Clinical trials: Pregnancy Related Complications
Diabetes Mellitus, Type 2, Kidney Diseases
Effect of Weekly High-dose Vitamin D3 Supplementation on the Association Between Circulatory FGF-23 and A1c Levels
Among Jordanians, there is a high prevalence of T2DM. VDD has also spread rapidly in the past decade. Preliminary results of recent studies have shown that VD3 has a potential role in reducing FBG.
- Trial name
- NCT04682626
- Testing
- Soft gelatin capsules each contains 50 000 IU VD3 (cholecalciferol) equivalents to 1.25 mg.
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
HPV-Related Squamous Cell Carcinoma, HPV-Related Cervical Squamous Cell Carcinoma
Phase 1/2 Study of Autologous SCG142 TCR T Cells in Patients With HPV16/52-positive Carcinoma
This is a phase 1/2, open-label, single arm, multicenter study in patients with advanced or metastatic HPV16- or HPV52-positive carcinomas who have progressed after at least one line of systemic therapy, including but not limited…
- Conditions
- HPV-Related Squamous Cell Carcinoma, HPV-Related Cervical Squamous Cell Carcinoma, HPV-Related Vulvar Squamous Cell Carcinoma, HPV-Related Penile Squamous Cell Carcinoma
- Trial name
- NCT06505551
- Testing
- SCG142, Cyclophosphamide, Fludarabine
- Volunteers
- 66 people
- Sponsor
- SCG Cell Therapy Pte. Ltd.
Post-traumatic Stress Disorder, Miscarriage
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
This is a randomised controlled trial designed to investigate the impact of a brief-cognitive task based intervention on intrusive memories, mental health symptoms and daily functioning, in women following an early pregnancy loss.
- Conditions
- Post-traumatic Stress Disorder, Miscarriage, Ectopic Pregnancy, Pregnancy Loss
- Trial name
- IMPREL (NCT05039853)
- Testing
- Brief cognitive task-based intervention
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Premature Birth
Fathers and Late Preterm Babies Study
The purpose of this study is to test an educational intervention for first-time fathers of late preterm (34 to 36 weeks gestation) infants.
- Trial name
- FLPTB (NCT01056653)
- Testing
- Standard Dose, High Dose, Comparison Group
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- University of Calgary
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of Drug BAY1817080 at Different Doses and the Way the Body Absorbs and Eliminates the Drug in Japanese Healthy Adult Male Participants
Researchers in this study want to learn about the safety of drug BAY1817080 at different doses and the resulting blood levels of the study drug in Japanese healthy adult male participants.
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04265781
- Testing
- BAY1817080
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bayer
Urinary Incontinence,Stress, Urinary Incontinence, Urge
Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults
The aim of our study is to provide a holistic analysis of the geriatric syndromes associated with urinary incontinence, which can result in significant adverse outcomes in the elderly, and to explore the gender-specific…
- Conditions
- Urinary Incontinence,Stress, Urinary Incontinence, Urge, Depressive Disorder, Insomnia
- Trial name
- NCT06627400
- Where
- Turkey (Türkiye)
- Volunteers
- 635 people
- Sponsor
- Kastamonu University
Acute Kidney Injury, Anemia
Urinary NGAL Acute Kidney Injury After Stored Red Blood Cells Transfusion in Critically Ill Patients.
The study aims to explore the association of the novel urinary bio marker NGAL with the age of PRBCs(packed red blood cells) transfusion in critically ill patients.
- Trial name
- NCT03560921
- Testing
- urinary NGAL
- Where
- Egypt
- Volunteers
- 147 people
- Sponsor
- Kasr El Aini Hospital
Brain Tumor, Central Nervous System Tumor
Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy
RATIONALE: Sodium thiosulfate may reduce or prevent hearing loss in young patients receiving cisplatin for cancer. It is not yet known whether sodium thiosulfate is more effective than no additional treatment in preventing…
- Conditions
- Brain Tumor, Central Nervous System Tumor, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
- Trial name
- NCT00716976
- Testing
- sodium thiosulfate, examination
- Where
- 76 sites in United States, Australia and 1 more
- Volunteers
- 131 people
- Sponsor
- Children's Oncology Group
Ovarian Cancer, Clinical Marker
The Clinical Markers for PARP Inhibitors-related Efficacy in Ovarian Cancer
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy. PARP inhibitors(PARPi) are an important progress in EOC treatment.
- Conditions
- Ovarian Cancer, Clinical Marker, PARP Inhibitor
- Trial name
- ROMP (NCT04582552)
- Testing
- PARP inhibitors
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaoxiang Chen
Menopausal Complaints, Vaginal Atrophy
Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV
This is a research study about the effects of vaginal estradiol compared to moisturizer on vaginal symptoms of menopause and the microbiome in women with HIV.
