Clinical trials: Pregnancy, Physical Activity
Gestational Diabetes Mellitus in Pregnancy
Telerehabilitation Exercise: Effects on Maternal Quality of Life, Fetal and Neonatal Health.
Gestational diabetes mellitus (GDM) occurs when blood sugar levels rise during pregnancy, typically between 24-28 weeks, affecting about 2-18% of all pregnancies.
- Trial name
- NCT06480292
- Testing
- telerehabilitation exercise, routine medical care
- Where
- 2 sites in Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Clear Cell Renal Cell Carcinoma
1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC
The main purpose of this study is to find out how useful dovitinib is when given as the initial treatment to participants with advanced kidney cancer, that has spread to other parts of the body.
- Trial name
- DILIGENCE-1 (NCT01791387)
- Testing
- Dovitinib
- Where
- New Zealand
- Volunteers
- 30 people
- Sponsor
- Auckland District Health Board
Castration-Resistant Prostate Cancer (CRPC), Colorectal Cancer
177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
This is a Phase 1/2a dose escalation and expansion study to determine the safety, tolerability, and preliminary clinical activity of 177LuBetaBart, a lutetium-labeled anti-B7-H3 monoclonal antibody, in patients with…
- Conditions
- Castration-Resistant Prostate Cancer (CRPC), Colorectal Cancer, NSCLC (Non-small Cell Lung Cancer), Ovarian Cancer
- Trial name
- BetaBart (NCT07189871)
- Testing
- 177Lu-BetaBart, BetaBart + unlabeled BetaBart
- Where
- 5 sites in United States
- Volunteers
- 61 people
- Sponsor
- Radiopharm Theranostics, Ltd
Multiple Sclerosis, Urinary Incontinence
The Effect of Health Belief Model-Based Pelvic Floor Muscle Exercise Training on Urinary Incontinence and Quality of Life in Female Patients With Multiple Sclerosis
The aim of this study is to evaluate the effect of Pelvic Floor Muscle Exercise Training According to the Health Belief Model on Urinary Incontinence and Quality of Life in Female Patients with Multiple Sclerosis.
- Trial name
- NCT06805331
- Testing
- Intervention group(Pelvic Floor Muscle Exercise Training), control group
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Nurgül KAPLAN
Primary Nocturnal Enuresis, Nocturnal Enuresis in Children
Effectiveness of Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in Children With Primary Monosymptomatic Nocturnal Enuresis
The aim of this randomized controlled trial is to evaluate the effects of Structured Pelvic Floor Muscle Rehabilitation (SPFMR) in children with Primary Monosymptomatic Nocturnal Enuresis (PMNE) who are undergoing desmopressin…
- Trial name
- NCT06883851
- Testing
- Structured pelvic floor rehabilitation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bahçeşehir University
Chronic Kidney Diseases
Cerebrovascular Dysregulation in Chronic Kidney Disease
The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).
- Trial name
- NCT05571605
- Testing
- Exercise, Stretching
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Texas, Denton, TX
Urinary Tract Infections (UTIs), Catheter-Associated Urinary Tract Infections (CAUTIs)
Antibiofilm Activity of Chitosan Nanoparticles Against Uropathogenic Escherichia Coli
1. Isolation of uropathogenic Escherichia coli (UPEC) and determination of their Antimicrobial sensitivity Patterns. 2. Evaluation of biofilm-forming capacity of UPEC isolates. 3.
- Conditions
- Urinary Tract Infections (UTIs), Catheter-Associated Urinary Tract Infections (CAUTIs), Biofilm Formation by Uropathogenic Escherichia Coli (UPEC)
- Trial name
- NCT07482553
- Testing
- chitosan nanoparticles
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Endometrial Diseases
The Effect of Progressive Muscle Relaxation Exercise Applied Before Endometrial Biopsy on Pain, Anxiety Level and Patient Comfort in Premenopausal Women
This study was designed to determine the effect of progressive muscle relaxation exercises performed before endometrial biopsy on pain, anxiety levels, and patient comfort in premenopausal women.
