Clinical trials: Pregnancy Anemia
Anemia in Chronic Kidney Disease in Non-dialysis Patients
Roxadustat in the Treatment of Anemia in Chronic Kidney Disease Patients Not Requiring Dialysis
This study was conducted to treat anemia in patients with chronic kidney disease. Anemia is a reduced number of red blood cells or hemoglobin. Hemoglobin is important for the transport of oxygen in your blood.
- Trial name
- ALPS (NCT01887600)
- Testing
- Roxadustat
- Where
- 138 sites in Belarus, Belgium and 20 more
- Volunteers
- 594 people
- Sponsor
- Astellas Pharma Europe B.V.
Cervical Cancer, Cervical Carcinoma
Pembrolizumab and Olaparib in Cervical Cancer Patients
The study is a non-randomized, open-label phase II clinical trial to test the investigational combination of the drug pembrolizumab with the drug olaparib in patients diagnosed with advanced or recurrent cervical carcinoma after…
- Trial name
- NCT04483544
- Testing
- pembrolizumab, olaparib
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Baptist Health South Florida
Chronic Kidney Disease, Anemia
Study of the Safety and Effectiveness of Rilonacept (IL-1 Trap) Administered Subcutaneously in Subjects With Non Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) and Anemia
Anemia of inflammation is a common complication in patients with chronic kidney disease (CKD). Patients with CKD and anemia of inflammation also exhibit decreased response to erythropoietic agents, even in the presence of…
- Trial name
- NCT00609544
- Testing
- Rilonacept
- Where
- 27 sites in United States
- Sponsor
- Regeneron Pharmaceuticals
Anemia, Iron-Deficiency, Puerperal Disorders
Controlled Randomised Trial of Ferric Carboxymaltose and Oral Iron to Treat Postpartum Anemia
200 patients with post partum anemia will be randomised to receive either intravenous iron (intervention group) or peroral iron (control group).
- Conditions
- Anemia, Iron-Deficiency, Puerperal Disorders, Depression, Postpartum
- Trial name
- NCT00929409
- Testing
- Ferric carboxymaltose, Ferrous sulfate tablets
- Where
- 3 sites in Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology
Iron Deficiency Anaemia in Childbirth
Ferric Derisomaltose (Iron Isomaltoside) Versus Iron Sucrose for Treatment of Iron Deficiency in Pregnancy
Ion deficiency anemia (IDA) is associated with poor neonatal outcomes and maternal morbidity. Iron replacement may be done with oral iron or intravenous iron, with intravenous iron being utilized later in pregnancy or if there is…
- Trial name
- NCT05251493
- Testing
- Iron Isomaltoside 1000, ferric derisomaltose, Iron sucrose
- Where
- Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Saskatchewan Health Authority - Regina Area
Pregnancy
To Compare the Efficacy of I.V 200 mg Iron Sucrose and 500 mg Iron Sucrose to Treat Anemia in Pregnancy
This study is aimed to compare the efficacy of 2 doses of iron sucrose given intravenously - 200 mg versus 500 mg.
- Trial name
- NCT02441439
- Testing
- Iron sucrose 200 mg, Iron sucrose 500 mg
- Sponsor
- HaEmek Medical Center, Israel
Delivery Hemorrhage
Evaluation of a Patient Blood Management Protocol Impact on the Transfusion Rate in Delivery Hemorrhage
According to the WHO, anemia is one of the ten most serious health problems in the world. During pregnancy, it affects 42% of women worldwide and 25% in France.
- Trial name
- PALOMA (NCT06916832)
- Where
- France
- Volunteers
- 397 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Preterm, Infant Death
Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks…
- Trial name
- CORDMILK-PT (NCT06240715)
- Testing
- Umbilical cord milking
- Where
- 9 sites in India
- Volunteers
- 800 people
- Sponsor
- Nemours Children's Clinic
Anaemia
A Study to Evaluate Efficacy and Safety of Daprodustat Compared to Darbepoetin Alfa in Japanese Hemodialysis (HD)-Dependent Subjects With Anemia Associated With Chronic Kidney Disease (CKD)
Daprodustat is a drug that is currently being developed as a treatment for renal anemia . This study is to evaluate the efficacy and safety of daprodustat following a switch from erythropoiesis-stimulating agent (ESA) in Japanese…
- Trial name
- NCT02969655
- Testing
- Daprodustat small, Daprodustat large, Darbepoetin alfa
- Where
- 50 sites in Japan
- Volunteers
- 271 people
- Sponsor
- GlaxoSmithKline
Fetal Conditions, Maternal; Procedure
A Prospective Study on the Role of Karl Storz Curved and Straight Fetoscopes (11508AAK and 11506AAK) for Fetoscopic Intrauterine Procedures
In this research study, the investigators want to learn more about the role of new innovative surgical devices, the Karl Storz Curved and Straight Fetoscopes for in-utero surgery.
