Clinical trials: Pregnancy Induced Hypertension
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Preeclampsia, Coagulation Disorder
Thromboelastogram in Postdelivery Preeclamptic Patients
There are no studies evaluating the effect of aging on hemostasis of preeclamptic patients. Additionally, although there are some studies that establish normal reference values for TEG profiles in healthy term pregnant patients…
- Conditions
- Preeclampsia, Coagulation Disorder, Pregnancy Complications
- Trial name
- NCT03555630
- Testing
- Thromboelastogram
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Augusta University
Preeclampsia
microRNAs Role in Pre-eclampsia Diagnosis
Pre-eclampsia is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved.The aim of our study was to identify…
- Trial name
- NCT03562715
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Preeclampsia Postpartum
Aspirin for Postpartum Patients With Preeclampsia
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth.
- Trial name
- ASAPP (NCT05924971)
- Testing
- Aspirin 81Mg Ec Tab
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- MemorialCare Health System
Hypertension, Preeclampsia
A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia
This is an open-label, randomized feasibility trial in which patients admitted to Oregon Health \& Science University (OHSU) after a pregnancy complicated by preeclampsia who are considering a progestin-only pill contraception…
- Trial name
- NCT07293728
- Testing
- Norethindrone 0.35 MG, Drospirenone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Pregnancy Related, Pre-Eclampsia
CONNEQT Pulse Validation Study
The purpose of this study is to validate the accuracy of the CONNEQT Pulse blood pressure monitoring system for the measurement of blood pressure as compared to a gold standard, auscultatory sphygmomanometer in a pregnant…
- Conditions
- Pregnancy Related, Pre-Eclampsia, Gestational Hypertension
- Trial name
- NCT06002971
- Testing
- Blood pressure measurement
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Mount Carmel Health System
Preeclampsia
Validation of the French Translation of a Self-questionnaire Looking for a History of Pre-eclampsia.
PRERETRO is a study for validation of the French translation of a self-questionnaire looking for a history of pre-eclampsia of more than 5 years in women who have already had a pregnancy of more than 6 months with childbirth at…
- Trial name
- PRERETRO (NCT04658966)
- Testing
- administration of a self-questionnaire
- Where
- France
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Rupture of Membranes; Premature, Cesarean Section; Infection
The Effects of Labor Stages and Interventions on Hemodynamic Measures During & After Childbirth With Noninvasive Sensors
The Effects of Labor Stages and Interventions on Hemodynamic Measures During and After Childbirth ( Epidural, Rupture Membranses Cesarean Sections and Preeclampsia) With Noninvasive Sensors.
- Conditions
- Rupture of Membranes; Premature, Cesarean Section; Infection, Preeclampsia
- Trial name
- NCT03838965
- Testing
- biobeat sensor
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Preeclampsia
Hemodynamic Measurements in Women With Serious Preeclampsia
This trial is examining hemodynamic measurements in women with serious preeclampsia.
- Trial name
- NCT00199810
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- Oslo University Hospital
Pre-Eclampsia
Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in Preeclampsia
The aim of the present study is to evaluate the implication of adipokines, inflammation, insulin resistance and endothelial dysfunction in the pathogenesis of preeclampsia and in pregnancy related complications.
- Trial name
- NCT04455204
- Testing
- Serum asymmetteric dimethyl arginine, serum lipid profiles, Serum vaspin
- Volunteers
- 60 people
- Sponsor
- Tanta University
Pre-Eclampsia
Prediction of Preeclampsia by Comprehensive Markers.
Preeclampsia is one of the most serious complications in pregnancy that causes maternal death and preterm delivery. Series studies has show that the competing risk model developed by the Fetal Maternal FouNdation in early…
- Trial name
- NCT03665623
- Where
- China
- Volunteers
- 11,741 people
- Sponsor
- Peking Union Medical College Hospital
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Preeclampsia, Gut Dysbiosis
Probiotic Supplementation During Pregnancy in Women With High-Risk Pregnancies
Preeclampsia (PE) is a complication during pregnancy characterized by hypertension, organ damage, and inflammation, without an effective treatment. The underlying mechanisms causing the disease also remain partly unknown.
