Clinical trials: Pregnancy Trimester, Second
Abortion Early, Abortion, Complete
Clotting Parameters After Medical Abortion
Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women.
- Conditions
- Abortion Early, Abortion, Complete, Abortion, Second Trimester, Termination of Pregnancy Complicated by Embolism
- Trial name
- C-PLAN (NCT04824118)
- Testing
- Thromboelastometry, Clotting Studies, Full Blood Count
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Abortion in Second Trimester
Assessing Outpatient 'Day Procedure' for Second-trimester Medical Abortion at Two Public Sector Hospitals in Nepal
This study seeks to evaluate the safety, acceptability and feasibility of an outpatient "day procedure" for medical abortion at 13-18 weeks gestation in two public sector facilities.
- Trial name
- NCT05046041
- Testing
- Mifepristone + Misoprostol
- Where
- 2 sites in Nepal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Medical; Abortion, Fetus
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia
This study included women who underwent voluntary second trimester termination of pregnancy. Patients were randomized to programmed intermittent epidural anesthetic bolus or continuous epidural infusion for pain analgesia.
- Trial name
- NCT01860521
- Testing
- Programmed Intermittent Epidural Bolus, Continuous Epidural Infusion, Procedure of interruption of pregnancy
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Induced; Abortion, Nonmedical
Comparison of Laminaria and Misoprostol for Cervical Preparation Before Second Trimester Surgical Abortion
This study compares the effectiveness of cervical preparation before second trimester abortion using laminaria versus vaginal Misoprostol.
- Trial name
- NCT01678703
- Testing
- Laminaria, MedGyn Products, Inc. USA., Misoprostol
- Where
- Israel
- Volunteers
- 84 people
- Sponsor
- Wolfson Medical Center
Pregnancy Termination, Catheter
Foley Catheter vs Double-balloon Catheter
The efficiency of double-balloon and Foley catheters in the second trimester medical termination of pregnancies will be compared.
- Trial name
- NCT03521674
- Testing
- pregnancy termination
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Pregnancy Trimester, Second, Misoprostol
Misoprostol With And Without Transcervical Balloon Catheter In Second Trimester Termination Of Pregnancy
This randomized controlled study will be performed to compare the benefits and risks associated with the administration of misoprostol with or without the use of a transcervical balloon catheter to terminate pregnancy in the…
- Conditions
- Pregnancy Trimester, Second, Misoprostol, Catheters, Abortion, Second Trimester
- Trial name
- NCT03106389
- Testing
- Misoprostol, Misoprostol/Transcervical catheter
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Ain Shams Maternity Hospital
Abortion; Attempted
Misoprostol in Missed Abortion
In this study we compare between the effectiveness of combined Foley's catheter with Misoprostol and intracervical Foley's catheter alone for termination of second trimester abortion.
- Trial name
- NCT06818903
- Testing
- Misopristol, Foley catheter
- Volunteers
- 122 people
- Sponsor
- Assiut University
Pain Management, Abortion
Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement
The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.
- Conditions
- Pain Management, Abortion, Second Trimester Abortion, Dilation and Evacuation
- Trial name
- PCB-KinD (NCT07487246)
- Testing
- Ketorolac, oral ibuprofen, Lidocaine HCl 1%
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Rush University Medical Center
Placenta, Retained, Postpartum Hemorrhage
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00120042
- Testing
- Misoprostol, Oxytocin
- Where
- Australia
- Volunteers
- 251 people
- Sponsor
- The University of Western Australia
Termination of Pregnancy
Multi-Media E-Book for Second-Trimester Termination Due to Fetal Anomaly
The subjects of this study are married couples who received termination of pregnancy, the main purpose is to explore the effectiveness of the e-book education model.
- Trial name
- NCT04303949
- Testing
- Behavioral:
- Volunteers
- 96 people
- Sponsor
- China Medical University Hospital
Pregnancy, HIV
The Effect of Pregnancy on the Pharmacokinetics of the Kaletra Tablet
In this study, we are looking at blood concentrations of Kaletra in HIV positive patients during pregnancy. The patients will come in for 4 visits lasting ~24hrs.
