Clinical trials: Pregnancy Induced Hypertension
Pre-Eclampsia
Impact of Body Mass Index on Serum Maternal and Fetal Magnesium Level
Magnesium sulphate is an inorganic salt with multiple therapeutic applications in medicine it has been widely utilized and studied on a diverse set of conditions such as asthma, cardiac arrhythmia and stroke.
- Trial name
- NCT03928691
- Testing
- Magnesium Sulfate
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Assiut University
Hypertension, Pregnancy-Induced
Postpartum Management of Gestational Hypertensive Disorders Using Furosemide
The main purpose of this study is to learn if incorporating a loop diuretic such as furosemide along with labetalol in the routine management of postpartum gestational hypertensive disorders could lower the need for additional…
- Trial name
- NCT04343235
- Testing
- furosemide, labetalol
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wright State University
Preeclampsia
Prediction of Chronic Kidney Disease Following Pre-eclampsia: Diagnosis and Early Care
Pre-eclampsia (PE) is a pregnancy-associated syndrome of variable severity, classically defined by the combination of hypertension and proteinuria in a previously non-hypertensive or proteinuric patient.
- Trial name
- PRECEDE (NCT05056701)
- Testing
- annual follow-up during 10 years
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier le Mans
Preeclampsia
Low Dose Aspirin for the Prevention of Preeclampsia
Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results.
- Trial name
- NCT01890005
- Testing
- Aspirin
- Where
- Panama
- Volunteers
- 476 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia
A Novel Multiomic AI Approach for Early Preeclampsia Prediction in Pregnancy
Preeclampsia (PE) is a leading cause of maternal-fetal morbidity and mortality, affecting 3-8% of pregnancies and causing over 76,000 maternal deaths annually.
- Trial name
- PREMEM (NCT06430398)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Venous Thromboembolism, Postpartum Period
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity
The goal of the PARTUM trial is to determine if taking low-dose aspirin daily for 6 weeks after delivery is similar (non-inferior) to usual care low-molecular-weight heparin injections to prevent venous thromboembolism (VTE…
- Conditions
- Venous Thromboembolism, Postpartum Period, Aspirin, Low Molecular Weight Heparin
- Trial name
- NCT06494878
- Testing
- Aspirin, Low-molecular-weight heparin
- Where
- 12 sites in Belgium, Canada and 5 more
- Volunteers
- 8,805 people
- Sponsor
- University of Calgary
Preeclampsia, Pregnancy Loss
Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.
Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization to evaluate the pharmacological effect in terms of placentation, gene expression, protein synthesis…
- Conditions
- Preeclampsia, Pregnancy Loss, Preterm Birth, Healthy
- Trial name
- PLORG (NCT06893978)
- Testing
- Placenta organoids treatment
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pre-Eclampsia, Hypotension
Inferior Vena Cava Collapsibility Index Guide for Preoperative Fluid Therapy in Preeclampsia
The routine assessment of fluid status depends on clinical evaluation and invasive monitoring. The clinical assessment lacks objectivity and the invasive monitoring carries risks.
- Conditions
- Pre-Eclampsia, Hypotension, Fluid Overload
- Trial name
- NCT06539026
- Testing
- fluid therapy, 300 ml of crystalloid Ringer's solution.
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Preeclampsia, Pregnancy Complications
Climate-Safe Pregnancy Intervention for Women With Preeclclampsia
This randomized controlled trial aims to evaluate the effectiveness of a climate-related nursing intervention in improving pregnancy-specific climate change knowledge, health beliefs, and protective behaviors among pregnant women…
- Conditions
- Preeclampsia, Pregnancy Complications, Climate Change and Maternal Health
- Trial name
- NCT07564856
- Testing
- Climate-Related Nursing Intervention, Routine Antenatal Care
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Benha University
Preeclampsia
Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia
The purpose of this study is to determine the prevalence of positive antiphospholipid antibodies among women with preeclampsia and to determine the effect of antiphospholipid antibodies on the severity of preeclampsia and the…
- Trial name
- NCT02699437
- Testing
- Testing for antiphospholipid antibodies
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mohamed Sayed Abdelhafez
Pre-Eclampsia
Prospective Case-Control Study of Cardiovascular Changes in Pregnancy Related Hypertensive Disorders
This is a research study to understand the changes in the heart and the cardiovascular system that may occur in women who develop high blood pressure during pregnancy.
