Clinical trials: Pregnancy Termination
Abortion, Spontaneous, Pregnancy Complications
Relation Between Subclinical Hypothyroidism and Outcome of Pregnancy
Studies have demonstrated a relationship between subclinical hypothyroidism and obstetrics complications like preterm delivery, pre-eclampsia, placental abruption and stillbirth.
- Conditions
- Abortion, Spontaneous, Pregnancy Complications, Subclinical Hypothyroidism
- Trial name
- GravThyr (NCT01335802)
- Where
- Denmark
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Naestved Hospital
Completion of Medical Abortion
Use of Low Sensitivity Pregnancy Test for Self-assessment of Medical Abortion
The purpose of the study is to design a self-assessment package that could be the preferred option to a follow-up visit at the clinic by the majority of women having early medical abortion.
- Trial name
- m-Assist+ (NCT02231619)
- Testing
- Baseline verbal instruction on LSUPT
- Where
- South Africa
- Volunteers
- 525 people
- Sponsor
- University of Cape Town
Legally Induced Abortion Without Mention of Complication
Mifepristone Versus Osmotic Dilators in Conjunction With Misoprostol for Cervical Preparation Prior to D&E at 14-19 Weeks
Dilation and evacuation (D\&E) is a common surgical procedure in the U.S. Adequate pre-operative preparation of the uterine cervix is an important part of preventing complications of the procedure.
- Trial name
- NCT02679092
- Testing
- Misoprostol, Mifepristone, Hygroscopic cervical dilators
- Where
- United States
- Sponsor
- Stanford University
Medical; Abortion, Fetus
Fertility and Obstetric Outcomes After Medical Management Versus Surgical Treatment for First-trimester Miscarriage First-trimester Miscarriage
Study Objective: To compare the time to new pregnancy and pregnancy outcomes in women who received Misoprostol for uterus evacuation versus those treated surgically with dilatation and curettage.
- Trial name
- NCT03570307
- Testing
- medical VS surgical evacuation of the uterus
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain
Pain Control In First Trimester Medical Abortion: A Randomized Trial
This trial will compare two oral analgesic regimens in women undergoing first trimester medical abortion with mifepristone and misoprostol. The primary study outcome is pain.
- Trial name
- NCT01457521
- Testing
- Ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Gynuity Health Projects
Pregnancy, High Risk
Use of Dietary Supplements in Patients at Risk of Abortion Treated With Progesterone.
The trial aims to investigate the effect of supplementation with hyaluronic acid, alpha-lipoic acid, magnesium, vitamin D and vitamin B6 in progesterone-treated pregnant women with risk factors for abortion.
- Trial name
- NCT04874285
- Testing
- HA
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Induced Abortion, Postaboral Pelvic Inflammatory Disease
To Compare the Strategies of Universal Antibiotic Prophylaxis Versus Screen-and-treat in Reducing Infective Complications and Re-infection in Women Who Undergo Termination of Pregnancy
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when…
- Conditions
- Induced Abortion, Postaboral Pelvic Inflammatory Disease, Sexually Transmitted Infections
- Trial name
- NCT01842100
- Testing
- Universal antibiotic prophylaxis, Screen-and-treat
- Where
- China
- Volunteers
- 2,193 people
- Sponsor
- The University of Hong Kong
Abortion, First Trimester
Acceptability and Feasibility of Medical Abortion Using Mifepristone and Buccal Misoprostol
This study examined the acceptability and feasibility of introducing a mifepristone-misoprostol regimen of medical abortion into abortion services in two private clinics in Puerto Rico; 2 clinics in Baku, Azerbaijan; 3 clinics in…
- Trial name
- NCT00386282
- Testing
- mifepristone-misoprostol treatment
- Where
- 11 sites in Armenia, Azerbaijan and 2 more
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion in First Trimester
Intravenous Ketamine for Pain Control During First Trimester Surgical Abortion
A therapeutic abortion is one of the most common procedures performed in Canada, with approximately 100,000 occurring annually. 95% of induced abortions are done surgically, with just over two thirds of these procedures taking…
- Trial name
- NCT03751423
- Testing
- PO Morphine, IV Fentanyl, IV Ketamine
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Dr. Marie Eve Sophie Bussiere-Cote
Miscarriage
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol…
- Trial name
- NCT05304273
- Testing
- Mifepristone, Letrozole
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Calcutta National Medical College and Hospital
Pregnancy Related, Pregnancy Complications
The Heartland Study
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..
- Conditions
- Pregnancy Related, Pregnancy Complications, Birth Defect, Gestational Age and Weight Conditions
- Trial name
- NCT05492708
- Where
- 4 sites in United States
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Heartland Health Research Alliance
Incomplete Abortion
Sublingual Misoprostol Versus Standard Surgical Care for the Treatment of Incomplete Abortion
In this study, we will compare the safety and efficacy of 400 mcg sublingually administered misoprostol alone to standard surgical care for the treatment of incomplete abortion.
- Trial name
- NCT00466999
- Testing
- misoprostol, surgery
- Where
- 6 sites in Burkina Faso, Egypt and 3 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Contraception
Immediate Versus Delayed Insertion of the Copper Intrauterine Device (IUD) After Medication Abortion
After medication abortion, women may quickly become pregnant again and therefore need an effective birth control method right away. Intrauterine devices (IUDs) are very effective for preventing pregnancy.
- Trial name
- NCT00737178
- Testing
- CuT380A
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Columbia University
Miscarriage in First Trimester, Prenatal Genetic Diagnosis
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
- Trial name
- GRACE (NCT07639333)
- Testing
- Non invasive prenatal test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Medical Abortion
The Extended Gestational Age Medical Abortion Study
This open-label, comparative study will compare the efficacy, safety, and acceptability of 200 mg mifepristone followed in 24-48 hours by 800mcg buccal misoprostol or 400mcg sublingual misoprostol for termination of pregnancy in…
- Trial name
- NCT00997347
- Testing
- Mifepristone and misoprostol
- Where
- 12 sites in United States, Georgia and 3 more
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Early Pregnancy Loss, Delayed Pregnancy Loss
CCT-102 or Expectant Management in Delayed Pregnancy Loss
A Phase 3, multi-center clinical trial of a CCT-102 regimen or expectant management to promote uterine evacuation in first trimester non-progressing Delayed Pregnancy Loss (DPL).
- Trial name
- MERMAID (NCT06121063)
- Testing
- CCT-102 A and CCT-102 B
- Where
- 15 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Conceptra Biosciences, LLC
Pregnancy Loss, Miscarriage
Implantation Test for Endometrial Receptivity
Background Miscarriage is the most frequent complication of pregnancy and represents the spontaneous loss of the embryo or foetus before it is able to survive independently (24 weeks of gestation).
- Trial name
- NCT03442335
- Testing
- Chromohysteroscopy, Endometrial biopsy (Pipelle)
- Where
- 6 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Birmingham
Medical Abortion
Self-Assessment of Medical Abortion Outcome Using Serial Multi-level Pregnancy Tests
This study aims to investigate the effectiveness and acceptability of the multi-level pregnancy test for self-assessment of abortion outcomes, without a routine provider contact.
- Trial name
- NCT02570204
- Testing
- Self-assessment
- Where
- 3 sites in United States
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Cervical Insufficiency
Multifactorial Approach to Emergent Cerclage
Though cervical insufficiency is a common cause of second trimester pregnancy loss, the placement of an emergent cerclage in these patients is thought to improve perinatal outcomes.
- Trial name
- RECIA (NCT01114516)
- Testing
- Indomethacin and antibiotics (cefazolin or clindamycin)
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Northwestern University