Clinical trials: Pregnancy; Infection
Urinary Schistosomiasis, Schistosoma Haematobium
Efficacy of Bilhvax in Association With Praziquantel for Prevention of Clinical Recurrences of Schistosoma Haematobium
Objectives:To reduce the risk of S. haematobium pathology recurrences during the three years following vaccine administration and to control the safety of this therapeutic strategy in children exposed to urinary schistosomiasis.
- Trial name
- Bilhvax3 (NCT00870649)
- Testing
- Bilhvax vaccine (Sh28GST)
- Where
- Senegal
- Volunteers
- 250 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth
Genital Tract Infections, the Vaginal Microbiome and Gestational Age at Birth Among Pregnant Women in South Africa
This cohort study plans to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth.
- Conditions
- Sexually Transmitted Infections (Not HIV or Hepatitis), Premature Birth, Pregnancy; Infection, Microbial Colonization
- Trial name
- NCT06131749
- Testing
- No intervention
- Where
- South Africa
- Volunteers
- 603 people
- Sponsor
- University of Bern
Urinary Tract Infection
Cranberry for UTI Prevention in Residents of Long Term Care Facilities
Urinary tract infections (UTIs) affect over 7 million men and women per year and cost the health care industry over 1 billion dollars annually.
- Trial name
- PACS (NCT00596635)
- Testing
- Once Daily Cranberry Capsule, Twice Daily Cranberry Capsules
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yale University
Respiratory Syncytial Virus Infections
A Study of Outcomes and Events of Interest in Pregnant Women, Neonates and Infants and of RSV Surveillance
The purpose of this study is to assess pregnancy outcomes, and maternal, as well as neonatal events of interest in healthy pregnant women and their new-borns.
- Trial name
- PEPNI (NCT03614676)
- Testing
- Blood sample collection, Cord blood sample collection, Maternal Diary Card
- Where
- 40 sites in Argentina, Bangladesh and 8 more
- Volunteers
- 4,493 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
SARS-CoV-2 Infection, Acute Kidney Injury
Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection
An interventional clinical trial using oral nicotinamide riboside (NR) in hospitalized patients with COVID-19 infection and acute kidney injury to determine the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+)…
- Trial name
- NIRVANA (NCT04818216)
- Testing
- Nicotinamide riboside
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pregnant
DV2-HBV-27: Observational Pregnancy Registry
Purpose of the study is to evaluate pregnancy outcomes among women who received a dose of HEPLISAV-B within 28 days prior to conception or at any time during pregnancy
- Trial name
- HBV-27 (NCT03664648)
- Testing
- HEPLISAV-B
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dynavax Technologies Corporation
Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
Maternal Vitamin D for Acute Respiratory Infections in Infancy
There is a growing body of data suggesting that vitamin D modulates the host's immune response to acute respiratory infection (ARI).
- Trial name
- MDARI (NCT02388516)
- Testing
- Vitamin D3
- Where
- Bangladesh
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Infections, Papillomavirus
Safety Study of GSK Biologicals' Human Papillomavirus Vaccine in 580299/008 Subjects From Canada or the US
This phase 3b study is designed to assess the safety of GlaxoSmithKline Biological's HPV vaccine GSK580299 in female subjects who took part in study 580299/008 and received the control vaccine (Hepatitis A vaccine).
- Trial name
- NCT00799825
- Testing
- GSK Biological's HPV vaccine GSK580299 (Cervarix™)
- Where
- 48 sites in United States, Canada
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Melanoma, Merkel Cell Carcinoma
REVEAL Study of NKTR-262 in Combination With NKTR-214 and Nivolumab in Patients With Locally Advanced / Metastatic Solid Tumor Malignancies
Patients received intratumoral (IT) injections of NKTR-262 in 3-week cycles for up to 3 cycles; bempegaldesleukin with or without nivolumab was administered every 3 weeks (q3w), and treatment continued until unacceptable…
- Conditions
- Melanoma, Merkel Cell Carcinoma, Triple Negative Breast Cancer, Head and Neck Squamous Cell Carcinoma
- Trial name
- REVEAL (NCT03435640)
- Testing
- NKTR-262, bempegaldesleukin, nivolumab
- Where
- 14 sites in United States
- Volunteers
- 64 people
- Sponsor
- Nektar Therapeutics
Bacterial Vaginosis
Safety and Efficacy of a Vaginally Administered Probiotic Lactobacilli Delivery System.
