Clinical trials: Pregnancy, High-Risk
Abnormal Vaginal Flora, Clindamycin Vs Metronidazole
Comparison Between Oral Clindamycin Vs Metronidazole for the Treatment of Abnormal Vaginal Flora in High Risk Pregnancies
Abnormal vaginal flora is a risk factor for preterm labor. Therefore, in high risk pregnancies for preterm labor the diagnosis and treatment of abnormal flora is indicated.
- Conditions
- Abnormal Vaginal Flora, Clindamycin Vs Metronidazole, High Risk Pregnancies for Preterm Labor
- Trial name
- NCT01722708
- Testing
- Clindamycin, Metronidazole
- Where
- 2 sites in Israel
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Pregnancy, High-Risk Pregnancy
UCLA Perinatal Biospecimen Repository
The purpose of this investigator-initiated prospective observational cohort study is to establish the new UCLA Perinatal Biospecimen Repository (Perinatal Repository) for collection, storage, and distribution of the human data…
- Trial name
- NCT05035160
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yalda Afshar, MD, PhD
Preterm Labour, Cervical Insufficiency
Intramuscular vs Rectal Progesterone in Preventing Preterm Labour After Cervical Cerclage
Preterm labour is a major cause of neonatal morbidity and mortality worldwide. Progesterone supplementation is known to help reduce the risk of preterm birth in high-risk women.
- Conditions
- Preterm Labour, Cervical Insufficiency, Pregnancy, High-Risk
- Trial name
- PROCER (NCT07307092)
- Testing
- Intramuscular Progesterone, Rectal Progesterone
- Where
- Pakistan
- Volunteers
- 820 people
- Sponsor
- Hina Mukhtar
High-risk Pregnancy, Breast Feeding
Effect of Hypnobreastfeeding Education in High-Risk Pregnant Women
It is thought that hypnobreastfeeding training given to high-risk pregnant women will reduce anxiety levels, increase lactation, encourage breastfeeding, reduce the perception of insufficient milk, and facilitate adaptation to…
- Trial name
- NCT07281339
- Testing
- Hypnobreastfeeding Education
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Amasya University
Pregnancy, High-Risk
The Effect of Showing Fetal Images to High-Risk Pregnant Women on Stress and Sleep
The study will be conducted to determine the effect of showing fetal images to high-risk pregnant women on pregnancy stress and sleep quality.
- Trial name
- NCT07260838
- Testing
- Showing fetal images
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Melike Nur SÖNMEZ
Pregnancy, High Risk, Anticoagulants
Anticoagulation Profile in Pregnant Women Treated With Three Times a Day of Low Molecular Weight Heparin (LMWH)
Pregnancy is associated with a increased risk of developing blood clots. There is nearly a 5 times greater risk of developing a blood clot in pregnancy.
- Trial name
- NCT04861103
- Testing
- Lovenox
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Gestational Diabetes Mellitus, Pregnancy, High Risk
Continuous Glucose Monitoring (CGM) Substudy of the DECIDE RCT
This is a nested multicenter prospective cohort conducted concurrently and in conjunction with the DECIDE two-arm, pragmatic non-inferiority comparative effectiveness Randomized Controlled Trial (RCT) (NCT06445946) of metformin…
- Trial name
- DECIDE CGM (NCT06490874)
- Testing
- CGM device - Metformin group, CGM device - Insulin group
- Where
- 4 sites in United States
- Sponsor
- Ohio State University
Fetal Growth Restriction, Perinatal Outcome
Relationship of DV Doppler Parameters to Perinatal Outcomes in IUGR vs Non-IUGR
This observational study investigates whether blood flow in the ductus venosus, a small fetal vein measured by Doppler ultrasound, is related to pregnancy outcomes.
- Conditions
- Fetal Growth Restriction, Perinatal Outcome, Pregnancy, High Risk
- Trial name
- DV-FGR (NCT07190157)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Izmir City Hospital
Pregnancy, High Risk, Child Development
Nurse Family Partnership for Women With Previous Live Births
The goal of this clinical trial is to test the Nurse Family Partnership (NFP) in mothers with previous live births (multiparous or multip individuals).
- Conditions
- Pregnancy, High Risk, Child Development, Post Partum Depression
- Trial name
- NCT05887115
- Testing
- Nurse Family Partnership
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pregnancy Related, Pregnancy Complications
Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring
The Relugolix Pregnancy Registry is a prospective, observational cohort study designed to evaluate the association between relugolix-containing therapy exposure during pregnancy and subsequent maternal, fetal, and infant…
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk
- Trial name
- NCT05739123
- Testing
- Relugolix-Containing Product
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Pregnancy, High Risk
Remote Cardiotocography Telemonitoring Within High-risk Pregnancy Care
The overall aim of this research proposal is to explore the feasibility and acceptability of home antenatal maternal-fetal monitoring technology within a high-risk pregnancy group.
