Clinical trials: Prefrontal Cortex
Caffeine
Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive Control
Cognitive control driven by the prefrontal cortex (PFC) of the brain is thought to be important for goal-directed control over stimulus-driven processes.
- Trial name
- NCT02940808
- Testing
- Caffeine (200mg)
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Impulsivity
fNIRS Neurofeedback in Highly Impulsive Participants With ROI Regions DLPFC and IFG
The aim of the following study is to investigate which is the best region of interest (ROI) for a functional near-infrared spectroscopy (fNIRS)-based neurofeedback (NF) training for highly-impulsive individuals (and consequently…
- Trial name
- NCT05863169
- Testing
- fNIRS-Neurofeedback
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Depression
High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Major Depression
This trial will compare the efficacy and tolerability of 20 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered twice daily over 15 days, in patients with a…
- Trial name
- NCT02702154
- Testing
- High-frequency rTMS, Low-frequency rTMS
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Anxiety Disorders, Anxiety
Prefrontal Oscillations in Social Anxiety Disorder (POSAD)
Experimental fear in rodents is correlated with slow oscillations in electrical recordings of prefrontal cortex activities. The present study aims to test whether slow prefrontal oscillations is a biomarker of pathological…
- Conditions
- Anxiety Disorders, Anxiety, Anxiety and Fear
- Trial name
- POSAD (NCT03821779)
- Testing
- In vivo social exposure, Social exposure in a virtual reality setting, EEG recording
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy Participants
Functional Roles of Dorsolateral Prefrontal Cortex
Dorsolateral prefrontal cortex (DLPFC) has been found to be involved in cognitive functions such as executive function, response selection, and working memory.
- Trial name
- NCT03882931
- Testing
- Theta Burst Transcranial Magnetic Stimulation, Focused Ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Schizophrenia
Brain Stimulation, Clinical Symptoms and Cognition
The purpose of this study is to test the impact of non-invasive brain stimulation, transcranial direct current stimulation (tDCS), on auditory hallucinations, negative symptoms and cognition in schizophrenia.
- Trial name
- NCT05053451
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy
Brain Encoding for Memory
This two-part study will use transcranial magnetic stimulation, or TMS (see below), to explore how the brain forms memories. People remember only some of the events they experience every day, such as faces they perceive, words…
- Trial name
- NCT00051870
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Involutional Depression, Anxiety Disorders
MRI Study of Brain Activity and Risk for Depression in Adolescents
Anxiety in children of parents with major depressive disorder (MDD) poses a particularly high risk for later-life MDD. In adults, MDD involves dysfunction in prefrontal brain regions that regulate attention to emotional stimuli.
- Trial name
- NCT00047944
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute of Mental Health (NIMH)
PTSD, Post Traumatic Stress Disorder
High-Frequency Repetitive Transcranial Magnetic Stimulation of the Right Dorsolateral Prefrontal Cortex in PTSD
The purpose of this study is to compare two slightly different methods of transcranial magnetic stimulation (TMS) to treat Post Traumatic Stress Disorder (PTSD)
- Trial name
- rTMS (NCT02873299)
- Testing
- 10 Hz rTMS of the right dorsolateral prefrontal cortex, 20 Hz rTMS of the right dorsolateral prefrontal cortex
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Impaired Insight
Study on Deep Transcranial Magnetic Stimulation for Enhancing Insight
Impaired insight is a key factor in the conversion of high-risk individuals to schizophrenia, but there is a lack of targeted interventions.
- Trial name
- NCT06831877
- Testing
- active-dTMS
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Shanghai Mental Health Center
Healthy
Effect of Hydrocortisone on the Brain
The purpose of this study is to use brain imaging technology to examine the effect of the hormone hydrocortisone on the brain's response to various facial expressions.
- Trial name
- NCT00055003
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Mental Health (NIMH)
Chronic Pain
Neuronavigated Repetitive Transcranial Magnetic Stimulation (nrTMS) of the Dorsolateral Prefrontal and Primary Motor Cortex for the Treatment of Chronic Pain
This study investigated the effects of navigated repetitive Transcranial Magnetic Stimulation on nociception and quality of life in patients suffering from chronic pain conditions.
- Trial name
- NCT04934150
- Testing
- navigated repetitive Transcranial Stimulation
- Where
- Austria
- Volunteers
- 34 people
- Sponsor
- Medical University of Graz
Healthy
Effects of Transcranial Direct Current Stimulation Over the Left VLPFC on Cognitive Reappraisal
This study aims to investigate the role of the left ventrolateral prefrontal cortex (VLPFC) on cognitive reappraisal, using the reinterpretation strategy.
- Trial name
- NCT03224897
- Testing
- Cathodal tDCS, Anodal tDCS
- Where
- 2 sites in Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Attention Deficit Hyperactivity Disorder
Deep Transcranial Magnetic Stimulation (DTMS) as a Treatment for Attention Deficit Hyperactivity Disorder (ADHD) in Adults
The aim of the study is to assess the effect of left or right high-frequency DTMS on ADHD symptoms, cognitive performance and decision-making ability of ADHD adults, and to compare this to the effect of sham DTMS on ADHD adults
- Trial name
- NCT01196910
- Testing
- treatment by HLPFC coil
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- Brainsway
Cocaine Dependence, Alcohol Dependence
10 Days of Theta Burst Stimulation as a Tool to Treat Cocaine Dependence
The goal of this double-blind sham controlled study is to evaluate the effeicacy of continuous theta burst stimulation to the frontal pole as a tool to decrease drug cue reactivity and improve treatment outcomes in…
- Trial name
- NCT03238859
- Testing
- Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Medical University of South Carolina
Prefrontal Hemodynamics, Muscle Strength
Lower Limb Strength and Power as Predictors of Brain Blood Flow During Exercise
This study aims to investigate the predictive value of lower limb muscle strength and explosive power on exercise-induced prefrontal hemodynamic responses.
- Conditions
- Prefrontal Hemodynamics, Muscle Strength, Physical Performance
- Trial name
- LLSPP (NCT07575802)
- Testing
- Standardized Lower-Limb Physical Performance Assessment and Aerobic Exercise Task
- Where
- Russia
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Lincoln University College
Healthy
Role of the Brain in Making Economic Decisions
This study will identify which areas of the brain mediate the interaction between people involved in economic decision-making. Healthy, right-handed native English speakers between 21 and 55 years of age may be eligible for this…
- Trial name
- NCT00083317
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Treatment Resistant Depression
Epidural Cortical Stimulation for Depression
Objective: Chronic epidural cortical stimulation (ECS) involves the neurosurgical placement of an electric wire on the surface of the brain with intermittent activation.
- Trial name
- EpCS-D (NCT00565617)
- Testing
- Synergy, Epidural cortical stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical University of South Carolina
Schizophrenia, Cognition
Effects of Atomoxetine on Cognitive Function in Schizophrenia
The purpose of this study is to examine the effects of atomoxetine (Strattera™) on prefrontal cognitive functioning in persons with schizophrenia.
- Conditions
- Schizophrenia, Cognition, Smoking
- Trial name
- NCT00420498
- Testing
- Atomoxetine (Strattera™)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Healthy
Investigating the Cognitive Processes That Underlie Social Knowledge and Behavior
The purpose of the protocol is to localize the neural regions and systems mediating the forms of knowledge representations hypothesized by the principal investigator to be stored in the human prefrontal cortex.
- Trial name
- NCT00061334
- Where
- United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)