Clinical trials: Pregnancy Related Complications
Preterm Birth, Bronchopulmonary Dysplasia
Improving Prematurity-Related Respiratory Outcomes at Vanderbilt
The goal of IMPROV is to identify molecular mechanisms that contribute to lung injury and long-term breathing problems in preterm infants by investigating two interrelated biochemical pathways: the urea cycle-nitric oxide pathway…
- Conditions
- Preterm Birth, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- IMPROV (NCT01460576)
- Where
- 2 sites in United States
- Volunteers
- 253 people
- Sponsor
- Vanderbilt University Medical Center
Turner Syndrome, Aortic Aneurysm
Prospective Characterization of the Heart, Aorta and Blood Pressure in Turner Syndrome. Association With Aortic Dissection.
Turner syndrome is a congenital complete or partial lack one of the female sex chromosomes affecting 1 of 2000 live born girls. The syndrome is characterized by an increased prevalence of ischemic heart disease, aortic dilation…
- Conditions
- Turner Syndrome, Aortic Aneurysm, Ischemic Heart Disease, Hypertension
- Trial name
- TSCORII (NCT01678274)
- Where
- Denmark
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pelvic Floor Disorders
Educational Intervention Related to Pelvic Floor Care in Females in Sport: ACTITUD
Pelvic floor dysfunctions (PFD) are especially prevalent among females who practice and compete in sport. One of the main reason is the great physical effort required to achieve the maximal sports performance.
- Trial name
- ACTITUD (NCT06355297)
- Testing
- Education about pelvic floor
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
Pregnancy Related, Weight Gain, Maternal
Healthier At-home Meals for Expectant Mothers
This study is being done to test the feasibility, acceptability, and preliminary efficacy of a meal delivery intervention for managing gestational weight gain among pregnant women with overweight or obesity.
- Trial name
- Her HOME (NCT05605340)
- Testing
- Meal Delivery
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Alabama at Birmingham
Cervical Cancer
Carboplatin and Topotecan in Treating Patients With Relapsed or Metastatic Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin and topotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00807079
- Testing
- carboplatin, topotecan hydrochloride
- Where
- France
- Volunteers
- 12 people
- Sponsor
- ARCAGY/ GINECO GROUP
Human Papillomavirus Associated Carcinomas, Cervical Cancer
SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas
A multicenter, open, single arm dose escalation and dose expansion phase I study to evaluate the safety, tolerability, and efficacy of SCG142 TCR-T cells in Subjects with advanced HPV associated carcinomas.
- Conditions
- Human Papillomavirus Associated Carcinomas, Cervical Cancer, Head and Neck Cancers, Anal Cancer
- Trial name
- NCT06544720
- Testing
- SCG142 TCR-T cells
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Autoimmune Thyroiditis, Recurrent Miscarriage
Thyroid Hormone Values and Anti-thyroid Peroxidase Antibody Positivity in Recurrent Pregnancy Loss
The aim of this study is to compare the thyroid hormone values and anti-thyroid peroxidase (anti-TPO) levels of women with a diagnosis of recurrent pregnancy loss (RPL) and healthy pregnancies.
- Trial name
- NCT05680376
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Zonguldak Bulent Ecevit University
End-stage Renal Disease (ESRD), Kidney Transplantation
Microbiota Changes Related to Outcomes in Kidney Transplantation
Chronic kidney disease affects approximately 10% of the world population. End-stage renal disease (ESRD) is associated with immune dysregulation, chronic inflammation, and alteration of the gut and urinary microbiota.
- Trial name
- MICRO-KT (NCT07893691)
- Testing
- Fecal samples, Urinary sample, Blood samples
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Infertility, Female
Testing a New Self-help Intervention for Infertility Related Distress: a Pilot Study
This pilot study will test the effect of a 6-week self-help program in improving fertility-related quality of life as well as anxious and depressive symptoms, in women with infertility.
- Trial name
- NCT05103982
- Testing
- Coping with Infertility Program
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Regina
Post Partum Depression
Early Intervention to Protect the Mother-Child Relationship After Postpartum Depression
Postpartum depression (PPD) may impair the mother-infant relationship and lead to both short and long-term suboptimal development of the baby.
