Clinical trials: Prefrontal Cortex
Schizophrenia, Cognitive Dysfunction
Transcranial Direct and Alternating Stimulation of the Prefrontal Cortex for Cognitive Improvement in Schizophrenia
The purpose of this study is to investigate different stimulation intensities and frequencies of transcranial direct and alternating current stimulation over the dorsolateral prefrontal cortex for cognitive improvement in…
- Trial name
- NCT05342727
- Testing
- transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS)
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- The National Brain Mapping Laboratory (NBML)
Cognition Disorders
PET Scan to Map the Areas of the Brain Involved in Planning
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal…
- Trial name
- NCT00001363
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Overweight, Obesity and Other Hyperalimentation (E65-E68)
Transcranial Random Noise Stimulation in Food Addiction Treatment
Obesity is worldwide a public health problem. According to World Health Organization (WHO), overweight and obesity are the fifth death risk factor worldwide. At least 2.8 million adults die each year.
- Trial name
- tRNS-FA (NCT02717247)
- Testing
- Active tRNS
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hôpital le Vinatier
Alcohol Use Disorder
The Effect of rTMS to the Prefrontal Cortex in Alcohol Use Disorder
The goal of this study is to investigate a treatment approach for alcohol use disorder (AUD) using a novel form of brain stimulation called deep repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- MAGNA (NCT03809286)
- Testing
- active rTMS, Inpatient admission
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- New York State Psychiatric Institute
Cerebral Small Vessel Disease, Vascular Cognitive Impairment
Personalized Intermittent Theta Burst Stimulation for Cognitive Impairment Related to Cerebral Small Vessel Disease
This study will evaluate whether personalized intermittent theta burst stimulation (iTBS), a form of noninvasive transcranial magnetic stimulation, can safely improve cognitive function in people with cognitive impairment related…
- Trial name
- NCT07891650
- Testing
- Active Personalized Intermittent Theta Burst Stimulation
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Xuanwu Hospital, Beijing
Traumatic Brain Injury
Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury
Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients.
- Trial name
- NCT04239274
- Testing
- transcranial direct current stimulation, transcranial pulsed current stimulation
- Sponsor
- Medical University of South Carolina
Stress Disorders, Post-Traumatic
Salience Network Informed rTMS for PTSD
The proposed study will test whether magnetic resonance imaging (MRI)-guided transcranial magnetic stimulation (TMS) can reduce posttraumatic stress disorder (PTSD) symptoms in Veterans.
- Trial name
- NCT07886840
- Testing
- Active MRI-Guided intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- VA Office of Research and Development
Nicotine Use Disorder, Nicotine Dependence
Accelerated rTMS for the Reduction of Nicotine Craving
The purpose if this study is to determine if five treatments of repetitive transcranial magnetic stimulation (rTMS) can reduce craving for cigarettes in smokers.
- Trial name
- NCT03352609
- Testing
- Active rTMS with MagVenture MagPro double blind rTMS system
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Attention Deficit Hyperactivity Disorders
Low-dose vs. Normal-dose Psychostimulants on Executive Functions in Individuals With ADHD
This double-blind crossover study aims to compare cognitive performance (e.g., working memory, selective attention and cognitive flexibility) of children ages 6-18 years diagnosed with ADHD of the combined type (ADHD-C) or…
- Trial name
- NCT02167048
- Testing
- Psychostimulants
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Addiction
Effects of Transcranial Direct Current Stimulation on Cigarette Addiction
Tobacco addiction is treatable with behavioral and pharmacological means, but results are often less than optimal. Transcranial direct current stimulation is a new non-invasive technique that applies weak electrical currents…
- Trial name
- NCT02146014
- Testing
- Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Brasilia
Recurrent Pregnancy Loss(RPL), Anxiety
High-Intensity, Low-Frequency Periodic rTMS Over the Right Dorsolateral Prefrontal Cortex on Cardiac Autonomic Regulation in Women With Recurrent Pregnancy Loss and Anxiety
The goal of this clinical trial is to determine whether high-intensity, low-frequency periodic repetitive transcranial magnetic stimulation (rTMS) applied to the right dorsolateral prefrontal cortex (DLPFC) can modulate cardiac…
- Trial name
- NCT07233278
- Testing
- Rhythmic repetitive transcranial magnetic stimulation (rTMS) at 120% RMT, 1 Hz, 60-s cycles
- Where
- 3 sites in China
- Volunteers
- 48 people
- Sponsor
- Shenyang Medical College
Apathy, Stroke
Transcranial Direct Current Stimulation (tDCS) in Chronic Post-Stroke Apathy
The purpose of this study is to test the efficacy and safety of tDCS (Transcranial Direct Current Stimulation) on apathy in stroke patients.
- Trial name
- TDCS-PSA (NCT02915484)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stony Brook University
Healthy
Investigating the Cognitive Processes That Underlie Social Knowledge and Behavior
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex.
- Trial name
- NCT00061334
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression
High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Major Depression
This trial will compare the efficacy and tolerability of 20 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered twice daily over 15 days, in patients with a…
- Trial name
- NCT02702154
- Testing
- High-frequency rTMS, Low-frequency rTMS
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Depressive Disorder, Major
Treatment of Major Depression by rTMS on Dorsolateral Prefrontal Cortex: Study of Underlying Mechanisms
The study aims to evaluate the impact of repeated Transcranial Magnetic Stimulation (rTMS) on underlying neuronal mechanisms of adults suffering from major depression disorder (MDD).
- Trial name
- DEPSTIM (NCT05121129)
- Testing
- iTBS
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Memory Deficits, tACS
tACS Improves Memory in Elders With Subjective Memory Complaints
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people.
- Trial name
- NCT05569902
- Testing
- active tACS
- Where
- Iran
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Tehran
Alzheimer Disease
Effect of Acupuncture on the Gait Disturbance and Hemodynamic Changes in the Prefrontal Cortex
Background: Alzheimer's disease (AD) is characterized by cognitive impairment and behavioral impairment, and increasing attention is paid in the gait of AD patients.
- Trial name
- NCT06346275
- Testing
- Acupuncture
- Volunteers
- 108 people
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Alzheimer Disease, Electric Stimulation Therapy
Clinical Exploratory Research of Medial Prefrontal Cortex Combined With Dorsolateral Prefrontal Cortex Electrical Stimulation in the Treatment of Alzheimer's Disease
Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive cognitive impairment and memory impairment, and is also a major cause of global dementia, characterized by progressive decline in memory…
- Trial name
- CBS-m/dlPFC-AD (NCT05971030)
- Testing
- Cortical brain stimulation of mPFC and dlPFC
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Xuanwu Hospital, Beijing
Schizophrenia
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated…
- Trial name
- MESSI (NCT04807530)
- Testing
- TMS
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco