Clinical trials: Pregnancy Termination
Abortion
Side Effects and Adherence Associated With Doxycycline Use Following Medical Abortion
The effectiveness of antibiotic treatment at reducing post-abortion infection is unclear. The experiences of women prescribed routine antibiotics after medical abortion is missing from the existing evidence.
- Trial name
- NCT01799252
- Where
- 7 sites in United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Preterm Labour, Cervical Insufficiency
Intramuscular vs Rectal Progesterone in Preventing Preterm Labour After Cervical Cerclage
Preterm labour is a major cause of neonatal morbidity and mortality worldwide. Progesterone supplementation is known to help reduce the risk of preterm birth in high-risk women.
- Conditions
- Preterm Labour, Cervical Insufficiency, Pregnancy, High-Risk
- Trial name
- PROCER (NCT07307092)
- Testing
- Intramuscular Progesterone, Rectal Progesterone
- Where
- Pakistan
- Volunteers
- 820 people
- Sponsor
- Hina Mukhtar
Surgical Abortion
Cervical Preparation of Abortions Under Paracervical Block in the First Trimester:
Surgical abortion is one of the most frequently surgery of women in the world. 43 millions are annually performed in the world. 90% of the abortions are performed during the first trimester of pregnancy before 13 weeks.
- Trial name
- BPCEN (NCT03043014)
- Testing
- Mifépristone versus Misoprostol
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Early Pregnancy Loss, Spontaneous Miscarriage
Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients
Early pregnancy loss (or spontaneous miscarriage) is the loss of a pregnancy before 14 weeks of amenorrhea. Its incidence is estimated at between 10 and 15%, and increases with maternal age.
- Trial name
- MISC-TRAIN (NCT06647849)
- Testing
- centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department
- Where
- 28 sites in France
- Volunteers
- 607 people
- Sponsor
- University Hospital, Angers
Abortion Early, Pregnancy Related
Improving Access to Abortion in the Republic of Georgia
In the Republic of Georgia, the medical abortion regimen involves three in-person visits. This study aims to pilot and evaluate a simplified medical abortion service delivery model that will reduce the number of in-person visits…
- Trial name
- NCT04458558
- Testing
- Mifepristone
- Where
- 3 sites in Georgia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Center for Information and Counseling on Reproductive Health - Tanadgoma
Etiology, Cohort Study
A Cohort Study for Occupational Stress Induced Early Embryonic Death
Occupation stress can be the risk factors of early embryonic death
- Conditions
- Etiology, Cohort Study, Early Embryonic Death, Occupational Stress
- Trial name
- NCT02115438
- Volunteers
- 3,405 people
- Sponsor
- Peking University Third Hospital
Down Syndrome
Non Invasive Prenatal Testing of Down Syndrome
This is a randomized controlled trial in women at risk following combined prenatal screening for Down Syndrome. Women will be asked about their preferences between NIPT and routine prenatal diagnosis based on a dedicated…
- Trial name
- SAFE 21 (NCT02127515)
- Testing
- Non Invasive Prenatal Testing, Invasive Prenatal Testing
- Where
- France
- Volunteers
- 2,111 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Missed Abortion
Repeated Doses of Misoprostol for Medical Treatment of Missed Miscarriage
Missed abortion is a condition where the fetus has perished but the miscarriage is not expelled. Women often present at a routine ultrasound or with a slight brownish discharge.
- Trial name
- NCT01615224
- Testing
- misoprostol
- Where
- Sweden
- Volunteers
- 23 people
- Sponsor
- Kristina Gemzell Danielsson
First Trimester Abortion
A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions
This study, a double blinded randomized controlled trial, is being done to compare side effects of commonly used antibiotic regimens prior to same day abortion procedures.
- Trial name
- NCT02756403
- Testing
- Azithromycin, Doxycycline, Metronidazole
- Where
- 2 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Pregnancy, COVID-19
SARS-COV-2 VARIANTS' EFFECT ON PREGNANCY AND LONG-TERM OUTCOMES AMONG PREGNANT WOMEN AND THEIR NEWBORNS IN ESTONIA
The main aim of the study is to describe the possible impacts of SARS-CoV-2 and its various genotypes on pregnancy and long-term outcomes among pregnant women and their newborns in Estonia.
- Conditions
- Pregnancy, COVID-19, Post-COVID / Long-COVID, Newborn Health
- Trial name
- NCT06806696
- Testing
- COVID-19 infection
- Where
- Estonia
- Volunteers
- 60,739 people
- Sponsor
- University of Tartu
Miscarriage Threatening
Comparison of Dydrogesterone and Micronized Progesterone Treatments in the Treatment of Threatened Miscarriage.
In this study, we aimed to compare the effects of two drugs used for the threated miscarriage on the miscarriage rate.
- Trial name
- NCT05542797
- Testing
- Duphastone
- Volunteers
- 140 people
- Sponsor
- Konya Meram State Hospital
Abortion in Second Trimester
Outpatient Service for Mid-trimester Termination of Pregnancy
This study seeks to evaluate the safety, acceptability and feasibility of an outpatient "day procedure" for medical abortion at 13-18 weeks gestation.
- Trial name
- NCT03346629
- Testing
- Mifepristone + Misoprostol
- Where
- 3 sites in Nepal
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Reproductive Health
Improving Person Centered Care for Abortion Clients in India
The purpose of this study is to understand the effect of providing pharmacists in UP, India with additional information about medication abortion.
- Trial name
- SPARQ_ACI (NCT04307641)
- Testing
- 2 Page Information Sheet
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oral Health, Miscarriage
Is There an Interaction Between Recurrent Miscarriage and Dental Health
Oral infections can trigger the production of pro-inflammatory mediators that may be risk factors for miscarriage. The investigators investigated whether oral health care patterns that may promote or alleviate oral inflammation…
- Trial name
- NCT03577314
- Testing
- miscarriage
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Preterm Birth Complication, Preterm Birth
Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities
The goal of this clinical trial is to learn if a personalized prenatal support program [(Personalized Toolkit Building a Comprehensive Approach to Resource optimization and Empowerment in Pregnancy \& Beyond, (PTBCARE+)] works to…
- Conditions
- Preterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, Preeclampsia
- Trial name
- PTBCARE+ (NCT06915428)
- Testing
- Care coordination, Electronic massage, support gift #1
- Where
- United States
- Volunteers
- 1,228 people
- Sponsor
- University of North Carolina, Chapel Hill
Undesired Pregnancy
Comparing the Effectiveness of Oral Versus Intravenous Pain Medicine for Suction Curettage (D&C)
The main objective of this study is to determine the equivalency of oral conscious sedation and intravenous conscious sedation for first trimester surgical abortion.
- Trial name
- NCT00337792
- Testing
- oxycodone + lorazepam versus fentanyl + midazolam
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Contraception
Immediate Versus Delayed Initiation of Intrauterine System
Contraception for teenagers and young adults presents a huge challenge for the clinician as more than half of all unintended pregnancies occur as a result of inconsistent or discontinued use of contraceptives .
- Trial name
- JANESS (NCT03708809)
- Testing
- Intrauterine system, Alternative contraception to intrauterine system
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Blood Loss
Blood Loss at the Time of First Trimester Surgical Abortion in Anticoagulated Women
The primary objective of this study is to compare blood loss resulting from surgical termination of pregnancy up to 12 weeks gestation between women who are anticoagulated to therapeutic levels and those who are not…
- Trial name
- NCT00614432
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Pain, Anxiety
The Use of Music for Pain and Anxiety Control During Abortion
Most first trimester abortions are performed under local anesthesia using either manual or electric vacuum suction aspiration. The majority of women undergoing these procedures experience some amount of pain and anxiety.
- Trial name
- NCT01013363
- Testing
- iPod Nano digital music player
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC