Clinical trials: Preeclampsia
Preeclampsia, Hypertension
Cardiac and Immune Cell Function in Preeclampsia
Preeclampsia is a multi-system vascular disease which affects 2-5% of pregnancies. It is also a risk factor for the development of cardiovascular disease later in life and a number of functional and structural cardiac changes…
- Conditions
- Preeclampsia, Hypertension, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- NCT04508582
- Testing
- Cardiovascular magnetic resonance, Echocardiography, Blood test
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Vitamin d Deficiency, Preeclampsia
25- Hydroxyvitamin D Levels in Pregnancy and Effects on Pregnancy Related Disorders
Evaluation of 25- Hydroxyvitamin D levels in pregnant women in Austria and potential related disorders Hypothesis: Austrian pregnant women are Vitamin D deficient Present vitamin D supplementation in pregnancy is insufficient…
- Conditions
- Vitamin d Deficiency, Preeclampsia, Preterm Delivery, Gestational Hypertension
- Trial name
- VIDIS (NCT04637880)
- Where
- Austria
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pre-Eclampsia, Intrauterine Growth Restriction
Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Due to the fetoneonatal pathway it is possible to identify pregnant women with an increased risk of fetal growth restriction or pre-eclampsia in early stages (from 10th week of pregnancy).
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Maternal Care for Known or Suspected Poor Fetal Growth
- Trial name
- NCT04514276
- Testing
- consecutive fetoneonatal healthcare pathway
- Where
- 2 sites in Germany
- Volunteers
- 828 people
- Sponsor
- Technische Universität Dresden
Severe Pre-Eclampsia, Antepartum
Oral Nifedipine Versus IV Labetalol in Severe Pre Eclampsia
OBJECTIVE: To determine the efficacy of nifedipine and labetalol in terms of control of BP in pre eclamptic pregnant patients Design: Randomised control trial SETTING: Department Obstetrics \& gynaecology, Services Hospital…
- Trial name
- NCT03325348
- Testing
- Nifedipine 10 mg, Labetalol
- Where
- Pakistan
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Pre-Eclampsia, Critical Illness
Homocysteine in Critically Ill Preeclampsia
Preeclampsia is a disorder characterized by the new onset of hypertension and proteinuria typically presenting after 20 weeks of gestation.
- Trial name
- NCT06413576
- Testing
- homocysteine measurement
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Severe Preeclampsia
Comparative Study of Intravenous Labetalol Versus Intravenous Nitroglycerin Versus Sublingual Nifedipine
Pre-eclampsia (PE) is one of the most frequent pregnancy complications and is one of the main causes of maternal and fetal morbidity and mortality in its severe form.control of blood pressure is of crucial importance to avoid…
- Trial name
- NCT06265415
- Testing
- Labetalol, Nitroglycerine, Nifedipine
- Volunteers
- 60 people
- Sponsor
- Sohag University
Pre-Eclampsia, Pregnacy
Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies
Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver.
- Trial name
- BEET_PE (NCT06387784)
- Testing
- Beetroot juice
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Preeclampsia/Toxemia
The Prediction of Preeclampsia/Toxemia in Twin Pregnancy
The purpose of this study is to finout whetere uterinae artery flow , PP13 and endogolin levels in the serum and kongo red in the urine can predict preeclamsia toxemia in twin pregnancies.
- Trial name
- NCT01255202
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy
MH-Rx Study (Baby on Board: Check-in on You, Your Medication, & Your Blood Pressure)
This randomized controlled trial will evaluate whether adding Community Health Worker (CHW)/Social Worker (SW)-led support for non-medical health related needs (NMHRN) and clinician-led Medication Therapy Management (MTM) to…
- Conditions
- Hypertensive Disorders of Pregnancy, Chronic Hypertension in Pregnancy, Gestational Hypertension
- Trial name
- NCT07842341
- Testing
- Community Health Worker (CHW)/Social Worker (SW)-led non-medical health related needs (NMHRN) intervention + Clinician-Led Medication Therapy Management (MTM) with remote blood pressure monitoring, Active Comparator (Control group)
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Texas Southern University
Hypertension in Pregnancy, Pre-Eclampsia
Mobile Health Interventions to Prevent Heart Disease After Hypertensive Disorders of Pregnancy
The purpose of this research is to study digital health interventions to prevent cardiovascular disease in individuals who have had a hypertensive disorder of pregnancy (HDP).
