Clinical trials: Prefrontal Cortex
Stroke
Effects of rTMS Combined With Dual-Task Gait Training on Walking and Cognition After Stroke
This randomized, double-blind, placebo-controlled trial will investigate whether repetitive transcranial magnetic stimulation (rTMS) applied to the dorsolateral prefrontal cortex (DLPFC) can enhance the effects of dual-task gait…
- Trial name
- NCT07356687
- Testing
- active rTMS with dual-task training
- Where
- Hong Kong
- Volunteers
- 184 people
- Sponsor
- The Hong Kong Polytechnic University
Languages
Impact of Theta Burst Stimulation Over the Left DLPFC on Language Switching
The purpose of this study is to investigate whether theta burst stimulation (TBS) over the left dorsolateral prefrontal cortex (DLPFC) influences language switching and cognitive flexibility.
- Trial name
- NCT03148470
- Testing
- intermittent theta burst stimulation (iTBS), continuous theta burst stimulation (cTBS)
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jean-Marie Annoni
Unipolar Major Depressive Disorder
Non-invasive Brain Stimulation and Cognitive Processing in Depression
Depression is a serious mental health problem that affects millions. Depression is usually treated using drugs and/or psychotherapy, but neither approach is successful for everyone, and some people do not respond to either.
- Trial name
- NCT01875419
- Testing
- Transcranial direct current stimulation (tDCS), Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Healthy
Direct Current Brain Polarization of the Frontal Lobes
This study will explore what effects, if any, direct current (DC) brain polarization may produce on mental processes, such as attention, reaction time, working memory, speed of information processing and mood or emotional states.
- Trial name
- NCT00424216
- Testing
- DC Polarization
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Panic Disorder, Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Panic Disorder With Comorbid Major Depression
This study will evaluate the efficacy of 1-Hz rTMS applied to the right Dorsolateral Prefrontal Cortex (DLPFC) in patients with Panic Disorder (PD) and comorbid Major Depressive Disorder (MDD) who have not fully responded to…
- Trial name
- rTMS (NCT00521352)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Depressive Disorder, Major
Treatment of Major Depression by rTMS on Dorsolateral Prefrontal Cortex: Study of Underlying Mechanisms
The study aims to evaluate the impact of repeated Transcranial Magnetic Stimulation (rTMS) on underlying neuronal mechanisms of adults suffering from major depression disorder (MDD).
- Trial name
- DEPSTIM (NCT05121129)
- Testing
- iTBS
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Health Adult Subjects
Prefrontal Neuroplasticity and Coping Strategies in Healthy Population
The current study serves as a pilot for the GRF project "Predicting illness trajectories in fully remitted major depression using concurrent TBS/fNIRS." The project examines whether intermittent theta-burst stimulation (iTBS)…
- Trial name
- NCT07433829
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Heroin Addiction, Relapse
PET/MRI Study on the Neurological Mechanism of rTMS Treatment for Heroin Addiction
Heroin addiction is a serious problem and the relapse rate of existing treatment methods is extremely high. Recently, international journals such as Science reported that repetitive transcranial magnetic stimulation (rTMS) can…
- Trial name
- NCT04086459
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Tobacco Use Disorder
Influence of tDCS on the Brain Activation Measured During the Decision Not to Smoke in High-risk Situations
Substance use disorders (SUD) are characterized by increased automatized responses to drug-related cues (cue-reactivity) and deficient cognitive control. Cue-reactivity (CR) can be elicited by internal (e.g.
- Trial name
- NCT05875194
- Testing
- active transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Healthy
The Functional Anatomy of Personality Trait Knowledge: An fMRI Study
This study will identify the regions of the brain that are involved in personality trait knowledge-that is, what a person knows about aspects of personality such as "generous," "honest," and others.
- Trial name
- NCT00095407
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Developmental Coordination Disorder
Effects of Acute Exercise on Motor Learning and Brain Activity in Children With DCD
The aim of this study is to investigate the impact of an acute intense physical exercise bout on the learning ability of children with typical motor development (TD) and children with developmental coordination disorder (DCD).
