Clinical trials: Pregnancy Hemorrhage
Heavy Menstrual Bleeding
Quality of Life in Premenopausal Women With Heavy Menstrual Bleeding
Heavy menstrual bleeding or menorrhagia, is a common problem on women's lives and can burden both patients and health care systems. HMB is defined as cyclic heavy vaginal bleeding.
- Trial name
- NCT03368898
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Heavy Menstrual Bleeding, Menorrhagia
Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids
This is a randomized controlled trial (RCT) to assess the comparative effectiveness of Levonorgestrel Intrauterine System (LNG-IUS) to Tranexamic Acid (TA) for the treatment of heavy menstrual bleeding (HMB) in women with…
- Conditions
- Heavy Menstrual Bleeding, Menorrhagia, Uterine Fibroids
- Trial name
- NCT03317795
- Testing
- Levonorgestrel IUS, Tranexamic Acid
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Shannon K. Laughlin-Tommaso
Postpartum Hemorrhage
Management of the Third Stage of Labor
To compare the efficacy of three different protocols of third stage management in preventing PPH.
- Trial name
- NCT02319707
- Testing
- Oxytocin, Oxytocin in 100 ml NaCl 0.9%
- Volunteers
- 500 people
- Sponsor
- Yariv yogev
Delivery Delayed, Mode of Delivery
Early Versus Delayed Oxytocin Infusion Following Amniotomy in Nulliparous Women
In UKM Medical Centre (UKMMC), delayed oxytocin augmentation at two hours following amniotomy is the routine obstetric practice in spontaneous or induced labour with intact membranes.
- Conditions
- Delivery Delayed, Mode of Delivery, Post Partum Hemorrhage, Uterine Hyperstimulation
- Trial name
- NCT04200599
- Testing
- duration of initiation of oxytocin
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
High Risk Pregnant Women Undergoing Elective Cesarean Section
The Prophylactic Role of Tranexamic Acid in High Risk Pregnant Women Undergoing Elective Cesarean Section in Prevention of Postpartum Hemorrhage
The aim of the study is to assess the prophylactic role of tranexamic acid in reducing blood loss during and after elective cesarean section delivery in high risk patients.
- Trial name
- NCT05434533
- Testing
- Tranexamic acid (Kapron, Amoun Pharmaceuticals SAE, Egypt. 5ml Amp, 100mg /1ml)
- Where
- Egypt
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Cairo University
Migraines, Bleeding
Prevention of Menstrual Migraines: Using Frovatriptan or Placebo During Hormone Free Intervals
This study will examine the combined effects of a continuous oral contraceptive (OC) regimen with supplemental frovatriptan therapy on headache severity and occurrence in subjects with documented Menstrually Associated Migraines…
- Conditions
- Migraines, Bleeding, Spotting
- Trial name
- MAM (NCT00700128)
- Testing
- frovatriptan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Postpartum Hemorrhage
Feasibility Trial of the Circumferential Abdominal Pelvic Pressure Device (CAPP)
A group of midwives and obstetric nurses have been trained to use circumferential abdominal pelvic pressure (CAPP) to treat postpartum hemorrhage.
- Trial name
- NCT01497756
- Testing
- CAPP use
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of New Mexico
Pregnancy Hemorrhage, Postpartum Hemorrhage
Implementation of the NPMS Obstetric Hemorrhage Bundle at a Tertiary Center: Utilization of the Delphi Method
The National Partnership for Maternal Safety (NPMS) developed an obstetric hemorrhage consensus bundle to provide every United States birthing facility consistent, validated practice guidelines.
- Trial name
- NCT03018119
- Testing
- Survey
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Venous Thromboembolism, Venous Thromboses
TRanEXamic Acid to Decrease Heavy Menstrual Bleeding in Individuals Anticoagulated for Venous Thromboembolism Pilot Study
T-REX HMB is a pilot randomized controlled trial (RCT) designed to assess the feasibility of a full trial comparing tranexamic acid (TXA) to placebo in decreasing HMB in premenopausal individuals anticoagulated for VTE.
- Conditions
- Venous Thromboembolism, Venous Thromboses, Heavy Menstrual Bleeding, Anticoagulants and Bleeding Disorders
- Trial name
- T-REX HMB (NCT06452342)
- Testing
- Tranexamic acid, No Tranexamic acid
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Post Partum Hemorrhage
Oral Tranexamic Acid Plus Sublingual Misoprostol in Atonic Postpartum Hemorrhage
The aim of the study is to evaluate the effect of oral tranexamic acid plus, sublingual misoprostol in the management of atonic postpartum hemorrhage (PPH) after vaginal delivery
- Trial name
- NCT03870256
- Testing
- misoprostol, Carbetocin, TA
- Where
- Egypt
- Volunteers
- 135 people
- Sponsor
- Aswan University Hospital
Postpartum Hemorrhage
Carbetocin at Elective Cesarean Delivery Part 3
Post-partum hemorrhage (PPH) is a major cause of maternal death worldwide. Oxytocin is the most common uterotonic drug used to prevent and treat PPH in North America, however, there are some limitations to its use.
