Clinical trials: Pregnancy Induced Hypertension
Preeclampsia
Longitudinal Study: Diagnosis and Prediction of Pre-Eclampsia by Using Congo Red Dot Test in Bangladesh and Mexico
A population-based prospective cohort design will evaluate the progression of urine congophilia in pregnancy using the Congo Red Dot test by following patients longitudinally across gestation in Bangladesh and Mexico City.
- Trial name
- NCT02381197
- Testing
- Congo Red Dot test
- Where
- 2 sites in Bangladesh, Mexico
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pre Eclampsia
Study of Coagulation Activation Markers and Pre Eclampsia
The primary purpose of the trial is to evaluate coagulation activator markers in patients with pre eclampsia compared to control (normal pregnancy) and to correlate these markers with the severity of the pathology.
- Trial name
- PRESTIGE (NCT01261351)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Lille
Gestational Hypertension, Toxemia
A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy
The investigators aim to determine if Vitamin D prophylaxis in pregnancy reduces the incidence of hypertensive disorders of pregnancy.
- Conditions
- Gestational Hypertension, Toxemia, Superimposed Preeclampsia, Eclampsia
- Trial name
- NCT02920593
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Gestational Hypertension
Relation Between Protein 13 and Gestational Hypertensive Disorder
the attendants of the clinic with a one-missed period (T0) underwent determination of baseline blood pressure (BP) measures and gave blood samples for estimation of levels of placental growth factor (PLGF), soluble fms-like…
- Trial name
- NCT05517512
- Testing
- Estimation of Protein 13
- Where
- Egypt
- Volunteers
- 138 people
- Sponsor
- Benha University
Congenital Heart Disease
Preeclampsia and Fetal Heart Malformations: Looking to Maternal Heart
The goal of this study is to describe the maternal hemodynamic parameters detected by UltraSonic Cardiac Output Monitor (USCOM®) in women carrying a fetus with a congenital heart disease (CHD) and to possibly describe an…
- Trial name
- MAMAH (NCT07092644)
- Testing
- UltraSonic Cardiac Output Monitor (USCOM®)
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypertension
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and…
- Trial name
- CARDAMOM (NCT07238400)
- Testing
- Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Hypertension in Pregnancy, Hypertension
Enhancing Intergenerational Health in Nigeria: Peripartum as Critical Life Stage for Cardiovascular Health
The purpose of the ENHANCE-CVH study is to promote intergenerational cardiovascular health (CVH) of women and children in Abuja and the surrounding Federal Capital Territory of Nigeria.
- Conditions
- Hypertension in Pregnancy, Hypertension, Obesity and Overweight, Maternal Morbidity and Mortality
- Trial name
- ENHANCE-CVH (NCT06773299)
- Testing
- PAT+HEALTH curriculum - Nigeria
- Where
- Nigeria
- Volunteers
- 1,000 people
- Sponsor
- Washington University School of Medicine
Hypertension, Pregnancy-Induced, Pre-Eclampsia
Early Vascular Adjustments During Hypertensive Pregnancy
Paradoxical fetal and maternal results of studies have led to inconsistent use of antihypertensive drugs or no treatment at all in mild to moderate gestational hypertension in the Netherlands.
- Trial name
- EVA (NCT02531490)
- Testing
- Labetalol, Nifedipine, Methyldopa
- Where
- Netherlands
- Volunteers
- 368 people
- Sponsor
- Maastricht University Medical Center
Preeclampsia
Ibuprofen vs Dipyrone After C-section in Preeclampsia
The goal of this randomized, triple-masked clinical trial is to compare the effectiveness and safety of the use of ibuprofen versus dipyrone for postoperative analgesia in postpartum women with preeclampsia undergoing cesarean…
- Trial name
- DIPROFEN (NCT05586373)
- Testing
- medication 1, medication 2
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Hypertension, Pregnancy-Induced
Arm and Finger Measurement for Blood Pressure Surveillance
Accurate blood pressure (BP) measurement is critical in peripartum care. The cuff and bladder sizes affects the accuracy of BP measurement.