- Trial name
- ExLeBrainDCD (NCT05936372)
- Testing
- Acute intense aerobic exercise
- Where
- 3 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Institut Nacional d'Educacio Fisica de Catalunya
Depressive Disorder, Major Depressive Disorder, Healthy Volunteer
Exploring the Role of the Prefrontal Cortex in Decision-Making
The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major…
- Conditions
- Depressive Disorder, Major Depressive Disorder, Healthy Volunteer, Aging
- Trial name
- NCT07080489
- Testing
- Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/F4, Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3/ kathodal F4
- Where
- Switzerland
- Volunteers
- 444 people, healthy volunteers welcome
- Sponsor
- University of Bern
Generalized Anxiety Disorder (GAD)
Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety Disorder
This randomized, double-blind, sham-controlled clinical trial will evaluate whether individualized alpha-frequency transcranial alternating current stimulation (tACS) can enhance the effects of mindfulness therapy in adults with…
- Trial name
- NCT07648797
- Testing
- Synchronous Individualized Alpha-Frequency tACS, Desynchronous Individualized Alpha-Frequency tACS, Mindfulness Therapy
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Central South University
Schizophrenia
Effects of Acute Nicotine Treatment on Neuroplasticity and Memory in Patients With Schizophrenia
Patients with schizophrenia display cognitive impairments, such as reduced attention and problems with memory. Available medications for schizophrenia poorly alleviate memory problems however, research indicates that nicotine…
- Trial name
- NIC-PAS (NCT01465074)
- Testing
- Nicotine polacrilex, Regular chewing gum; Dentyne Ice, Wrigely´s Mint Gum
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia, Memory Disorders
The Effects of Atomoxetine on Cognition and Brain Function Based on Catechol-O-methyltransferase(COMT) Genotype
This study will evaluate whether Atomoxetine improves cognition in healthy volunteers as well as patients with schizophrenia. Atomoxetine is a drug that has been Food and Drug Administration (FDA) approved for Attention Deficit…
- Conditions
- Schizophrenia, Memory Disorders, Cognition Disorders
- Trial name
- Atomoxetine (NCT00548327)
- Testing
- Atomoxetine, Functional magnetic resonance imaging, Neuropsychological Testing
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Methamphetamine Dependence
Transcranial Magnetic Stimulation Used to Both Measure Cortical Excitability and Explore Methamphetamine Cue Craving
Specific Primary Aims include: Aim # 1. The investigators explore the feasibility of using the TMS to investigate the cortical excitability and to inhibit meth cue craving in meth dependent population.
- Trial name
- NCT01685463
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cognition Disorders
PET Scan to Map the Areas of the Brain Involved in Planning
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal…
- Trial name
- NCT00001363
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Central Nervous System Disease, Cerebrovascular Accident
Brain Processing of Language Meanings
This research trial will study discourse processing-that is, how the brain processes the meaning of language. It will examine, for example, how words and sentences are interpreted in cases where more than one meaning is possible.
- Conditions
- Central Nervous System Disease, Cerebrovascular Accident, Craniocerebral Trauma, Head Injury
- Trial name
- NCT00005004
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Cerebral Hemodynamics, Cognitive Change
Effects of Pulsed Electromagnetic Fields (PEMFS) On Cerebral Haemodynamics
The investigators are looking to determine the effects of PEMFs device on cerebral blood flow and cognition in healthy volunteers.
- Trial name
- EPOCH (NCT03944993)
- Testing
- Pulsed Electromagnetic Fields Therapy (Dominant leg), Pulsed Electromagnetic Fields Therapy (Non-dominant leg)
- Where
- Singapore
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Migraine
Transcranial Magnetic Stimulation in Episodic Migraine (Magnet-EM)
This study will assess the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) as new preventive treatment of migraine.
- Trial name
- Magnet-EM (NCT03556722)
- Testing
- Repetitive Transcranial Magnetic Stimulation.
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Universiti Putra Malaysia