- Trial name
- NCT00766818
- Testing
- Kaletra
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of North Carolina, Chapel Hill
Preterm Premature Rupture of Membrane, Amniotic Fluid Leakage
The Accuracy of Amniotic Fluid Ferning in the Second Trimester in the Diagnosis of Preterm Prelabor Rupture of Membranes
Although much investigation has been done on the use of ferning in the second and third trimesters, particularly with the development of rapid protein clinical assays, there appears to be lower ferning rates in clinical practice…
- Trial name
- NCT04963465
- Testing
- Ferning on microscopy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albany Medical College
Preterm Birth
Can Cervical Stiffness in the Second Trimester Predict Preterm Birth in High-Risk Singleton Pregnancies?
Preterm birth (PTB), defined as delivery before 37 weeks gestation, is a common complication of pregnancy and affects up to 1 in 10 women in the UK.
- Trial name
- PRECISION (NCT05837390)
- Testing
- Cervical stiffness assessment, Cervical length measurement, Fetal fibronectin
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- University of Liverpool
Induction of Abortion
Different Methods of Termination of Second Trimester Abortion
The Patient are divided into 3 groups group 1 included 50 cases using misoprostol only. group 2 included also 50 cases in which using misoprostol with letrozole.
- Trial name
- NCT03400683
- Testing
- Misoprostol, Letrozole, Foley's catheter
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Second Trimester Abortion, Uterocervical Angle
The Role of Cervical Consistency Index and Uterocervical Angles in Medical Termination
The main aim of the investigator study is the success of predictivity cervical consistency index (CCI), anterior uterocervical angle (aUCA) and posterior uterocervical angle (pUCA) in second trimester terminations.
- Conditions
- Second Trimester Abortion, Uterocervical Angle, Cervical Consistency Index
- Trial name
- NCT06164067
- Testing
- abortus within 24 hours or 24-48 hours
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Pregnancy Trimester, Second, Induced Abortion
Randomized Trial Comparing Misoprostol and Foley Bulb for Pregnancy Termination in the Second Trimester
The purpose of this study is to compare two methods of pregnancy termination on the time to delivery in the second trimester.
- Trial name
- NCT00324519
- Testing
- Foley bulb, misoprostol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Multiple Sclerosis (MS)
An Observational Study to Learn About the Interferon-beta Exposure of Pregnant Women During the Second and Third Trimester in Finland and Sweden
Observational data have suggested no increased risk of adverse pregnancy outcomes associated with exposure to interferon-beta (IFNB) before or during pregnancy.
- Trial name
- INFORM (NCT06053749)
- Testing
- Avonex (IFNβ-1-a, Biogen Netherlands B.V), Rebif (IFNβ-1-a, Merck Europe B.V.), Extavia (IFNβ-1-b, Novartis Europharm Limited)
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 4 people
- Sponsor
- Bayer
Anemia, Iron Deficiency, Pregnancy Anemia
Iron Deficiency Anemia in the Second and Third Trimester of Pregnancy
Iron deficiency is the most frequent cause of anemia during pregnancy and of maternal blood transfusion during the post-partum period.
- Trial name
- PESO (NCT07163390)
- Testing
- Sideral Folico
- Volunteers
- 82 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Abortion, Second Trimester, Abortion, Medical
Foley Balloon for Cervical Preparation Before Dilation and Evacuation
To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation…
- Trial name
- NCT06850974
- Testing
- Foley Balloon Catheter, Misoprostol, Laminaria
- Where
- Mozambique
- Volunteers
- 102 people
- Sponsor
- Stony Brook University
Preterm Labor, Preterm Birth
The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth
Preterm birth (PTB) is the primary cause of infant death worldwide. It has been shown that a vaginal microbiota deplete in Lactobacillus species is a risk factor for preterm labour.
- Conditions
- Preterm Labor, Preterm Birth, Preterm Premature Rupture of Membrane, Cervical Incompetence
- Trial name
- NCT03992534
- Testing
- LACTIN-V
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Imperial College London