Clinical trials: Prediction of Disease Progression
Membranous Nephropathy, Nephrotic Syndrome
Clinical Prediction Model for Disease Progression in Primary Membranous Nephropathy
This prospective observational study aims to evaluate predictors of disease progression in patients with primary membranous nephropathy and to assess the performance of a prognostic nomogram in predicting renal outcomes in the…
- Conditions
- Membranous Nephropathy, Nephrotic Syndrome, Kidney Diseases
- Trial name
- NCT07785739
- Volunteers
- 128 people
- Sponsor
- Assiut University
Acute Kidney Injury, Chronic Kidney Diseases
Molecular Prediction of Development, Progression or Complications of Kidney, Immune or Transplantation-related Diseases
Managing patients with renal failure requires an understanding of the molecular mechanisms that lead to its occurrence (i.e. upstream of the disease), its worsening and its persistence (i.e.
- Conditions
- Acute Kidney Injury, Chronic Kidney Diseases, Solid-organ Transplantation, Cancer
- Trial name
- NEPHROGENE2 (NCT05318196)
- Testing
- Biological samples collection
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Toulouse
Soft Tissue Sarcoma, Adult Soft Tissue Sarcoma
Multiparametric Quantitative MRI and Response to Neoadjuvant Radiotherapy for Soft-tissue Sarcoma
This trial is a prospective, monocentric, with minimal risks and constraints study, conducted in patients with Soft Tissue Sarcoma (STS) of the limbs and trunk with indication for neoadjuvant radiotherapy (RT).
- Conditions
- Soft Tissue Sarcoma, Adult Soft Tissue Sarcoma, Resectable Soft Tissue Sarcoma
- Trial name
- SarQuantIRM (NCT05684874)
- Testing
- Neoadjuvant RT, Pre-radiotherapy mpMRI, Post-radiotherapy mpMRI
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Leon Berard
Chronic Respiratory Diseases
Belgian Lung Function Study
Currently, it remains unclear how to manage serial lung function measurements in a clinical setting. The investigators aimed to tackle this problem by developing a machine learning (ML) model that can accurately predict…
- Trial name
- AIRCAST (NCT07419555)
- Where
- 5 sites in Belgium
- Volunteers
- 5,000 people
- Sponsor
- KU Leuven
Uveitis
Development of AI Model for Uveitis Progression and Prognosis
Uveitis is a recurrent inflammation of the eye that can lead to vision loss with various and complicated etiologies. There are many difficulties in uveitis management due to the requirement of long-term monitoring and treatment.
- Trial name
- NCT04705103
- Volunteers
- 450 people
- Sponsor
- Sun Yat-sen University
Progressive Multiple Sclerosis
Multiple Sclerosis Prediction and Monitoring of Progression Study
Multiple sclerosis (MS) is a auto-immune disease that is mostly characterized by acute clinical relapses and/or focal inflammation in the central nervous system (CNS) followed by recovery.
- Trial name
- PREMONITION (NCT05685784)
- Testing
- Bytelfies kit - sensor dot
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Assess the Variation of Apparent Diffusion Coefficient
Contribution of MRI in the Evaluation of Apparent Diffusion Coefficient and Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer
The main objective of the study is to assess the sensitivity and the specificity of the variation of apparent diffusion coefficient for prediction, after a course of neoadjuvant chemotherapy or after modification of the treatment…
- Trial name
- ADC (NCT01956513)
- Testing
- MRI (Magnetic resonance imaging)
- Sponsor
- Centre Jean Perrin
Dementia, Mild Cognitive Impairment (MCI)
Predictors Of Cognitive Decline Using Digital Devices
The overall aim of this study is to find out if people with cognitive difficulties will wear and use different types of digital technology, and if they will allow data from that technology and their clinical profile to be…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Rapid Eye Movement Sleep Behavior Disorder
- Trial name
- CODEC-II (NCT07051408)
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University College, London
Bladder Cancer, Disease Progression
In the Prediction of Recurrence and Progression of NMIBC; EORTC or CUETO or Both?
