Clinical trials: Pregnancy Prevention
Prevention of Post Partum Haemorrhage
A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section
This is a randomized trial comparing oxytocin versus oxytocin + syntometrine in the prevention of post partum haemorrhage in patients undergoing caesarean section
- Trial name
- NCT02046499
- Testing
- Oxytocin, Oxytocin ergometrine
- Where
- South Africa
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- University of Pretoria
Prevention of Iron Deficiency
Efficacy of Probiotics on Iron Status During Pregnancy
Determine the effect of probiotics on improving iron status in a population of healthy, pregnant women.
- Trial name
- NCT02912416
- Testing
- Probiotics
- Where
- Sweden
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Probi AB
Premature Birth
Fish Oil Supplementation to Pregnant Women in China
This randomized controlled trial with fish oil supplementation to pregnant women conducted in areas of China, which are generally low in fish intake and low income, aims at answering the following primary questions: Is a dose of…
- Trial name
- FOPCHIN (NCT02770456)
- Testing
- High dose fish oil, Low dose fish oil, Olive oil
- Volunteers
- 5,531 people, healthy volunteers welcome
- Sponsor
- Centre for Fetal Programming, Denmark
Pregnancy Prevention
Using Social Media to Enhance the Impact of the Teen Outreach Program
The investigators are exploring the use of short message service (text) messaging by cell phones to enhance the effects of the Teen Outreach Program, an effective teen pregnancy prevention program.
- Trial name
- TOP4ME (NCT01535651)
- Testing
- Teen Outreach Program with Media Enhancement (TOP4ME)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- Colorado School of Public Health
Hematopoietic Stem Cell Transplantation, Premature Ovarian Failure
A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT
HSCT is an effective method to cure hematologic malignancies. However, the reproductive system is prone to be damaged during radiotherapy and chemotherapy before transplantation, leading to ovarian failure, followed by…
- Trial name
- NCT05667428
- Testing
- leuprorelin, normal saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Pyelonephritis
Antibiotic Prophylaxis in Children With Pyelonephritis
Children who present with pyelonephritis undergo many investigations, and long term care to prevent renal damage. The focus is primarily on preventing renal failure however along the way and particularly with children, other…
- Trial name
- NCT00752375
- Testing
- Trimethoprim Sulfamethoxazole
- Where
- Canada
- Sponsor
- University of Alberta
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Urinary Tract Infections
Fecal Microbiota Transplantation (FMT) for MDRO UTI
The purpose of this study is to determine the safety and impact of fecal microbiota transplantation (FMT) on the fecal and urine microbiome, urine metabolome, risk of recurrent urinary tract infection (UTI), and persistent…
- Trial name
- NCT03367910
- Testing
- Fecal microbiota transplant
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Preterm Birth
Oral Progesterone for Prevention of Preterm Birth
To evaluate whether daily oral micronized progesterone is effective in preventing recurrent spontaneous preterm birth (RSPB) and whether micronized progesterone use increases maternal serum progesterone levels.
- Trial name
- NCT01180296
- Testing
- oral micronized progesterone
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Fetal Medicine Foundation
Coronary Artery Disease, Nephropathy; Toxic, Drugs
Ameliorating Contrast Induced Nephropathy After Coronary Angiography
Given the limited understanding of the impact of statin and N-acetyl cysteine use before angiography in preventing contrast-induced nephropathy (CIN), the objective of this study is to evaluate the effectiveness of atorvastatin…
- Trial name
- NCT06139952
- Testing
- Atorvastatin 80mg, N-acetyl cysteine, Normal Saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Postpartum Hemorrhage, Tranexamic Acid
Tranexamic Acid in the Prevention of Postpartum Hemorrhage in Elective Caesarean Section
In obstetrics, postpartum haemorrhage (PPH) continues to be a major contributor to maternal morbidity and mortality worldwide. Uterine atony is the most common cause of PPH, and the prophylactic use of uterotonics, specifically…
- Trial name
- NCT04427618
- Testing
- Tranexamic acid, Normal saline
- Where
- Singapore
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Cascade Testing, Lynch Syndrome
Initial Testing of a Behavioral Intervention About Genetic Services for Families at Risk of Lynch Syndrome
The purpose of the study is to see if our education materials help people at risk for Lynch syndrome decide about seeking genetic services.