- Trial name
- ARMFIN (NCT04012151)
- Testing
- Physical measurement, Cuff size fitting
- Where
- Singapore
- Volunteers
- 300 people
- Sponsor
- KK Women's and Children's Hospital
Preeclampsia
Human Epididymis Protein 4 in Women With Severe Preeclampsia / HELLP Syndrome
Pre-eclampsia seems to be associated with a four to five times increase risk of later microalbuminuria and CKD which might suggest a possible direct renal damage from pre-eclampsia
- Trial name
- NCT03891394
- Testing
- Human epididymis protein 4
- Volunteers
- 110 people
- Sponsor
- Ain Shams University
Obstructive Sleep Apnea
Targeted CPAP Therapy for Obstructive Sleep Apnea in Pregnancy
Prospective, randomized controlled trial. Pregnant women in early pregnancy will be randomized to either the Sleep Study + CPAP (Continuous Positive Airway Pressure Therapy) group or to a Standard Prenatal Care group.
- Trial name
- NCT02755831
- Testing
- CPAP, Pre-natal care
- Where
- United States
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Preeclampsia, Preterm Birth
Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening
Preterm birth (PTB), preeclampsia (PE), fetal growth restriction (FGR) and intra-uterine fetal death (IUFD) constitutes the main causes of perinatal morbidity and mortality and are called "Great Obstetrical Syndromes".
- Conditions
- Preeclampsia, Preterm Birth, Fetal Growth Restriction, Intra Uterine Fetal Death
- Trial name
- PREDICTION2 (NCT03067298)
- Where
- Canada
- Volunteers
- 805 people, healthy volunteers welcome
- Sponsor
- Emmanuel Bujold
Preeclampsia
Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Case-control Study
A case-control study will evaluate the clinical utility of the Congo Red test GV-005 in following women with a clinical diagnosis of preeclampsia and clinically healthy women in the postpartum period
- Trial name
- NCT02610972
- Testing
- Congo Red test GV-005
- Where
- 2 sites in Bangladesh, Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Gestational Diabetes Mellitus, Preeclampsia
MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is a heterogeneous condition, characterised by metabolic disturbances, insulin resistance and hyperandrogenism.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Preterm Birth, Polycystic Ovary Syndrome
- Trial name
- MYPP (NCT05524259)
- Testing
- Myo-inositol and routinely recommended folic acid, Routinely recommended folic acid
- Where
- Netherlands
- Volunteers
- 464 people
- Sponsor
- Erasmus Medical Center
Preeclampsia (PE)
Impact of First-trimester Preeclampsia Screening on Perinatal and Maternal Morbidity (RANSPRE)
The purpose of this study is to determine whether first-trimester screening for preeclampsia based on the FMF algorithm (a combination of maternal clinical, sonographic and biochemical parameters), improves maternal or perinatal…
- Trial name
- RANSPRE (NCT05521776)
- Testing
- First-trimester preeclampsia screening (FMF triple test)
- Where
- 22 sites in France
- Volunteers
- 14,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pre-Eclampsia
Association Between Pococyturia and Pre-eclampsia Severity
Pre-eclampsia is an hypertensive disorder appearing during pregnancy, inducing serious maternal, fetal and neonatal mortality and morbidity.
- Trial name
- PEPOD2 (NCT03316391)
- Testing
- Dosage of urinary podocyturia
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Hospices Civils de Lyon
Pre-Eclampsia
Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension
In 2017, the American College of Cardiology and the American Heart Association changed the diagnostic criteria for hypertension in non-pregnant adults.
- Trial name
- NCT04908982
- Testing
- Aspirin 81mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Eastern Virginia Medical School
Preeclampsia
New Therapeutic Strategy Against Preeclampsia
Preeclampsia is a hypertensive disorder of pregnancy associated with important maternal and perinatal mortality. It complicates 2 to 5% of pregnancies and causes more than 70 000 maternal deaths each year worldwide.
- Trial name
- APHERESE2 (NCT06464159)
- Testing
- Biological collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Central Blood Pressure
The aim of the study is to check standard screening blood pressure in the arm and central blood pressure, the blood pressure at the heart in pregnant women.
- Trial name
- NCT03026010
- Testing
- central blood pressure
- Volunteers
- 100 people
- Sponsor
- St. Louis University
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