- Trial name
- NCT01651130
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Postpartum Hemorrhage (Primary)
Carbetocin Versus Oxytocin for the Prevention of Postpartum Hemorrhage in Emergency Caesarean Delivery
Postpartum haemorrhage keeps to be the leading cause of maternal mortality in middle and low-income countries, including Iraq. Much advancement had been made in the field of treatment for postpartum haemorrhage but no much…
- Trial name
- NCT03755531
- Testing
- Carbetocin, Oxytocin
- Where
- Iraq
- Volunteers
- 300 people
- Sponsor
- Al-Kindy College of Medicine
Lupus Nephritis, Proteinuria
Velcade for Proliferative Lupus Nephritis
The primary objective is to test the safety and efficacy of Velcade to induce remission in WHO class III/IV/V lupus nephritis that are refractory to standard medications.
- Conditions
- Lupus Nephritis, Proteinuria, Hematuria
- Trial name
- NCT01169857
- Testing
- Velcade
- Where
- United States
- Sponsor
- The Rogosin Institute
Blood Platelet Disorder, Hemorrhage
Correlation Between Platelet Function Analyzer-100 Testing and Bleeding Events After Percutaneous Kidney Biopsy
Kidney biopsy represents the criterion standard to obtain information on diagnosis and prognosis of renal dysfunctions . Many patients with kidney disease have a predisposition to bleed, especially when they undergo an invasive…
- Conditions
- Blood Platelet Disorder, Hemorrhage, Kidney Diseases
- Trial name
- NCT03762707
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Postpartum Hemorrhage
Four Different Methods of Performing External Aortic Compression After Caesarean Section
After childbirth, bleeding from the uterus occurs, which can quickly become very profuse if the uterus does not contract. Annually, around 80000 women die because profuse bleeding associated with childbirth, mainly in low -and…
- Trial name
- KEXAC (NCT06157307)
- Testing
- Aortic compression
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Hemophilia A, Hemophilia A, Severe
Hemophilia A Research Program
This study longitudinally observes the intergenerational (mother-child) continuum in hemophilia A from pregnancy through early childhood.
- Conditions
- Hemophilia A, Hemophilia A, Severe, Factor VIII (FVIII), FVIII Deficiency
- Trial name
- HARP (NCT07414511)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Abnormal Uterine Bleeding (AUB)
Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy in Women With Abnormal Uterine Bleeding
women globally, often requiring endometrial tissue sampling for accurate evaluation and diagnosis. Traditional office-based sampling techniques like Pipelle are widely used, but the disposable instruments can be relatively…
- Trial name
- NCT07731581
- Testing
- Manual Vacuum Aspiration (MVA) Cannula, Pipelle Endometrial Suction Curette
- Volunteers
- 80 people
- Sponsor
- University of Health Sciences Lahore
Obstetric Labor Complications, Hemorrhage
Coagulation Factor Changes Associated With Postpartum Hysterectomies
The purpose of this study is to examine components of the coagulation system in women undergoing postpartum hysterectomy and to compare laboratory parameters of coagulation in these women to women at increased risk for a…
- Conditions
- Obstetric Labor Complications, Hemorrhage, Complications; Cesarean Section
- Trial name
- NCT00456547
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hematuria, Bladder Cancer
A Trial of a Modified Cystoscopy Method to Reduce Pain Perception
The goal of this project is to improve patient experience of cystoscopy using a non-pharmacologic modification of procedure. Cystoscopy is a common outpatient procedure for urology patients and is usually performed without…
- Conditions
- Hematuria, Bladder Cancer, Bladder Disease
- Trial name
- NCT03257293
- Testing
- Modified Cystoscopy, Routine Cystoscopy
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- Western University, Canada
Postpartum Hemorrhage, Hyperfibrinolysis
Haemostasis and Tranexamic Acid in Caesarean Delivery
The aim of the study is to evaluate haemostasis and fibrinolysis in peripartum of caesarean delivery and the effect of tranexamic acid (TXA) given in prevention of post-partum haemorrhage (PPH).
- Trial name
- BIO-TRAAP (NCT03742947)
- Testing
- peripartum haemostasis
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Bordeaux
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