- Trial name
- NCT07694037
- Testing
- progressive muscle relaxation exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Ovarian Neoplasms, Endometrial Neoplasms
A Study of PF-07260437 in Advanced or Metastatic Solid Tumors
A study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of PF-07260437, a B7-H4 x CD3 bispecific mAb, in participants aged ≥18 years of age with advanced or metastatic…
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Breast Neoplasms
- Trial name
- C4431001 (NCT05067972)
- Testing
- PF-07260437, B7-H4 IHC
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 30 people
- Sponsor
- Pfizer
Accidental Falls, Chronic Renal Insufficiency
Fall Prevention by Alfacalcidol and Training
Objective of the study is to evaluate the effect of a multimodal therapy on the basis of current guidelines on fall prevention consisting of a 12-months intervention with Alfacalcidol and calcium, patient education and a mobility…
- Conditions
- Accidental Falls, Chronic Renal Insufficiency, Aged
- Trial name
- SPALT (NCT00483275)
- Testing
- Alfacalcidol, Balance, gait and strength training, Patient education
- Where
- Germany
- Volunteers
- 484 people
- Sponsor
- Ruhr University of Bochum
Solid Tumors, Urothelial Carcinoma
A Study Evaluating MM-310 in Patients With Solid Tumors
MM-310 is a liposomal formulation of a docetaxel prodrug that targets the EphA2 receptor on cancer cells. Docetaxel is an approved chemotherapeutic drug.This study is a Phase 1 open-label study of MM-310 in patients with solid…
- Conditions
- Solid Tumors, Urothelial Carcinoma, Gastric Carcinoma, Squamous Cell Carcinoma of the Head and Neck
- Trial name
- NCT03076372
- Testing
- MM-310
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Merrimack Pharmaceuticals
Neonatal Disease, Parenting
Neonatal Neurobehavioral And Motor Behavior In Ultra Early Physical Therapy Intervention
Investigation of the combination of neonatal neurobehaviourism and motor behavior in the assessment and ultra-early physical therapy intervention of premature neonates and parental support.
- Conditions
- Neonatal Disease, Parenting, Premature Birth
- Trial name
- NCT05565287
- Testing
- ultra early physiotherapy intervention
- Where
- 3 sites in Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Chronic Renal Diseases
Intradialytic Physiotherapy in Patients With Chronic Kidney Disease
The objective is to evaluate in adult patients with chronic kidney disease the effect of neuromuscular electrical stimulation (NMES) in the upper limbs associated with a cycle ergometer in the lower limbs, during hemodialysis, on…
- Trial name
- NCT05374863
- Testing
- Neuromuscular electrical stimulation (NMES) - Active, Aerobic exercise with cycle ergometer
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Marcela Cangussu Barbalho
Overactive Bladder Syndrome
Overactive Bladder Syndrome and Hypopressive Exercise
Overactive Bladder Syndrome (OAB) is a condition characterized by a sudden and urgent need to urinate, with or without urge incontinence, accompanied by increased urinary frequency.
- Trial name
- NCT06780657
- Testing
- Online hypopressive exercise training program
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people
- Sponsor
- Pamukkale University
Chronic Kidney Disease, Obesity
Weight Loss Interventions in Obese Patients With Stages 3-4 Chronic Kidney Disease: a Randomised Controlled Trial
Weight loss surgery is the most effective weight loss treatment available, but the direct effect on chronic kidney disease is less widely understood.
- Trial name
- NCT01053130
- Testing
- laparoscopic sleeve gastrectomy, weight management program
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- King's College Hospital NHS Trust
Stress Urinary Incontinence, Diaphragmatic Breathing
360 Degree Expanded Diaphragm Exercises in Women With Stress Urinary Incontinence
This study was planned to examine and compare the effects of standard diaphragm exercises with Pelvic floor muscle exercises (PFME) and 360-degree expanded diaphragm exercises with PFME on urinary symptoms, PFM functions and…
- Conditions
- Stress Urinary Incontinence, Diaphragmatic Breathing, Pelvic Floor Muscle Exercise, Intra-abdominal Pressure
- Trial name
- NCT06120699
- Testing
- Pelvic floor muscle training with 360 degree expanded diaphragm exercises, Pelvic floor muscle training with standard diaphragm exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Izmir University of Economics
Pregnancy Related
Pregnant Women Doing Resistance Exercise Training
Despite the increase in numbers of women who engage in heavy, free-weight resistance exercise training (e.g. powerlifting, weightlifting, cross fit), the knowledge on how such exercise may affect fertility, pregnancy and birth…
- Trial name
- PREG_RET (NCT04780087)
- Where
- Norway
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Ostfold University College
Preeclampsia
Detection of Epileptiform Activity in Severe Preeclampsia
The primary aim of this pilot study is to prospectively quantify epileptiform activity in a cohort of preeclamptic patients before and after intravenous magnesium administration.
- Trial name
- NCT03494517
- Testing
- Magnesium Sulfate
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- Pascal Vuilleumier
Hypertension, Heart Failure
Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity
The study is aiming to document the long-term safety and effectiveness of renal denervation in patients with hypertension and other diseases characterized by elevated sympathetic drive.
- Conditions
- Hypertension, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- NCT01888315
- Testing
- Renal denervation with Symplicity Flex Medtronic/Ardian, Renal denervation with EnligHTN St. Jude Medical, Renal denervation with Paradise Recor
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Saarland
Chronic Kidney Disease Requiring Chronic Dialysis
Intradialytic Pedalling Exercise and Vascular Hemodynamic Parameters Among Prevalent Hemodialysis Population
The purpose of this pilot study is to evaluate 1) the effect of intradialytic pedaling exercise on arterial stiffness and other arterial hemodynamic parameters over 4 months, and 2) the longer-term effect of pedaling on arterial…
- Trial name
- NCT03027778
- Testing
- Exercise
- Volunteers
- 32 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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