Clinical trials: Precision Treatment
Crohn Disease (CD), Ulcerative Colitis (UC)
Research for the Precision Medicine in the Treatment of Inflammatory Bowel Disease
This study aims to establish an integrated cohort of patients with inflammatory bowel disease (IBD) from Seoul National University Hospital, Seoul National University Boramae Medical Center, and Seoul National University Bundang…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- PREDICT (NCT07166588)
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University Hospital
Treatment Resistant Depression, Refractory Depression
Ketamine for Older Adults Pilot
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine in older adults with Treatment-Resistant Depression (TRD).
- Conditions
- Treatment Resistant Depression, Refractory Depression, Therapy-Resistant Depression, Late Life Depression
- Trial name
- NCT04504175
- Testing
- Ketamine
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Primary Dystonia, Transcranial Magnetic Stimulation
Precision-targeted Transcranial Magnetic Stimulation in the Treatment of Primary Dystonia
In this scheme, TMS treatment of Primary dystonia is planned by precise magnetic resonance positioning.
- Trial name
- NCT04727177
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Recurrence Hepatocellular Carcinoma, Advanced Hepatocellular Carcinoma
Immunotherapy Using Precision T Cells Specific to Multiple Common Tumor-Associated Antigen Combined With Transcatheter Arterial Chemoembolization for the Treatment of Advanced Hepatocellular Carcinoma
Objectives: The purpose of this study is to evaluate the safety and efficacy of dendritic cell-precision multiple antigen T cells with transcatheter arterial chemoembolization in the treatment of hepatocellular carcinoma.
- Trial name
- NCT02638857
- Testing
- TACE, Dendritic Cell, lipiodol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Military Medical University
Chronic Obstructive Pulmonary Disease
Using Clinical Prediction Models to Improve Treatment for Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is a chronic disease of the lungs that affects more than 2.5 million Canadians. Patients with COPD experience episodes of lung attacks (or exacerbations).
- Trial name
- NCT05309356
- Testing
- ACCEPT Decision Intervention, Comparator
- Where
- 2 sites in Canada
- Volunteers
- 1,130 people
- Sponsor
- University of British Columbia
Atrial Fibrillation, Thrombus; Embolism
Study on the Significance of Auricular Clip in Prevention and Treatment of Valvular Heart Disease Atrial Thrombosis
To evaluate the safety and clinical efficacy of left atrial appendage in the prevention of thrombus in patients with valvular heart disease, to improve the product according to clinical conditions, to achieve clinically accurate…
- Conditions
- Atrial Fibrillation, Thrombus; Embolism, Warfarin, Atrial Appendage
- Trial name
- NCT05263024
- Testing
- atrial appendage clip
- Volunteers
- 118 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Liver Neoplasms, Ablation Techniques
Standardization of Multi-modal Tumor Ablation Therapy System
This study will document for the safety and efficacy of image guided multi-mode precision ablation system (the combination of cryoablation and radiofrequency ablation) for the treatment of liver malignant, as well as provide the…
- Conditions
- Liver Neoplasms, Ablation Techniques, Cryoablation, Safety
- Trial name
- SMTATS (NCT03223142)
- Testing
- Multi-modal Precision Ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Model Informed Precision Dosing
Model-Informed Precision Dosing on Amikacin and Vancomycin Therapy in Critically Ill Children
Achieving optimal antibiotic exposure in critically ill pediatric patients is difficult due to (their) dynamic physiology and variability.
- Trial name
- NCT07315438
- Testing
- MIPD Tool
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Hacettepe University
Tumor, Colorectal, Organoids
Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)
COSENSE-1 is an unblinded, phase II, single-armed, single center feasibility study for using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens, for male and female…
- Conditions
- Tumor, Colorectal, Organoids, Tumoroid, Metastatic Colorectal Cancer
- Trial name
- COSENSE-1 (NCT06907342)
- Testing
- FOLFOX or FOLFIRI
- Where
- Norway
- Volunteers
- 148 people
- Sponsor
- St. Olavs Hospital
Cognitive Impairment
AI-Driven Cognitive Digital Therapeutics for Dementia Management
The study would investigate the effect of a cognitive digital therapeutics system. The intervention group would receive three digital therapeutics sessions per week for 8 weeks, while the control group would receive usual care.
