Clinical trials: Pregnancy Loss
Weight Gain, Weight Loss
Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight)
The purpose of this study is to enroll approximately 450 subjects to see if a behavioral weight management program is successful in helping TRICARE beneficiaries who are pregnant or post-partum to manage their weight during and…
- Trial name
- NCT03057808
- Testing
- Gestational weight gain intervention, Postpartum weight loss intervention
- Where
- 2 sites in United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Second Trimester Abortion
Laminaria Compared to Dilapan-S for Cervical Preparation Before Dilation and Evacuation at 18-24 Weeks of Gestation
Primary objective: To study the difference in dilation and evacuation (D\&E) procedure time following overnight cervical preparation with laminaria or Dilapan-S™.
- Trial name
- NCT02033083
- Testing
- Laminaria, Dilapan-S
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Obesity; Familial, Pregnancy Related
Maternal Metabolic and Molecular Changes Induced by Preconception Weight Loss and Their Effects on Birth Outcomes
Our hypothesis is that aggressive preconception weight loss in obese women will improve the metabolic health of the mother and the intrauterine environment.
- Trial name
- NCT03244722
- Testing
- Very-low energy Diet (VLED), Standard of care (SOC)
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Abortion in First Trimester
Dextromethorphan as a Novel Non-opioid Adjunctive Agent for Pain Control in Medication Abortion
This study evaluates dextromethorphan as a non-opioid adjunctive medication for pain control during medication abortion. This is double-blinded, four-arm randomized controlled trial enrolling 156 women over a period of 9-12…
- Trial name
- DexMab (NCT03480009)
- Testing
- Dextromethorphan Hydrobromide, Avicel PH101 (Microcrystalline Cellulose NF) for Compounding, Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Study Investigator-Sponsor
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Medical; Abortion, Fetus
Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion
Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester abortion.
- Trial name
- NCT02694198
- Testing
- fetal fibronectin measurement
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Contraception
RCT: Can a Single Counseling Phone Call Improve Contraception After an Abortion?
Hypothesis: Use of an effective contraceptive six weeks after abortion will be higher in the treatment group than in the control group.
- Trial name
- PPR (NCT01199952)
- Testing
- Treatment group: receives counseling phone call intervention
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion
Intrafetal Digoxin as an Adjuvant for Dilation and Evacuation at 20 to 24 Weeks' Gestation
This is a research study to measure the effect of digoxin injection on Dilation and Evacuation (D\&E) procedure duration. Digoxin is the most commonly used feticidal agent among family planning subspecialists, and is commonly…
- Trial name
- NCT03136068
- Testing
- Digoxin
- Where
- 3 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Post Abortion Care
Contraceptive Counseling Following an Abortion
The purpose of this study is to determine whether contraceptive counseling is effective on acceptance and use of methods in women following an abortion.
- Trial name
- APA (NCT00756314)
- Testing
- Personalized contraceptive counseling
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Leiomyoma, Laparoscopy
Combined Vaginal Misoprostol and Perivascular Vasopressin
Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal.
- Conditions
- Leiomyoma, Laparoscopy, Uterine Myomectomy
- Trial name
- NCT03815344
- Testing
- Standard, Standard-vaginal misoprostol
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Hemorrhage
Uterotonic Prophylaxis Trial
Excessive bleeding after dilation and evacuation (D\&E) requiring interventions is common, occurring in approximately 30% of cases at one large abortion-providing clinic.
- Trial name
- UPT (NCT02408965)
- Testing
- Methergine
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy; Habitual Aborter, Weeks of Gestation 37 or More
Accuracy and Reliability of Fetal Heart Rate and Uterine Contraction Monitoring Method
Clinical Investigation Protocol for a study designed to determine the equivalence of the Monica AN24 monitor to Philips 50XM for fetal heart rate (FHR) and uterine contraction (UC) monitoring during labor.
- Trial name
- NCT01280357
- Testing
- Monica AN24 (K101081), Philips 50XM
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Monica Healthcare Ltd
Surgical Abortion, Patient Satisfaction
Effects of Aromatherapy on Patient Satisfaction With Surgical Abortion at Less Than 10 Weeks Gestation
The investigators propose a single-site, double-blinded, placebo-controlled clinical trial of lavender aromatherapy versus placebo for patient satisfaction in adult women having a surgical abortion before 10 weeks and 0 days…
- Conditions
- Surgical Abortion, Patient Satisfaction, Anesthesia, Pain
- Trial name
- NCT04969900
- Testing
- Lavender oil.
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postpartum Weight Retention
A Personalized Telehealth Intervention for Health and Weight Loss in Postpartum Women
The purpose of this study is to help women lose the weight they gained during their pregnancy using a SmartPhone app the investigators have developed called E-Moms.
- Trial name
- E-Moms (NCT01751230)
- Testing
- WIC E-Moms
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Induced Abortion
Study of the Sensitivity of Manual vs Electric Aspiration to Detect Completed Early Abortion
With sensitive urine pregnancy tests, women are now able to confirm very early pregnancies. However, approximately one third of abortion facilities do not offer abortions at less than six weeks of pregnancy.
- Trial name
- NCT01085825
- Testing
- D & C abortion
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Pain Control
Gabapentin for Perioperative Pain Relief in Surgical Abortion
Gabapentin preoperative use for evaluation of benefit to reduce pain during and after surgical office-based abortion.
- Trial name
- NCT04292171
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Postpartum Hemorrhage
Accuracy of Blood Loss Estimation After Vaginal Delivery
Post-partum hemorrhage (PPH) is defined as blood loss greater than 500 mL after vaginal delivery. Delayed diagnosis of PPH is a major cause of maternal morbidity and mortality.
- Trial name
- NCT00462839
- Testing
- blood loss estimation
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Abortion Early
Transabdominal and Transvaginal Sonography in Medical Abortion
The investigator will perform a multicenter, randomized controlled trial in practices that routinely use transvaginal sonography (TVS) to compare how often clinicians order additional testing prior to medical abortion after the…
- Trial name
- TASvTVS (NCT03047551)
- Testing
- Transabdominal sonography, Transvaginal sonography
- Where
- 2 sites in United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Columbia University
Nausea, Pain
Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days
Randomized trial which will aim to evaluate whether prophylactic use of ondansetron and ibuprofen will decrease side effects associated with medical abortion and increase patient satisfaction.
- Trial name
- NCT05819619
- Testing
- Prophylactic use of ibuprofen and ondansetron post misoprostol administration, Use of ibuprofen and ondansetron at symptom onset post misoprostol administration
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Abortion Early
Auriculotherapy During Medication Abortion
This randomized trial will evaluate the effect of adding auriculotherapy (i.e. acupuncture applied to the ear) using either gold beads or Pyonex needles in addition to usual care for the relief of pain and anxiety during…
- Trial name
- NCT03900728
- Testing
- Auriculotherapy with needles, Auriculotherapy with beads
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Columbia University