Clinical trials: Pregnancy Termination
Incomplete Abortion
Sublingual Misoprostol for the Treatment of Incomplete Abortion: Operations Research
This study will investigate the use of misoprostol for first-line treatment of incomplete abortion at tertiary hospitals in Myanmar.
- Trial name
- NCT02707653
- Testing
- Misoprostol
- Where
- 2 sites in Burma
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Incomplete Abortion
Treatment of Incomplete Abortion With 600 Mcg Oral Misoprostol Compared to Standard Surgical Treatment
This study aims to compare the efficacy, side effects profile and acceptability of a single dose of 600mcg misoprostol taken orally compared to standard surgical treatment as per local protocols for the treatment of incomplete…
- Trial name
- NCT00674232
- Testing
- 600 mcg misoprostol, Surgical treatment
- Where
- 3 sites in Ecuador, Venezuela
- Volunteers
- 311 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Down Syndrome
Non Invasive Prenatal Testing of Down Syndrome
This is a randomized controlled trial in women at risk following combined prenatal screening for Down Syndrome. Women will be asked about their preferences between NIPT and routine prenatal diagnosis based on a dedicated…
- Trial name
- SAFE 21 (NCT02127515)
- Testing
- Non Invasive Prenatal Testing, Invasive Prenatal Testing
- Where
- France
- Volunteers
- 2,111 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Abortion Early
Auriculotherapy During Medication Abortion
This randomized trial will evaluate the effect of adding auriculotherapy (i.e. acupuncture applied to the ear) using either gold beads or Pyonex needles in addition to usual care for the relief of pain and anxiety during…
- Trial name
- NCT03900728
- Testing
- Auriculotherapy with needles, Auriculotherapy with beads
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Columbia University
Abortion in First Trimester, Abortion Early
Research on Equity in Abortion Care by TeleHealth
This study will examine the ways in which telehealth for reproductive healthcare affects timing, costs, and follow-up care; whether telehealth reaches people in areas with greater health inequities; and the attributes of…
- Conditions
- Abortion in First Trimester, Abortion Early, Abortion; Attempted
- Trial name
- REACH (NCT06787274)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy
Task Sharing to Improve Post Abortion Care at District Health Care Level- Trial in Uganda
Uganda is one of the countries with highest fertility rate in the world, 6.7 children per women. It is estimated that 56 percent of all pregnancies are unintended and the contraceptive prevalence rate in Uganda is 23 percent.
- Trial name
- NCT01844024
- Testing
- misoprostol by midwife
- Where
- Uganda
- Volunteers
- 1,010 people
- Sponsor
- Karolinska Institutet
Abortion, Induced
Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00969982
- Testing
- mifepristone+misoprostol
- Where
- 2 sites in Moldova, Tunisia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Grief, Post Traumatic Stress Disorder
Walk With Me (WWM) for Perinatal Grief
The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss.
- Conditions
- Grief, Post Traumatic Stress Disorder, Suicidal Ideation, Miscarriage
- Trial name
- PeriGrief-II (NCT07011940)
- Testing
- Along With Me, Peer Guide
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Infections, Papillomavirus
Post-marketing Safety Study to Assess the Risk of Spontaneous Abortions in Women Exposed to Cervarix Residing in UK
This study will assess the risk of spontaneous abortion during weeks 1-23 and weeks 1-19 of gestation, respectively, and other pregnancy outcomes, in an exposed cohort, i.e.
- Trial name
- NCT01905462
- Testing
- Data Collection, Cervarix
- Where
- United Kingdom
- Volunteers
- 1,046 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Abortion Early
Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy
Medication abortion is a way of ending a pregnancy using pills. The current FDA-approved regimen for medication abortion uses mifepristone and misoprostol.
- Trial name
- NCT05342974
- Testing
- Atorvastatin, Misoprostol
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Utah
Topical Heat Application for Intraoperative Abortion Pain Management
Applied Topical Heat as an Adjunct for Pain Control in First-Trimester Surgical Abortionl
Paracervical blocks are routinely used in first trimester surgical abortions and are a proven method for decreasing procedural pain.
- Trial name
- HAPPE (NCT02536235)
- Testing
- heat
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood of Greater New York
Medical; Abortion, Fetus
Simplified Medical Abortion Screening: A Pilot Demonstration Project
This study aims to collection additional data on the safety and acceptability of medical abortion without pretreatment pelvic ultrasound or exam in woman who meet certain criteria.
- Trial name
- NCT02381223
- Where
- 5 sites in United States, Mexico and 1 more
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Late Second Trimester Termination of Pregnancy
Vaginal Misoprostol and Foley Catheter for Late Second Trimester Termination of Pregnancy
Vaginal Misoprostol Versus Combined Low Dose Misoprostol Plus Foley Catheter for Late Second Trimester Termination of Pregnancy With Previous Multiple Cesarean Sections
- Trial name
- NCT02989324
- Testing
- MisoprostoL, Foley Catheter
- Where
- Egypt
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Miscarriage
Management of Women With an Incomplete Miscarriage
Miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks' gestation, that is, before the fetal viability. The clinical signs of miscarriage are usually vaginal bleeding associated abdominal pain and cramping…
- Trial name
- NCT03148561
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Birth Defects, Miscarriages
Pesticides--Health Fertility and Reproductive Risk
This project is designed to establish whether pesticides or other environmental agents have a role in the excess birth defects identified in the Red River Valley of Minnesota.
- Conditions
- Birth Defects, Miscarriages, Cancer
- Trial name
- NCT00015561
- Where
- United States
- Volunteers
- 1,803 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Habitual Abortion
Use of G-CSF for the Treatment of Unexplained Recurrent Miscarriage
In order to investigate the effectiveness of G-CSF in preventing embryo demise, the investigators administered this cytokine to women with recurrent miscarriage in a randomized controlled study compared to women treated with…
- Trial name
- NCT00772122
- Testing
- G-CSF, saline solution
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- University of Florence
Abortion, Blood Loss
Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion
Misoprostol is a medication used extensively in obstetrics and gynecology for its ability to aid in softening the cervix as well as decreasing blood loss after abortion or vaginal delivery.
- Trial name
- PreopMiso (NCT01436266)
- Testing
- Misoprostol, Folic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Boston University
Abortion, Medical
The Misoprostol-Only Regimen Evidence Study
The goal of this study is to evaluate the effectiveness, non-inferiority, and side-effect profile of an updated misoprostol-only regimen, as compared to the combined mifepristone-misoprostol regimen, among people seeking…
- Trial name
- MORE (NCT07174856)
- Testing
- Misoprostol-only medication abortion regimen, Combined regimen
- Where
- United States
- Volunteers
- 1,900 people
- Sponsor
- Ibis Reproductive Health
Pregnancy Related, Cervical Insufficiency
Cervical Stiffness Measurement in Cervical Insufficiency
The goal of this cross sectional study is to evaluate the differences in cervical stiffness between patients who present for cerclage placement versus normal pregnancies.
- Conditions
- Pregnancy Related, Cervical Insufficiency, Preterm Birth
- Trial name
- NCT04158401
- Testing
- Pregnolia
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Abortion, Induced, Cervical Preparation
Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial
Women having abortion procedures between 15 weeks 0 days and 23 weeks 6 days gestational age on the day of their procedure commonly have dilators placed in their cervix overnight before the abortion procedure.
- Conditions
- Abortion, Induced, Cervical Preparation, Pain
- Trial name
- GABA (NCT03080493)
- Testing
- Gabapentin 600mg, acetaminophen/codeine and ibuprofen
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of California, Davis