Clinical trials: Pregnancy Transient Hypertension
Gestational Hypertension
Role of the Oral Microbiome in Blood Pressure Regulation in Pregnancy
High blood pressure in pregnancy is associated with poor outcomes for both mum and baby, increasing the risk of pregnancy complications including pre-eclampsia, fetal growth restriction and preterm birth.
- Trial name
- NCT03930693
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Weifang (PKUBC-WF)
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- NCT06234332
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Peking University
Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension
No-worry Baby Project
The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Thyroid Disease Pregnancy, Obesity
- Trial name
- NCT03922087
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,216 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Maternal Hypertension
The Effect of CPAP on Maternal and Infant Outcomes in Pregnant Women With OSAS
The goal of this clinical trial is to learn about the impact of CPAP on the maternal and infant outcomes of women with obstructive sleep apnea syndrome.
- Trial name
- NCT06344702
- Testing
- CPAP
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Gestational Diabetes, Gestational Hypertension
sFlt-1:PlGF Ratio in Gestational Diabetes: PREDICTION (PREeclampsia in DIabetiC gestaTION) Study
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia and can be used to predict the preeclampsia.
- Conditions
- Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- PREDICTION (NCT04877119)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Tongzhou
The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- PKUBC-T (NCT03814395)
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,426 people, healthy volunteers welcome
- Sponsor
- Peking University
Hypertensive Disorder of Pregnancy, Pre-Eclampsia
Optimal Blood Pressure Treatment Thresholds Postpartum
The objective of this research project is to conduct a single-site pilot trial within our institution's clinical remote blood pressures (BP) management program to assess the feasibility and effect of tight blood pressure control…
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia
- Trial name
- NCT06069102
- Testing
- Usual care, Tight blood pressure control
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Alisse Hauspurg
Hypertension Disorders in Pregnancy, Gestational Hypertension
Vascular Biomarkers Predictive of the Progression From Hypertensive Disorders in Pregnancy to Preeclampsia in Pregnant Women
Hypertension during pregnancy remains a leading cause of maternal and fetal morbidity and mortality. The frequency (5 to 10% of pregnancies) and potential severity of these diseases, both for the mother and the child, are reasons…
- Conditions
- Hypertension Disorders in Pregnancy, Gestational Hypertension, Pre-Eclampsia
- Trial name
- BIOVASC-PreHTA (NCT04520048)
- Testing
- Determination of the UEMP levels, Aortic central pressure and the carotid-femoral pulse wave velocity, Vascular biomarker assay
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertensive Disorder of Pregnancy, Gestational Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation…
- Conditions
- Hypertensive Disorder of Pregnancy, Gestational Hypertension, Preeclampsia
- Trial name
- HYPER-endoEV-p (NCT07728656)
- Where
- Croatia
- Volunteers
- 80 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Hypertension
Central Blood Pressure
The aim of the study is to check standard screening blood pressure in the arm and central blood pressure, the blood pressure at the heart in pregnant women.
- Trial name
- NCT03026010
- Testing
- central blood pressure
- Volunteers
- 100 people
- Sponsor
- St. Louis University
Preeclampsia and Eclampsia, Preeclampsia Severe
Preeclampsia Risk Assessment: Evaluation of Cut-offs to Improve Stratification
The purpose of this study is to 1. Identify a cut-off for the ratio of the serum proteins soluble FMS-like Tyrosine Kinase 1 (sFLT-1) and placental growth factor (PlGF) that identifies women will who develop preeclampsia with…
- Conditions
- Preeclampsia and Eclampsia, Preeclampsia Severe, Gestational Hypertension, Chronic Hypertension in Obstetric Context
- Trial name
- PRAECIS (NCT03815110)
- Where
- 18 sites in United States
- Volunteers
- 1,050 people
- Sponsor
- Cedars-Sinai Medical Center
Pre-Eclampsia, Gestational Hypertension
The Effect of Foot Massage on Blood Pressure and Anxiety Levels in Pregnants With Hypertension
This research was conducted as a prospective, experimental and randomised controlled research to determine the effect of foot massage applied to pregnant women with hypertension on blood pressure and anxiety levels.