The purpose of this study is to assess the safety and the efficacy of vaginally administered probiotic lactobacilli in combination with antibiotic therapy (metronidazole) in women with microbiologically defined bacterial…
- Trial name
- NCT00752193
- Testing
- Probiotic lactobacilli
- Where
- Belgium
- Volunteers
- 206 people
- Sponsor
- University Ghent
Urinary Tract Infections
Clinical Trial to Study the Safety and Effectiveness of MK0826 and Other Antibiotic Therapy in Patients With Complicated Urinary Tract Infection (0826-054)
The purpose of this study is to demonstrate that MK0826 is comparable to Meropenem in the treatment of complicated Urinary Tract Infections (UTIs) in adults.
- Trial name
- NCT00771316
- Testing
- MK0826 (ertapenem), Comparator: meropenem
- Volunteers
- 6 people
- Sponsor
- Merck Sharp & Dohme LLC
Pregnancy, Birth Weight
Periodontal Condition in Pregnancy and Low Birth Delivery Incidence
The objective of this study was the evaluation of periodontal condition in pregnant women and the effect of the treatment of periodontal disease upon low birth weight.
- Conditions
- Pregnancy, Birth Weight, Periodontal Diseases
- Trial name
- NCT02613468
- Testing
- collection of periodontal records, pregnancy parameters, Initial Periodontal Therapy
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Malaria Infection, Pregnancy
Diagnostic Access to Self-Care and Health Services in Low and Middle Income Countries (DASH) - Phase II
Our primary goal is to determine if on-demand, home-based rapid testing, or rapid testing done by a community health worker (CHW) results in people testing for diseases more frequently and getting care more quickly.
- Conditions
- Malaria Infection, Pregnancy, HIV, Diabetes
- Trial name
- DASH (NCT06588790)
- Testing
- Home-based rapid testing, Community health worker rapid testing
- Where
- 3 sites in Kenya, South Africa and 1 more
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infertility, Female, Genital Tuberculoses, Female
The Prevalence and Reproductive Outcome of Infertile Women With Genital Tuberculosis
Female genital tuberculosis infection (FGTB) is an important cause of female infertility in TB-endemic areas. The pregnancy rate of assisted reproductive treatment (ART) in the infertile women with FGTB is still unsatisfied even…
- Trial name
- TB-PRIME (NCT05311423)
- Testing
- QuantiFERON-TB test & endometrial pathology & endometrial tissue GeneXpert Ultra
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Huashan Hospital
Acute Respiratory Distress Syndrome Related to SARS-CoV-2
COronaVirus Induced Acute Respiratory Disease Syndrome During PREGnancy
Few data are available on the management of critically ill pregnant women with pneumonia related to SARS-CoV-2. In the absence of clear recommendations for the management of delivery, clinicians are faced with the risk of…
- Trial name
- COVADIS-PREG (NCT05193526)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Sexually Transmitted Infections(STIs), HIV/AIDS
Promoting Safer Sexual Dual Protection Behaviors for Female University Students to Reduce Risks of Both STI/HIV and Unintended Pregnancy
Background: Young women are at the greatest risk for STI/HIV infections and unintended pregnancy resulting from unsafe sexual practices.
- Conditions
- Sexually Transmitted Infections(STIs), HIV/AIDS, Unintended Pregnancy
- Trial name
- NCT06952582
- Testing
- The IMB model-based safer sexual dual protection educational intervention
- Where
- Ethiopia
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Jimma University
Vaginosis, Bacterial, Vaginal Flora Imbalance
Vaginal Ovule With Flavonoid Tea Extract for the Correction of Imbalance in the Vaginal Environment
Randomized, blinded vehicle-controlled multicenter clinical trial (MAT072017) to determine the effect of vaginal ovules containing 2 mg of the tea extract Matuzalem on the subjective symptoms (5-point scale pruritus (itching)…
- Trial name
- MAT072017 (NCT04171947)
- Testing
- Matuzalem ovule, Vehicle ovule
- Where
- 14 sites in Czechia
- Volunteers
- 274 people
- Sponsor
- Value Outcomes Ltd.
Chronic Kidney Disease, Tuberculosis
A Pilot Study for Pharmacokinetic Parameter of Colchicine in Patient Taking Rifampin
The purpose of this study is to examine the colchicine concentration before and after the administration of rifampicin.
- Trial name
- NCT01932268
- Testing
- Rifampicin
- Volunteers
- 2 people
- Sponsor
- Seoul National University Hospital
Covid19, Chronic Kidney Diseases
Physical Activity Level in Patients with Chronic Kidney Disease During COVID-19 Pandemic
In the literature, there are no studies evaluating fear of COVID-19, anxiety, depression, physical activity, fear of movement and quality of life in patients with chronic kidney disease during COVID-19 pandemic.
- Trial name
- NCT04745923
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Hacettepe University