Investigators aimed to evaluate the performance of The European Organization for Research and Treatment of Cancer(EORTC) and the Spanish Urology Association for Oncological Treatment(CUETO) risk tables on all non-muscle invasive…
- Conditions
- Bladder Cancer, Disease Progression, Recurrent Bladder Cancer
- Trial name
- NCT03174912
- Testing
- Intravesical BCG instillation
- Volunteers
- 400 people
- Sponsor
- Ankara Training and Research Hospital
Cervical Intraepithelial Neoplasia
Comparison of Human Papillomavirus Integrated DNA and Messenger RNA in Cervical Neoplasia
The investigators hypothesis is HPV integration could result in expression of oncogene transcripts, and not only constitutive expression but also the level of expression will be decisive for transformation and the maintenance of…
- Trial name
- NCT02198365
- Where
- Taiwan
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Heart Failure Acute, Acute Myocardial Infarction
The SWISSHEART Failure Network (SHFN)
A retrospective cohort study will be conducted on patients who were hospitalized at the University Hospital Basel (USB), University Hospital Bern (Inselspital), University Hospital Geneva (HUG) and the University Hospital Zurich…
- Trial name
- Swissheart (NCT05603247)
- Where
- 4 sites in Switzerland
- Volunteers
- 8,000 people
- Sponsor
- University of Zurich
Diabetes Mellitus Type 2
Rate of Change of HbA1c (dx/dt) May Predict Progression to Type 2 DM
The investigators hypothesize that the HbA1c shows a rising trend in pre-diabetics and normal population with risk factors of developing type 2 DM.
- Trial name
- NCT01315808
- Where
- United States
- Volunteers
- 542 people
- Sponsor
- Wyckoff Heights Medical Center
Heart Failure
Decision Support System for Diagnosis and Progression of Heart Failure
Heart failure (HF) is a complex clinical syndrome associated with impaired heart function, poor quality of life for patients and high healthcare costs.
- Trial name
- STRATIFYHF (NCT06377319)
- Testing
- Cardiac Output Response to Stress (CORS) test
- Volunteers
- 1,600 people
- Sponsor
- Coventry University
Prostate Cancer
Prospective Prolaris Value and Efficacy
This is a prospective study to measure the impact on first-line therapy of genomic testing of biopsy tissue from recently diagnosed treatment-naïve patients with early stage localized prostate cancer.
- Trial name
- P-PROVE (NCT03152448)
- Testing
- Prolaris
- Where
- 12 sites in United States
- Volunteers
- 1,511 people
- Sponsor
- Myriad Genetic Laboratories, Inc.
Breast Cancer
Clinico-biological Data Collection Study of Metastatic Breast Cancer
RATIONALE : Currently, the mechanisms associated with the response or resistance to treatment are poorly understood and are multifactorial.
- Trial name
- EPICURE_SEIN (NCT03958136)
- Testing
- Metastasis biopsy, Biomarkers blood, urine and microbiota samples, Patient Reported Outcome (PRO)
- Where
- 2 sites in France
- Volunteers
- 289 people
- Sponsor
- Institut Cancerologie de l'Ouest
Aortic Stenosis
18F-NaF Uptake and Aortic Stenosis Progression
This study aims to evaluate whether baseline 18F-sodium fluoride uptake activity at aortic valve could predict aortic stenosis progression in moderate aortic stenosis.
- Trial name
- NCT02740088
- Testing
- Imaging test: 18F-NaF PET/CT
- Volunteers
- 28 people
- Sponsor
- Seoul St. Mary's Hospital
Multiple Sclerosis, Gait Disorders, Neurologic
Gait Pattern and Its Relation to Cognition and VEP in Multiple Sclerosis
This cross-sectional study aims to assess the pattern of gait in patients with multiple sclerosis and to evaluate its relation to cognitive function, visual evoked potentials, and radiological findings.
- Trial name
- NCT07847086
- Volunteers
- 70 people
- Sponsor
- Assiut University
Parkinson Disease, Alzheimer Disease
Biomarkers in Alzheimer's and Parkinson's Diseases for IA
Investigate whether endogenous and exogenous risk factors, the presence of pathological amyloid aggregates and alpha-synuclein in the CSF, brain connectivity, and some clinical and biological indices such as vigilance, general…
- Conditions
- Parkinson Disease, Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- PREDICT-NEUR (NCT07651085)
- Testing
- Neuropsycological assesment, cerebral MRI, EEG
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- IRCCS San Raffaele Roma
Monitoring, Clinical Deterioration
Continuous Monitoring of Patients in and After the Acute Admission Ward to Optimize Clinical Pathways
Hospitals aim to hospitalize patients when necessary and discharge patients when possible. However, the triage process and discharge management of patients in e.g. the Acute Admission Ward, is not a trivial task.
- Conditions
- Monitoring, Clinical Deterioration, Acute Disease
- Trial name
- NCT05181111
- Testing
- Wearable Sensor, Usual Care
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Rijnstate Hospital
Coronary Disease, Young Adult
Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis
This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults.
- Trial name
- NCT07316452
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Fu Wai Hospital, Beijing, China