Clinical trials: Prediabetes
Pre-diabetes
Reducing Risk of Type 2 Diabetes: Hydroxychloroquine Use in Pre-Diabetes
The purpose of this study is to determine the short-term effects of the antimalarial medication, hydroxychloroquine (HCQ), compared with placebo using frequently sampled intravenous glucose tolerance testing (FSIGTT) methodology…
- Trial name
- NCT01326533
- Testing
- hydroxychloroquine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Heart Diseases, Diabetes Mellitus, Type 2
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
This single-arm trial of the Cardiovascular Risk Reduction Among People Experiencing Homelessness (CV-Homes) intervention alone (n=8) will test the perception and feasibility of anticipated study procedures.
- Conditions
- Heart Diseases, Diabetes Mellitus, Type 2, Pre-diabetes, Hypertension
- Trial name
- CV-Homes (NCT06025721)
- Testing
- Cardiovascular Risk Homeless Support
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Katherine Vickery
Obesity, Impaired Glucose Tolerance
Effects of Rosiglitazone on the Metabolic Phenotype of Impaired Glucose Tolerance in Youth
The purpose of the study is to determine whether treatment of children and adolescents with Impaired Glucose Tolerance (IGT) with rosiglitazone will lead to improvements in insulin sensitivity and glucose tolerance.
- Conditions
- Obesity, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT00413335
- Testing
- Rosiglitazone
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Cystic Fibrosis, Prediabetes
Prevention of Cystic Fibrosis Diabetes
Acute systemic hyperglycemia causes oxidative stress and a pro-inflammatory response. The pro-inflammatory cytokines induced by hyperglycemia are toxic to islet insulin producing cells, and thus worsen glucose intolerance.
- Trial name
- Prevent (NCT00967798)
- Testing
- Sitagliptin
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Impaired Glucose Tolerance
Renin-Angiotensin and Fibrinolysis in Humans: Effect of Long-Term PDE5 Inhibition on Glucose Homeostasis
The purpose of this study is to determine the effect of chronic PDE5 inhibitor therapy on glucose metabolism in persons with prediabetes.
- Trial name
- NCT01409993
- Testing
- Sildenafil, Hyperglycemic clamp, Euglycemic clamp
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Vanderbilt University
Impaired Glucose Tolerance, Type 2 Diabetes
Actos Now for Prevention of Diabetes (ACT NOW)
The purpose of this study is to examine whether pioglitazone versus placebo can reduce the conversion rate of impaired glucose tolerance (IGT) to type 2 diabetes mellitus
- Trial name
- NCT00220961
- Testing
- Pioglitazone
- Where
- 8 sites in United States
- Volunteers
- 602 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes, Pre-Diabetes
Power-Up: An Effectiveness Trial of the Diabetes Prevention Program
The goal of this study is to address the risk of diabetes among men by creating a Diabetes Prevention Program (DPP) tailored to men.
- Trial name
- Power-Up (NCT04104243)
- Testing
- Men-Tailored DPP (Power-Up)
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- Albert Einstein College of Medicine
Elevated Blood Sugar
Power of Choice on Autonomy, Motivation, Exercise Adherence, and Cardiorespiratory Fitness
People with elevated blood sugar levels are at increased risk of developing chronic medical conditions such as obesity, type 2 diabetes, and cardiovascular disease.
- Trial name
- NCT03576924
- Testing
- MICT, HIIT, CHOICE
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Metabolic Syndrome X, Prediabetic State
Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation
The relationship between obesity and insulin resistance is known, however the mechanism(s) associating obesity with insulin resistance is not well understood.
- Trial name
- NCT00470262
- Testing
- Fenofibrate 145mg PO QD, Pioglitazone 45 mg PO QD
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
A diagnosis of gestational diabetes mellitus (GDM)has significant implications for the future health of the mother. GDM is often the culmination of years of unrecognized and unmodified diabetes risk factors that lead to overt and…
- Conditions
- Gestational Diabetes Mellitus, Type 2 Diabetes Mellitus, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT01234649
- Testing
- Metformin XR plus liraglutide
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Woman's
Prediabetes
ForgIng New Paths to Prevent DIabeTes (FINDIT)
This study will evaluate the effects of screening for type 2 diabetes mellitus (T2DM) and brief counseling about screening test results on weight and key health behaviors among Veterans with risk factors for T2DM.
