Clinical trials: Pregnancies, open to volunteers
PCOS (Polycystic Ovary Syndrome)
The Effects of the Mediterranean Diet and Synbiotics in Polycystic Ovary Syndrome
This study will look at whether a reduced-calorie Mediterranean-style eating plan, together with a synbiotic supplement, can improve health measures and quality of life in women who have polycystic ovary syndrome (PCOS) and are…
- Trial name
- NCT07342946
- Testing
- Synbiotic Supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Atlas University
Ectopic Pregnancy
Letrozole Versus Methotrexate for Management of Undisturbed Ectopic Pregnancy
The aim of work is to study the effectiveness of letrozole in treatment of early undisturbed ectopic pregnancy in comparison with Methotrexate.
- Trial name
- NCT07624903
- Testing
- Methotrexate (drug), Letrozole 2.5Mg Tab
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Kafrelsheikh University
Kidney Calculi, Ureteral Calculi
New Laser and Suction Sheath for Kidney Stone Treatment
The goal of this clinical trial is to learn if the combination of super pulsed thulium fiber laser (sTFL) with a flexible negative pressure suction sheath is more effective and safer than sTFL with a conventional sheath in…
- Trial name
- NCT06667466
- Testing
- Super Pulsed Thulium Fiber Laser (sTFL) + Flexible Negative Pressure Ureteral Access Sheath (UAS) Intervention, Super Pulsed Thulium Fiber Laser (sTFL) + Conventional Ureteral Access Sheath (UAS) Intervention
- Volunteers
- 140 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Bladder Hyperactivity, Sacral Neuromodulation
Evaluation of Autonomic Nervous System Changes in Response to Stimulation by Sacral Neuromodulation
Overactive bladder syndrome (OAB) is defined by urgent and frequent urges to urinate associated with frequent night-time urination and sometimes urinary incontinence.
- Trial name
- ESTIME (NCT06434831)
- Testing
- Medical device for SNM: Interstim X or Interstim micro
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Premature, Feeding Disorders
Effect OF Lactase Enzyme Supplements ON Intolerance IN Preterm Neonates
This study aims to study the effect of lactase enzyme in preventing feeding intolerance in preterm neonates in neonatal intensive care unit at Alexandria University Children's Hospital.
- Conditions
- Premature, Feeding Disorders, Lactase Deficiency, Congenital
- Trial name
- NCT07088302
- Testing
- lactase administration
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease
Effect of Secukinumab on Cardiorenal Outcomes in Patients With Cardiorenal Metabolic Syndrome and Atherosclerotic Cardiovascular Disease
This is a prospective, randomized, open-label, parallel-controlled clinical trial to evaluate the efficacy and safety of targeted IL-17A inhibition with secukinumab on cardiovascular and renal endpoints in 100 patients with…
- Conditions
- Cardiorenal Metabolic Syndrome, Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease, Coronary Artery Disease
- Trial name
- NCT07704190
- Testing
- Secukinumab (75 mg), Standard Medical Therapy
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital
Acute Kidney Injury, Cardiac Surgery
Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery
Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if <48h, persistent if >48h), the…
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Venous Congestion, Hemodynamic Stability
- Trial name
- VeXUS (NCT06251713)
- Testing
- VeXUS score guided fluid management strategy, Usual care
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Lupus, Systemic Lupus Erythematosus
A Study to Evaluate Mosunetuzumab in Participants With Systemic Lupus Erythematosus With or Without Active Lupus Nephritis
This study will assess how mosunetuzumab works in people who have systemic lupus erythematosus (SLE) who may or may not also have active lupus nephritis (LN).
- Conditions
- Lupus, Systemic Lupus Erythematosus, Lupus Nephritis
- Trial name
- SOLUNA (NCT07598396)
- Testing
- Mosunetuzumab
- Where
- 24 sites in Argentina, Brazil and 4 more
- Volunteers
- 30 people
- Sponsor
- Hoffmann-La Roche
Ovarian Cancer
OCS Products Based on Exosome Technology Were Applied in the Recurrence Monitoring Study After the Initial Treatment of Baseline CA125-negative Ovarian Cancer
To study the performance of OCS products based on exosome detection technology in monitoring the recurrence of baseline CA125-negative ovarian cancer patients after initial treatment, and to explore reliable methods for…
- Trial name
- NCT07153705
- Volunteers
- 32 people
- Sponsor
- Beihua Kong
Threatened Abortion
Serum Progesterone and Threatened Abortion During Lactation
This study aims to evaluate the effect of first-trimester maternal serum progesterone levels on threatened abortion in women who conceive during the lactation period.