- Conditions
- Menopausal Complaints, Vaginal Atrophy, Genitourinary Symptoms, HIV (Human Immunodeficiency Virus)
- Trial name
- NCT07526948
- Testing
- Vaginal estradiol tablets, Vaginal moisturizer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Ovarian Reserve, Endometrioma
Endometrioma Per se Versus Treatment Related Reduction in Ovarian Reserve (ERROR-2 Trial)
The present multi-center study aimed to evaluate whether endometrioma-associated decline in ovarian reserve is progressive in the absence of an intervention and is greater in magnitude than the natural decline over time.
- Trial name
- ERROR2 (NCT03620838)
- Testing
- oral contraceptive pill, oral progesterone
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Uludag University
End Stage Renal Disease, Inflammation
A Study Evaluating the Association of Inflammation With Hemodialysis Access Type
To determine if the type of hemodialysis vascular access correlates with markers of inflammation, namely C-reactive protein and interleukin-6, and with both access and patient survival in the end stage renal disease population.
- Trial name
- NCT01011985
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Montefiore Medical Center
Sepsis-Related Mortality, Acute Kidney Injury
Predictive Value of the Uric Acid/Albumin Ratio and Lactate in Sepsis Patients
Sepsis is a life-threatening condition characterized by organ dysfunction resulting from a dysregulated host response to infection and remains a leading cause of morbidity and mortality in intensive care units.
- Trial name
- NCT07332715
- Testing
- Non-interventional / Observational Study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University
Diastasis Recti, Sacroiliac Joint Somatic Dysfunction
Diastasis Recti Abdominis Association With Sacroiliac Joint and Pelvic Floor Dysfunction in Postpartum C-section Women
Purpose: The purpose of the proposed study is to examine the ability of diastasis recti abdominis to predict outcomes of Sacroiliac joint dysfunction and pelvic floor dysfunction.
- Conditions
- Diastasis Recti, Sacroiliac Joint Somatic Dysfunction, Pelvic Floor Disorders
- Trial name
- NCT04519840
- Testing
- nill
- Where
- United Arab Emirates
- Volunteers
- 32 people
- Sponsor
- Dubai Health Authority
Fetal Alcohol Syndrome (FAS), Fetal Alcohol Spectrum Disorders
Preventing FAS/ARND in Russian Children
The purpose of this study is to evaluate an intervention aimed at reducing risk for alcohol-exposed pregnancies and preventing Fetal Alcohol Spectrum Disorders in Russian children.
- Conditions
- Fetal Alcohol Syndrome (FAS), Fetal Alcohol Spectrum Disorders, Alcohol Abuse in Pregnancy
- Trial name
- NCT01961050
- Testing
- Dual-Focused Brief Physician Intervention (DFBPI), Services as usual
- Where
- 2 sites in Russia
- Volunteers
- 767 people
- Sponsor
- University of Oklahoma
Gestational Diabetes, Prediabetes; Complicating Pregnancy
Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring
Gestational diabetes is one of the most common medical disorders in pregnancy and is a major risk factor for the postpartum development of dysglycemia.
- Conditions
- Gestational Diabetes, Prediabetes; Complicating Pregnancy, Type 2 Diabetes, Pregnancy Related
- Trial name
- PREDISPOSE (NCT04972955)
- Testing
- Freestyle Libre 2
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Manitoba
Fetal Alcohol Spectrum Disorders
Dose Escalation Study of Vinpocetine in Healthy Volunteers
The objective of this study is to determine whether vinpocetine is safe when taken at higher doses.
- Trial name
- NCT06635746
- Testing
- Vinpocetine
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Large Volume Resuscitation, Acute Kidney Injury
Resuscitation Fluid Choice and Clinical Outcomes
This observational study evaluates the potential benefits, costs and clinical outcomes of albumin over saline and other non-saline fluids in patients receiving large volume resuscitation.
- Conditions
- Large Volume Resuscitation, Acute Kidney Injury, Hyperchloremic Metabolic Acidosis
- Trial name
- NCT02641119
- Volunteers
- 65,800 people
- Sponsor
- University of Pittsburgh
Metabolic Syndrome, Cardiovascular Diseases
CKM Syndrome Prevalence and Its Association With SCORE-2 and BRI
This cross-sectional study aims to determine the prevalence of Cardiovascular-Kidney-Metabolic (CKM) syndrome in a community-based adult population in Gaziantep, Türkiye.
- Conditions
- Metabolic Syndrome, Cardiovascular Diseases, Chronic Kidney Disease(CKD)
- Trial name
- CKM-PREV (NCT06944236)
- Testing
- No intervention is applied. This is a non-interventional, observational study. Anthropometric measurements and existing laboratory data are used for CKM staging and risk assessment.
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- University of Gaziantep
Acute Kidney Injury, Adverse Drug Reaction
The Drug Induced Renal Injury Consortium
Some medications are known to cause kidney damage because the person is allergic to the medication while others cause direct damage to the kidney because they are toxic at certain concentrations.
- Conditions
- Acute Kidney Injury, Adverse Drug Reaction, Acute Kidney Failure, Kidney Failure
- Trial name
- DIRECT (NCT02159209)
- Where
- 18 sites in United States, Bolivia and 4 more
- Volunteers
- 634 people
- Sponsor
- Ravindra Mehta
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