- Conditions
- Fetal Conditions, Maternal; Procedure, Pregnancy Related, Twin to Twin Transfusion Syndrome
- Trial name
- NCT06056635
- Testing
- Karl Storz Curved Scope, Karl Storz Straight Scope
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Endometriosis
Visanne Post-approval Observational Study (VIPOS)
The study assesses safety aspects of Dienogest (DNG) 2mg/day (Visanne) used as endometriosis therapy and of other hormonal treatments for endometriosis.
- Trial name
- NCT01266421
- Where
- Germany
- Volunteers
- 27,840 people
- Sponsor
- Center for Epidemiology and Health Research, Germany
Hemolytic Uremic Syndrome
Study of 'Vascular Competence' Profile and Endothelial Activation in the Hemolytic Uremic Syndrome in Children and Adults
The Hemolytic Uremic Syndrome (HUS) is a rare thrombotic microangiopathy (TMA), affecting both children and adults. HUS is characterized by the abnormal occurrence of diffuse thrombosis in the microcirculation resulting in the…
- Trial name
- SHU (NCT02904863)
- Testing
- Extra blood draw samples
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Anemia
Study of SAL-0951 Compared to Recombinant Human Erythropoietin in Anemic Patients Receiving Maintenance Hemodialysis
The purpose of this study is to evaluate the safety and efficacy of SAL-0951 in Chinese patients undergoing maintenance hemodialysis with chronic kidney disease and anemia，who are receiving stable treatment with erythropoietic…
- Trial name
- NCT06720025
- Testing
- SAL-0951 tablets, rHuEPO injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Chronic Myeloproliferative Disorders, Kidney Cancer
Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia
RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Kidney Cancer, Leukemia, Lymphoma
- Trial name
- NCT00295997
- Testing
- anti-thymocyte globulin, filgrastim, graft-versus-tumor induction therapy
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of California, San Francisco
Iron-Deficiency Anemia, Inflammation
Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients
The purpose of this study is to investigate the efficacy of ferumoxytol for the repletion of iron stores and correction of iron deficiency anaemia in patients with severe chronic kidney disease or end-stage chronic kidney disease…
- Conditions
- Iron-Deficiency Anemia, Inflammation, Oxidative Stress
- Trial name
- NCT01942460
- Testing
- Ferumoxytol
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Georges Ouellet
Chronic Renal Disease, Iron-Deficiency Anemia
Oral Iron Supplementation for Patients With Chronic Kidney Disease
The hypothesis of this research is that oral iron prescribed in a single dose in alternate day could mitigate the side effects with regard to intestinal microbiota, inflammation, oxidative stress and improve the hematological…
- Conditions
- Chronic Renal Disease, Iron-Deficiency Anemia, Anemia of Chronic Kidney Disease, Dysbiosis
- Trial name
- NCT05544513
- Testing
- Ferrous sulfate 3 days week, Ferrous sulfate daily, Ferrous sulfate higher concentration
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- Universidade Federal Fluminense
HIV, Syphilis
Evaluating the Effectiveness of Point-of-care Diagnostic Technologies in MCH Services in Mozambique
The general goal of the proposed study is to evaluate the cost-effectiveness of POC technologies for diagnosis of syphilis, quantitative analysis for hemoglobin and CD4 counting performed within MCH services to improve maternal…
- Conditions
- HIV, Syphilis, Anemia During Pregnancy
- Trial name
- NCT02191527
- Testing
- PIMA® for quantitative analysis of CD4-count, Hemocue® (HemoCue AB, Angelhom, Sweden) for quantitative analysis of hemoglobin, SD Bioline® (Standard Diagnostics Inc., South-Korea) for qualitative analysis of syphilis
- Volunteers
- 1,673 people
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
Anemia
A Phase 2a Study To Evaluate The Pharmacokinetics, Safety, Efficacy, Tolerability, And Pharmacodynamics of Sotatercept (ACE-011) for the Correction of Anemia in Subjects With End-stage Renal Disease on Hemodialysis.
This is the first study in hemodialysis subjects with anemia to evaluate the pharmacokinetics, safety, efficacy, tolerability, and pharmacodynamics of sotatercept (ACE-011)
- Trial name
- NCT01146574
- Testing
- Sotatercept
- Where
- 24 sites in United States
- Volunteers
- 50 people
- Sponsor
- Celgene
Anaemia, Chronic Kidney Disease
Probiotics Against Erythropoietin Resistance in Chronic Kidney Disease Patients.
The goal of this clinical trial is to assess whether probiotic supplementation can improve the hematological response of CKD patients to erythropoietin therapy and prevent or reduce erythropoietin resistance.
- Conditions
- Anaemia, Chronic Kidney Disease, Regular Hemodialysis
- Trial name
- NCT07296146
- Testing
- Erythropoietin + Probiotic, EPO
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Badr University
Chronic Kidney Insufficiency, Chronic Kidney Diseases
Oral Iron in Children With Chronic Kidney Disease
This is a pilot clinical trial of oral iron therapy in children with chronic kidney disease (CKD) and mild anemia. Eligible children will be randomized into a standard of care (iron sulfate) arm vs.
- Trial name
- FeTCh-CKD (NCT03991169)
- Testing
- Ferrous Sulfate
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University