Clinical trials: Pregnancy Induced Hypertension
Preeclampsia, Cesarean Birth
Norepinephrine Infusion vs Bolus vs Ephedrine for Blood Pressure Stability During Cesarean Delivery in Women With Preeclampsia
This randomized controlled trial will compare norepinephrine infusion, norepinephrine bolus, and ephedrine bolus for maintaining hemodynamic stability during spinal anesthesia for scheduled cesarean delivery in women with…
- Conditions
- Preeclampsia, Cesarean Birth, Hypotension During Surgery
- Trial name
- NCT07842783
- Testing
- Norepinephrine (0.05 μg/kg/min), Norepinephrine 4mcg, Ephedrine Bolus 6 mg
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Benha University
Preeclampsia
Prevalence Study of Sleep Apnea in Women With Preeclampsia
Hypothesis: The prevalence of sleep apnea is greater in pregnant women with preeclampsia than in pregnant women without preeclampsia.The presence of sleep apnea will be associated with poor blood pressure control, worsening blood…
- Trial name
- NCT00259688
- Testing
- CPAP therapy for subjects diagnosed with sleep apnea
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Pre-Eclampsia, Asymptomatic Bacteriuria
Prevalence of Asymptomatic Bacteriuria Among Pregnant Women With Pre-eclampsia in Women Health Hospital Assiut University
Pre-eclampsia is a hypertensive disorder of pregnancy that can lead to significant health complications for both the mother and the fetus.
- Trial name
- NCT07866196
- Volunteers
- 129 people
- Sponsor
- Assiut University
Maternal Sepsis During Labor, Hemorrhage, Postpartum
Scaling Up an Integrated Approach to Improve Delivery Care in North Guatemala With Stepped Wedge Design
"¡Que Vivan las Madres!: Venga a tener su parto al CAP" (QVLM) is a guatemalan quasi-experimental study that has been performed from January 2014 to January 2017 by the Epidemiological Research Center in Sexual and Reproductive…
- Conditions
- Maternal Sepsis During Labor, Hemorrhage, Postpartum, Eclampsia; Complicating Pregnancy, Pre-Eclampsia
- Trial name
- QVLM (NCT03151070)
- Testing
- QVLM Intervention package
- Volunteers
- 32,000 people
- Sponsor
- Hospital San Juan de Dios Guatemala
HELLP Syndrome, Preeclampsia
Analysis of Biological Progression and Regression of HELLP Syndrome in Time
Prospective observational study about progression and regression of biological parameters of HELLP syndrome
- Trial name
- NCT06758960
- Where
- Morocco
- Volunteers
- 72 people
- Sponsor
- CHU Mohammed VI Marrakech
Preterm Birth, Preeclampsia
Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia
The goal is to demonstrate the relationship of the circulating pool of T-regulatory lymphocytes in the mother's peripheral blood with populations in the placentas and to compare with controls, what is the difference in the…
- Trial name
- PRIME (NCT06281262)
- Testing
- Peripheral blood collection, Swab sample collection
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- General University Hospital, Prague
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Telocytes in Umbilical Cord of Pregnancies Complicated by Chronic Hypertension, Gestational Hypertension and Preeclampsia
Telocytes in Umbilical Cord of Patients With and Without Pre-eclampsia
Studying the ultrastructural and immunohistochemical characteristics of Telocytes from umbilical cord vessels wall in PE patients compared to control and its relation to severity of disease whether controlled or uncontrolled.
- Trial name
- NCT05305339
- Testing
- Placental and Umbilical cord biopsy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Preeclampsia
Inflammatory Markers in Pregnant Women Destined to Develop Preeclampsia
The purpose of this study is to assess the predictive role of serum inflammatory markers in pregnant women who subsequently develop preeclampsia.
- Trial name
- NCT01388283
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Neurodevelopmental Abnormality
ASPIRIN: Neurodevelopmental Follow-up Trial
A total of 620 children will be enrolled in this study from six sites in sub-Saharan Africa, South Asia, and Latin America. Half of the children's mothers will have taken aspirin and half will have taken placebo.