- Trial name
- FINDIT (NCT02747108)
- Testing
- Blood Test Group Intervention, Brochure Group Intervention
- Where
- United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PreDiabetes
MINDD 3: Prediabetes and Delay Discounting
The proposed research will translate research on delay discounting to the prevention of Type 2 diabetes (T2D) in persons with prediabetes.
- Trial name
- MINDD (NCT03664726)
- Testing
- Episodic Future Thinking, Episodic Recent Thinking, Scarcity Narrative
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Leonard Epstein
Pre-diabetic State, Overweight
Feasibility of a Partnered Approach to Prevent Diabetes
The Diabetes Prevention Program (DPP) demonstrated that an intensive lifestyle intervention resulting in modest weight loss and increased physical activity can delay or prevent the development of type 2 diabetes in those at…
- Conditions
- Pre-diabetic State, Overweight, Obesity
- Trial name
- NCT00302055
- Testing
- Clinical referral to diabetes prevention lifestyle, Clinical referral to group diabetes prevention lifestyle
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Northwestern University
Prediabetes
Diabetes Prevention Using SMS Technology
Type 2 diabetes is a major healthcare problem in the developed and developing world. Recent clinical trials have demonstrated that it may be prevented by lifestyle intervention focused on diet and physical activity.
- Trial name
- NCT01795833
- Testing
- Short text messages
- Where
- United Kingdom
- Volunteers
- 2,062 people
- Sponsor
- Imperial College London
Type 2 Diabetes, Healthy
Effect of Pioglitazone and Exenatide on Body Weight and Beta Cell Function
Pioglitazone, a drug used in treatment of type 2 diabetes has been shown to improve insulin sensitivity in skeletal muscle, liver, and fat cells.
- Conditions
- Type 2 Diabetes, Healthy, Impaired Glucose Tolerance
- Trial name
- PIO-EX (NCT00845182)
- Testing
- Pioglitazone, Exenatide, Pioglitazone and Exenatide
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Metabolic Syndrome
The HOMBRE Trial: Comparing Two Innovative Approaches to Reduce Chronic Disease Risk Among Latino Men
The purpose of this study is to test a flexible lifestyle program designed to help Latino men make healthy lifestyle changes to lower their risk of developing diabetes and heart disease.
- Conditions
- Obesity, Metabolic Syndrome, Lifestyle Intervention, Pre Diabetes
- Trial name
- HOMBRE (NCT03092960)
- Testing
- Minimal intensity intervention, HOMBRE
- Where
- United States
- Volunteers
- 424 people
- Sponsor
- Palo Alto Medical Foundation
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
PreDiabetes
Weight Loss for Prediabetes Using Episodic Future Thinking
The goals of the UH3 are to assess the effectiveness of adding Episodic Future Thinking (EFT) to the investigators standard behavioral weight control program to improve weight loss, delay discounting (DD), working memory…
- Trial name
- MINDD4 (NCT03670602)
- Testing
- Episodic Future Thinking, Daily Check in
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Endocrine System Diseases
Soluble Epoxide Hydrolase Inhibition and Insulin Resistance
The purpose of this study is to test how soluble epoxide hydrolase (sEH) inhibition with GSK2256294 affects tissue sEH activity and insulin sensitivity.
- Conditions
- Diabetes Mellitus, Endocrine System Diseases, Glucose Metabolism Disorders, PreDiabetes
- Trial name
- NCT03486223
- Testing
- GSK2256294
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cystic Fibrosis Related Diabetes, Pancreatic Insufficiency
Pilot and Feasibility Study for the Treatment of Pre-diabetes in Patients With Cystic Fibrosis
The purpose of this study is to provide the necessary data and experience to design a larger, full scale clinical trial to determine if a certain medicine (repaglinide), which increases the amount of insulin secreted by the…
- Trial name
- NCT00763412
- Testing
- repaglinide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Arbelaez, Ana Maria