Clinical trials: Pregnancy
Poly Drug Exposed Pregnancies
Fetal Neurobehavior in Poly-drug Dependent Women
This project examines fetal neurobehavior and maternal physiology in poly-drug dependent women. This study also evaluates infant neonatal abstinence syndrome, infant neurobehavior and vagal tone in the post-partum period.
- Trial name
- NCT00653692
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Johns Hopkins University
Polycystic Ovary Syndrome
SGLT2 Inhibitors in Treating Patients With PCOS
Chronic inflammation is the core of Polycystic ovary syndrome (PCOS), and obesity and overweight further exacerbate the level of inflammation in the peripheral circulation and ovarian tissue in PCOS patients.
- Trial name
- NCT05966792
- Testing
- SGLT2 inhibitors, metformin
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Shanghai 10th People's Hospital
Chronic Kidney Disease (CKD)
Tamsulosin and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiating a higher dose of tamsulosin (0.8 mg/day) compared to a lower dose (0.4 mg/day) in older adults with advanced chronic kidney disease (CKD) (an estimated…
- Trial name
- NCT07274228
- Testing
- Tamsulosin
- Where
- Canada
- Volunteers
- 14,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pregnancy, Newborn Health
Study to Identify Factors Influencing Access of Pregnant Women and Their Infants to Local Healthcare Systems
This study collected information regarding the factors that might influence access of pregnant women to the local healthcare system. The main visits of the study screened \& enrollment, delivery and 90 day infant follow-up.
- Trial name
- NCT01734434
- Where
- 10 sites in Dominican Republic, Mozambique and 2 more
- Volunteers
- 3,243 people
- Sponsor
- Novartis Vaccines
Infant, Newborn, Infant, Low Birth Weight
Delayed Cord Clamping in VLBW Infants
This study tested the feasibility of conducting a randomized controlled trial to vary the timing that doctors clamp the umbilical cord after birth in extremely low birthweight infants.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- NCT01222364
- Testing
- Standard Cord Clamping, Delayed Cord Clamping
- Where
- 4 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Post Partum Hemorrhage, Fibrinolysis; Hemorrhage
Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery
The investigators prepared a novel study of tranexamic acid (TXA) designed to estimate the quantity of blood loss in women undergoing elective repeat cesarean deliveries.
- Conditions
- Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss
- Trial name
- TXA (NCT03856164)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Pregnancy Related
Optimization of Fetal Biometry With 3D Ultrasound and Image Recognition
In the proposed clinical investigation, the investigational device (BabySize3D) will provide automated plane extraction and automated biometry measurements from 3D US volumes. The results obtained from the investigational software
- Trial name
- EPICEA (NCT03812471)
- Testing
- 3D volume acquisitions, 2D standard measurements and 3D volumes acquisitions
- Where
- France
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Cervical Cancer
Phase II Study of Pazopanib and Topotecan in Cervical Cancer
The goal of this clinical research study is to learn if the combination of topotecan and pazopanib can help to control recurrent cervical cancer. The safety of the study drug combination will also be studied.
- Trial name
- NCT02348398
- Testing
- Pazopanib, Topotecan, Phone Call
- Sponsor
- M.D. Anderson Cancer Center
Chronic Kidney Disease
A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
The study evaluates the safety of different doses of a new medicine called NNC0519 0130. It also looks into how the medicine may improve kidney function in participants with chronic kidney disease with or without type 2 diabetes…
- Trial name
- NCT06717698
- Testing
- NNC0519-0130, Semaglutide
- Where
- 147 sites in United States, Argentina and 12 more
- Volunteers
- 465 people
- Sponsor
- Novo Nordisk A/S
Advance Solid Tumors, Colon and Rectal Cancer
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced Solid Tumors Harboring KRAS G12D Mutations
This is a Phase 1 and Phase 2 study to evaluate the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of INV-8989 in patients with advanced solid tumors harboring KRAS G12D mutations.
- Conditions
- Advance Solid Tumors, Colon and Rectal Cancer, Non - Small Cell Lung Cancer NSCLC, Pancreatic Adenocarcinoma Advanced or Metastatic
- Trial name
- NCT07610798
- Testing
- INV-8989
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Shenzhen Ionova Life Sciences Co., Ltd.
Kidney Failure, Chronic, Anemia
Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients
The purpose of this study is to determine whether cholecalciferol supplementation decrease the blood concentrations of hepcidin-25 in hemodialysis patients.
