Clinical trials: Pregnancy, Ceasarian Section, Anaesthesia, open to volunteers
Spinal Anesthesia, Pregnancy
Preoperative Shock Indexes and Post-Spinal Hypotension in Cesarean Surgery
This prospective observational study aims to evaluate the predictive performance of preoperative Shock Index (SI) and Modified Shock Index (MSI) for hypotension following spinal anesthesia in elective cesarean surgery.
- Conditions
- Spinal Anesthesia, Pregnancy, Hypotension Postprocedural
- Trial name
- NCT07500519
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Marmara University
Anesthesia, Pregnancy Related
Upper vs Lower Extremity BP in Spinal Cesarean Using ClearSight
This is a single-center, prospective observational study in patients undergoing cesarean delivery under spinal or combined spinal-epidural anesthesia.
- Conditions
- Anesthesia, Pregnancy Related, Blockades Neuromuscular
- Trial name
- NCT07685730
- Testing
- ClearSight
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Post Spinal Anesthesia Shivering
Intrathecal DEX With Bupivacaine Inpost-spinal Shivering After CS.
This prospective, randomized, double-blind, placebo-controlled study to determine whether intrathecal dexmedetomidine, administered along with hyperbaric bupivacaine for covering Cesarean delivery decreases the incidence of…
- Trial name
- DEX (NCT06942000)
- Testing
- dexmedetomidine 3mcg group, dexmedetomidine 5mcg, preservative-free 0.9% saline.
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Gestational Diabetes Mellitus (GDM), Obstetric Anesthesia
Ultrasound Assessment Of Gastric Volume In Pregnant Women Undergoing Elective Cesarean Section
The primary objective of this study is to compare gastric volume prior to elective cesarean section between pregnant women diagnosed with gestational diabetes mellitus (GDM) and those without GDM.
- Trial name
- GDM (NCT07816705)
- Testing
- GASTRIC ULTRASONOGRAPHY
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Pressor Response
Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients
Dexmedetomidine nebulization in sever preeclamptic patients
- Trial name
- NCT07164326
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
Spinal Anesthesia-Induced Hypotension, Preeclampsia
Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induced Hypotension in Preeclamptic Parturients
This prospective, single-center observational study aims to evaluate the predictive value of the internal jugular vein collapsibility index (IJVCI) for spinal anesthesia-associated hypotension in preeclamptic parturients…
- Conditions
- Spinal Anesthesia-Induced Hypotension, Preeclampsia, Cesarean Section
- Trial name
- NCT07496788
- Testing
- Internal Jugular Vein Collapsibility Index Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ankara City Hospital Bilkent
Pregnancy, Neonatal Hearing Function
Comparison of Different Anesthetic Techniques on Hearing Outcomes in Neonates After Cesarean Delivery
This is a single-center, prospective, single-blind randomized controlled trial. The investigators plan to recruit 144 pregnant women scheduled for cesarean delivery.
- Trial name
- ATHNCD (NCT07852624)
- Testing
- Combined spinal-epidural anesthesia, General Anesthesia (GA)
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
General Anaesthesia During Pregnancy
A Longitudinal, Cohort Study Investigating the Impact of General Anaesthetic Caesarean Birth, With or Without ICU Admission, on Maternal Mental Health and Mother/Infant Bonding
In the UK, approximately 6000 women every year undergo caesarean sections with general anaesthetic. Additionally, around 1300 women are admitted to Intensive Care Units (ICU) annually, typically due to pregnancy or childbirth…
- Trial name
- GABI (NCT07115823)
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- King's College London
Urinary Retention
Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.
Peri-medullary anesthesia is the preferred anesthetic technique for Caesarean surgery. Compared with general anesthesia, it reduces maternal and fetal morbidity and mortality, as well as postoperative pain.
