Clinical trials: Prediabetes or Overweight
Arterial Stiffness, Dietary Modification
Egg Protein Hydrolysate and Vascular Function
The incidence of type 2 diabetes mellitus (T2DM) is rapidly growing. Patients with T2DM are at increased risk of developing long term micro- and macrovascular complications.
- Conditions
- Arterial Stiffness, Dietary Modification, Impaired Glucose Tolerance, Type 2 Diabetes Mellitus
- Trial name
- NCT01559896
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Overweight or Obesity, Pregnancy
DPP Feasibility Study of Breastfeeding - eMOMS 2.0
The purpose of this study is to investigate the impact of a comprehensive intervention that combines breastfeeding support with a diabetes prevention-based program (DPP) on postpartum weight retention and lactation duration among…
- Trial name
- NCT06372860
- Testing
- Diabetes Prevention Program, Breastfeeding, Usual Care
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Kansas Medical Center
PreDiabetes, Pre Diabetes
STAR Study Investigating Performance and Safety of the Medical Device SiPore15™
The primary objective of STAR01 is to evaluate the performance and safety of the medical device (class IIb) SiPore15™ after a 12-week long treatment in the target population of obese and overweight subjects with prediabetes or…
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State, Type2 Diabetes
- Trial name
- NCT03823027
- Testing
- SiPore15™
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 43 people
- Sponsor
- Sigrid Therapeutics AB
Prediabetes, Hyperglycemia
β-alanine Supplementation in Adults With Overweight/Obesity
The study will investigate the safety, feasibility, and efficacy of beta-alanine supplementation in adults with overweight or obesity.
- Conditions
- Prediabetes, Hyperglycemia, Overweight or Obesity
- Trial name
- BASA-O (NCT05329610)
- Testing
- Beta-alanine
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nottingham Trent University
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities
The main purpose of this phase 3b study is to evaluate the efficacy and safety of tirzepatide compared with semaglutide in adult participants who have obesity or overweight with weight related comorbidities without Type 2…
- Trial name
- SURMOUNT-5 (NCT05822830)
- Testing
- Tirzepatide, Semaglutide
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 751 people
- Sponsor
- Eli Lilly and Company
Obesity, Pregnancy in Diabetic
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
The obesity epidemic is growing worldwide and in the UK this is perpetuated with a third of women classified as overweight/obese in 2020.
- Conditions
- Obesity, Pregnancy in Diabetic, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05753124
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Obesity, Overweight
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss
This was a study of tirzepatide in participants with obesity or overweight. The main purpose was to learn more about how tirzepatide maintained body weight loss.
- Trial name
- SURMOUNT-4 (NCT04660643)
- Testing
- Tirzepatide
- Where
- 70 sites in United States, Argentina and 3 more
- Volunteers
- 783 people
- Sponsor
- Eli Lilly and Company
Prediabetes or Overweight
Whole Food Fibers for Support of Key Gut Bacteria for Human Health
The purpose of this supplementation study is to understand how whole food fibers may affect gut microbiota composition and overall health. The investigators will enroll up to 24 people in this study.
- Trial name
- NCT07840170
- Testing
- Whole food fiber mixture, inulin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Purdue University
Overweight or Obesity, Prediabetes or Diabetes
Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women
The purpose of this study is to collect preliminary data on the feasibility, acceptability, and potential effects of a novel, remotely delivered resistance training program.
- Conditions
- Overweight or Obesity, Prediabetes or Diabetes, Prehypertension (Elevated Blood Pressure) or Hypertension, Resistance Training
- Trial name
- OVERCOME-IT (NCT06360536)
- Testing
- Resistance Training
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Alabama at Birmingham
Glucose Intolerance, Hyperinsulinemia
Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 Diabetes
This study is for women who have already decided to undergo liposuction at Georgetown University Medical Center in Washington, D.C.
- Conditions
- Glucose Intolerance, Hyperinsulinemia, Diabetes Mellitus, Non Insulin Dependent, Obesity
- Trial name
- NCT00005760
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Continuous Glucose Monitoring, Prediabetic State
Effect of Real-time Continuous Glucose Monitoring System in Overweight or Obese Adults With Prediabetes
In Korea, 5 million adults aged 30 years or older have diabetes. The development and expansion of Korea's economy and society, has led to dramatic chances in people's lifestyle and diet habits, and an increase in life expectancy.
