Clinical trials: Pregnancy, Physical Activity
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC)
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)").
- Conditions
- Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC), Advanced Solid Tumors
- Trial name
- BrILliance (NCT06413680)
- Testing
- REGN10597, Cemiplimab
- Where
- 11 sites in United States
- Volunteers
- 240 people
- Sponsor
- Regeneron Pharmaceuticals
Endometrial Cancer
Physical Activity After Endometrial Cancer
Researchers propose to apply Social Cognitive Theory to improve understanding of the mechanisms of physical activity adherence for endometrial cancer survivors participating in a physical activity intervention.
- Trial name
- NCT00501761
- Testing
- Personalized Exercise Program, Questionnaire, Suggested Exercise Program
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Preterm Birth
Exercise in Prematurely Born Preadolescents to Mitigate Cardiovascular Risk and Improve Cognitive Impairment
EXCELSIOR is a randomized controlled trial to investigate the effect of physical exercise on cardiovascular health in prematurely born children.
- Trial name
- EXCELSIOR (NCT06500910)
- Testing
- Physical Exercise
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Henner Hanssen
Breast Cancer, Colorectal Cancer
Adapting Multiple Behavior Interventions That Effectively Improve Cancer Survivor Health Cancer Survivor Health
This research study will test the efficacy of interactive, web-based interventions that improve diet, physical activity and weight management changes among early stage survivors of breast, prostate, colorectal, endometrial…
- Conditions
- Breast Cancer, Colorectal Cancer, Endometrial Cancer, Kidney Cancer
- Trial name
- AMPLIFY (NCT04000880)
- Testing
- Adapting MultiPLe Behavior Interventions That eFfectively Improve (AMPLIFI) Cancer Survivor Health, Diet-Exercise, Exercise-Diet
- Where
- 2 sites in United States
- Volunteers
- 603 people
- Sponsor
- University of Alabama at Birmingham
Kidney Failure, Chronic
Effects of Intradialytic Exercise as Assessed by Bioimpedance Analysis and Blood Volume Monitoring
The purpose of this study is to examine the impact of exercise during dialysis using objective measures of fluid status determination, specifically bioimpedance analysis (BIA) and blood volume monitoring (BVM).
- Trial name
- NCT01273753
- Testing
- Intradialytic exercise
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Michigan
Carcinoma, Renal Cell
Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer
Patients with metastatic renal cell cancer will be enrolled to receive either Trovax® alone or Trovax® plus Interferon Alfa. The study will try to determine whether the use of Trovax® will delay tumor progression.
- Trial name
- NCT00445523
- Testing
- TroVax® (Immunological Vaccine Therapy), Interferon-alpha
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The Methodist Hospital Research Institute
Diabetes, Obesity & Overweight
Exercise and Tissue-Specific Insulin Sensitivity in South Asian and Nordic Women With Previous Gestational Diabetes
South Asian women have a high risk of developing type 2 diabetes, and the risk is particularly high after gestational diabetes. This study examined whether eight weeks of supervised vigorous exercise improves insulin sensitivity…
- Trial name
- DIASA-Ex (NCT07843082)
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 43 people
- Sponsor
- Oslo University Hospital
Urinary Incontinence
Augmenting Urinary Reflex Activity: Study 3
AURA-3 study (Augmenting Urinary Reflex Activity Study 3) is a single arm, short-duration (8 month) cohort follow up study of preceding interventional medical device study, AURA-2.
- Trial name
- AURA-3 (NCT06597994)
- Testing
- Amber UI system
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- Amber Therapeutics Ltd
Pregnancy
The Relationship Between Healthy Lifestyle Behaviors, Physical Activity and Blood Tests in Pregnancy
Pregnancy is a significant phase in women's lives, marked by psychological, biological, and emotional changes. It lasts for approximately nine months and is divided into three trimesters.
- Trial name
- NCT06733272
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 649 people
- Sponsor
- Inonu University
Chronic Kidney Diseases, Hemodialysis
Dialysis Training Therapy: The DiaTT Trial
DiaTT is an interventional, cluster-randomized (1:1), multicenter trial for patients with chronic kidney disease undergoing hemodialysis (n=1,100).
