Clinical trials: Prediabetes or Diabetes
Diabetes Mellitus, Type 2, Insulin Resistance
The Acute T-Rex (Timing of Resistance Exercise) Study
The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Glucose Intolerance, Sleep Disturbance
- Trial name
- NCT06366399
- Testing
- Resistance Exercise Timing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Obesity
Effect of a Very Low-Calorie Ketogenic Diet on Gut Microbiota and Fat Distribution
Short-term interventions that use very low-calorie ketogenic diets and meal replacements may be prescribed for selected overweight or obese patients with type 2 diabetes or prediabetes.
- Trial name
- NCT04019431
- Testing
- Whey protein, vegetable protein or animal protein
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
Type II Diabetes Mellitus
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes
Polyphenols belong to the largest group of secondary metabolites produced by plants, mainly, in response to biotic or abiotic stresses such as infections, wounding, UV irradiation, exposure to ozone, pollutants, and other hostile…
- Trial name
- NCT01076829
- Testing
- Spice polyphenols
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetes Mellitus, Prediabetic State
Effect of Pravastatin in the Subjects With Prediabetes or Early Diabetes
An increased risk of incident diabetes with statin therapy have been reported in several studies. However, it is not recommended to limit the use of statin for this reason since the absolute risk increase was small, and the…
- Trial name
- NCT02754739
- Testing
- Pravastatin, Nutritional education only
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
Diabetes Mellitus, Non-Insulin-Dependent
The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention)
The primary objectives of the ORIGIN study were: To determine whether insulin glargine-mediated normoglycemia can reduce cardiovascular morbidity and/or mortality in people at high risk for vascular disease with either Impaired…
- Trial name
- ORIGIN (NCT00069784)
- Testing
- insulin glargine (HOE901), omega-3 polyunsaturated fatty acids (PUFA), reusable pen device for insulin injection
- Where
- 40 sites in United States, Argentina and 38 more
- Volunteers
- 12,537 people
- Sponsor
- Sanofi
Congestive Heart Failure
Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes
This study will evaluate the safety and effectiveness of the drug rosiglitazone for improving heart function in patients with heart failure and glucose intolerance or type II (adult-onset) diabetes, or both.
- Trial name
- NCT00064727
- Testing
- Avandia (Rosiglitazone), Avanclia (Rosiqlitazone)
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder
The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body…
- Conditions
- Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators, Cardiometabolic Risk Factors, Metabolic Syndrome
- Trial name
- ROACH (NCT07804680)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Insulin Resistance, Insulin Sensitivity
Fructose: Substrate, Stimulus, or Both?
This objective of this study is to use sensitive methodology under controlled conditions to investigate the mechanisms by which fructose consumption contributes to excess fatty acid synthesis and elevations in blood glucose…
- Conditions
- Insulin Resistance, Insulin Sensitivity, Pre Diabetes
- Trial name
- NCT04168372
- Testing
- High fructose, fructose labeled meal, High fructose, pyruvate labeled meal, Low fructose, fructose labeled meal
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Diabetes Mellitus, Impaired Glucose Tolerance
Skin Autofluorescence (AF) Decision Tree in Detecting Impaired Glucose Tolerance (IGT) or Diabetes Mellitus (DM)
Early detection of (pre)diabetes, including impaired glucose tolerance is currently deficient because the best accepted standard, an oral glucose tolerance test (oGTT), is not feasible in a setting of screening or broad…
- Trial name
- NCT01406665
- Where
- 2 sites in Netherlands
- Volunteers
- 218 people
- Sponsor
- University Medical Center Groningen
Prediabetes, Normal Plasma Glucose
The Effects of Nextida-GC and Whey Protein on Postprandial Glycemic and Insulinemic Responses When Given 30min Before, 10min Before or With a Standardized Breakfast Test-meal in Healthy Adults With and Without Prediabetes
The goals of this clinical trial are to learn if Nextida-GC (a peptide derived from collagen) will reduce postprandial glucose responses when taken 30 minutes before, 10 minutes before or with the first bite of a breakfast…
- Conditions
- Prediabetes, Normal Plasma Glucose, Normoglycemia
- Trial name
- NCT07174323
- Testing
- Peptide derived from collagen protein, Whey protein isolate
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- INQUIS Clinical Research
Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Lipid and Glycogen Metabolism in Patients With Impaired Glucose Tolerance and Calcium Sensing Receptor Mutations
Background: Type 2 diabetes mellitus is a main risk factor for cardiovascular disease and heart failure, in part due to diabetic cardiomyopathy.
