Clinical trials: Predictors
Atrial Fibrillation
Validation of Predictors of OAC Initiation Using EMR Data
The objectives of this study are, first, to identify select clinical covariates from electronic medical records (EMR) that might be associated with initiation of oral anticoagulant medications (dabigatran or warfarin) in patients…
- Trial name
- NCT03006341
- Testing
- Dabigatran etexilate, Warfarin
- Where
- United States
- Volunteers
- 140,187 people
- Sponsor
- Boehringer Ingelheim
Colorectal Carcinoma
Health Service Intervention for the Improvement of Access and Adherence to Colorectal Cancer Screening
This phase I study investigates how well a health service program called Witness CARES Services works in increasing access and adherence to colorectal cancer screening in patients who have not undergone a colorectal screening in…
- Trial name
- NCT04607291
- Testing
- Community Health Service, Survey Administration
- Where
- United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Bipolar Disorder
16-week Comparative Effectiveness Trial of Lamotrigine vs. Fluoxetine for Bipolar Depression
The FLAME Study is a 16-week clinical trial to study treatment with lamotrigine or fluoxetine in bipolar I, II and bipolar schizoaffective depressed adults.
- Trial name
- FLAME (NCT02389712)
- Testing
- Lamotrigine, Fluoxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Anterior Cruciate Ligament Rupture
Are Opioids Needed After ACL Reconstruction
As the public health sector continues to confront the opioid epidemic, orthopaedic surgeons must revisit pain management protocols to reduce unnecessary opioid prescriptions.
- Trial name
- NCT04285853
- Testing
- Oxycodone
- Where
- 3 sites in United States
- Volunteers
- 98 people
- Sponsor
- Emory University
Depression
Identifying Factors That Predict Antidepressant Treatment Response
This study will compare different treatments for depression in order to identify which factors predict effectiveness, and will include a companion study which investigates combining treatments and long term effectiveness.
- Trial name
- NCT00360399
- Testing
- Escitalopram, Duloxetine, Cognitive behavioral therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 344 people
- Sponsor
- Emory University
Rheumatoid Arthritis
Predictors of Response to Tofacitinib Treatment in Rheumatoid Arthritis Patients
This is a 24-month, prospective, non-interventional, multi-center study with primary aim to identify baseline characteristics of patients that predict response at 6 months of treatment.
- Trial name
- TREAT-RA (NCT04079920)
- Where
- 18 sites in Greece
- Volunteers
- 198 people
- Sponsor
- Pfizer
Carcinoma, Non-Small-Cell Lung
Genetic Predictors of Benefit to Pembrolizumab
The primary objective is to determine if mutation load underlies sensitivity to pembrolizumab alone and in combination with chemotherapy.
- Trial name
- NCT02710396
- Testing
- Pembrolizumab, Carboplatin, Nab-paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Columbia University
Migraine
Biomarker and Genetic Predictors of Erenumab Treatment Response
To explore the relationship between clinical response to erenumab and genetic biomarkers
- Trial name
- INTERROGATE (NCT04265755)
- Testing
- Erenumab
- Where
- 2 sites in Denmark, Iceland
- Volunteers
- 1,406 people
- Sponsor
- Amgen
Abdominal Aortic Aneurysm (AAA)
Predictors of AAA Expansion and/or Rupture
Eligible subjects in this study will have either a known abdominal aortic aneurysm (AAA) or because they do not have an AAA (control group).
- Trial name
- NCT03231397
- Testing
- Assess AAA rupture risk by PET-CTA scans, 18F-fludeoxyglucose (FDG), 11C-PBR28
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Aphasia, Stroke
Dosage and Predictors of Naming Treatment Response in Aphasia
This study examines aphasia treatment response among Veterans and non-Veterans living with aphasia. It seeks to identify cognitive and neural factors which are predictive of positive response to treatment targeting naming…
- Trial name
- NCT02005016
- Testing
- Naming therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Borderline Personality Disorder, Suicide
Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder
This study will compare the effectiveness of two treatments, dialectical behavior therapy versus fluoxetine with clinical management, for reducing the risk of self-injury and suicidal behavior in people with borderline…
- Trial name
- NCT00834834
- Testing
- Fluoxetine, DBT, Citalopram
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Effectiveness and Neuropsychological Predictors of Guided Self-Help for Obsessive-Compulsive Disorder (OCD)
The primary aim of this study is to learn about who is most likely to benefit from guided self-help (GSH) for obsessive-compulsive disorder (OCD).
- Trial name
- NCT01659125
- Testing
- "OCFighter"
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Hartford Hospital
Congestive Heart Failure
Oxidative Stress Markers and Cardiac Resynchronization Therapy (CRT) Outcomes
This is a research study that is evaluating blood markers which may predict which patients who receive CRT will improve. Congestive heart failure (CHF) is associated with increased oxidative stress, a condition where abnormal…
- Trial name
- NCT01151553
- Testing
- CRT Therapy
- Volunteers
- 5 people
- Sponsor
- Emory University
Cocaine Use Disorder
Neurocognitive Factors in Substance Use Treatment Response: The Ways of Rewarding Abstinence Project
The proposed work will investigate changes in brain signaling and cognitive functioning that support recovery from addiction, as well as use of pretreatment neurocognitive functioning to inform substance use treatment planning.
- Trial name
- WRAP (NCT03799341)
- Testing
- Prize-Based Contingency Management, Treatment As Usual Outpatient Substance Use Treatment
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Thromboembolic Disease Recurrent, Deep Vein Thrombosis
Clinical Predictors for Venous Thromboembolism in Patients With a History of Thrombosis (PREDICTORS)
Patients with a history of blood clots are at risk of developing additional clots in the future. Doctors use a tool called a clinical decision rule to tell them how likely it is that a patient has a blood clot and if they should…
- Conditions
- Thromboembolic Disease Recurrent, Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- PREDICTORS (NCT02297373)
- Where
- 9 sites in Canada, Netherlands and 1 more
- Volunteers
- 744 people
- Sponsor
- Ottawa Hospital Research Institute
Pain
Mechanistic Study of Duloxetine in Breast Cancer Patients With Chronic Pain
Early stage breast cancer is typically treated with surgery, chemotherapy, radiation therapy, and/or endocrine therapy. Following treatment, 25-60% of breast cancer survivors have reported chronic pain, which can be difficult to…
- Trial name
- NCT01912612
- Testing
- Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- University of Michigan Rogel Cancer Center
Alcohol Use Disorder
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
The purpose of this study is to evaluate the safety and efficacy of dutasteride in reducing drinking and heavy drinking in men and women with alcohol use disorder.
- Trial name
- NCT04098302
- Testing
- Dutasteride Capsules
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- UConn Health
Heart Failure, Wide QRS Complex
Predictors of Response to Biventricular Pacing in Heart Failure
Heart Failure (HF) is a disease of epidemic proportion in the U.S. affecting over 5 million individuals. It is estimated that in the next year nearly 400,000 new cases will be diagnosed, 1 million individuals will be hospitalized…
- Trial name
- NCT00156390
- Testing
- echo-guided left ventricular lead placement, LV lead placement as per standard of care (without echo guidance)
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Samir Saba