- Trial name
- HUGS (NCT05209789)
- Testing
- HUGS, Playtime
- Where
- 7 sites in France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Toulouse
Pelvic Organ Prolapse, Uterovaginal Prolapse
Absorbable Suture vs Permanent Suture in Sacrospinous Ligament Suspension
Sacrospinous ligament suspension (SSLS) was first described in 1958. It is commonly performed for correction of apical prolapse. A combination of delayed absorbable and/or permanent sutures are commonly used for the procedure.
- Conditions
- Pelvic Organ Prolapse, Uterovaginal Prolapse, Vaginal Vault Prolapse, Cystocele
- Trial name
- NCT05688059
- Testing
- Absorbable Suture and Permanent Suture
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Atlantic Health System
Anemia, Iron Deficiency, Uterine Bleeding
IV Iron Trial for Anemia Related to Uterine Bleeding in Female Patients Presenting to the Emergency Department
The primary aim of this randomized trial is to assess the efficacy of IV Ferric Derisomaltose vs Oral Iron in the management of women with severe Iron Deficiency Anemia due to Uterine Bleeding in the emergency department.
- Trial name
- NCT05304442
- Testing
- Ferric Derisomaltose 1000 Mg in 10 mL INTRAVENOUS SOLUTION [Monoferric], Ferrous Sulfate 65 mg elemental iron (325 mg tablets)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Pregnancy Related, Tuberculosis Infection
Effects of Tuberculosis Infection on Development and Function of the Placenta
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on…
- Conditions
- Pregnancy Related, Tuberculosis Infection, Placenta Diseases
- Trial name
- NCT06352970
- Testing
- TB infection
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Lund University
Fetal Alcohol Syndrome
In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions
This study aims to validate that PLGF is a biomarker of cerebral lesions and therefore of secondary developmental disorders and disabilities that will be best diagnosed at 2 and 6 years of age.
- Trial name
- ALCOBRAIN (NCT03371641)
- Testing
- ASQ parental questionnaire, Development scales, Scale of Conners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Sickle Cell Anemia (HbSS, or HbSβ-thalassemia0), Albuminuria
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
Sickle cell anemia (SCA) is an inherited red blood disorder. The kidneys are among the most commonly affected organ systems in SCA.
- Trial name
- EMPA-CKD (NCT07175051)
- Testing
- Empagliflozin (oral)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Illinois Chicago
Gynaecological Disease, Vitamin D Deficiency
Association Between Vitamin D and the Development of Uterine Fibroids
the aim of this randomised clinical trial study is to evaluate whether supplementation with vitamin D could inhibit the growth of uterine fibroids in reproductive stage women.
- Trial name
- NCT03584529
- Testing
- Vitamin D 3
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Renal Cell Carcinoma
Outcome-related Factors in Patients With Metastatic Renal Cell Carcinoma Treated With Everolimus (ORCHIDEE)
Evaluation of unfavourable outcome-related factors in patients affected by renal cell cancer in treatment with everolimus and previously treated with a Vascular endothelial growth factor (VEGF) inhibitor (i.e.
- Trial name
- ORCHIDEE (NCT02338570)
- Testing
- Everolimus
- Where
- 8 sites in Italy
- Volunteers
- 31 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Autosomal Dominant Polycystic Kidney Disease
NOX4 and Related Biomarkers in ADPKD
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT04630613
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Respiratory Control in Premature Infants
Prematurity-Related Ventilatory Control
The purpose of this research study is to improve our understanding of unstable breathing and heart blood flow patterns seen in premature infants.
- Trial name
- PreVent (NCT03464396)
- Testing
- Bedside Physiology study, Carotid Body Function Test, Room Air Challenge
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Washington University School of Medicine
Postpartum Depression
Postpartum Depression and Cesarean Section
The purpose of this retrospective study is to determine if there is an increase in postpartum depression (PPD) among women who undergo an emergency cesarean section as opposed to a planned cesarean section.
- Trial name
- NCT00370903
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
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