- Trial name
- DiaTT (NCT03885102)
- Testing
- Intradialytic exercise intervention, Usual Care
- Where
- 21 sites in Germany
- Volunteers
- 1,211 people
- Sponsor
- Prof. Dr. med. Martin Halle
Pregnancy, Dietary Habits
E-health App and Lifestyle Changes During Pregnancy
The purpose of this online follow-up study is to investigate health app use in pregnant women and through a pilot intervention trial investigate whether the addition of evidence-based information on health-promoting lifestyle…
- Conditions
- Pregnancy, Dietary Habits, Physical Activity, Gestational Weight Gain
- Trial name
- E-HEALTH (NCT05094479)
- Testing
- Health information delivered via health app
- Where
- Finland
- Volunteers
- 1,047 people, healthy volunteers welcome
- Sponsor
- University of Turku
Bladder (Urothelial, Transitional Cell) Cancer, Kidney (Renal Cell) Cancer
Effectiveness of a Personalized 6-month Programme on Frailty in Older Patients Treated for Bladder or Kidney Cancer.
Bladder and kidney cancers are commonly diagnosed in older adults. Surgery remains the primary treatment modality for patients with kidney or bladder cancer.
- Trial name
- FRAGECO (NCT07073703)
- Testing
- APA, Therapeutic education workshops, DAPAP
- Where
- 2 sites in France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypertension ,Pregnancy
Aerobic Exercises vs Device Guided Breathing on Gestational Hypertension
Aim To compare between the effect of aerobic exercise versus device guided breathing (DGB) on blood pressure in gestational hypertensive patients.
- Trial name
- NCT04352374
- Testing
- Aerobic exercise, Device guided breathing
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer, Ovarian Cancer
Study to Evaluate TNG348 Alone and With a PARP Inhibitor in Patients With BRCA 1/2 Mutant or HRD+ Solid Tumors
The goal of this interventional clinical trial is to learn about TNG348, a ubiquitin specific peptidase 1 (USP1) inhibitor, alone and in combination with olaparib in patients with BRCA 1/2 mutant or HRD+ solid tumors.
- Conditions
- Breast Cancer, Ovarian Cancer, Pancreas Cancer, Prostate Cancer
- Trial name
- NCT06065059
- Testing
- TNG348, Olaparib
- Where
- 7 sites in United States
- Volunteers
- 7 people
- Sponsor
- Tango Therapeutics, Inc.
Labor Onset, Gravidity
Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms
The purpose of our study is correlate between premature delivery (between week 23-35 of the pregnancy) in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor.
- Trial name
- NCT00433303
- Testing
- Correlation between early delivery and coital activity
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Non-Small Cell Lung Cancer, Urothelial Cancer
A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF)
This is a Phase 2 study to evaluate the safety and efficacy of avelumab in combination with axitinib in patients with advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least one prior platinum…
- Trial name
- NCT03472560
- Testing
- Avelumab (MSB0010718C), Axitinib (AG-013736)
- Where
- 39 sites in United States, Hungary and 6 more
- Volunteers
- 61 people
- Sponsor
- Pfizer
Urinary Incontinence, Pelvic Floor Muscle Weakness
Dose-response of Physical Exercise on Pelvic Floor Muscle Function in Postmenopausal Women With Urinary Incontinence
Urinary incontinence (UI) symptoms are highly prevalent among women, and menopause is one of the risk factors for UI. During the menopausal transition, not only the hormonal secretion is changed but also the level of physical…
- Trial name
- NCT04351750
- Testing
- general exercise, pelvic floor muscle training
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- National Cheng Kung University
End-Stage Renal Disease (ESRD), Maintenance Hemodialysis (MHD)
Exercise Rehabilitation for Functional Impairment in Maintenance Hemodialysis Patients
Maintenance hemodialysis (MHD) is the main treatment for patients with end-stage renal disease (ESRD). Although dialysis prolongs survival, many patients experience reduced physical function, poor quality of life, and higher…
- Trial name
- NCT07303179
- Testing
- Exercise Rehabilitation Therapy (ERT)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First People's Hospital of Yunnan
Pelvic Floor Disorder, Pelvic Floor Muscle Exercise
Video-Based Pelvic Floor Muscle Therapy
This study is a feasibility, pilot trial of remote, video-based pelvic floor muscle therapy (PFMT) for patients with pelvic floor disorders, including pelvic organ prolapse, urinary incontinence and anorectal dysfunction.
- Trial name
- NCT06689891
- Testing
- Pelvic Floor Muscle Therapy Website
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Ovarian Cancer, Melanoma
A First-in-human, Phase I, Open-label, Multicenter Study of NM1F(Anti-PVRIG) in Patients With Advanced Solid Tumors
A Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics/Pharmacodynamics, and Antitumor Activity of NM1F as Monotherapy and in Combination with Pembrolizumab in Subjects with Locally Advanced/Metastatic Solid…
- Conditions
- Ovarian Cancer, Melanoma, Triple Negative Breast Cancer, Colorectal Cancer
- Trial name
- NCT05746897
- Testing
- NM1F Injection, Pembrolizumab injection
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Hefei TG ImmunoPharma Co., Ltd.
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