Clinical trials: Prediabetes / Type 2 Diabetes
Diabetes Mellitus, Type 2
Long-term Study of Nateglinide+Valsartan to Prevent or Delay Type II Diabetes Mellitus and Cardiovascular Complications
This study is a test of the safety and effectiveness of two drugs, one for diabetes and one for hypertension, in keeping patients with high lab values of glucose from progressing to frank diabetes and developing cardiovascular…
- Trial name
- Navigator (NCT00097786)
- Testing
- Valsartan 160 mg + nateglinide 60 mg
- Where
- 38 sites in United States, Argentina and 36 more
- Volunteers
- 9,306 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes
Lifestyle Control of Postprandial Hyperglycemia
Large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. Low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes…
- Trial name
- NCT02683135
- Testing
- High-carbohydrate diet, Low-carbohydrate diet, Low-carbohydrate diet with post-meal walking
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of British Columbia
Type 2 Diabetes, Glucose Tolerance Impaired
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM
With REMD's glucagon receptor antagonist, the study team propose to provide a comprehensive examination of the effect of elevated plasma glucagon concentrations in Type 2 Diabetes Mellitus (T2D) patients on: (i) glucose…
- Conditions
- Type 2 Diabetes, Glucose Tolerance Impaired, Insulin Sensitivity
- Trial name
- NCT05093517
- Testing
- REMD-477
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes, PreDiabetes
Evaluating a Type 2 Diabetes Prevention Program
This study aims to test the effectiveness of a Type 2 Diabetes (T2D) prevention program for individuals who have been diagnosed with prediabetes compared to a T2D educational control group.
- Trial name
- NCT05822648
- Testing
- Project Health, Educational Video Control
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Stanford University
Prediabetes
Effects of Yoghurt Consumption on Glucose Metabolism in Prediabetic Subjects
The purpose of this study is to explore the effects of yoghurt consumption on glucose metabolism in prediabetic subjects.
- Trial name
- SNOWFALL (NCT06836752)
- Testing
- Yoghurt, Milk
- Where
- France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Type 2 Diabetes Mellitus (T2DM), Cognitive Function
Prediabetes and Type 2 Diabetes in Aging
This case-control study will evaluate the effects of geriatric individuals on cognitive status, physical function and fatigue. Our study aims to compare the effects of geriatric individuals with prediabetes and type 2 diabetes…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cognitive Function, Dual Task, Fatigue
- Trial name
- NCT06953609
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Uşak University
Diabetes Mellitus, Type 2, PreDiabetes
iCan Diabetes Self-management and Prevention Program
The purpose of this study is to test the feasibility and preliminary efficacy of the iCan Diabetes Self-Management and Prevention Support Group using a single arm clinical trial.
- Trial name
- NCT05571436
- Testing
- iCan Diabetes Self-management and Prevention Support Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Type 2 Diabetes Mellitus, Hypercholesterolemia
Effects of Metformin Hydrochloride (HCl) in Combination With Colesevelam HCl, Compared to Metformin HCl Alone, in Patients With Type 2 Diabetes Mellitus and the Effects of Colesevelam HCl on Lipids and Glucose on Pre-diabetic Patients.
This is a 16-week double-blind, placebo-controlled (for colesevelam hydrochloride (HCl)) study in the type 2 diabetic subjects and pre-diabetic subjects.
- Conditions
- Type 2 Diabetes Mellitus, Hypercholesterolemia, Pre-diabetes
- Trial name
- NCT00570739
- Testing
- Metformin HCl tablets and Colesevelam tablets, Colesevelam
- Where
- 31 sites in United States, Colombia and 2 more
- Volunteers
- 502 people
- Sponsor
- Daiichi Sankyo
Diabetes
Relation of White Blood Cell Function to Diabetes
Background: Patients who are pre-diabetic or have adult onset (type 2) diabetes have a significantly greater risk of developing heart, blood vessel, or kidney diseases.
- Trial name
- NCT00570154
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Truway Diagnostic Tools in Primary Care
This study evaluates the effectiveness of Truway Health-sourced portable diagnostic devices, including ultrasound and blood glucose monitors, in early detection of chronic conditions in outpatient primary care settings.
