Clinical trials: Pregnancy Induced Hypertension
Pre-Eclampsia, Intrauterine Growth Restriction
Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Due to the fetoneonatal pathway it is possible to identify pregnant women with an increased risk of fetal growth restriction or pre-eclampsia in early stages (from 10th week of pregnancy).
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Maternal Care for Known or Suspected Poor Fetal Growth
- Trial name
- NCT04514276
- Testing
- consecutive fetoneonatal healthcare pathway
- Where
- 2 sites in Germany
- Volunteers
- 828 people
- Sponsor
- Technische Universität Dresden
Hypertension in Pregnancy, Pre-Eclampsia
The BEET-BP Trial - Investigating the Effect of Dietary Nitrates on Hypertension in Pregnancy
This is a randomised placebo controlled trial investigating the effects of dietary nitrate supplementation on hypertension in pregnancy
- Conditions
- Hypertension in Pregnancy, Pre-Eclampsia, Gestational Hypertension, Pregnancy Induced Hypertension
- Trial name
- NCT04604535
- Testing
- Concentrated beetroot juice
- Where
- United Kingdom
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Preeclampsia, Fullpairs
fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Preeclampsia
Apredictive formula, fullPIERS (Pre-eclampsia Integrated Estimate of Risk Score), can be used to estimate the risk of suffering an adverse outcome using information obtained within 48 hours of admission with pre-eclampsia.
- Trial name
- Aprospective (NCT07316140)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Preeclampsia
Diuretics for Postpartum High Blood Pressure in Preeclampsia
The purpose of this study is to determine if furosemide administered after the first 24 hours of delivery, in women with severe peeclampsia and eclampsia accelerates high blood pressure control and diminishes hospital stay.
- Trial name
- DIUPRE (NCT02163655)
- Testing
- FUROSEMIDE
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Pregnancy Complication
Vitamin D During In Vitro Fertilisation (IVF) - A Prospective Randomized Trial
During IVF treatment women will be randomized into supplementation with a high or a low dose of Vitamin D Main outcome Laboratory pregnancy, live pregnancy at 12 weeks, Baby take home rate, OHSS Secondary outcome: 1.
- Trial name
- Delivery (NCT01019785)
- Testing
- Ergocalciferol
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Preeclampsia
Anti-Angiogenic Preeclampsia Milieu Impairs Infant Lung and Vascular Development
Pregnant mothers who develop high blood pressure and other vascular problems (preeclampsia) deliver babies with increased neonatal health problems, which include lung disease and vascular complications, later in life.
- Trial name
- NCT02639676
- Testing
- Diffusion Lung Capacity (DLCO), Vascular Challenge, Video Imaging, Specimen Collections
- Where
- United States
- Volunteers
- 292 people
- Sponsor
- Indiana University
PE (Pre-eclampsia) High-risk Population With Gut Microbiota Dysbiosis During Their Pregnancy
Probiotic Supplementation During Pregnancy in Preeclampsia High-risk Groups
In this randomized controlled study, preventive intervention of aspirin combined with probiotics or aspirin combined with placebo would given to PE (pre-eclampsia) high-risk population with gut microbiota dysbiosis during their…
- Trial name
- NCT05554185
- Testing
- aspirin 100mg and probiotics 1 bag
- Volunteers
- 338 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Preeclampsia, Spinal Anesthesia-Induced Hypotension
Dexamethasone Versus Ondansetron for Preventing Post-Spinal Hypotension in Preeclampsia
This study compares the efficacy and safety of intravenous dexamethasone versus intravenous ondansetron in preventing low blood pressure (hypotension) following spinal anesthesia in pregnant women with preeclampsia undergoing…
- Conditions
- Preeclampsia, Spinal Anesthesia-Induced Hypotension, Cesarean Section
- Trial name
- NCT07793760
- Testing
- Dexamethasone, Ondansetron
- Volunteers
- 110 people
- Sponsor
- Assiut University
Hypertension in Pregnancy
Persistent Postpartum Hypertension Pilot Trial
This study is a pilot, open-label, randomized controlled trial of postpartum women with hypertensive disorders pregnancy and persistent non-severe blood pressure.
- Trial name
- NCT04349124
- Testing
- Nifedipine Extended-Release Tablets
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Preeclampsia, Chronic Periodontitis
microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia.
Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria…
- Trial name
- NCT04277390
- Testing
- clinical intervention for microbial analysis and MIR155 as biomarker
- Where
- India
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Perinatal Death, Hypertension, Pregnancy-Induced
Pregnancy in the Context of Urbanicity and Climate Change. The Overall Aim of the Project is to Co-create, Implement, and Test New Clinical Guidelines in Order to Improve the Quality of Care in Antenatal Clinics in the Context of Urbanisation and Climate Change in Dar es Salaam, Tanzania.