- Conditions
- Pregnancy, High Risk, Telemonitoring, Telemedicine
- Trial name
- NCT07124325
- Testing
- Pregnabit Pro device and PregnaOne platform
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Pregnancy Related, Pregnancy Complications
MYFEMBREE®: A Retrospective Cohort Study Using an Administrative Healthcare Database to Assess Pregnancy Outcomes in Women Treated With Relugolix Combination Therapy
This is a retrospective cohort study that will be conducted using secondary de-identified electronic healthcare data (EHD) that originally were collected for the purposes of health insurance billing and/or routine patient care…
- Conditions
- Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk
- Trial name
- NCT05739136
- Testing
- Relugolix + Estradiol + Norethindrone Acetate
- Where
- United States
- Volunteers
- 530 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
High-risk Pregnancy, Pregnancy
AI-Powered CURAᵀᴹ Application for Identifying At-Risk Pregnancies in Obstetric Management
It is important to identify high pregnancies early through screening so that appropriate care and intervention may be instituted.
- Conditions
- High-risk Pregnancy, Pregnancy, Antenatal Health
- Trial name
- CURAte (NCT06974188)
- Testing
- AI-risk Stratification
- Where
- Singapore
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Gestational Diabetes Mellitus, Pregnancy in Diabetic
Patient Versus Provider-led Titration of Insulin for Glycemic Control in Gestational Diabetes (EMPOWER)
We propose a pragmatic, unblinded, randomized controlled, single center trial of 56 pregnant individuals with Gestational diabetes mellitus (GDM).
- Conditions
- Gestational Diabetes Mellitus, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT05922033
- Testing
- Patient-led Insulin (intervention group), Provider-led Insulin (standard care)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ohio State University
Pregnancy, High Risk
Validation of a Non-invasive Hemoglobin Measurement Device in Pregnancy and Postpartum in Kenya, Pakistan, and Zambia
Accurate, precise, and comparable hemoglobin measurements is of great importance, both for clinical value in diagnosing anemia and ensuring pregnant women receive appropriate treatment.
- Trial name
- NCT05656352
- Testing
- Masimo Total Hemoglobin SpHb® Continuous Non-invasive Hemoglobin Monitoring Device, Complete Blood Count
- Where
- 4 sites in Kenya, Pakistan and 1 more
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- George Washington University
Preeclampsia, Immunologic Disease
Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome
The purpose of the study is to evaluate the ability of placental angiogenesis markers to predict the risk of PE in pregnancy in women with primary APS.
- Conditions
- Preeclampsia, Immunologic Disease, Antiphospholipid Antibody Syndrome Primary, Pregnancy Complications
- Trial name
- NCT05786235
- Testing
- Collection of epidemiological and anamnestic data and collection of biological material (peripheral blood)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Rheumatic Diseases, Fertility Disorders
Medically Assisted Fertilization Techniques in Systemic Immunoreumatologic Diseases
Systemic rheumatological diseases often occur in young women of childbearing age and can therefore impact fertility. There are diseases, such as arthritis, which present no contraindication to assisted reproductive techniques…
- Conditions
- Rheumatic Diseases, Fertility Disorders, Pregnancy, High Risk, Pregnancy Complications
- Trial name
- NCT05807256
- Testing
- collection and analysis of treatments and procedures already performed by normal clinical practice
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Gestational Diabetes, Pregnancy Complications
Gestational Diabetes Monitoring and Management
The primary goal is to predict the clinical outcomes of mother and baby using blood glucose and other routinely collected clinical data in pregnancy to predict adverse outcomes at birth in women with GDM.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT06963528
- Where
- United Kingdom
- Volunteers
- 1,800 people
- Sponsor
- University of Oxford
High-Risk Pregnancies
The Effect of Paint-by-Numbers Activity on Stress and Prenatal Attachment in High-Risk Pregnancies
Pregnancy, a physiological state, is defined both as a turning point and a developmental crisis . Pregnancy directly affects maternal and child health, and in cases of complications, it can lead to morbidity and mortality…
- Trial name
- NCT06955312
- Testing
- Experimental
- Volunteers
- 60 people
- Sponsor
- Erzurum Technical University
Gestational Diabetes, PreDiabetes
mHealth Smartphone App and Postpartum Glucose Intolerance for Patients With GDM
Without intervention, approximately 70% of women diagnosed with GDM will develop type 2 diabetes mellitus in their lifetime. Abnormal results of a 2 hour oral glucose tolerance test (OGTT) performed as early as 2 days postpartum…
- Conditions
- Gestational Diabetes, PreDiabetes, Pregnancy Related, Pregnancy, High Risk
- Trial name
- NCT05597943
- Testing
- Malama App
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center