Clinical trials: Pregnancy Induced Hypertension
Pre-Eclampsia
Association Between Pococyturia and Pre-eclampsia Severity
Pre-eclampsia is an hypertensive disorder appearing during pregnancy, inducing serious maternal, fetal and neonatal mortality and morbidity.
- Trial name
- PEPOD2 (NCT03316391)
- Testing
- Dosage of urinary podocyturia
- Where
- 2 sites in France
- Volunteers
- 14 people
- Sponsor
- Hospices Civils de Lyon
Pregnancy Complications, Endothelial Dysfunction
Oxidative Stress and Endothelial Function in Pregnancy Complications
Pregnancy complications like pre-eclampsia (PE), pregnancy induced hypertension (PIH), intra-uterine growth restriction (IUGR) and preterm labor (PTL), (i.e.
- Trial name
- ENDOPREG (NCT02603913)
- Where
- Belgium
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Severe Preeclampsia
Factors Associated With Blood Pressure Control Failure to Intravenous Labetalol in Severe Preeclampsia
Severe preeclampsia is a serious pregnancy complication that can lead to severe maternal and fetal outcomes, particularly when blood pressure is not adequately controlled.
- Trial name
- RELAPSE (NCT07547046)
- Where
- 14 sites in France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Difficult; Intubation, Postpartum, During Puerperium
Ultrasound Airway Assessment of Critically Ill Preeclamptic; Comparison Between Two Technique
Unexpected difficult airway exposes the patient to serious morbidity and even mortality. The changes in pregnancy and preeclampsia increase the risk of difficult intubation.
- Conditions
- Critical Illness, Difficult; Intubation, Postpartum, During Puerperium, Pre-Eclampsia
- Trial name
- NCT06651879
- Testing
- techniques of ultrasound examination of the airway
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Preeclampsia
Novel Biomarkers of Preeclampsia, Aquaporin, Fatty Acid, and S110B
This is a research study designed to help identify preeclampsia in pregnant women earlier, and possibly lead to better treatment for women preeclampsia.
- Trial name
- NCT03567551
- Testing
- Women w/ Preeclampsia w/o Visual Disturbances or Headache, Women w/ Preeclampsia w/ Visual Disturbances or Headaches, Women w/o Preeclampsia
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pre-Eclampsia, Eclampsia
Postpartum Uterine Curettage in the Recovery From Preeclampsia/Eclampsia
Use of Postpartum uterine curettage in reducing hospitalization time or in improving the clinical evolution of the patient with preeclampsia/eclampsia.
- Trial name
- NCT03028194
- Testing
- Curettage
- Where
- 2 sites in Panama
- Volunteers
- 442 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia (PE), Endothelial Dysfunction
Does Nicotine Influence the Risk of Preeclampsia?
This prospective cohort study explores the long-term impact of pre-pregnancy smoking on vascular health in women predisposed to preeclampsia, conducted at the Medical University of Graz.
- Conditions
- Preeclampsia (PE), Endothelial Dysfunction, Hypertension in Pregnancy
- Trial name
- PRE_Smoking (NCT06645340)
- Testing
- This high-risk cohort underwent the same measurements during pregnancy: endothelial function, arterial stiffness, retinal microvasculature profile, measurement of Neprilysin, cotinine, telomere length
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Pregnancy Related, Hypertension in Pregnancy
Development and Validation of a Short Tool to Assess the Awareness of Pregnancy-induced Hypertension
Background: Pregnancy-induced hypertension (PIH) is responsible for most perinatal and fetal mortality. Few programs are patient-centered during pregnancy, increasing the risks of misinformation and misconceptions among pregnant…
- Trial name
- NCT05859282
- Testing
- Survey
- Where
- Lebanon
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Georges Hatem
Hypertensive Disorder of Pregnancy
Improving Maternal Cardiovascular Outcomes Through the Implementation of a Hypertensive Disorders of Pregnancy Bundle in Nigeria
The goal of this interventional study is to learn from patients and healthcare providers at 4 health institutions (study sites) in Abuja and Kano in Nigeria what ways to best develop the content of a Hypertensive Disorders of…
- Trial name
- IMPACT-HDP (NCT06859359)
- Testing
- Hypertension Disorders of Pregnancy (HDP) Implementation Bundle
- Where
- 4 sites in Nigeria
- Volunteers
- 1,200 people
- Sponsor
- Washington University School of Medicine
Twin Pregnancy, Preeclampsia
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth.