- Conditions
- Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Familiar Hypocalcuric Hypercalcemia, Healthy Volunteers
- Trial name
- RISC_7T (NCT02023489)
- Testing
- 1H/ 13C and 31P Magnetic Resonance Spectroscopy, Meal Tolerance Test, Hyperglycemic-hyperinsulinemic clamp
- Where
- Austria
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Impaired Glucose Tolerance
Additional Glucose Lowering and Anti-Inflammatory Effects by Acarbose and Alcohol in Subjects With Impaired Glucose Tolerance or Mild Type 2 Diabetes
To understand if acarbose, an alpha-glucosidase inhibitor usually for treating diabetes, will further lower post meal glucose and inflammatory state when taking together with moderate amount of alcohol during meal tolerance test…
- Trial name
- NCT00417950
- Testing
- Acarbose
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taichung Veterans General Hospital
Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy
Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes
The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation
- Trial name
- NCT06548828
- Testing
- NNS Restriction Intervention, Control Intervention
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- George Washington University
Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities, Overweight (BMI > 25)
AIM-WEIGHT: AI-Guided Microbiome-Targeted Nutritional Intervention for Weight Loss
AIM-WEIGHT is a clinical study evaluating whether a fixed microbiome-targeted nutritional supplement can support weight loss in adults with overweight or obesity who do not have prediabetes or diabetes.
- Trial name
- AIM-WEIGHT (NCT07736547)
- Testing
- AI-Guided Microbiome-Targeted Nutritional Supplement, Lifestyle counselling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Varol TUNALI
Diabetes, Hypertension
Mobile Phone-based Intervention for Promoting Healthy Habits and Weight Loss
A self administered 16 weeks plus follow up study to explore the efficacy of mobile phone driven apps for stress reduction coupled with guidance for healthy living among obese and overweight populations.
- Conditions
- Diabetes, Hypertension, Pre-diabetes, Overweight
- Trial name
- NCT02621008
- Testing
- Stress Reduction& Healthy living
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Eco Fusion
Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus
Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 Diabetes
This is a multicentre, prospective, observational study of the medicine tirzepatide as it is used in routine clinical care in Pakistan.
- Conditions
- Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
- Trial name
- TRIBUTE-PK (NCT07809568)
- Where
- 9 sites in Pakistan
- Volunteers
- 330 people
- Sponsor
- Universiti Sains Malaysia
Prediabetes
Effects of a Mediterranean Diet With Sequential Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes or Prediabetes Remission
The goal of this clinical trial is to learn how a Mediterranean-style diet, with and without added exercise, affects blood sugar control in women with prediabetes.
- Trial name
- NCT07326891
- Testing
- Mediterranean Diet, Supervised Sequential Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Begüm Yücesoy Güneysu
Prediabetes, Hyperglycemia
β-alanine Supplementation in Adults With Overweight/Obesity
The study will investigate the safety, feasibility, and efficacy of beta-alanine supplementation in adults with overweight or obesity.
- Conditions
- Prediabetes, Hyperglycemia, Overweight or Obesity
- Trial name
- BASA-O (NCT05329610)
- Testing
- Beta-alanine
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nottingham Trent University
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Type 2 Diabetes, Prediabetes
Seum Bile Acid Profile in Type 2 Diabetes and Association Between Bile Cid Profile and Adipokine or Oxidative Stress
"The goal of this work is to critically test the hypothesis that there exists a different profile of bile acids (BAs) in patient with type 2 diabetes mellitus (T2DM) compared with normal controls.
- Conditions
- Type 2 Diabetes, Prediabetes, Non-alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02650830
- Where
- South Korea
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Yonsei University