- Trial name
- NCT06783465
- Testing
- Digital therapeutics session
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Haematological Malignancy, Solid Tumour
DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol
DETERMINE is an open-label phase II/III trial. It will look at targeted treatments in rare cancers or common cancers with rare genetic change (mutation). Patients must have a cancer with an identified mutation.
- Trial name
- DETERMINE (NCT05722886)
- Testing
- Alectinib, Atezolizumab, Entrectinib
- Where
- 27 sites in United Kingdom
- Volunteers
- 825 people
- Sponsor
- Cancer Research UK
Suicidal Thoughts and Behaviors, Major Depressive Episode (MDE)
Biomarker Discovery for Suicide Precision Circuit Therapeutics
This is a prospective observational biomarker study assessing changes in clinical, behavioral, neuroimaging, and neurophysiological measurer following ketamine/esketamine or electroconvulsive therapy (ECT) in adults with suicidal…
- Trial name
- NCT07723066
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis, Knee, Insomnia
Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation.
- Trial name
- PREMEO (NCT05387473)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I) integrated in best-evidence usual care (CBTi-UC), Best-evidence usual care (UC) plus information sessions
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Vrije Universiteit Brussel
Bipolar Disorder
Utility of the Pharmacogenetic Information Provided by NEUROPHARMAGEN in the Treatment of Bipolar Depressionwith Bipolar Depression
Evaluation of the impact of the genetic variation of individual genes on the therapeutic response and side effects profile in a cohort of well-characterized patients with bipolar depression, using NEUROPHARMAGEN.
- Trial name
- NCT04923204
- Testing
- Pharmacogenomic-testing with NEUROPHARMAGEN
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- AB Biotics, SA
Stress, Emotional Wellbeing
Prospective Real World Study on Therapy Prediction Algorithm Training
This study examines the impact of using an algorithm to select therapy content for patients engaged with the mobile mental health platform AmDTx (Mobio Interactive).
- Trial name
- NCT06265909
- Testing
- AmDTx
- Where
- Singapore
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Mobio Interactive PTE LTD
Breast Neoplasm, Breast Cancer
Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
The purpose of this study is to establish a prospective, single-center platform research based on clinical subtypes to explore precision neoadjuvant therapy in patients with operable breast cancer who met the indications for…
- Conditions
- Breast Neoplasm, Breast Cancer, Breast Tumors, Triple-Negative Breast Cancer (TNBC)
- Trial name
- FASCINATE-N (NCT05582499)
- Testing
- Dalpiciclib, Pyrotinib, SHR-A1811
- Where
- China
- Volunteers
- 716 people
- Sponsor
- Fudan University
Osteoporosis
Precision Medicine Approach for Osteoporosis - Follow Up Study
Osteoporosis is a health problem of major proportions. It affects more than 40 million Americans and results in more than 2 million fractures annually among Medicare patients alone.
- Trial name
- NCT06264609
- Testing
- Alendronate, Teriparatide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Paul F Netzel
Pancreatic Cancer
Personalized Precision Diagnosis and Treatment of Pancreatic Cancer
Pancreatic cancer (PC) is the 4th common cancer in the world and occupied the second place for digestive tumors, of which the incidence has also increased sharply in China.
- Trial name
- PPDTPC (NCT04373928)
- Testing
- Drug guided by Mini-PDX/PDX
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Age-Related Osteoporosis
Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone Turnover
Osteoporosis affects 24.5% of women over 65 and results in fracture-related hospital admissions exceeding those of heart attacks, strokes and breast cancer combined.
- Trial name
- NCT05151484
- Testing
- Teriparatide, Alendronate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Madhumathi Rao
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
This study will evaluate the safety, tolerability, and efficacy of Orca-T, an allogeneic stem cell and T-cell immunotherapy biologic manufactured for each patient (transplant recipient) from the mobilized peripheral blood of a…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Mixed Phenotype Acute Leukemia, Undifferentiated Leukemia
- Trial name
- Orca-T (NCT05316701)
- Testing
- Orca-T, Standard-of-Care
- Where
- 19 sites in United States
- Volunteers
- 187 people
- Sponsor
- Orca Biosystems, Inc.