Clinical trials: Preconditioning, open to volunteers
Diffuse Large B Cell Lymphoma
Selinexor Combined With BEAM for ASCT in R/R DLBCL With MYC Positive
To evaluate the efficacy and safety of selinexor combined with BEAM pretreatment regimen in ASCT of recurrent and refractory DLBCL patients with immunohistochemical positive for MYC
- Trial name
- NCT06652139
- Testing
- selinexor combined with BEAM regimen, BEAM regimen
- Volunteers
- 82 people
- Sponsor
- Ruijin Hospital
Moya Moya Disease, Moyamoya Syndrome
Efficacy and Safety of Ischemic Preconditioning Therapy Versus Optimal Medical Therapy in Reducing the Recurrence of Ischemic Events in Symptomatic Moyamoya Disease
This clinical trial aims to investigate whether remote ischemic conditioning (RIC) can reduce the risk of cerebral ischemic events, delay clinical progression, and improve long-term outcomes in patients with symptomatic Moyamoya…
- Trial name
- NCT07889531
- Testing
- Standard Remote Ischemic Preconditioning
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Beijing Tiantan Hospital
Hemodialysis, Ischemia Preconditioning
Assessment of the Impact of Repeated Ischemic Preconditioning Episodes on Hemodynamic and Metabolic Parameters in Patients at Various Stages of Chronic Kidney Disease
The aim of our study is to evaluate the impact of repeated episodes of ischemic quenching on changes in blood pressure, heart rate and laboratory parameters of inflammation in patients with kidney diseases.
- Conditions
- Hemodialysis, Ischemia Preconditioning, Chronic Kidney Disease, Blood Pressure Disorders
- Trial name
- NCT07746102
- Testing
- Preconditioning with control ischemic episodes
- Where
- 2 sites in Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Cardiopulmonary Bypass, Cardiovascular Diseases
Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg.
- Conditions
- Cardiopulmonary Bypass, Cardiovascular Diseases, Inflammatory Response During Cardiac Surgery
- Trial name
- PANDA (NCT06707350)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Hemodialysis, Cardioprotection
Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury
The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment.
- Trial name
- NCT06735378
- Testing
- Intradialytic Cycling
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Disease
Long-term Remote Ischemic Preconditioning Improves Myocardial Perfusion and Prognosis of Patients After CABG
Remote Ischemic preconditioning (RIPC) has been reported to improve myocardial microcirculation, promote collateral circulation recruitment, and improve myocardial perfusion in patients.Two large randomized controlled trials…
- Trial name
- L-RIPC-CABG (NCT04779008)
- Testing
- remote ischemic preconditioning （RIPC）
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Acute Kidney Injury, Heart Failure
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
This is a prospective, double-blind, sham-controlled, multicenter, randomized clinical trial is to study the effects of remote ischemic preconditioning on contrast-associated acute kidney injury, functional capacity, and major…
- Conditions
- Acute Kidney Injury, Heart Failure, Contrast Induced Nephropathy, Coronary Angiography
- Trial name
- RICH (NCT04982419)
- Testing
- Remote ischemic preconditioning
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Esophageal Malignant Neoplasm Primary, Anastomotic Leak
Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak
The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an…
- Trial name
- NCT07449208
- Testing
- Esophagectomy
- Where
- 7 sites in United States
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Unresectable Metastatic Colorectal Cancer
Study of Pembrolizumab Treatment After CYAD-101 With FOLFOX Preconditioning in Metastatic Colorectal Cancer
The purpose of the CYAD-101-002 study is to assess the safety and clinical activity of CYAD-101 in patients with unresectable metastatic colorectal cancer administered concurrently with FOLFOX chemotherapy, followed by…
- Trial name
- NCT04991948
- Testing
- CYAD-101, FOLFOX, Pembrolizumab
- Where
- 5 sites in United States, Belgium
- Volunteers
- 34 people
- Sponsor
- Celyad Oncology SA
Obstructive Sleep Apnea, Vascular Aneurysm
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure.
- Conditions
- Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury
- Trial name
- NCT04630535
- Testing
- aorto-bifemoral bypass surgery
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Aneurysmal Subarachnoid Hemorrhage
Prevention of Ischemia in Aneurysmal Subarachnoid Hemorrhage Through Remote Ischemic Preconditioning
Aneurysmal subarachnoid hemorrhage (SAH) is a severe form of stroke caused by bleeding around the brain. Despite early treatment of the initial hemorrhage, many patients develop delayed cerebral ischemia several days later, which…
- Trial name
- HMA (NCT07761520)
- Testing
- Remote Ischemic Preconditioning
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Mild Cognitive Impairment, Memory Impairment
IHT for Mild Cognitive Impairment
This phase I clinical trial will examine the safety and efficacy of intermittent hypoxia training (IHT) for up to 12 weeks to treat subjects with mild cognitive impairment (MCI).