- Trial name
- ARTSEN (NCT04713228)
- Testing
- ARTSENS Pen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Pre-Eclampsia
Precision Medicine for Prediction & Prevention of Early Pre-eclampsia
This study aims to evaluate the feasibility of implementing a clinical model for precision screening of early pre-eclampsia into the current prenatal screening service at Sunnybrook Health Sciences Center (SHSC).
- Trial name
- NCT04412681
- Testing
- Enhanced PE Screening
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Pre-Eclampsia Onset Less Than 37 Weeks, Pre-Eclampsia
Preeclampsia Intervention Netherlands
The goal of this study is to find out if pregnant individuals with preterm preeclampsia (PE) who are treated with metformin can stay pregnant for longer, and if this is safe(r) for the mother and child.
- Conditions
- Pre-Eclampsia Onset Less Than 37 Weeks, Pre-Eclampsia, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia as Antepartum Condition
- Trial name
- PI-NL (NCT06452498)
- Testing
- Metformin Hydrochloride
- Volunteers
- 180 people
- Sponsor
- Amsterdam UMC
Severe Pre-Eclampsia, Antepartum
Oral Nifedipine Versus IV Labetalol in Severe Pre Eclampsia
OBJECTIVE: To determine the efficacy of nifedipine and labetalol in terms of control of BP in pre eclamptic pregnant patients Design: Randomised control trial SETTING: Department Obstetrics \& gynaecology, Services Hospital…
- Trial name
- NCT03325348
- Testing
- Nifedipine 10 mg, Labetalol
- Where
- Pakistan
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Pregnancy Induced Hypertension, Preeclampsia and Eclampsia
Role of L-citrulline in Prevention of Pregnancy Associated Hypertension
The target population for our study is healthy nulliparous pregnant women (first pregnancy) between the 12-16 week of pregnancy. If a subject is eligible, written consent will be obtained by person to person contact.
- Conditions
- Pregnancy Induced Hypertension, Preeclampsia and Eclampsia, Gestational Hypertension
- Trial name
- NCT04979793
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Pre-Eclampsia
Correlation Between Changes in Liver Stiffness and Preeclampsia as Shown by Fibroscan
Compare the Fibroscan results of preeclamptic women to normal controls and to find out if the changes are reversible after labor. Materials and Methods
- Trial name
- NCT03299777
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Western Galilee Hospital-Nahariya
Hypertension
Prevention of Severe Postpartum Hypertension
The purpose of this study is to determine whether postpartum administration of furosemide to women with antepartum hypertensive disorders (gestational hypertension, preeclampsia) or elevated blood pressure in the first 24 hours…
- Trial name
- NCT02450773
- Testing
- Furosemide, Potassium chloride
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Pre-Eclampsia
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia
1. To measure the level of expression of MXRA5 and ANXA4 genes in preeclampsia (PE). 2. To detect the effect of heavy metals (lead (Pb) and arsenic (AR)) on these two genes in the pathology of PE. 3.
- Trial name
- NCT04287998
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Maternal Hypertension
Perinatal Outcomes Following Change in Clinical Criteria in for Treatment of Maternal Hypertension
The purpose of this study is observe outcomes before and after a change in clinical practice in the threshold for management of severe hypertension in pregnancy and the post-partum period.
- Trial name
- NCT05881252
- Testing
- Clinical blood pressure threshold of SBP >= 160 mmHg for acute treatment of hypertension, Clinical blood pressure threshold of SBP >= 180 mmHg for acute treatment of hypertension
- Where
- United States
- Volunteers
- 1,003 people
- Sponsor
- The University of Texas Health Science Center, Houston
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