Clinical trials: Pregnancy Induced Hypertension
Postpartum Preeclampsia, Hypertension in Pregnancy
Labetalol or Nifedipine for Control of Postpartum Hypertension: A Randomized Controlled Trial
Randomized trial comparing risk of hospital readmission and hypertensive complications between patients managed on Labetalol compared to Nifedipine.
- Trial name
- NCT05309460
- Testing
- Labetalol Oral Tablet, NIFEdipine ER
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Nebraska Methodist Health System
Pre-Eclampsia
Measuring Practice Pattern Changes and Clinical Utility of a Novel Test for Preeclampsia
This study will collect high-quality data on how practicing obstetricians across the U.S. currently manage patients showing signs and/or symptoms of preeclampsia and how the results of Progenity's test change clinical decision…
- Trial name
- NCT04204018
- Testing
- Experimental Arm
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Eclampsia, Seizures
Comparing Intravenous and Intramuscular Magnesium Sulphate for Preventing Seizure Recurrence in Women With Eclampsia
The goal of this clinical study is to learn whether the way we give magnesium sulphate-into a vein (intravenous, IV) versus into a muscle (intramuscular, IM)-affects how often women with eclampsia have repeat seizures.
- Conditions
- Eclampsia, Seizures, Pregnancy
- Trial name
- NCT06997575
- Testing
- Magnesium Sulphate infusion, Magnesium sulphate intramuscular
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Nishtar Medical University
Pre-Eclampsia
Evaluation of Electrical Velocimetry for Assessment of Extra-vascular Lung Water in Pre-eclamptic Patients
The purpose of this study is to compare the sensitivity and the specificity of electrical cardiometry to the lung ultrasound in measuring thoracic lung water in pregnant females with pre-eclampsia.
- Trial name
- NCT03127865
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Severe Preeclampsia
The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia
pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the…
- Trial name
- NCT07125599
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Cairo University
Preeclampsia, Perinatal Haemorrhage
Aspirin Discontinuation in High-Risk Pregnant Women of Preeclampsia
Low-dose aspirin (LDA) is considered to be the most effective agent to prevent preeclampsia (PE). At present, there is little exploration about the timing of aspirin discontinuation.
- Trial name
- NCT06111079
- Testing
- aspirin discontinuation, aspirin continuation
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- FANG HE
Pre-Eclampsia
Pilot Study of Microvesicles in Pre-eclamptic and Non-pre-eclamptic Women With Threatened Preterm Delivery
A large number of studies on MVs from syncytiotrophoblasts support the hypothesis of their involvement in pre-eclampsia, via their multiple effects, among others as pro-coagulant, immuno-stimulatory and anti-angiogenic factors.
- Trial name
- MICROVES-PE (NCT05675969)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Woman's Role, Preeclampsia
Women's Perspective on First-trimester Preeclampsia Screening
The aim of this study is to evaluate women's perception on first-trimester preeclampsia screening as it is performed currently in daily practice.
- Conditions
- Woman's Role, Preeclampsia, Screening
- Trial name
- NCT05123560
- Testing
- Anonymous online questionnaire
- Where
- Spain
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pregnancy Related
Refusal to Participate in a Randomized Trial Involving Pregnancy and Childbirth: Factors Associated With Refusal and Reasons for Refusal and Acceptance
The main objective is to assess whether there are factors associated with women's refusal to participate in a randomized clinical trial involving pregnancy and childbirth in France.
- Trial name
- REFWIT (NCT06612320)
- Testing
- Questionnaire about acceptance, Questionnaire about refusal
- Where
- 4 sites in France
- Volunteers
- 526 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preeclampsia, Cardiovascular Risk Factor
Cardiac Dysfunction and Remodeling in Patients With Preeclampsia
Preeclampsia (PE) is a pregnancy-related hypertensive disorder drive by an anti-angiogenic environment. Women with PE have 2-4 time higher risk of developing cardiovascular disease (CVD), although the specific mechanism relating…
- Conditions
- Preeclampsia, Cardiovascular Risk Factor, Pregnancy Complications
- Trial name
- ANGIOCOR (NCT04162236)
- Testing
- Ecocardiographyc ultrasound
- Where
- Spain
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hypertension in Pregnancy
L-arginine Effects on Chronic Hypertension in Pregnancy
The purpose of this study is to evaluate the effects of oral L-arginine administration on pregnant women at second trimester of gestation with chronic hypertension, respect with placebo.