- Conditions
- Cascade Testing, Lynch Syndrome, Decision Making, Colorectal Cancer
- Trial name
- NCT07106359
- Testing
- Information Letter and Booklet, Information Letter
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Breast Carcinoma, Cervical Carcinoma
CATCH-UP Intervention in Increasing Cancer Screening and Prevention Care in Uninsured Patients at Community Health Centers
This randomized research trial studies the Community-based Health Information Technology (HIT) Tools for Cancer Screening and Health Insurance Promotion (CATCH-UP) intervention in increasing cancer screening and prevention care…
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma, Health Status Unknown
- Trial name
- NCT02355262
- Testing
- Informational Intervention
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Human Papilloma Virus, Cervical Intraepithelial Neoplasia
HPV-based Screening Among Women 23-29 Years of Age
The aim of the trial is to determine whether organized screening with primary HPV analysis provide higher cancer protection in the age group 23-29 years compared to primary cytology.
- Conditions
- Human Papilloma Virus, Cervical Intraepithelial Neoplasia, Cervical Cancer
- Trial name
- NCT05229679
- Testing
- HPV testing
- Where
- 2 sites in Sweden
- Volunteers
- 180,000 people
- Sponsor
- Karolinska Institutet
Gestational Diabetes, Pregnancy Complications
Lifestyle Interventions to Improve Glycemic Parameters and Reduce Gestational Diabetes in High-risk Pregnant Individuals
The goal of this study is assess the impact of a higher intensity dietary and activity counseling program to improve blood sugar control and reduce the chance of developing gestational diabetes (GDM) as compared to the current…
- Trial name
- NCT06445270
- Testing
- GDM Prevention Program
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Post Partum Hemorrhage
Carbetocin in the Prevention of Primary Postpartum Haemorrhage
Postpartum haemorrhage (PPH) ranks as the first cause of maternal mortality in developing countries and it is the cause of 25% of maternal deaths worldwide.
- Trial name
- NCT06159959
- Testing
- Carbetocin
- Where
- Egypt
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Ministry of Health and Population, Egypt
Preterm Birth, Short Cervix
Pessary Versus Progesterone in Singletons
This study compares the effectiveness of cervical pessary to vaginal progesterone for prevention of preterm birth in women with singleton pregnancies and a cervix ≤25 mm.
- Trial name
- NCT04300322
- Testing
- Cervical pessary, Vaginal Progesterone
- Where
- 3 sites in Vietnam
- Volunteers
- 804 people
- Sponsor
- Mỹ Đức Hospital
Rhesus Negative Pregnant Women
Routine Fetal RhD Genotyping for RhD- Pregnant Women
The study is divided in two sub-studies. The first one is an economical and performance comparison between two antenatal management strategies of RhD negative pregnant women: the first one will comprise non invasive RhD fetal…
- Trial name
- GENIFERH (NCT00832962)
- Testing
- Genotyping, Usual prophylaxis
- Where
- France
- Volunteers
- 2,532 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Transplantation
REgulatory T Cell Therapy to Achieve Immunosuppression REduction
The goal of this multi-national, multi-center, open-label, randomized Phase 2 trial is to determine the safety and efficacy of administering expanded regulatory T cells (TRK-001) to prevent allograft rejection in living donor…
- Trial name
- RETIRE (NCT06552169)
- Testing
- Arm 1: SOC (mTOR + CNI), Arm 2A: TRACT/MONO mTOR, Arm 2B: TRACT/MONO CNI
- Where
- 7 sites in United States, Taiwan
- Volunteers
- 34 people
- Sponsor
- Singulera Therapeutics Inc.
Gestational Diabetes
Effect of Fibre Supplements on Gestational Diabetes
The primary aim of this study is to evaluate the effect of a soluble fibre supplement in the development of gestational diabetes in women at high-risk.
- Trial name
- GG-GDM (NCT03547960)
- Testing
- Guar gum, Cellulose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London