- Conditions
- Hypertension in Pregnancy, Pre-Eclampsia, Eclampsia, Gestational Hypertension
- Trial name
- mHEART (NCT06523569)
- Testing
- Digital Blood Pressure Monitoring System, Mobile health application
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern University
Hypertension in Pregnancy, Postpartum Preeclampsia
Rhode Island - Statewide Postpartum Hypertension Remote Surveillance
This is a hybrid type 1 non-inferiority implementation effectiveness trial among postpartum patients with hypertension (N=1536) that will test the hypothesis that RI-SPHERES (a technologically enabled collaborative care model) is…
- Conditions
- Hypertension in Pregnancy, Postpartum Preeclampsia, Postpartum Complication
- Trial name
- RI-SPHERES (NCT06842875)
- Testing
- RI-SPHERES, Standard self-measured blood pressure program
- Where
- 5 sites in United States
- Volunteers
- 1,536 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Preeclampsia
KW-3357 Study in Patients With Early Onset Severe Preeclampsia
The purpose of this study is to evaluate the efficacy of intravenous KW-3357 in patients with early-onset severe preeclampsia by comparing the prolongation days of pregnancy with that of placebo.
- Trial name
- NCT04182373
- Testing
- Antithrombin gamma, physiological saline
- Where
- 63 sites in Japan
- Volunteers
- 181 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Hypertension, Pregnancy-Induced, Postpartum Preeclampsia
Comprehensive Postpartum Management for Women With Hypertensive Disorders of Pregnancy
Investigators propose a comprehensive management program for postpartum patients with HDP who are at risk for severe maternal morbidity and mortality.
- Conditions
- Hypertension, Pregnancy-Induced, Postpartum Preeclampsia, Hypertension; Maternal
- Trial name
- NCT05849103
- Testing
- Blood Pressure Control Targets, Hypertension Management
- Where
- United States
- Volunteers
- 343 people
- Sponsor
- Vanderbilt University Medical Center
Preeclampsia
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery
Preeclampsia is a syndrome that occurs in approximately 3% to 8% of pregnancies and is associated with considerable maternal and neonatal morbidity and mortality.
- Trial name
- RAAPID-II (NCT01404910)
- Testing
- Apheresis using Liposorber LA-15 System
- Where
- 3 sites in United States, Germany
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Preeclampsia, Hypertensive Disorder of Pregnancy
Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy
The present study is a single-centre prospective study that will enrol pregnant women during their first trimester of pregnancy (11+0 - 13+6 weeks of gestation).
- Trial name
- EDIPE (NCT05999851)
- Testing
- Arterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Preeclampsia, Gestational Diabetes
Exercise and Pregnancy: Randomized Clinical Trial
The effects of physical exercise on pregnancy remain to be elucidated. A randomized controlled trial will be conducted to study the impact of exercise on maternal and perinatal outcomes.
- Trial name
- NCT00641550
- Testing
- Physical exercise
- Where
- 2 sites in Brazil
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual da Paraiba
Pre-Eclampsia
L-Arginine and Antioxidant Vitamins During Pregnancy to Reduce Preeclampsia
This study is intended to assess the efficacy of L-arginine supplementation with antioxidant vitamins delivered in a medical food in reducing the incidence of preeclampsia in a high-risk population.
- Trial name
- L-Arg (NCT00469846)
- Testing
- L-arginine supplementation in a medical food, Vitamin C and E supplementation in a medical food
- Where
- 2 sites in United States, Mexico
- Volunteers
- 585 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Procedural Sedation
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative…
- Trial name
- NCT04873596
- Testing
- Nebulized dexmedetomidine, Nebulized midazolam
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Gestational Diabetes Mellitus, Preeclampsia
MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is a heterogeneous condition, characterised by metabolic disturbances, insulin resistance and hyperandrogenism.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Preterm Birth, Polycystic Ovary Syndrome
- Trial name
- MYPP (NCT05524259)
- Testing
- Myo-inositol and routinely recommended folic acid, Routinely recommended folic acid
- Where
- Netherlands
- Volunteers
- 464 people
- Sponsor
- Erasmus Medical Center
Pregnancy Related, Diet Modification
Effects of Diet on Pregnancy Outcome and Child Obesity
The purpose of the study is to compare 3 different diets in pregnancy, equal in calories, and fats, different in refined grains compared to whole grains as a source of carbohydrates, and in calories from carbohydrate, compared to…
- Conditions
- Pregnancy Related, Diet Modification, Obesity, Hypertension
- Trial name
- NCT03232762
- Testing
- Refined Grains, Whole Grains
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health