Using 40mg With Landmark Guidance and 20mg With Ultrasound Guidance
The purpose of this study is to determine whether a lower dose of corticosteroid injection with ultrasound-guidance for the treatment of knee osteoarthritis can be as effective as a higher dose that is landmark-guided.
- Trial name
- PRECISION-Knee (NCT07544576)
- Testing
- Triamcinolone knee injection without ultrasound guidance, Triamcinolone knee injection with ultrasound guidance
- Where
- 4 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sosi Dzhugarian
Mucosal Melanoma of the Head and Neck, Oral Melanoma
CLASSIFY-OMM: Multicenter Rare Disease Cohort for T-Stage Reclassification and Molecular Subtyping-Based Precision Therapy in Oral Mucosal Melanoma
This bidirectional cohort study (retrospective + prospective) focuses on three key challenges in oral mucosal melanoma (OMM): clinical staging based on depth of invasion (DOI), molecular subtyping, and precision therapy.
- Trial name
- CLASSIFY-OMM (NCT07662694)
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Depression - Major Depressive Disorder, Schizophrenia Disorders
Development and Application of Precision Treatment Strategies for Common Mental Disorders
Schizophrenia (SCH), major depressive disorder (MDD), and bipolar disorder (BPD) are prevalent, disabling psychiatric conditions that not only cause significant suffering for affected individuals and their families but also…
- Conditions
- Depression - Major Depressive Disorder, Schizophrenia Disorders, Bipolar Disorder (BD)
- Trial name
- NCT06729541
- Testing
- Multigenetic Pharmacogenomics-Guided Treatment (MPGT)
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Peking University
Metastatic Breast Cancer
Phase II Study Using Genomic & Proteomic Profiling to Influence Treatments for Patients With Metastatic Breast Cancer
Genes are the basic "instruction book" for the cells that make up our bodies and are made out of DNA. Many research studies are done to find the best possible way to treat patients with cancer.
- Trial name
- NCT02008994
- Testing
- Genomic and Proteomic Profiling
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sanford Health
Cancer Metastatic
Improving Public Cancer Care by Implementing Precision Medicine in Norway
IMPRESS-Norway is a prospective, non-randomized clinical trial evaluating efficacy of commercially available, anti-cancer drugs prescribed for patients with advanced cancer diagnosed with potentially actionable alterations as…
- Trial name
- IMPRESS-N (NCT04817956)
- Testing
- Atezolizumab
- Where
- 17 sites in Norway
- Volunteers
- 3,000 people
- Sponsor
- Oslo University Hospital
Sepsis, Septic Shock
OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study
This study examines how well the Oxiris® hemofilter works over time in adults with septic shock who require continuous kidney support in the intensive care unit (ICU).
- Conditions
- Sepsis, Septic Shock, Blood Purification, Hemoadsorption
- Trial name
- OxiCLEAR (NCT07419802)
- Testing
- AN69-polyethylenimine hemofilter (Oxiris®) used for continuous veno-venous hemofiltration (CVVH)
- Where
- Latvia
- Volunteers
- 29 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Cancer, Metastatic, Cancer
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and…
- Conditions
- Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver
- Trial name
- NCT03452774
- Testing
- Clinical Trial Matching
- Where
- 68 sites in United States, Puerto Rico
- Volunteers
- 50,000 people
- Sponsor
- Massive Bio, Inc.
PARKINSON DISEASE (Disorder), Alzheimer s Disease
Precision Medicine and Neurodegenerative Diseases: Advanced Systems for the Diagnosis and Treatment of Parkinson's Disease and Alzheimer's Disease.
In recent decades, advances in medicine have significantly improved both quality of life and life expectancy. However, these positive effects are also associated with a considerable increase in the prevalence of age-related…
- Conditions
- PARKINSON DISEASE (Disorder), Alzheimer s Disease, Diabete Type 2
- Trial name
- NEUROTECHNO (NCT07467460)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Pain, Acute, Pain, Chronic
EHR Precision Drug Treatment in Neonates
This observational study is designed to evaluate the integration of a model-informed, clinically individualized pharmacokinetics (PK) profile (precision dosing dashboard) into prescribing clinicians' existing workflows to improve…
- Trial name
- NCT04850079
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Adverse Drug Events, Adverse Drug Reactions
YouScript IMPACT Registry
This multicenter observational study aims to investigate the benefits of providing pharmacogenetic testing with the YouScript Personalized Prescribing System which includes a clinical decision support tool and individualized…
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- IMPACT (NCT02191358)
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Genelex Corporation
Schizophrenia, Major Depressive Disorder
Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individuals
This study aims to screen and validate multi-scale bio-markers for early diagnosis and medication monitoring for early schizophrenia, including the genetic, neurobiochemistry, neuroimaging and eletrophysiological measures.
- Conditions
- Schizophrenia, Major Depressive Disorder, Anxiety Disorders
- Trial name
- NCT03790085
- Testing
- Risperidone, Olanzapine, Aripiprazole
- Where
- China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Recurrent High Grade Glioma
PTCs-based Precision Treatment Strategy on Recurrent High-grade Gliomas
This trial is an open-label, single-arm, phase 0/1 study of high-grade glioma that aims to evaluate the feasibility, preliminary efficacy and safety of the precision treatment strategy.
- Trial name
- NCT05473923
- Testing
- Receiving chemotherapeutic or targeted drugs recommended by molecular tumor board.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Tiantan Hospital
TNBC - Triple-Negative Breast Cancer
An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC.
This is a Phase II, open-label, randomized controlled umbrella trial evaluating the efficacy and safety of multiple targeted treatment in patients with metastaticTNBC.
- Trial name
- FUTURE-SUPER (NCT04395989)
- Testing
- A1: Pyrotinib with nab-paclitaxel, A2: nab-paclitaxel, B1: everolimus with nab-paclitaxel
- Where
- China
- Volunteers
- 139 people
- Sponsor
- Fudan University
Acute Ischemic Stroke, Clopidogrel Resistance
Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE
The objective of this clinical trial is to evaluate the efficacy and safety of platelet aggregation function - guided precision anti - platelet therapy in patients with acute cerebral infarction.
- Trial name
- PATH STROKE C (NCT06853535)
- Testing
- The ticagrelor, The Clopidogrel
- Where
- China
- Volunteers
- 5,138 people
- Sponsor
- Sichuan Provincial People's Hospital