- Trial name
- NCT05495087
- Testing
- IHT Treatment
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of North Texas Health Science Center
Romberg Disease, Craniofacial Microsomia
Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting…
- Conditions
- Romberg Disease, Craniofacial Microsomia, Burn Scar, Post-Traumatic Scar (Disorder)
- Trial name
- NCT05610878
- Testing
- Cultured ASCs enrichment fat grafting, Curcumin-preconditioned ASCs enrichment fat grafting, Conventional fat grafting
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- University of the Punjab
Low Back Pain, Knee Osteoarthritis
Ischemic Preconditioning in Osteoarthritis and Back Pain
We are examining the use of restricted blood flow, through full occlusion, on a single thigh for 50 minutes (5 minutes on, 5 minutes off), completed every other day for 2 weeks to improve function in individuals with knee…
- Trial name
- NCT07003113
- Testing
- Ischemic Preconditioning
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Illinois Chicago
DLBCL
Zanubrutinib Combined With BEAM for ASCT in Relapsed and Refractory DLBCL
This trial is a prospective, single-center, randomized controlled clinical research. The intention is to evaluate the efficacy and safety of zanubrutinib combined with BEAM as a pretreatment regimen for ASCT in relapsed and…
- Trial name
- NCT06652165
- Testing
- zanubrutinib combined with BEAM, BEAM
- Volunteers
- 66 people
- Sponsor
- Ruijin Hospital
Contrast-induced Acute Kidney Injury (CI-AKI) Following Coronary Angiogram (CI-AKI), Contrast-induced Nephropathy Following Coronary Angiogram (CIN)
Effectiveness of Remote Ischemic Preconditioning for Prevention of Contrast Induced Acute Kidney Injury in Patients Undergoing Coronary Angiograms.
The use of imaging is increasing in clinical practice, either for diagnosis or intervention. In these imaging processes, contrast medium (CM) is widely used.
- Trial name
- RIP-CI-AKI (NCT05147831)
- Testing
- Remote Ischemic Preconditioning
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The University of Texas Medical Branch, Galveston
NK T-Cell Lymphoma
Preconditioning With a Combination of Thiotepa, Cyclophosphamide, and Busulfan for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of NK/T-Cell Lymphoma
Evaluation of the efficacy and safety of Thiotepa combined with Cyclophosphamide and Busulfan as conditioning regimen before allo-HSCT for the treatment of NK/T cell lymphoma
- Trial name
- NCT07276737
- Testing
- Thiotepa
- Volunteers
- 37 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Osteoarthritis, Hip, Cardiovascular Diseases
Effects of Remote Ischaemic Preconditioning in Cemented Hip Arthroplasty.
Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis. Cemented hip arthroplasty is mainly indicated for elderly patients with poor bone quality and multiple comorbidities.
- Conditions
- Osteoarthritis, Hip, Cardiovascular Diseases, Bone Cement Implantation Syndrome, Kidney Diseases
- Trial name
- PRINCIPAL (NCT06323018)
- Testing
- Remote Ischemic Preconditioning
- Where
- Estonia
- Volunteers
- 200 people
- Sponsor
- University of Tartu
DLBCL
Pirtobrutinib Combined With BEAM for ASCT in Relapsed and Refractory DLBCL
This trial is a prospective, multi-center, single-arm clinical research. The intention is to evaluate the efficacy and safety of pirtobrutinib combined with BEAM as a pretreatment regimen for ASCT in relapsed and refractory DLBCL…
- Trial name
- NCT07774299
- Testing
- pirtobrutinib combined with BEAM
- Volunteers
- 28 people
- Sponsor
- Ruijin Hospital
Submucosal Tumor of Gastrointestinal Tract, Gastrointestinal Stromal Tumor (GIST)
Mesenteric Vascular Preconditioning Combined With Laparoscopic and Endoscopic Cooperative Surgery for Submucosal Tumor at the Gastroesophageal Junction
This study is a single-center, prospective, single-arm, exploratory clinical study (phase II exploratory trial). No parallel control group was established in the study, and all subjects who met the inclusion criteria underwent a…
- Trial name
- SAVE-GEJ (NCT07550582)
- Testing
- laparoscopic and endoscopic cooperative surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital