Clinical trials: Precision Treatment
AML
ALLG AMLM26 INTERCEPT (Investigating Novel Therapy to Target Early Relapse and Clonal Evolution as Pre-emptive Therapy in AML): A Multi-arm, Precision-based, Recursive, Platform Trial
To demonstrate the efficacy of targeted and tailored sequential therapy in patients with AML.
- Trial name
- NCT06664879
- Testing
- MBG-453 + Azacitidine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Osteoarthritis, Knee, Insomnia
Added Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis
Knee osteoarthritis (KOA) is the leading and fastest increasing cause of disability in older adults. It is a serious health issue related with a high health care utilisation.
- Trial name
- PREMEO (NCT05387473)
- Testing
- Cognitive behavioral therapy for insomnia (CBT-I) integrated in best-evidence usual care (CBTi-UC), Best-evidence usual care (UC) plus information sessions
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Vrije Universiteit Brussel
Breast Cancer Stage IV, HER2-low Breast Cancer
HER2-PET as a Precision Imaging Tool for Treatment With HER2-ADC in HER2-expressing mBC
This is a prospective, multi-center, open-label, exploratory diagnostic phase II imaging trial for patients with metastatic breast cancer with at least one line of systemic therapy.
- Conditions
- Breast Cancer Stage IV, HER2-low Breast Cancer, Molecular Imaging
- Trial name
- NCT06830382
- Testing
- Positron emission tomografy with [68Ga]Ga-ABY-025
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Renske Altena
Obstructive Sleep Apnea
Precision OSA Therapy Based on Phenotypes and Endotypes
Analyzing the phenotypic and endotypic characteristics of Sleep Apnea, along with DISE obstruction situations, is crucial for precise diagnosis and treatment.
- Trial name
- NCT06825923
- Testing
- Clinical and Endotypic Assessmen
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing Medical University
Adverse Drug Events, Adverse Drug Reactions
YouScript IMPACT Registry
This multicenter observational study aims to investigate the benefits of providing pharmacogenetic testing with the YouScript Personalized Prescribing System which includes a clinical decision support tool and individualized…
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- IMPACT (NCT02191358)
- Where
- 7 sites in United States
- Volunteers
- 800 people
- Sponsor
- Genelex Corporation
Lung Cancer
Precision Diagnosis and Therapy for Early Stage Lung Cancer
The present study is a single arm clinical trial aiming to improve the key technology in the diagnosis and treatment of early stage lung cancer.
- Trial name
- NCT02936804
- Testing
- Low Dose Computed Tomography
- Where
- China
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Chest Hospital
Liver Metastasis, Gastric Cancer
Immunotherapy Using Pluripotent Killer-Human Epidermal Growth Factor Receptor-2 (PIK-HER2) Cells for the Treatment of Advanced Gastric Cancer With Liver Metastasis
Objectives: The purpose of this study is to evaluate the safety and efficacy of PIK-HER2 cells in the treatment of advanced Her2 high expressed gastric cancer with liver metastasis patients.
- Trial name
- NCT02632201
- Testing
- PIK-HER2, DC-PMAT
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Military Medical University
Locally Advanced Thyroid Gland Carcinoma, Thyroid Cancer
Efficacy of Organoid-Based Chemotherapy Drug Precision Screening to Guide Treatment for Thyroid Cancer
The current study aims to explore the potential advantages of chemotherapy that is implemented based on drug sensitivity testing.
- Trial name
- NCT06713057
- Testing
- Cyclophosphamide+Pemetrexed+5-Fluorouracil, Cyclophosphamide+Doxorubicin+5-Fluorouracil, Vindesine + Cisplatin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Lung Neoplasms, Second Primary Lung Cancer (SPLC)
Advancing Precision Lung Cancer Surveillance and Outcomes in Diverse Populations
This observational study evaluates the effectiveness of computed tomography (CT) imaging surveillance after curative-intent treatment for stage I-IIIA non-small cell lung cancer (NSCLC) in a diverse U.S. population.
- Conditions
- Lung Neoplasms, Second Primary Lung Cancer (SPLC), Non-Small Cell Lung Cancer (NSCLC), Stage I-IIIA, Lung Cancer (Diagnosis)
- Trial name
- PLuS2 (NCT07581379)
- Where
- United States
- Volunteers
- 1,826 people
- Sponsor
- University of Florida
Cancer
Exome Analysis (Complexe vs Simple) to Help the Therapeutic Decision for the Precision Medicine
The "simple" analysis of the exome can determine somatic and constitutional mutations. The major challenge lies in the translation of sequencing data into clinically relevant information allowing the clinician to guide his…
- Trial name
- EXOMA2 (NCT04614480)
- Testing
- Exome analysis
- Where
- 12 sites in France
- Volunteers
- 7,976 people
- Sponsor
- Centre Georges Francois Leclerc
Haematological Malignancy, Colorectal Neoplasms
DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations
This clinical trial is looking at a combination of drugs called trastuzumab and pertuzumab. This combination of drugs is approved together as standard of care treatment for adult patients with breast cancer (often with other…
- Conditions
- Haematological Malignancy, Colorectal Neoplasms, Urinary Bladder Neoplasm, Gallbladder Neoplasms
- Trial name
- DETERMINE (NCT05786716)
- Testing
- Trastuzumab, Pertuzumab
- Where
- 27 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Schizophreniform Catatonia, Treatment Resistant
Personalized Non-invasive Neuromodulation by rTMS for Chronic and Treatment Resistant Catatonia
Investigators hypothesize that personalizing rTMS targets using functional MRI will allow to improve symptoms of patients suffering from chronic catatonia.