- Conditions
- Twin Pregnancy, Preeclampsia, Preterm Birth, Fetal Growth Restriction
- Trial name
- NCT04051567
- Testing
- Aspirin 100mg
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Pre-Eclampsia, Gestational Hypertension
Physician Optimised Post-partum Hypertension Treatment Trial
It has been shown in a pilot randomised controlled study [SNAP-HT [4]; REC 14/SC/1316] that blood pressure self-management during the post-partum period after hypertensive pregnancies, results in lower blood pressure after six…
- Trial name
- POP-HT (NCT04273854)
- Testing
- OMRON Evolv® blood pressure monitor (Blue-tooth® enabled) & Proprietary Smartphone POP-HT app®
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Obstetric Labor Complications, Preeclampsia
Platelet Count Trends in Pre-eclamptic Parturients
Thrombocytopenia (platelet count < 100,000/mL) occurs in approximately 15% of women with preeclampsia. Neuraxial analgesia is contraindicated in parturients with a coagulopathy; therefore, the platelet count(PC) is routinely…
- Conditions
- Obstetric Labor Complications, Preeclampsia, Thrombocytopenia
- Trial name
- NCT00787241
- Where
- United States
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pre-eclampsia, Hypertension, Pregnancy Induced
Community Level Interventions for Pre-eclampsia
This project is being undertaken to test the hypothesis that implementing a community based package of care for women with hypertensive disorders of pregnancy will result in overall improvement in maternal and neonatal outcomes.
- Trial name
- CLIP (NCT01911494)
- Testing
- Community Engagement, PIERS on the Move mHealth decision aid, Magnesium Sulfate
- Where
- 4 sites in India, Mozambique and 2 more
- Volunteers
- 87,500 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Preeclampsia
Predictors of Aspirin Failure in Preeclampsia Prevention
Hypertensive disorders of pregnancy (including preeclampsia) are among the leading causes of pregnancy complications and maternal deaths worldwide. They also increase the risks to the babies.
- Trial name
- NCT05709483
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Preeclampsia, Maternal Hypertension
PROtecting Maternal Brains From Injury and Stroke
The purpose of this study is to test a new approach to blood pressure management in postpartum preeclampsia. There will be two groups of patients in this early stage single center trial.
- Trial name
- PROMIS (NCT05726279)
- Testing
- NIRS based personalized blood pressure management
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Columbia University
Pre-Eclampsia
Factors Predicting Transformation of Non Severe Pre-eclampsia Into Pre-eclampsia With Severe Features
Preeclampsia is a multi-system progressive disorder characterized by the new onset of hypertension and proteinuria, or hypertension and significant end-organ dysfunction with or without proteinuria, in the last half of pregnancy…
- Trial name
- NCT05152550
- Testing
- Non-severe pre-eclampsia
- Where
- Egypt
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Ahmed Nagy Abdul-Rahman Younis
Gestational Diabetes
Myo-inositol in Obese Pregnant Women
Myo-Inositol is classified as a member of the vitamin B complex. It is a constituent of living cells and is widespread in many food.
- Trial name
- NCT01047982
- Testing
- myo-inositol, folic acid 400 mcg
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Messina
Adolescent Pregnancy, Preeclampsia and Eclampsia
Blood Pressure in Adolescents With PReclampsia and Eclampsia.
Levels of blood pressure in adolescents with preeclampsia and eclampsia: Multicenter case-control study (Latin America). Maternities in Latin America: Two hospitals in Panama, one hospital in Mexico, one hospital in El Salvador…
- Trial name
- ADPRE (NCT03360240)
- Where
- 8 sites in Bolivia, Colombia and 4 more
- Volunteers
- 1,050 people
- Sponsor
- Complejo Hospitalario Dr. Arnulfo Arias Madrid
Pre-Eclampsia
Detection of False Positives From First-trimester Preeclampsia Screening (StopPRE) at the Second-trimester of Pregnancy
Pregnant women at a higher risk for pre-eclampsia (PE) should be offered preventive daily treatment with acetylsalicylic acid (ASA) started before 16 weeks of gestation.
- Trial name
- StopPRE (NCT03741179)
- Testing
- ASA-withdrawn group
- Where
- Spain
- Volunteers
- 974 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pre-Eclampsia, Obesity
Weight Loss Following an Episode of Pre-eclampsia Using a Dissociated or Hypocaloric Diet in Overweight or Obese Patients
In view of the known link between pre-eclampsia, overweight/obesity and chronic kidney disease, the aim is to offer for obese and overweight patients to reduce their BMI without reducing lean body mass.
- Trial name
- POPADIPE (NCT06067906)
- Testing
- Hypocaloric diet, Dissociated diet
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier le Mans
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