Clinical trials: Prediction Model
Colon Cancer, Model Disease
BMA and Dynamic Nomogram for Survival Prediction in Patients With CRC
This project will examine the outstanding statistical techniques for predicting the survival of patients with colorectal cancer (CRC) (colorectal neoplasia database).
- Trial name
- NCT06268379
- Testing
- Surgery
- Where
- Australia
- Volunteers
- 2,475 people
- Sponsor
- Cabrini Health
Clear Renal Cell Cancer (< 7cm Size)
Development and Evaluation of High Risk Group Prediction Model in T1 Stage Renal Cell Cancer Using Molecular Biomarkers
For the appropriate individualized treatment of T1-stage renal cell carcinoma with heterogeneous biological features, the expression of PBRM1, SETD2, BAP1, KDM5C and the newly proposed FOXC2 and CLIP4, are compared with clinical…
- Trial name
- NCT03694912
- Testing
- Partial or radical nephrectomy
- Where
- South Korea
- Volunteers
- 426 people
- Sponsor
- Yonsei University
HCC - Hepatocellular Carcinoma, Microvascular Invasion (MVI)
Microvascular Invasion Artificial Intelligence Prediction Via Contrast-enhanced Ultrasound With Explainability
An artificial intelligence (AI) model to predict MVI of HCC using contrast-enhanced ultrasound was constructed. This model also has biological explainability.
- Trial name
- MAPUSE (NCT06760494)
- Testing
- the MAPUSE model
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Chinese PLA General Hospital
Lung Adenocarcinoma
Radiomics-based Prediction Model of Tumor Spread Through Air Space in Lung Adenocarcinoma
Spread through air space (STAS) has been reported as a negative prognostic factor in patients with lung cancer undergone sublobar resection. Its preoperative assessment could thus be useful to customize surgical treatment.
- Trial name
- NCT04893200
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Non-Small Cell Lung Cancer, Brain Metastases
Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis
This retrospective multicenter observational study aims to develop and externally validate a noninvasive deep learning model based on routine brain MRI to identify actionable driver alterations in patients with non-small cell…
- Trial name
- DL-DriverBM (NCT07373951)
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Ming Yang
Liver Transplant Disorder, Liver Cancer
Deep Learning Model for the Prediction of Post-LT HCC Recurrence
Identifying patients at high risk for recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) represents a challenging issue.
- Conditions
- Liver Transplant Disorder, Liver Cancer, Recurrent Cancer
- Trial name
- TRAIN-AI (NCT05200195)
- Testing
- Liver transplantation
- Where
- Italy
- Volunteers
- 4,026 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
Severe Infection
Validation of the Quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) in Obstetric Patients
Research problem: In 1991, the terms Systemic Inflammatory Response Syndrome (SIRS), severe sepsis, and septic shock were introduced, based on the pro-inflammatory theory, conforming to a list of classification criteria for each…
- Trial name
- COLOSSAL (NCT04621539)
- Where
- Colombia
- Volunteers
- 2,125 people
- Sponsor
- Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia
Diabete Mellitus
Prediction Model for the Risk of Developing Foot Ulcers in Diabetes
Introduction Foot ulcers in diabetes mellitus (DM) are a common and serious complication that can lead to infection, amputation, and increased mortality.
- Trial name
- NCT07307183
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Sahlgrenska University Hospital
Pregnancy Complications, Delivery Complications
CoPPer Study - Complications of Polycystic Ovary Syndrome (PCOS) Pregnancy: Evaluating Risk
The CoPPer study is a follow-up study of women diagnosed with Polycystic Ovary Syndrome (PCOS). Women will be included pre-conceptional and followed-up until after delivery.
- Conditions
- Pregnancy Complications, Delivery Complications, Neonatal Complications
- Trial name
- CoPPer (NCT00821379)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- UMC Utrecht
Adrenal Hyperplasia, Congenital
Growth Hormone (GH) in Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia (CAH) is a genetic rare disease, which alters the adrenal production of gluco and mineralo corticoids. The treatment consists in supplementing children using hydrocortisone.
- Trial name
- OPALE GH (NCT03162172)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Pediatric Abdominal Trauma
Pediatric Blunt Abdominal Trauma Clinical Prediction Model
The submitted proposal is designed to reduce morbidity and mortality to injured children. Significant variability in the initial trauma assessment exists among institutions.