- Trial name
- EPIMAG (NCT06442995)
- Testing
- Injection of 500 mg magnesium sulfate + 2 mg morphine into the epidural space, Injection of Isotonic saline + 2 mg morphine into the epidural space
- Where
- France
- Volunteers
- 290 people
- Sponsor
- CHU de Reims
Preeclampsia, Spinal Anesthesia-Induced Hypotension
Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia
This study compares the efficacy and safety of intravenous dexamethasone versus intravenous ondansetron in preventing low blood pressure (hypotension) following spinal anesthesia in pregnant women with preeclampsia undergoing…
- Conditions
- Preeclampsia, Spinal Anesthesia-Induced Hypotension, Cesarean Section
- Trial name
- NCT07793760
- Testing
- Dexamethasone, Ondansetron
- Volunteers
- 110 people
- Sponsor
- Assiut University
Pregnancy, Cesarean Section
Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section
The goal of this randomized controlled clinical trial is to determine if low-dose intrathecal morphine is superior to a Transversus Abdominis Plane (TAP) block with ropivacaine and clonidine for postoperative analgesia in women…
- Conditions
- Pregnancy, Cesarean Section, Neuroaxial Analgesia Procedures
- Trial name
- MIRAGE (NCT07377630)
- Testing
- Intrathecal Morphine, TAP Block
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Giannina Gaslini
Pregnant People, Anxiety
Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial
Patients presenting for a scheduled cesarean delivery who require a neuraxial anesthetic will be randomized to receive intravenous remimazolam or dexmedetomidine for procedural sedation during the placement of their spinal or…
- Trial name
- NCT07651956
- Testing
- Remimazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pre-Eclampsia
Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia
The purpose of this study is to compare the effect of albumin versus routine care on hemodynamic response and stability in pre-eclamptic patients during cesarean delivery.
- Trial name
- NCT06107335
- Testing
- Human Albumin (colloid), Lactated Ringer's Injection (crystalloid), Edwards HemoSphere monitor with ClearSight-Acumen finger cuff
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pregnancy, Cesarean Section, Spinal Anesthesia
The Effectiveness of Binaural Beats on Midazolam Requirement During Cesarean Section With Spinal Anesthesia
Spinal anesthesia is preferred for cesarean section in many institutions due to concerns regarding the potential effects of general anesthetic agents on the fetus.
- Trial name
- NCT07386054
- Testing
- binaural beats, Midazolam
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Postpartum Hemorrhage, Uterine Atony
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Cesarean Section, Blood Loss, Surgical
- Trial name
- CARBOXY-RCT (NCT07636421)
- Testing
- Carbetocin, Oxytocin
- Where
- Saudi Arabia
- Volunteers
- 332 people
- Sponsor
- Mansoura University
Cesarean Section, Hypotension
Effect of Oxytocin Bolus Versus Slow Infusion on Haemodynamic Stability During Caesarean Section Under Spinal Anaesthesia
This study compares two standard ways of giving oxytocin (a medicine that helps the uterus contract) after the baby is born during a planned caesarean section performed under spinal anaesthesia.
- Conditions
- Cesarean Section, Hypotension, Postpartum Hemorrhage, Spinal Anesthesia
- Trial name
- NCT07784478
- Testing
- Oxytocin
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Khyber Girls Medical College
Pregnancy, Cesarean Section
Effects of High Flow Humidified Oxygen on Umbilical Artery Acid-base Balance in Cesarean Section Under Spinal Anesthesia
Spinal anesthesia is the most commonly used anesthetic technique for cesarean section in developed countries, but vasodilation and a decrease in systemic vascular resistance caused by sympathetic blockade result in hypotension in…
- Conditions
- Pregnancy, Cesarean Section, Spinal Anesthesia
- Trial name
- NCT07515716
- Testing
- high-flow nasal oxygen, conventional nasal cannula oxygen
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Spinal Anesthesia, Post Operative Analgesia
Dexamethasone in Prolonging the Duration of Spinal Anesthesia Among Pregnant Patients
Lower segment C section is one of the most commonly performed surgeries worldwide. It is performed in spinal anesthesia. During Spinal Anesthesia a local anesthetic drug is administered in a space surrounding spinal cord and it…
- Trial name
- NCT07088146
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College