- Conditions
- Kidney Failure, Chronic, Anemia, Vitamin D Deficiency, Bone Diseases, Metabolic
- Trial name
- CHAMBER (NCT02214563)
- Testing
- Cholecalciferol, Olive oil
- Where
- 7 sites in Japan
- Volunteers
- 90 people
- Sponsor
- Takayuki Hamano
Metastatic Esophageal, Gastric Cancer
Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors
This is an investigator-initiated industry-supported phase 1 clinical trial conducted in the phase 1 clinic at The University of Texas MD Anderson Cancer Center who will hold the Investigational New Drug (IND).
- Conditions
- Metastatic Esophageal, Gastric Cancer, Metastatic Head and Neck Carcinoma, Metastatic Hepatocellular Carcinoma
- Trial name
- NCT05075993
- Testing
- LVGN3616 + LVGN6051 + Nab-Paclitaxel, LVGN3616 + LVGN6051 + Bevacizumab + Cyclophosphamide, LVGN3616 + LVGN6051 + LVGN7409 + Nab-Paclitaxel
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- M.D. Anderson Cancer Center
Kidney Diseases, Kidney Dysfunction
Music Therapy Intervention During Kidney Biopsy.
Kidney biopsy (KB) is an invasive procedure that is very useful in diagnosing kidney disease in both the native kidney and the transplanted kidney. Patients undergo KB can feel anxiety and pain.
- Conditions
- Kidney Diseases, Kidney Dysfunction, Kidney Disease, Chronic
- Trial name
- MTI-KB (NCT05119816)
- Testing
- music therapy intervention
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Birth Weight, Birth, Preterm
The Effect of Non-surgical Periodontal Therapy on Adverse Birth Outcomes Randomized Controlled Trial
The main objective of this study is to determine whether the provision of non-surgical periodontal therapy to pregnant women with periodontitis is effective in reducing the incidence of low birth weight, preterm birth and still…
- Trial name
- NSPT (NCT03126006)
- Testing
- NSPT plus oral hygiene, Oral hygiene alone
- Where
- Pakistan
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Most Common Musculoskeletal Problems in Pregnancy
Musculoskeletal Problems During Pregnancy
Aim: This study was conducted to identify the most common musculoskeletal problems according to trimester, experienced by pregnant women.
- Trial name
- NCT04496206
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Eskisehir City Hospital
Gestational Diabetes
Oral Glucose Tolerance Test and Post Partum Diagnosis of Diabetes Mellitus, Type 2 (DT2 Post-Partum)
Diabetes mellitus, type 2, is a chronic disease which can be linked with many complications in connexion with impaired blood glucose balance.
- Trial name
- NCT03644004
- Testing
- frequency of diabetes mellitus, type 2, diagnosis in patients with medical history of gestational diabetes.
- Where
- France
- Volunteers
- 173 people
- Sponsor
- Hospices Civils de Lyon
Renal Cell Carcinoma, Gastrointestinal Stromal Tumor
Study to the Optimal Duration of Therapy With Oral Angiogenesis Inhibitors
The purpose of this study is to determine if and how often an unexpected fast increase of disease and complaints shows after stopping the anti-angiogenetic therapy
- Trial name
- NCT00777504
- Testing
- usage oral angiogenesis inhibitor, stop oral angiogenesis inhibitor
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Prematurity, Development Delay
Maternal Voice and Quantitative EEG (qEEG)
A short-term randomized, blinded placebo-controlled trial, in premature infants in the neonatal intensive care unit (NICU) at 33-35 weeks post-conceptional age, of recorded maternal voice on quantitative EEG (spectral power…
- Conditions
- Prematurity, Development Delay, Premature Birth
- Trial name
- NCT05391633
- Testing
- Recorded Maternal Voice
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of New Mexico
Pregnancy
Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings
This clinical trial is performed as proof of pharmacological action investigation by demonstration of ovulation inhibition (dose-response study) under treatment with three Test vaginal rings releasing varying doses of estriol…
- Trial name
- NCT03343912
- Testing
- Estriol 0.400 mg/day and Trimegestone 0.06 mg/day, Estriol 0.300 mg/day and Trimegestone 0.12 mg/day, Estriol 0.200 mg/day and Trimegestone 0.18 mg/day
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Stress Levels During Pregnancy, Levels of Alexithymia During Pregnancy
THE EFFECT OF MOTIVATIONAL INTERVENTIONS LED PREGNANCY ON STRESS AND ALEXITHYMIA IN COUPLES
The aim of this study is to examine the effect of midwife-led motivational interviewing during pregnancy on couples' stress and alexithymia levels.
- Trial name
- ALEXITHYMIA (NCT07663812)
- Testing
- a group where motivational sessions are held for pregnant women and their partners
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University