Clinical trials: Prefrontal Cortex
Neuropathic Pain
Analgesic Effects of rTMS in Peripheral Neuropathic Pain
This study aims to evaluate the long term efficacy over 25 weeks of repeated sessions of magnetic transcranial stimulation of the motor cortex or prefrontal cortex on average pain intensity, quality of life, sleep, neuropathic…
- Trial name
- TRANSNEP (NCT02010281)
- Testing
- rTMS of prefrontal or motor cortex
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Craniomandibular Disorders
Analgesic Effect of Cathodal tDCS Over Right DLPFC in Subjects With Muscular TMD: a Double Blind Crossover RCT
1. BACKGROUND: Temporomandibular Disorders (TMD) have become part of the daily routine of all the health care professionals. Some studies have shown improvement in subjects with chronic pain using neuromodulation.
- Trial name
- NCT02152267
- Testing
- tDCS
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Federal University of Bahia
Alcohol Use Disorder (AUD), Alcoholism
Repetitive Transcranial Magnetic Stimulation for Alcohol Use Disorder
This study looked at whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation treatment, could help adults with alcohol use disorder when added to their usual treatment.
- Trial name
- NCT07755046
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Ting-Gang Chang
Unipolar Depression, Impulsive Behavior
How to Reduce Suicidal Thoughts and Impulsivity in Depression
The study aims at investigating if tDCS applied to left DLPFC or to right OFC to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode.
- Conditions
- Unipolar Depression, Impulsive Behavior, Suicidal Ideation
- Trial name
- DEPIMPULSE (NCT05894980)
- Testing
- active tDCS stimulating left DLPFC, active tDCS stimulating right OFC
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Depression, Anxiety
Neurofeedback Training For Older Adults
Symptoms of depression and anxiety are common in older adults and are associated with poor outcomes and the risk of dementia. The prefrontal cortex (PFC) is crucial for emotion regulation.
- Trial name
- NCT05936697
- Testing
- fNIRS, EEG, Baseline Training
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The Hong Kong Polytechnic University
Major Depressive Disorder
Treatment of Major Depressive Disorder With Bilateral Theta Burst Stimulation
This is a randomized, double-blind, sham-controlled multicenter clinical trial. The aim is to provide evidence for efficacy of TBS in the treatment of patients with major depression.
- Trial name
- TBS-D (NCT04392947)
- Testing
- Transcranial Magnetic Stimulation
- Where
- 7 sites in Germany
- Volunteers
- 238 people
- Sponsor
- University Hospital Tuebingen
Healthy Children, Preterm Birth
Executive Training and Brain in Children
The purpose of this study is to determine whether a daily executive training to cognitive inhibition, working memory or mindfulness as compared to an active control condition has a near- and far-transfer impact on brain and…
- Trial name
- APEX (NCT02989116)
- Testing
- Inhibition training, Working memory training, Mindfulness training
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Healthy
Magnetic Resonance Imaging of the Brain in Emotional Processing
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in performing certain tasks, especially those involving emotions.
- Trial name
- NCT00061204
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Alcohol Use Disorder
The Effect of rTMS to the Prefrontal Cortex in Alcohol Use Disorder
The goal of this study is to investigate a treatment approach for alcohol use disorder (AUD) using a novel form of brain stimulation called deep repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- MAGNA (NCT03809286)
- Testing
- active rTMS, Inpatient admission
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- New York State Psychiatric Institute
Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst
Causal Role of Rostromedial Prefrontal Cortex for Positive Savoring in Depression
This is a non-invasive brain stimulation and neuroimaging study that will examine how activity in the medial prefrontal cortex influences reward processing, particularly positive savoring, in individuals with depression.
- Conditions
- Left Rostromedial Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Dorsolateral Prefrontal Cortex - Accelerated Intermittent Theta Burst, Left Primary Somatosensory Cortex - Accelerated Intermittent Theta Burst
- Trial name
- rmPFC-Savoring (NCT07467473)
- Testing
- Accelerated Intermittent Theta Burst Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Florida State University
Disorder of Consciousness
tACS Alters EEG Microstates in DoC
Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), remain difficult to diagnose at the bedside.
- Trial name
- NCT07699055
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul Medipol University Hospital
Low Back Pain
Therapeutic Effects of Horticulture on Anterior Cingulate Cortex Activation in People With Chronic Low Back Pain
Chronic low back leads to a significant socio-economic burden. It is associated with physical and psychosocial deconditioning. Even a short "nature experience" has positive effects on the affective and cognitive factors involved…
- Trial name
- HORTICARE (NCT04656158)
- Testing
- Physical activity involving exposure to nature: Therapeutic horticulture
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Lithium Effects on Reward Processing and Reappraisal in Healthy Volunteers
Bipolar disorder has been associated with blunted activity in regions associated with emotional processing, such as striatal activity during reward anticipation as well as prefrontal activity during reappraisal.
- Trial name
- NCT03965247
- Testing
- Lithium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy Participants
Prefrontal Hemodynamics and Working Memory After Exhaustive Aquatic Exercise
This study compared prefrontal cortex hemodynamics and working memory performance following exhaustive aquatic exercise between endurance athletes and physically active individuals.
- Trial name
- NCT07837661
- Testing
- Incremental Exhaustive Aquatic Stepping Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Healthy
Theta Burst Transcranial Magnetic Stimulation of Fronto-parietal Networks: Modulation by Mental State
The purpose of this study is to improve understanding of the way transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation, affects the brain.
- Trial name
- TMScogMod (NCT04010461)
- Testing
- TMS, n-back working memory task
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Alcohol Drinking, Alcohol Use Disorder
Effect of Theta Burst Stimulation on Alcohol Cue Reactivity
Alcohol Use Disorder (AUD) is prevalent, devastating, and difficult to treat. The intransigence of AUD is readily apparent in the Trauma Unit of Wake Forest University Baptist Hospital, wherein 23% of trauma related admissions…
- Conditions
- Alcohol Drinking, Alcohol Use Disorder, Trauma Injury, Alcohol Dependence
- Trial name
- NCT04223154
- Testing
- Real iTBS to the dlPFC
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Cocaine Use Disorder
Efficacy of Repetitive Transcranial Magnetic Stimulation in Reducing Cocaine Intake in Addicted Patients
The study evaluates the efficacy of 3 weeks of repetitive transcranial magnetic stimulation (rTMS), 5 sessions/weekly, in reducing cocaine consumption immediately after and within the 8 weeks following the treatment in addicted…
- Trial name
- MagneTox (NCT03607591)
- Testing
- rTMS
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Parkinson Disease
Attentional Focus and Prefrontal Cortical Activation in Older Adults and Patients With Parkinson's Disease (PD)
Attention may influence the motor performance and frontal activity. This study will examine the effect of different attentional focus: internal, external and divided attention (dual task) on prefrontal cortical activation (fNIRS)…
- Trial name
- AttPark (NCT05073874)
- Testing
- Functional Near-Infrared Spectroscopy (fNIRS)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cocaine Dependence
Measuring Distress Tolerance With Functional MRI
Background: People who are in treatment for substance abuse often feel distress during the withdrawal period and afterward. Some individuals feel distress more acutely than others, and this distress has been linked to poor…
- Trial name
- NCT01038232
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)