- Trial name
- NCT00974714
- Testing
- L-arginine
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Modena and Reggio Emilia
Gestational Hypertension, Hypertension in Pregnancy
A Randomized, Placebo-controlled Trial of DAPAgliflozin (DAPA) for Cardiovascular Risk Reduction in the Postpartum Period of Hypertensive Pregnancies (HP)
This trial is a pilot-scale, single institution randomized, placebo-controlled trial to assess the feasibility, acceptability, and efficacy of administering dapagliflozin for cardiovascular risk reduction in the postpartum…
- Conditions
- Gestational Hypertension, Hypertension in Pregnancy, Pre-Eclampsia, Superimposed Pre-Eclampsia
- Trial name
- DAPA-HP (NCT06785116)
- Testing
- Dapagliflozin 10mg Tab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Michigan
Preterm Birth, Intra-uterine Growth Restriction
Consequences of Antiangiogenic Factors Involved in Preeclampsia on Intra-uterine Growth Restricted Preterm Newborn
Preeclampsia complicates about 2-7% of pregnancies and is a major contributor to maternal and neonatal morbidity and mortality worldwide.
- Conditions
- Preterm Birth, Intra-uterine Growth Restriction, Maternal Preeclampsia, Bronchopulmonary Dysplasia
- Trial name
- ANGIODYS (NCT01648855)
- Testing
- Biological samples
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gestational Diabetes Mellitus, Preeclampsia
User Testing and Feedback for a Mobile Health Program for Postpartum Women: A Pilot Study
Refine content and delivery of the mHealth delivered lifestyle intervention program through iterative testing with small groups of users who provide feedback through on-line asynchronous focus groups.
- Conditions
- Gestational Diabetes Mellitus, Preeclampsia, Gestational Hypertension, Pre-term Delivery
- Trial name
- NCT02384226
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Pre-eclampsia, Gestational Diabetes Mellitus (GDM)
Placental Biology in Health and Disease
Pre-eclampsia (PET) is a condition characterised by high blood pressure and damage to other organs, and is a leading cause of maternal and fetal complications such as fetal growth restriction (FGR).
- Conditions
- Pre-eclampsia, Gestational Diabetes Mellitus (GDM), Fetal Growth Restriction (FGR), Pregnancy Induced Hypertension (PIH)
- Trial name
- NCT07470320
- Testing
- There are no interventions for this study
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pre-eclampsia, Intra-uterine Growth Retardation
EG-VEGF : Potential Marker of Pre-eclampsia and / or Intrauterine Growth Restriction
The purpose of this study is to assess the potential prognostic value of seric concentrations of EG-VEGF for Pre-eclampsia and/or intrauterine growth restriction and will allow checking whether plasma levels of EG-VEGF at 14-18…
- Trial name
- EGEVE (NCT01490489)
- Testing
- blood sample and doppler Ultrasound of uterine arteries
- Where
- France
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Preeclampsia, Eclampsia
Vitamin D Supplementation Among Pregnant Women in Uganda for the Prevention of Hypertensive Disorders in Pregnancy, and Other Adverse Maternal and Foetal Outcomes
The goal of this randomised controlled trial is to investigate if vitamin D supplementation among pregnant women in Uganda prevents adverse maternal and foetal outcomes, with special emphasis on preeclampsia.
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome
- Trial name
- MAMA (NCT07510568)
- Testing
- oral 2.000 IU vitamin D3 (cholecalciferol) daily, in addition to routine ANC supplementations
- Volunteers
- 1,980 people
- Sponsor
- St Mary's Hospital, Lacor
Preeclampsia
Comparison of Random Spot Urine Protein:Creatinine Ratio to 24-Hour Timed Urine Protein Collection in the Evaluation of Preeclampsia
This is a non-inferiority, prospective study of the relationship between the 24-hour urine protein collection and spot protein:creatinine ratio in the diagnosis of preeclampsia involving a sample of 18-45 year-old pregnant women…
- Trial name
- P:C Ratio (NCT01447290)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mike O'Callaghan Military Hospital
Pre-eclampsia, Fetus or Newborn; Effects of Induction of Labor
Induction With Foley OR Misoprostol (INFORM) Study
Between 40,000 and 80,000 pregnant women die annually from pre-eclampsia and eclampsia. Magnesium sulphate and anti-hypertensive therapies can reduce the morbidity associated with pre-eclampsia.
- Trial name
- INFORM (NCT01801410)
- Testing
- Foley Catheter, Misoprostol
- Where
- 2 sites in India
- Volunteers
- 602 people
- Sponsor
- University of Liverpool
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