- Trial name
- NCT07357922
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Cervical Cancer
Para-aortic Prophylactic Irradiation for Locally Advanced Cervical Cancer
Para-aortic lymph node metastasis is a poor prognostic factor for locally advanced cervical cancer, but false negative diagnosis is easy to occur.
- Trial name
- PAILACC (NCT04974346)
- Testing
- Paraaortic prophylactic irradiation and pelvic definitive concurrent chemoradiation, Pelvic definitive concurrent chemoradiation
- Where
- 7 sites in China
- Volunteers
- 455 people
- Sponsor
- Zhejiang Cancer Hospital
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC)
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)").
- Conditions
- Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC), Advanced Solid Tumors
- Trial name
- BrILliance (NCT06413680)
- Testing
- REGN10597, Cemiplimab
- Where
- 11 sites in United States
- Volunteers
- 240 people
- Sponsor
- Regeneron Pharmaceuticals
Urinary Incontinence , Stress, Prostatectomy
Effect of High-Intensity Focused Electromagnetic (HIFEM) Technology in the Treatment of SUI in Chinese Men Undergone Robotic Radical Prostatectomy
This is a prospective, randomized trial to evaluate the efficacy and safety of High-Intensity Focused Electromagnetic (HIFEM) Technology in the treatment of stress urinary incontinence compared with standard of care in Chinese…
- Trial name
- NCT06589869
- Testing
- EM Chair, Standard of care
- Where
- Hong Kong
- Volunteers
- 184 people
- Sponsor
- Chinese University of Hong Kong
Polycystic Ovary Syndrome
DAISy-PCOS Phenome Study - Dissecting Androgen Excess and Metabolic Dysfunction in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 10% of all women and usually presents with irregular menstrual periods and difficulties conceiving.
- Trial name
- DAISy-PCOS (NCT03911297)
- Testing
- Women with polycystic ovary syndrome
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Premature Birth
Impact of Moderate Preterm Birth on Vocabulary Acquisition
Children born prematurely may present a neurodevelopmental disorder with a language delay diagnosed as early as 2-3 years of age.
- Trial name
- BABYLANG (NCT05397197)
- Testing
- Electroencephalography
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Systemic Lupus Erythematosus, Lupus Nephritis
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus
- Trial name
- NCT06121297
- Testing
- CABA-201
- Where
- 23 sites in United States, Canada and 1 more
- Volunteers
- 28 people
- Sponsor
- Cabaletta Bio
Uterine Cervical Neoplasms, Triple Negative Breast Neoplasms
A Phase II Study of GV20-0251 in Combination With Anti-PD-1 Monoclonal Antibodies in Patients With Unresectable, Locally Advanced, or Metastatic Solid Tumors.
This is a Phase 2 study of GV20-0251 in combination with anti-PD-1 monoclonal antibodies (including tislelizumab and toripalimab) for the treatment of participants with unresectable, locally advanced, or metastatic solid tumors…
- Conditions
- Uterine Cervical Neoplasms, Triple Negative Breast Neoplasms, Prostatic Neoplasms, Squamous Cell Carcinoma of Head and Neck
- Trial name
- NCT07623642
- Testing
- GV20-0251, anti-PD-1 monoclonal antibodies
- Where
- 2 sites in China
- Volunteers
- 227 people
- Sponsor
- GV20 Therapeutics
Prematurity
Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients
The purpose of this study is to develop biocompatible wireless electronic devices that will allow continuous, non-invasive hemodynamic and physiology measurements in the ICU.
- Trial name
- NCT04723654
- Testing
- Wireless Wearable Vital Sign Monitor
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Pelvic Radiotherapy, Vaginal Stenosis
Vaginal Dilator Therapy After Pelvic Radiation
This study is testing a new program to help women who have had pelvic radiation therapy to use vaginal dilators more regularly. Vaginal dilators are important tools that can help prevent or treat vaginal narrowing (called vaginal…
- Conditions
- Pelvic Radiotherapy, Vaginal Stenosis, Pelvic Cancer, Gynecologic Cancers
- Trial name
- NCT07216456
- Testing
- Improving Engagement with Vaginal Dilator Therapy after Pelvic Radiation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University
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