- Trial name
- NCT02206698
- Where
- 14 sites in United States
- Volunteers
- 2,800 people
- Sponsor
- Medical University of South Carolina
Bronchiectasis, Non-cystic Fibrosis Bronchiectasis
BASE: Bronchiectasis Severity and Exacerbation Risk Study
Non-cystic fibrosis bronchiectasis (NCFB) is a chronic airway disease characterized by permanent bronchial dilatation, impaired mucus clearance, recurrent infection, airway inflammation, and repeated exacerbations.
- Conditions
- Bronchiectasis, Non-cystic Fibrosis Bronchiectasis, Bronchiectasis With Acute Exacerbation
- Trial name
- BASE (NCT07599839)
- Where
- Egypt
- Volunteers
- 750 people
- Sponsor
- Assiut University
Unresectable Biliary Tract Cancer, Dynamic Prediction Model
Dynamic Prediction Model for Patients with Unresectable Biliary Malignancies Receiving Systemic Chemotherapy Combined with Immunotherapy: a Multicenter, Observational Study
This study focused on the longitudinal tumor burden profile (tumor macro features, histopathological types and imaging features, etc.), liver function, health status, tumor biomarkers, and serological indicators of patients with…
- Conditions
- Unresectable Biliary Tract Cancer, Dynamic Prediction Model, Immunotherapy
- Trial name
- BTCICTY-001 (NCT06849193)
- Testing
- Systemic chemotherapy combined with immunotherapy
- Where
- 2 sites in China
- Volunteers
- 332 people
- Sponsor
- Zhongda Hospital
Healthcare; Risk Prediction; Diabetic Patients With Osteoporosis
A Model for Risk Prediction of Fracture in Diabetic Patients With Osteoporosis
The fracture risk of diabetic patients proves to be higher than those without diabetesdue to thehyperglycemia, usage of diabetes drugs, the changes in insulin levels and excretion, and this risk begins as early as…
- Trial name
- NCT04534166
- Testing
- Risk Prediction of Fracture in Diabetic Patients with Osteoporosis
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Esophageal Cancer
Standard Follow-Up Program (SFP) for Patients With Esophageal Cancer
Motive: In order to improve the treatment technique, a comprehensive follow-up program is needed to obtain all relevant patient, treatment and toxicity data from esophageal cancer patients.
- Trial name
- SFP OES (NCT02454790)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- University Medical Center Groningen
Risk Malignant Index
Risk of Malignancy Index and Assiut Scoring Model for Adnexal Malignancy
The presence of an adnexal mass is a frequent reason for a woman to be referred to a gynaecologist. The discrimination between benign and malignant adnexal masses is central to decisions regarding clinical management and surgical…
- Trial name
- NCT03404687
- Testing
- ultrasound, cancer antigen 125 level, Doppler
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Assiut University
Breast Cancer, Skin Elasticity
Tridimensional Geometric Modeling of the Breast
The use of a personalized 3D model of the breast in the management of breast cancer would be very useful to help the surgeon better understand the three-dimensional location of tumors in the operative position and thus better…
- Trial name
- SENO 3D (NCT05301998)
- Testing
- Skin and thickness measurement/breast MRI
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Venous Thromboembolism
Venous thromboEmbolism Risk Profiles in Chinese hoSpitalized patiEnts (VERSE Study)
Venous thromboembolism (VTE) is a complex multifactorial disease, mainly manifested by deep vein thrombosis (DVT) and pulmonary embolism (PE).
- Trial name
- NCT05058521
- Where
- China
- Volunteers
- 27,490 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Rheumatoid Arthritis
A Specification Clinical Application Research of Tripterygium Wilfordii Treating Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is an autoimmune disease that results in a chronic inflammatory disorder that may affect many synovial joints, and may cause serious disability.
- Trial name
- NCT03337815
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Endometrial Cancer
Individualised Endometrial Cancer Risk Stratification by Bayesian Prediction Model (ENDORISK), Optimizing Clinical Implementation
Rationale: Preoperative identification of patients at risk for lymph node metastasis (LNM) is challenging in endometrial cancer (EC).
- Trial name
- ENDORISK-I (NCT07200466)
- Testing
- ENDORISK personalized risk assesment for lymph node metastases in endometrial cancer.
- Where
- 14 sites in Netherlands
- Volunteers
- 735 people
- Sponsor
- Radboud University Medical Center