Clinical trials: Pregnancy Induced Hypertension
Preeclampsia
Molecular Study of the Maternal-fetal Interface in Preeclampsia.
Preeclampsia (PE) is a major obstetric complication with short- and long-term consequences for the mother and the fetus. Early screening tools to reduce its mortality and morbidity, as well as to prevent the life-threatening…
- Trial name
- PREMAFE (NCT06232668)
- Testing
- Maternal-fetal interface biopsy and peripheral blood collection in cases group, Maternal-fetal interface biopsy and peripheral blood collection in control group
- Where
- 4 sites in Spain
- Volunteers
- 2,084 people
- Sponsor
- Carlos Simon Foundation
Preeclampsia, Pregnancy
Analgesia After Cesarean Section
Magnesium sulphate is the first line therapy for the management of preeclampsia and eclampsia in obstetrics. Perioperative administration of magnesium sulphate has been proved to be an effective as an analgesic adjuvant.
- Trial name
- NCT01360060
- Testing
- Magnesium Sulphate
- Where
- South Korea
- Volunteers
- 503 people
- Sponsor
- Seoul National University Bundang Hospital
Pregnancy Induced Hypertension
Breathing Exercise in Pregnancy-induced Hypertension
To determine the effects of Breathing control vs Alternate nostril breathing on maternal cardiovascular parameters in pregnancy and to determine the effect of breathing control vs Alternate nostril breathing on Fetal Heart rate.
- Trial name
- NCT05828615
- Testing
- Group A, Group B
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Hypertension in Pregnancy
Docosahexaenoic Acid Supplementation of Women With Hypertension in Pregnancy to Improve Endothelial Health
The Investigator would like to see if taking a DHA supplement at a dose recommended for heart health will improve brachial artery dilation (relaxation) and help blood pressure.
- Trial name
- DHA-2 (NCT02137408)
- Testing
- Docosahexaenoic acid 200 mg, Docosahexaenoic acid 1000 mg
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pre-Eclampsia
Glomerular Injury of Preeclampsia
Pre-eclampsia complicates 7 - 10% of pregnancies and constitutes a leading cause of fetal growth retardation and premature birth, as well as infant and maternal morbidity and mortality.
- Trial name
- NCT00275158
- Testing
- L-Arginine Supplementation
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Preeclampsia, Dyslipidemia
Prolongation of Pregnancy in Preeclampsia by Therapeutic Lipid Apheresis
Preeclampsia is a disease which occurs in about 6-8% of all pregnancies and is the main cause of maternal and fetal morbidity and mortality.
- Conditions
- Preeclampsia, Dyslipidemia, Proteinuria, Hypertension
- Trial name
- NCT01967355
- Testing
- lipid apheresis
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Karl Winkler
Preeclampsia, Postpartum
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
--- Why Is This Study Being Done? Women who have preeclampsia during pregnancy face a much higher risk of heart disease later in life.
- Conditions
- Preeclampsia, Postpartum, Endothelial Injury, Exosome Multiomics
- Trial name
- EXITPE (NCT07183384)
- Testing
- Mesenchymal Stem Cell-Derived Exosomes
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Padjadjaran
Fetal Growth Retardation, Pre-Eclampsia
Cardiac Output Monitoring to Predict Pre-Eclampsia and Restricted Growth (COMPaRE)
Pre-eclampsia (PET) and fetal growth restriction (FGR) are common complications of pregnancy that affect up to 15% of pregnancies in the UK.
- Trial name
- COMPaRE (NCT05123677)
- Testing
- Non-invasive haemodynamic assessment, Maternal ophthalmic artery doppler
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Hypertensive Disorder
Use of a Cloud-connected Remote Blood Pressure Monitoring Program During the Postpartum Period for Hypertensive Women
Hypertensive disorders (HD), including preeclampsia, gestational hypertension, chronic hypertension, and chronic hypertension with superimposed preeclampsia, affect around 10-20% of pregnant women in the United States and are…
- Trial name
- BP-ME (NCT06096701)
- Testing
- Blood pressure cuff
- Where
- United States
- Volunteers
- 421 people
- Sponsor
- University of South Carolina
Pregnancy Induced Hypertension, Superimposed Preeclampsia
Phase I Study of Nicotinamide for Early Onset Preeclampsia
This is a Phase I study of vitamin B3-amide (nicotinamide) dietary supplementation in pregnant women with early onset preeclampsia.
