Clinical trials: Precision Treatment
Pharmacogenomics, Depression
Pharmacogenomics on Individualized Precise Treatment of Patients With Depression
Based on pharmacogenomics analysis technology, this topic explored its impact on individualized precise treatment of patients with depression through randomized controlled trials.
- Trial name
- NCT05669391
- Testing
- Genomic analysis of antidepressants
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tongji University
Hepotacellular Carcinoma
Multimodal Deep Learning for Postoperative Liver Cancer Risk Stratification and Intervention
This study is for patients with early-stage liver cancer who are planning to have surgery. The goal of this research is to see if a personalized treatment plan, guided by a computer model (an artificial intelligence tool), can…
- Trial name
- NCT07282184
- Testing
- Neoadjuvant HAIC + Lenvatinib + PD-1 Inhibitor, Curative Liver Resection, Multimodal AI Risk Stratification
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Tongji Hospital
Rheumatoid Arthritis
PRECISion medicinE Across the Disease Continuum to Prevent and Treat Rheumatoid Arthritis
The study will recruit patients referred to the Rheumatology Out-patient departments. Patients will be recruited to the study or control groups (healthy or disease controls who will be age and sex-matched) as needed.
- Trial name
- PRECISE-RA (NCT04482335)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Manchester
ARDS, Human, Covid19
Associations Between COVID-19 ARDS Treatment, Clinical Trajectories and Liberation From Mechanical Ventilator - an Analysis of the NorthCARDS Dataset
The mortality rates associated with COVID-19 related ARDS (COVIDARDS) have varied from observational reports from around the world.
- Trial name
- NorthCARDS (NCT04729075)
- Testing
- ARDS and COVID19 treatments
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- Northwell Health
Ischemic and Non-ischemic Cardiomyopathy
OptiVol for Precision Medical Management of Heart Failure
This clinical study is designed to show that a multidisciplinary team following a pre-specified standard of care medication decision model based on data from an implanted cardioverter device will increase the rate of change in…
- Trial name
- (OPTIMED-HF) (NCT04206501)
- Testing
- Medtronic ICD with Opti Vol-Monitor
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Rochester
Recurrent Glioblastoma
Feasibility of Individualized Therapy for Recurrent Glioblastoma
The current study will test the ability and likelihood of successfully implementing individualized combination treatment recommendations for adult patients with surgically-resectable recurrent glioblastoma in a timely fashion.
- Trial name
- NCT03681028
- Testing
- Individualized therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jennifer Clarke
HCC, Precision Therapy
Precision Treatment of Unresectable HCC Guided by Multi-omics Deep Learning Models
Surgery is the main curative treatment for hepatocellular carcinoma(HCC) patients, but 70%-80% of HCC patients are in the middle and advanced stages at the time of diagnosis and cannot be surgically resected.
- Trial name
- NCT06463444
- Testing
- HAIC + Tislelizumab +lenvatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chen Xiaoping
Uncontrolled Asthma
Impact of GDMT in Uncontrolled Asthma Patients Receiving MHD Inhaled Corticosteroids + Long-acting β2 Agonist
The primary objective of this study is to evaluate whether GDMT can bring significant benefits to disease management in uncontrolled asthma patients receiving medium- to high-dose ICS-LABA.
- Trial name
- PRECISION (NCT07718724)
- Testing
- Intervention group
- Where
- 20 sites in China
- Volunteers
- 540 people
- Sponsor
- AstraZeneca
Stroke
Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.
- Trial name
- TIME-MINOR (NCT07476898)
- Testing
- Tenecteplase (0.25mg/kg), Standard Medical Management
- Where
- 30 sites in China
- Volunteers
- 864 people
- Sponsor
- First Hospital of China Medical University
Primary Liver Cancer
Prospective Randomised Study of Doxorubicin in the Treatment of Hepatocellular Carcinoma by Drug-Eluting Bead Embolisation
The objective of this study is to assess the safety and efficacy of DC Bead™ delivered by intra-arterial embolisation for the treatment of Hepatocellular Carcinoma
- Trial name
- PRECISIONV (NCT00261378)
- Testing
- Transarterialchemoembolisation (TACE), DC Bead with Doxorubicin
- Where
- 17 sites in Austria, France and 2 more
- Volunteers
- 212 people
- Sponsor
- Boston Scientific Corporation
Cardiovascular Disease (CVD), Stroke
A Genomic Approach for Clopidogrel in Caribbean Hispanics
Clopidogrel is a prescription medicine used to minimize blood clot formation in patients with cardiovascular disease, particularly those undergoing heart catheterization and stroke.