- Trial name
- NCT04888377
- Testing
- Aspirin
- Where
- 14 sites in United States, Democratic Republic of the Congo and 4 more
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Pregnancy Related, Remote Monitoring
Feasibility of Remote eCTG Monitoring Home@Hospital in Complicated Pregnancies
The objective of this single center, interventional cohort study is to evaluate the feasibility of remote electrophysiological cardiotocography (eCTG) monitoring in complicated pregnancies in a home@hospital setting.
- Conditions
- Pregnancy Related, Remote Monitoring, Feasibility
- Trial name
- HASTA (NCT06859177)
- Testing
- Remote eCTG
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Hypertension, Pregnancy Induced
Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy
Hypertensive crisis (defined as a systolic pressure > 160mmHg or a diastolic pressure > 110mmHg) in patients with a hypertensive disorder of pregnancy is a serious complication with severe and even deadly consequences.
- Trial name
- NCT01538875
- Testing
- Hydralazine, Labetalol
- Where
- Panama
- Volunteers
- 261 people
- Sponsor
- Saint Thomas Hospital, Panama
End Stage Renal Disease, End Stage Renal Disease on Dialysis
Evaluation of Non-Invasive Continuous vs Intermittent BloodPressure Monitors in Maintenance Dialysis (BP Dialysis)
Prospective, single center, open label, non-randomized, post-market study of the Tablo Hemodialysis System and VitalStream Monitor in participants with End-Stage KidneyDisease undergoing In-Center Hemodialysis.
- Conditions
- End Stage Renal Disease, End Stage Renal Disease on Dialysis, Dialysis Hypotension, Dialysis Induced Hypertension
- Trial name
- NCT05540457
- Testing
- Intermittent Non-InvasiveBlood Pressure Monitor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Rogosin Institute
Eclampsia
Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES):
This is a double blinded, placebo-controlled trial to determine if IV dexamethasone more quickly than placebo assists resolution of Posterior Reversible Encephalopathy Syndrome (PRES) encountered in eclamptic patients.
- Trial name
- PRESIDEX (NCT02027272)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Mississippi Medical Center
Microalbuminuria, Preeclampsia
Lisinopril for Renal Protection in Postpartum Preeclamptic Women
There may be a role for Lisinopril in improving renal protection in post-partum women who had preeclampsia during pregnancy. The aim of this study is to determine whether routine initiation of Lisinopril after delivery, in women…
- Trial name
- NCT05016440
- Testing
- Lisinopril
- Where
- United States
- Sponsor
- Eastern Virginia Medical School
Preeclampsia Postpartum
Guideline-directed Management and Therapy (GDMT) for the Prevention of Postpartum Cardiac Dysfunction in Preeclamptic African American Women
This is a single-center, open-label pilot study looking at how Guideline-directed management and therapy (GDMP) in post-partum women with preeclampsia can improve Global Longitudinal Strain (GLS).
- Trial name
- GDMT For PE (NCT05534932)
- Testing
- Remote Patient Monitoring
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Obstructive Sleep Apnea of Adult, Preeclampsia
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of…
- Conditions
- Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications
- Trial name
- SLEEP (NCT03487185)
- Testing
- Continuous Positive Airway Pressure, Sleep Advice Control
- Where
- 14 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia
Combined 3D Power Doppler Placental Volume and Vascular Flow Indices In the First Trimester of Pregnancy as Predictors Of Preeclampsia?.
200 women at risk factor for preeclampsia will be subjected to transabdominal Doppler ultrasonography for assessment of placental volume measurements, pulasatility index (PI) and resistivity index (RI) in both uterine arteries…
- Trial name
- NCT03399006
- Testing
- 2D ultrasound, Doppler Ultrasound, 3D ultrasound
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Pre-Eclampsia
Screening for Preeclampsia in Norway With Aspirin Discontinuation at 24-28 Weeks
Study population Around 3500 pregnant women attending a routine ultrasound scan at 11-14 weeks at St. Olavs hospital, Trondheim, Norway.
- Trial name
- PEScreenNor (NCT06108947)
- Testing
- Aspirin
- Where
- Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Hypertension, Preeclampsia
The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine
The objective of this study is to demonstrate that urapidil is not inferior to nicardipine for the treatment of hypertension associated with preeclampsia (PE) and that it is better tolerated.
- Trial name
- Uranic (NCT02558023)
- Testing
- Urapidil, Nicardipine
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Strasbourg, France