Tanzania's population is growing quickly, and Dar es Salaam is one of the fastest-growing cities in the world. At the same time, the city is increasingly affected by very hot weather, flooding, and air pollution.
- Conditions
- Perinatal Death, Hypertension, Pregnancy-Induced, Abortion, Spontaneous, Stillbirth
- Trial name
- NCT07751432
- Testing
- CC-ANC intervention group.
- Where
- Tanzania
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Pre-Eclampsia, Diphtheria, Tetanus and Pertussis Vaccine Reaction
Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 or at Week 36
Preeclampsia is a significant medical condition occurring in 3-8% of pregnancies and impacts deleteriously both maternal and fetal health.
- Trial name
- NCT04424693
- Testing
- Tdap Vaccine Administration
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Institute of Arthritis Research
Congenital Heart Disease
Preeclampsia and Fetal Heart Malformations: Looking to Maternal Heart
The goal of this study is to describe the maternal hemodynamic parameters detected by UltraSonic Cardiac Output Monitor (USCOM®) in women carrying a fetus with a congenital heart disease (CHD) and to possibly describe an…
- Trial name
- MAMAH (NCT07092644)
- Testing
- UltraSonic Cardiac Output Monitor (USCOM®)
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pre-Eclampsia
Autogenic Training Effects on Pre-eclampsia
The purpose of study is to find the effects of autogenic training on blood pressure and anxiety in preeclampsia females. There is little of evidence to allow conclusions about effectiveness of autogenic training on preeclampsia…
- Trial name
- NCT05709834
- Testing
- Autogenic training, Conventional treatment
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Low Birth Weight, Small for Gestational Age (SGA)
Improving Aspirin Prescription Rates in Outpatient Clinic
Ρrееςlаmpѕia is a syndrome characterised by the new onset of hуреrtеnѕion plus proteinuria, end-organ dysfunction, or both after 20 weeks of gestation. It complicates 3-5% of pregnancies.
- Conditions
- Low Birth Weight, Small for Gestational Age (SGA), Preeclampsia (PE), Prevention &Amp; Control
- Trial name
- NCT06694233
- Testing
- Aspirin prescription on outpatient basis
- Where
- Kuwait
- Volunteers
- 300 people
- Sponsor
- Cairo University
Hypertension in Pregnancy
Invasive Versus Non-invasive Assessment of Blood Pressure in Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy are important causes of maternal morbidity and mortality worldwide. Hypertension is one of the most commonly reported health conditions among pregnant women and complicates 5-10% of all…
- Trial name
- NCT04303871
- Testing
- Invasive blood pressure assessment by radial artery canulation
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Assiut University
Gestational Weight Gain, Diet, Healthy
Delivering HOPE (Helping Women Optimize Prenatal Equity)
The overarching research question is: "Does the provision of healthy food (Delivering HOPE) during pregnancy reduce the proportion of women who experience excessive gestational weight gain compared with enhanced standard of care…
- Conditions
- Gestational Weight Gain, Diet, Healthy, Gestational Hypertension, Gestational Diabetes
- Trial name
- NCT06814509
- Testing
- Enhanced Standard of Care (ESoC), Delivering HOPE
- Where
- 8 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia
Management of Hypertension in the Early Postpartum: a Randomized Controlled Trial
In hypertensive mothers, it is common in clinical practice to substitute methyldopa for another medication, such as captopril, immediately after delivery, which may, as a consequence, cause a rebound effect or an initial lack of…
- Conditions
- Pregnancy-Induced Hypertension in Postpartum, Postpartum Pre-Eclampsia, Hypertension
- Trial name
- NCT04835233
- Testing
- Methyldopa 250 MG
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Federal University of Paraíba
Pregnancy, High Risk, Pre-Eclampsia
Blood Pressure Monitoring in High Risk Pregnancy to Improve the Detection and Monitoring of Hypertension
Raised blood pressure is a common problem in pregnancy. Raised blood pressure and pre-eclampsia affect about one in ten women and are a major cause of death and premature birth in the United Kingdom and worldwide.
- Conditions
- Pregnancy, High Risk, Pre-Eclampsia, Hypertension, Hypertension, Pregnancy-Induced
- Trial name
- BUMP (NCT03334149)
- Testing
- Self-Monitoring of Blood Pressure
- Where
- 13 sites in United Kingdom
- Volunteers
- 3,042 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pre-Eclampsia, Fetal Growth Retardation
Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia
Placental insufficiency is the source of preeclampsia (PE) and intrauterine growth retardation (IUGR). Current data demonstrate a significant beneficial effect of prophylactic use of aspirin on the recurrence of placental…
- Conditions
- Pre-Eclampsia, Fetal Growth Retardation, Premature Birth, Placental Insufficiency
- Trial name
- NCT01352234
- Testing
- Acetylsalicylic Acid 160 mg, Acetylsalicylic Acid 80 mg
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
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