- Conditions
- Cardiovascular Disease (CVD), Stroke, Acute Coronary Syndrome, Peripheral Arterial Disease
- Trial name
- NCT03419325
- Testing
- CYP2C19 test, P2RY12 assay
- Where
- 2 sites in Puerto Rico
- Volunteers
- 150 people
- Sponsor
- University of Puerto Rico
Chronic Pain
Clinical Outcomes Study Using a New Implantable Neurostimulation System for Chronic Intractable Pain
The primary objective of this study is to investigate patient satisfaction with treatment using a new implantable neurostimulation system for chronic pain of the trunk and/or limbs.
- Trial name
- NCT01665040
- Testing
- Neurostimulation device implantation
- Where
- 7 sites in Australia, Belgium and 1 more
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm
A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer
This phase II trial tests the how well a precision medicine approach (serial measurements of molecular and architectural response to therapy [SMMART])-adaptive clinical treatment [ACT]) works in treating patients with sarcoma…
- Conditions
- Advanced Breast Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma, Advanced Pancreatic Carcinoma
- Trial name
- NCT06630325
- Testing
- Abemaciclib, Biopsy, Bone Scan
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- OHSU Knight Cancer Institute
Smoking, Smoking Cessation
Precision Prevention Strategy to Increase Uptake and Engagement in Lung Cancer Screening and Smoking Cessation Treatment
This trial tests the effects of two versions of RiskProfile, a clinically-informed and a genetically-informed version of a patient-specific risk feedback tool, in comparison to usual care, on lung cancer screening and tobacco…
- Conditions
- Smoking, Smoking Cessation, Tobacco Use Cessation
- Trial name
- PRECISE (NCT05627674)
- Testing
- Usual Care, RiskProfile-Clin, RiskProfile-Gen
- Where
- United States
- Volunteers
- 915 people
- Sponsor
- Washington University School of Medicine
Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA)
Identification of Biomarkers of Obstructive Sleep Apnea.
Obstructive sleep apnea (OSA) is a common sleep disorder associated with intermittent hypoxia, systemic inflammation, oxidative stress, and an increased risk of cardiovascular and metabolic diseases.
- Conditions
- Obstructive Sleep Apnea, Obstructive Sleep Apnea (OSA), Obstructive Sleep Apnea (OSAS), Obstructive Sleep Apnea (SAOS)
- Trial name
- NCT07723144
- Testing
- Positive Airway Pressure (PAP) Therapy
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Solid Tumor, Unspecified, Adult, Haematological Malignancy
Proseq Cancer: Genomic Profiling in Patients With Incurable Cancer in Search for Targeted Treatment
Proseq Cancer is a precision medicine program based on in-house whole exome sequencing (WES) and RNA sequencing. The approved protocol allows for biobanking, registration of clinical and laboratory data, and sharing of genomic…
- Trial name
- NCT05695638
- Where
- Denmark
- Volunteers
- 3,000 people
- Sponsor
- Morten Ladekarl
Knee Osteoarthritis
The Right Treatment for the Right Patient at the Right Time. A Study Following 5,000 Patients With Knee Osteoarthritis
The treatment that patients with knee OA are offered varies largely. There is a need for more evidence-based individualized guidance to treatment choice for knee osteoarthritis.
- Trial name
- TREATright (NCT03746184)
- Testing
- Treatment course
- Where
- Denmark
- Volunteers
- 3,507 people
- Sponsor
- Hvidovre University Hospital
Lung Cancer
Precision Diagnosis and Therapy for Early Stage Lung Cancer
The present study is a single arm clinical trial aiming to improve the key technology in the diagnosis and treatment of early stage lung cancer.
- Trial name
- NCT02936804
- Testing
- Low Dose Computed Tomography
- Where
- China
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Colorectal Adenoma, Artificial Intelligence (AI)
Development and Demonstration of a Precision Prevention and Treatment System for Colorectal Tubular Adenomas Lesions
This study is a prospective,multi-center and observational clinical study.Investigators would like to innovatively construct a "trinity" database of colorectal tubular adenomas based on white light - magnifying chromo …
- Trial name
- NCT07073430
- Testing
- AI models with NBI
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Renmin Hospital of Wuhan University
Oncology, Biomarker
Prospective Evaluation of Immunological, Molecular-genetic, Image-based and Microbial Analyzes to Characterize Tumor Response and Control in Patients With Inoperable Stage III NSCLC Treated With Chemoradiotherapy Followed by Consolidation Therapy With Durvalumab
This non-interventional single-center explorative biomarker study aims at longitudinal comprehensive characterization (molecular genetics, immunological, morphological, image-based and microbial features) of the patient (host)…
- Conditions
- Oncology, Biomarker, NSCLC, Stage III, Durvalumab
- Trial name
- PRECISION (NCT05027165)
- Testing
- Non-interventional
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- LMU Klinikum