Clinical trials: Prefrontal Cortex
Bulimia Nervosa, Anorexia Nervosa
High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Bulimia and Anorexia Nervosa
This trial will compare the efficacy and tolerability of 10 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered once daily over 30 days, in patients with a…
- Trial name
- NCT02702167
- Testing
- High-frequency rTMS, Low-frequency rTMS
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Bipolar Depression
Effect of Intermittent ThetaBurst Stimulation in Treatment-resistant Bipolar Depression
The aim is to evaluate the evaluate the clinical interest and the safety of repetitive transcranial magnetic stimulation (rTMS) delivered as intermittent Theta burst stimulation(iTBS) on severity of depression in patients with…
- Trial name
- iTBS-BIP (NCT02740244)
- Testing
- active iTBS
- Volunteers
- 20 people
- Sponsor
- Hôpital le Vinatier
Cognitive Aging
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
- Trial name
- NCT00935493
- Testing
- Guanfacine
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Magnetic Resonance Imaging of Calculus Problem Solving
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in solving algebraic math problems. It will examine brain activation according to the level of difficulty and the number of steps required to…
- Trial name
- NCT00060658
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy, Neurofeedback
Real-time Neurofeedback Training of the Medial Prefrontal Cortex Based on Imagined Social Support
Randomized active-sham controlled between-subject real-time fMRI neurofeedback trial aiming to modulate activity in the medial prefrontal cortex (mPFC) to improve subjective negative anticipation.
- Trial name
- NCT07364084
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Stress, Sleep
Effects of Transcranial Electrical Stimulation in Chronic Stress
This clinical trial aims to determine if Transcranial electrical stimulation by direct current (tDCS) and transauricular Vagus Nerve Stimulation (tVNS) treatments are effective in reducing stress symptoms, distress and improving…
- Trial name
- NEUROSTIM (NCT06813209)
- Testing
- tDCS, tVNS
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Mental Fatigue, Near Infrared Spectroscopy
The Effect of Mental Fatigue on the Cerebral Oxygenation During Endurance Exercise
The experiment will consist of 3 consecutive trials performed in a sound-insulated climate chamber (20°C and 40% RH) at the VUB. Participants will be asked to return 3 successive weeks.
- Conditions
- Mental Fatigue, Near Infrared Spectroscopy, NIRS, Condition
- Trial name
- NCT05355493
- Testing
- Time to Exhaustion cycling test, Go/NoGo task
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Depressive Disorder, Major
The Activation on Prefrontal Cortex With Acupuncture and Moxibustion for Major Depressive Disorder: A Study of Functional Near Infrared Spectroscopy
This study evaluates the activation on prefrontal cortex with acupuncture and moxibustion for major depressive disorder.Half of participants will receive the treatment of acupuncture and moxibustion, while the other participants…
- Trial name
- ACUfNIRS (NCT04272476)
- Testing
- acupuncture and moxibustion, Fluoxetine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression
Activation on LDPC Cortex With Different Acupoints: An fNIRS Study
This is a randomized, open-labelled study to study the effect of the different acupoints combination under TCM treatment principles by fNIRS.
- Trial name
- NCT02711527
- Testing
- Acupunture group A, Acupunture group B
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- The University of Hong Kong
Neuropathic Pain, Depression
Neuromodulation in Patients With Neuropathic Pain and Depression.
High-frequency repetitive transcranial magnetic stimulation of the primary motor cortex has shown its effect on refractory neuropathic pain, and rTMS of the dorsolateral prefrontal cortex is commonly used for treatment-resistant…
- Trial name
- DOLODEP (NCT06129890)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS) - M1/DLPFC, Repetitive transcranial magnetic stimulation (rTMS) - DLPFC/M1
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy Volunteers, Cognitive Function
Self-regulation of Prefrontal Cortex During Emotional Cognitive Control
Deficits in emotional cognitive control are present in a number of clinical psychiatric populations including depression, anxiety, and PTSD.
- Trial name
- SPrC (NCT04543500)
- Testing
- Real-time functional magnetic resonance neurofeedback (rtfMRI-nf)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Major Depressive Disorder
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated…
- Trial name
- NCT05194098
- Testing
- TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Alcohol Use Disorder, Alcohol Drinking
MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience
The purpose of this study is to develop transcranial magnetic stimulation (TMS), specifically TMS at a frequency known as theta burst stimulation (TBS), to see how it affects the brain and changes the brain's response to…
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Substance Use, Drinking, Alcohol
- Trial name
- NCT04998916
- Testing
- Real TBS to the mPFC
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Medical University of South Carolina
Chronic Low Back Pain
Transcranial Stimulation for Physiotherapy Optimisation - Chronic Low Back Pain (STOP-CLBP)
The main objective of this study is to investigate the effects of non-invasive brain stimulation (the so-called transcranial direct current stimulation ; tDCS) combined with an active physiotherapy program on the multidimensional…
- Trial name
- STOP-CLBP (NCT05757609)
- Testing
- Anodal tDCS combined with active physiotherapy
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Stephane ARMAND
Chronic Migraine Headache
Low-Intensity Focused Ultrasound Targeting the Dorsolateral Prefrontal Cortex for Preventive Treatment of Chronic Migraine
Chronic migraine is a disabling neurological disorder characterized by frequent headache attacks and significant impairment of quality of life.
- Trial name
- NCT07857109
- Testing
- Low-Intensity Focused Ultrasound Stimulation
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Chinese PLA General Hospital
Healthy
Positron Emission Tomography Imaging of Dopamine Receptors Using the Tracer [11C]NNC-112
This study will investigate the use of [11C]NNC-112 in positron emission tomography (PET) scanning. PET is a technique that uses radioactive isotopes called tracers to provide images of the brain.
- Trial name
- NCT00088517
- Testing
- [11C]NNC-112
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Loneliness
The Effects of Transcranial Direct Current Stimulation (tDCS) in Older Lonely Individuals
This randomized clinical trial aims to test the effects of 10 sessions of transcranial direct current stimulation (tDCS) on social and emotional functions in lonely older adults.
- Trial name
- NCT05937022
- Testing
- Experimental Transcranial Direct Current Stimulation (tDCS)
- Where
- Hong Kong
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dyspnea
Effect of Non-invasive Magnetic Stimulation of the Brain on Breathlessness in Healthy Individuals.
The purpose of this study is to see if the front part of the brain called the "Dorsolateral Prefrontal Cortex" (DLPFC) has a role in our ability to feel breathlessness.
- Trial name
- AHrTMS (NCT05623696)
- Testing
- rTMS-L-DLPFC, rTMS-R-DLPFC
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Recurrent Pregnancy Loss, Overweight , Obesity
Effects of High-frequency Left Dorsolateral Prefrontal rTMS on Heart-brain Coupling in Women With Recurrent Pregnancy Loss and Elevated BMI
This randomized, sham-controlled mechanistic trial will examine whether a single session of high-frequency repetitive transcranial magnetic stimulation, rTMS, applied to the left dorsolateral prefrontal cortex can modify…
- Conditions
- Recurrent Pregnancy Loss, Overweight , Obesity, Heart-Brain Coupling
- Trial name
- NEURO-CARD-BMI (NCT07561931)
- Testing
- Real repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenyang Medical College