- Trial name
- NCT06700044
- Testing
- GutMagnific
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Skane
Preeclampsia
Treatment Approaches to Preeclampsia
This pilot study will document the efficacy and acceptability of administration of magnesium sulfate with the Springfusor pump for patients and staff at two sites where treatment or preeclampsia with magnesium sulfate is limited…
- Trial name
- NCT01030627
- Testing
- Springfusor infusion pump
- Where
- 2 sites in India
- Volunteers
- 85 people
- Sponsor
- Gynuity Health Projects
Preeclampsia, Pregnancy Complications
Climate-Safe Pregnancy Intervention for Women With Preeclclampsia
This randomized controlled trial aims to evaluate the effectiveness of a climate-related nursing intervention in improving pregnancy-specific climate change knowledge, health beliefs, and protective behaviors among pregnant women…
- Conditions
- Preeclampsia, Pregnancy Complications, Climate Change and Maternal Health
- Trial name
- NCT07564856
- Testing
- Climate-Related Nursing Intervention, Routine Antenatal Care
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Benha University
Pre-Eclampsia
Serpin C and Soluble Fms-like Tyrosine Kinase-1 Levels in Normotensive Pregnant Women May Predict the Development of Preeclampsia
Evaluation of the predictability of estimated levels of Serpin C, sFlt-1 and placental growth factor (PLGF) in blood samples obtained during the 1st trimester from normotensive pregnant women for identification of women liable to…
- Trial name
- NCT06214702
- Testing
- ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe)
Impedance Cardiographic (ICG) Assessment of Pregnant Women With Severe Hypertension to Assess Impact of Standard Therapy
The utilization of external cardiohemodynamic patient assessment, applying non-invasive stick-on contact patches to the mother's neck on either side and chest wall on either side, enables the practitioner to have information…
- Conditions
- Pregnancy; Proteinuria, With Hypertension (Severe Pre-eclampsia), Delivery; Proteinuria, With Gestational Hypertension (Pre-eclampsia, Severe), Pregnancy; Hypertension, Gestational Hypertension, With Albuminuria (Severe Pre-eclampsia)
- Trial name
- ICASH (NCT01248169)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Mississippi Medical Center
Preeclampsia
Vanadium in Late-onset Preeclampsia
Introduction: Cadmium, lead and vanadium important pollutants produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in a lot of studies.
- Trial name
- Vanadium PE (NCT04200222)
- Testing
- cadmium, lead and vanadium measurements and compare
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Pre-Eclampsia, Atherosclerosis
The CoPenHagen PREeClampsia and cardIOvascUlar diSease Study
Women with a history of preeclampsia (PE) have increased risk of hypertension and cardiovascular disease (CVD) later in life. Thus, PE is acknowledged as an independent risk factor for CVD, which is the number one cause of death…
- Conditions
- Pre-Eclampsia, Atherosclerosis, Cardiovascular Diseases, Heart Disease in Women
- Trial name
- CPH-PRECIOUS (NCT03949829)
- Testing
- Cardiovascular CT
- Where
- 3 sites in Denmark
- Volunteers
- 921 people
- Sponsor
- Klaus Fuglsang Kofoed
Preeclampsia Severe
Transorbital Ultrasound of Optic Nerve Sheath Diameter Between Healthy Pregnant Women and Those With Severe Preeclampsia.
The neurological alterations associated with preeclampsia depend on cerebral autoregulation, a theory that outlines the mechanisms by which the nervous system controls cerebral perfusion.
- Trial name
- NCT05594056
- Testing
- Transorbital ultrasound of the optic nerve sheet
- Where
- Panama
- Volunteers
- 100 people
- Sponsor
- Saint Thomas Hospital, Panama
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