- Conditions
- Pre-Eclampsia, Gestational Hypertension, Chronic Hypertension With Pre-Eclampsia, Superimposed Pre-Eclampsia
- Trial name
- NCT05542654
- Testing
- Foot Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bandırma Onyedi Eylül University
Pregnancy Induced Hypertension
Prospects for the Prevention of Pregnancy-induced Hypertension and Preeclampsia Trial
Hypertensive disorders of pregnancy (HDP) are with 50.000 deaths every year one of the major causes of maternal mortality worldwide, especially in low and middle income countries.
- Trial name
- 4P (NCT02007837)
- Testing
- Combined aspirin and multinutrient supplement, Daily text reminder text messages
- Where
- 2 sites in Ghana
- Volunteers
- 440 people
- Sponsor
- UMC Utrecht
Hypertension in Pregnancy, Chronic Hypertension
Moms@Home: A Storytelling-based Mobile Health Intervention to Improve Blood Pressure Management in Pregnancy
This pilot study will examine the effects of a digital health approach, Moms@Home, on home blood pressure monitoring in a diverse population of pregnant women with hypertension.
- Conditions
- Hypertension in Pregnancy, Chronic Hypertension, Gestational Hypertension
- Trial name
- Moms@Home (NCT06835959)
- Testing
- Moms@Home, Enhanced Standard of Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Massachusetts, Worcester
Hypertension in Pregnancy, Preeclampsia
Blood Pressure Monitoring in Postpartum Women at Risk of Hypertension
Cardiovascular disease and hypertensive disorders of pregnancy (HDP) are the leading causes of maternal morbidity and mortality in the United States.
- Conditions
- Hypertension in Pregnancy, Preeclampsia, Gestational Hypertension, Chronic Hypertension With Pre-Eclampsia
- Trial name
- NCT05457504
- Testing
- Remote blood pressure monitoring, Usual Care
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Pregnancy-Induced, Hypertension in Pregnancy
Meditation as Complementary Treatment for Chronic Hypertension in Pregnancy
Pregnancy relates to arterial hypertension; it is an aggravating factor for pre-existing chronic arterial hypertension or a trigger for preeclampsia in normotensive women.
- Conditions
- Hypertension, Pregnancy-Induced, Hypertension in Pregnancy, Hypertension
- Trial name
- NCT03873194
- Testing
- Meditation, conventional treatment
- Where
- Brazil
- Volunteers
- 47 people
- Sponsor
- University of Sao Paulo General Hospital
Hypertensive Disorder of Pregnancy, Pre-Eclampsia
Treatment With Aspirin After Preeclampsia: TAP Trial
The objective of this research project is to conduct a single-site pilot trial to assess the feasibility and effect of low-dose aspirin to augment vascular recovery in the immediate postpartum period after preeclampsia through…
- Conditions
- Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia
- Trial name
- TAP (NCT06281665)
- Testing
- Low-dose aspirin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Malamo Countouris
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Gestational Hypertension
Effect of Pilates Exercise Versus Circuit Exercise Training on Gestational Hypertension
The purpose of the study is to investigate the effect of Pilates exercises versus circuit exercise training on blood pressure and lipids in gestational hypertensive women.
- Trial name
- NCT06618521
- Testing
- Anti-hypertensive drug (Methyldopa 250 mg), Pilates exercise, Circuit exercise training
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Cairo University
Preeclampsia, Gestational Hypertension
The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy.
The Achieve Trial is a randomized clinical trial to test whether lowering blood pressure to less than 140/90 mmHg in women with hypertensive disorders of pregnancy will prolong pregnancy.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- Achieve (NCT05676476)
- Testing
- Antihypertensive treatment
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Alabama at Birmingham