- Conditions
- Continuous Glucose Monitoring, Prediabetic State, Obesity
- Trial name
- NCT04099550
- Testing
- RT-CGM, SMBG
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetes
This trial is conducted in Africa, Asia, Europe, Oceania, North America and South America. The aim of this clinical trial is to evaluate the potential of liraglutide to induce and maintain weight loss over 56 weeks in obese…
- Trial name
- NCT01272219
- Testing
- liraglutide
- Where
- 226 sites in United States, Argentina and 27 more
- Volunteers
- 3,731 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2, Overweight and Obesity
Effect of a Low-calorie and High-protein Diet Specially Rich in Animal Protein Compared to a Low-calorie and High-protein Diet Specially Rich in Plant Protein on Glucose Metabolism in Subjects With Prediabetes or Type 2 Diabetes and Overweight or Obesity.
The aim of the study is to explore the effect of a low-calorie diet rich in protein (with a content of 35% of the total calories of the diet), mostly coming from animal sources (75% of total protein), compared to a hypocaloric…
- Conditions
- Diabetes Mellitus, Type 2, Overweight and Obesity, PreDiabetes
- Trial name
- NCT05456347
- Testing
- Low-calorie and high-protein diet with the majority of protein coming from animal sources., Low-calorie and high-protein diet with the majority of protein coming from plant sources.
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad de Zaragoza
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Overweight and Obesity, PreDiabetes
Effects of Gelesis200 on Appetite Parameters, Food Intake, and Glycemic Control in Overweight or Obese Prediabetic Subjects: A Sub-Study of LIGHT-UP
This study evaluates the effects of Gelesis200 on Appetite Parameters, Food Intake, and Glycemic Control in Overweight or Obese Prediabetic Subjects: A Sub-Study of LIGHT-UP.
- Conditions
- Overweight and Obesity, PreDiabetes, Type2 Diabetes
- Trial name
- MATCH (NCT03622424)
- Testing
- Gelesis200
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Gelesis, Inc.
Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus
Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 Diabetes
This is a multicentre, prospective, observational study of the medicine tirzepatide as it is used in routine clinical care in Pakistan.
- Conditions
- Prediabetes or Overweight, Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
- Trial name
- TRIBUTE-PK (NCT07809568)
- Where
- 9 sites in Pakistan
- Volunteers
- 330 people
- Sponsor
- Universiti Sains Malaysia
Over Age 60, Prediabetes or Overweight
Curcumin Supplementation for the Improvement of Diabetes-related Outcomes
The goal of this clinical trial is to learn about, test, and compare health outcomes of curcumin supplementation (400 mg). Two primary hypotheses are: 1.
- Trial name
- CUR-T2D (NCT06984640)
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Metabolic Syndrome, Overweight or Obesity
Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome
The main purpose of the clinical trial is to determine the health impact of a dietary intervention known as time-restricted eating (TRE) in patients with metabolic syndrome (defined as the presence of elevated fasting plasma…
- Conditions
- Metabolic Syndrome, Overweight or Obesity, PreDiabetes, Weight Loss
- Trial name
- TREMNIOS (NCT04328233)
- Testing
- Time-Restricted Eating
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- Nicolaus Copernicus University
Prediabetes, Type 2 Diabetes
Effect of Totum-63, Active Ingredient of Valedia, on Glucose and Lipid Homeostasis on Subjects With Prediabetes
Given the data on the active ingredients of Totum-63, this research aims to evaluate the effect of its chronic consumption (24 weeks) on glucose and lipid homeostasis and especially on fasting plasma glucose in volunteers with…
- Conditions
- Prediabetes, Type 2 Diabetes, Hypertriglyceridemia, Obesity
- Trial name
- TOTUM-63 TWO (NCT02868177)
- Testing
- Totum-63
- Where
- 6 sites in France, Ireland and 2 more
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Sleep Apnea, PreDiabetes
Technology-Supported Treatment of Sleep Apnea in Prediabetes
Despite the efficacy of intensive lifestyle interventions in prediabetes, the incidence of diabetes is rising, and thus there is a critical need for additional strategies to prevent diabetes and to reduce its cardiovascular…
- Conditions
- Sleep Apnea, PreDiabetes, Overweight or Obesity
- Trial name
- TECH (NCT04225507)
- Testing
- Diet and exercise coaching, CPAP Treatment
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Chicago