- Trial name
- RETONIC (NCT03116425)
- Testing
- Individualized rTMS on VERUM 1's region or network, Individualized rTMS on VERUM 2's region or network
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Strasbourg, France
Primary CNS Lymphoma
Diagnosis; Objective RespOnse; THErApy
Thi is a prospective and low-intervention clinical trial. We propose to design a panel of "core" genetic alterations by sequencing Cerebral Spinal Fluid (CSF) DNA in patients with confirmed or suspicious Primary Central Neurvous…
- Trial name
- DOROTHEA (NCT05036564)
- Testing
- Lumbar puncture
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- IRCCS San Raffaele
Precision Medicine
Preliminary Effectiveness of Process-Based Personalized Physiotherapy for (Sub)Acute Neck Pain
The goal of this clinical trial is to learn if personalized physiotherapy can lower neck pain in adults with recent (sub)acute neck pain who have a higher chance of the pain becoming long-lasting.
- Trial name
- NCT07704593
- Testing
- Personalized physiotherapy grounded in the PBT framework
- Where
- 9 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University of Applied Sciences Utrecht
Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP)
French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism Spectrum Disorders, and Healthy Controls
The goal of this study is to learn whether people living with severe psychiatric disorders can be grouped into more homogeneous subgroups, across usual diagnostic categories, based on two key dimensions: social withdrawal and…
- Conditions
- Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive Disorder (MDD
- Trial name
- FRENCH-MINDS (NCT07881016)
- Testing
- 3T Brain MRI, Biological Sampling, Clinical, Cognitive and Digital Assessments
- Where
- 17 sites in France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Fondation FondaMental
Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult
A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors
This is a multi-center, single arm, open-label, localized pharmacodynamic biomarker Phase 0 trial designed to study the biological effects within the tumor microenvironment of PBA-0405 when administered intratumorally in…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Soft Tissue Sarcoma Adult, Triple Negative Breast Cancer
- Trial name
- NCT06273852
- Testing
- PBA-0405
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pure Biologics S.A.
Congenital Ptosis
Research on Precision Diagnosis and Treatment Decision of Common Eye Diseases Based on Artificial Intelligence
The goal of this observational study is to investigate the clinical features of congenital ptosis in children by analyzing eyelid movement captured through smartphone videos.
- Trial name
- NCT07078552
- Testing
- ptosis
- Where
- China
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Musculoskeletal Injury, Musculoskeletal Strain
Multi-axis Assessment of Injured Workers
The percentage of loss time claims receiving Loss of Earnings benefits at 3 months has continued to rise amongst injured workers in Ontario despite the Workplace Safety and Insurance Board (WSIB) approach of "Better at Work".
- Conditions
- Musculoskeletal Injury, Musculoskeletal Strain, Low Back Pain, Neck Pain
- Trial name
- NCT06016647
- Testing
- Musculoskeletal-specific WSIB programs of care
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Dave Walton
NSCLC (Advanced Non-small Cell Lung Cancer), NSCLC Stage IIIB~IV
Immune-Marker Platform for Patients With Advanced Lung Cancer
The goal of this observational study is to better understand how the immune system and certain tumor markers are linked to treatment response in patients with advanced non-small cell lung cancer (NSCLC) who receive…
- Conditions
- NSCLC (Advanced Non-small Cell Lung Cancer), NSCLC Stage IIIB~IV, NSCLC Non-small Cell Lung Cancer
- Trial name
- IMPALUX (NCT07150598)
- Where
- 2 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Technische Universität Dresden
TNBC - Triple-Negative Breast Cancer
An Umbrella Trial Based on Molecular Pathway for Patients With Metastatic TNBC.
This is a Phase II, open-label, randomized controlled umbrella trial evaluating the efficacy and safety of multiple targeted treatment in patients with metastaticTNBC.
- Trial name
- FUTURE-SUPER (NCT04395989)
- Testing
- A1: Pyrotinib with nab-paclitaxel, A2: nab-paclitaxel, B1: everolimus with nab-paclitaxel
- Where
- China
- Volunteers
- 139 people
- Sponsor
- Fudan University