- Conditions
- Pregnancy Induced Hypertension, Superimposed Preeclampsia, Hypertension
- Trial name
- NCT02213094
- Testing
- Nicotinamide 500 mg, Nicotinamide 1000 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Gestational Hypertension, Prematurity
Effects of Exercise During Pregnancy on Maternal and Child Health: a Randomized Clinical Trial
The Pamela Study is a clinical trial carried out during pregnancy to assess the potential effects of physical activity during pregnancy among previously inactive women.
- Conditions
- Gestational Hypertension, Prematurity, Maternal Post-partum Depression, Maternal Post-partum Weight Retention
- Trial name
- PAMELA (NCT02148965)
- Testing
- Physical Exercise / Physical Activity
- Where
- Brazil
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Renal Cell Carcinoma, Cardiotoxicity
A Prospective Study of Acute Cardiovascular Effects of First-line Sunitinib in Metastatic Renal Cell Carcinoma Patients (SUnitinib Prospective CardiovasculaR Effect)
While sunitinib can be very helpful to treat kidney cancer, these medications can also cause side effects, including heart damage.
- Conditions
- Renal Cell Carcinoma, Cardiotoxicity, Heart Failure, Hypertension
- Trial name
- SUPER (NCT01014065)
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- AHS Cancer Control Alberta
Hypertension in Pregnancy, Diabetes Mellitus in Pregnancy
Insulin Resistance and Hypertensive Disorders in Pregnancy
The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester.
- Trial name
- NCT00412230
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Messina
Preeclampsia
Prediction and Prevention of Preeclampsia by First Trimester Ultrasound
The purpose of this study is to determine whether the Fetal Medicine Foundation algorithm for individual risk calculation for preeclampsia (PE) and pregnancy induced hypertension (PIH) is suitable to identify women in high risk…
- Trial name
- Screen-tox (NCT01195441)
- Where
- Norway
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Preeclampsia
Comparison of Intravenous Labetalol and Intravenous Hydralazine in Severe Preeclampsia
Due to limited data regarding preeclampsia from the local population, the debate is still ongoing in the study setting. Hence, the current study was planned to compare the efficacy of labetalol and hydralazine for the treatment…
- Trial name
- NCT07572656
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 132 people
- Sponsor
- Muhammad Aamir Latif
Pregnancy Complications, Maternal Death
Nutrition Optimalization Among Pregnant Women to Improve Maternal and Neonatal Outcome in DKI Jakarta
The goal of this MONAS Study is to learn about comprehensive monitoring and nutritional intervention among pregnant women in order to improve maternal and neonatal outcomes. The main questions it aims to answer are: 1.
- Conditions
- Pregnancy Complications, Maternal Death, Preeclampsia, Intrauterine Infection
- Trial name
- MONAS (NCT06268509)
- Testing
- Nutritional panel laboratory examination, Pregnancy supplements (other than provided by Ministry of Health), Fetomaternal ultrasound
- Where
- Indonesia
- Volunteers
- 245 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Sepsis, Pneumonia
Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
The purpose of this study is to determine whether an integrated EmONC package (community mobilization, training of community-based health care providers and a maternal and neonatal health pack) reduce perinatal and neonatal…
- Conditions
- Sepsis, Pneumonia, Omphalitis, Birth Asphyxia
- Trial name
- EmONC (NCT01751945)
- Testing
- EmONC package
- Where
- Pakistan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Pre-Eclampsia, Hippocampus
Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely…
- Trial name
- FHC-EOPE (NCT07245056)
- Testing
- FHC dimensions in EOPE and control groups
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Pulmonary Edema, Acute Lung Injury
Fluid Management in the Post-Anesthetic Care Unit (PACU) at Sourasky Medical Center
Peri-operative fluid therapy is a controversial area with few randomized trials to guide practice. Fluid management has a significant influence on outcome following surgery.
- Conditions
- Pulmonary Edema, Acute Lung Injury, Hypertension, Renal Failure
- Trial name
- NCT00995228
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center