- Conditions
- Chronic Disease, Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight, Hypertension, Cardiovascular Disease Acute
- Trial name
- TruDxPC (NCT07209527)
- Testing
- Truway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Truway Health, Inc.
NAFLD, Diabetes Mellitus, Type 2
Liver Fat as a Dietary Target for Treating Cardiometabolic Disorders in Prediabetes and Type 2 Diabetes
The overall aim of this study is to investigate the long-term impact of a customized diet aimed at reducing liver fat specifically and a healthy Nordic diet on ectopic fat (liver, pancreatic and visceral) and cardiometabolic risk…
- Conditions
- NAFLD, Diabetes Mellitus, Type 2, PreDiabetes
- Trial name
- NAFLDiet (NCT04527965)
- Testing
- Customized diet to reduce liver fat, Healthy Nordic diet, Control
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Uppsala University
Oxidative Stress
Vitamin E or Lipoic Acid on Serum Oxyphytosterol Concentrations
Background of the study: We now know that plant sterols can oxidize, which results in the formation of oxyphytosterols. Animal studies have suggested that oxyphytosterols are atherogenic components, however this relation has not…
- Trial name
- NCT01984567
- Testing
- Vitamin E, Lipoic acid, Control
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Glucose Intolerance
Effects of Vitamin D on Beta Cell Function and Insulin Sensitivity in Pre-diabetes and Diabetes Mellitus Type 2
The purpose of this study is to evaluate if treatment with vitamin D increase beta cell function and insulin sensitivity in subjects with pre-diabetes or newly diagnosed diabetes mellitus type 2.
- Conditions
- Diabetes Mellitus, Type 2, Glucose Intolerance, Vitamin D Deficiency
- Trial name
- EVIDENS (NCT01497132)
- Testing
- Vitamin D3
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, PreDiabetes
Effect of Low-Calorie Diet and Lifestyle Intervention on Reversal of T2DM
An increase in body fat, even when within the normal BMI range is one of the essential drivers of T2DM in Asian Indians. In this context, the relationship between excess hepatic fat and pancreatic fat appears to be necessary.
- Conditions
- Diabetes Mellitus, PreDiabetes, Diet Habit
- Trial name
- CURE-DM (NCT05925946)
- Testing
- CURE-DM
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Diabetes
The Effect of Korean Red Ginseng Supplementation on Glucose Control
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effect of Korean red ginseng supplementation on glucose control in subjects with impaired fasting glucose, impaired glucose…
- Trial name
- NCT01911663
- Testing
- KRG
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Peanuts for Cardiometabolic, Brain, and Intestinal Health
The overall objective of this 14-month randomized crossover study is to seek evidence demonstrating that daily consumption of peanuts and peanut products improve cardiometabolic, cognitive, and intestinal health in a racially…
- Conditions
- Prediabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Cognition, Microvascular Function
- Trial name
- NCT06867198
- Testing
- Peanuts
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Georgia State University
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Adolescent Obesity, Pre Diabetes
- Trial name
- NCT05008276
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Petter Bjornstad
Diabetes, Prediabetes
The Effect of Maximum Body Weight in Lifetime on the Development of Type 2 Diabetes
Hypothesis : The maximum body weight in lifetime is associated with the onset of development of type 2 diabetes.
- Trial name
- MAXWEL (NCT00816608)
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Seoul National University Bundang Hospital
Diabetes Mellitus, Type 2
Screening for Undiagnosed Type 2 Diabetes in New Classes of Subjects at High Risk
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and…
- Trial name
- NCT00520962
- Where
- Italy
- Volunteers
- 1,997 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Impaired Glucose Tolerance, Diabetes Mellitus, Type 2
The Interaction Between Metformin and Physical Training
Physical activity is a first line treatment for patients with type 2 diabetes (T2D), however, the vast majority of patients with T2D do not achieve satisfying glycemic control with physical activity alone, which is why…
- Trial name
- NCT03316690
- Testing
- Metformin treatment, Physical training
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kristian Karstoft