Clinical trials: Pregnancy in Diabetic
Diabetic Nephropathies
Doppler Ultrasound in Early Detection of Diabetic Nephropathy Type 2 Diabetes Mellitus.
Doppler sonography provides an easily applicable, non-invasive, and well-established method for investigating renal morphologic characteristics and measuring vascular resistance in the renal parenchyma.
- Trial name
- NCT03284996
- Testing
- Doppler ultrasonography
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 1 Diabetes, Diabetic Nephropathy
Microalbuminuria and Allopurinol in Type 1 Diabetes
The objective is to determine if lowering serum uric acid by means of allopurinol in the course of kidney disease may be effective in preventing or improving albuminuria and renal function in Type 1 Diabetic patients.
- Trial name
- MIKAL (NCT02829177)
- Testing
- Allopurinol
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Peter Rossing
Diabetic Kidney Disease, Type 1 Diabetes
Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
The primary objective of this study is to determine the effects of semaglutide on change in albuminuria from baseline to 26 weeks in type 1 diabetes.
- Trial name
- RT1D (NCT05822609)
- Testing
- Semaglutide
- Where
- 4 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- University of Washington
Diabetic Nephropathy Type 2, Type 2 Diabetes
Salivary and Serum Inflammatory Biomarkers in Diabetic Nephropathy by Periodontal Status
Chronic inflammation underlies the bidirectional relationship between diabetes and periodontitis, a process that may be further exacerbated in the presence of diabetic nephropathy.
- Conditions
- Diabetic Nephropathy Type 2, Type 2 Diabetes, Periodontitis, Gingivitis
- Trial name
- NCT07498894
- Testing
- clinical periodontal measurements, serum samples, saliva samples
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Pamukkale University
Diabetic Nephropathy
The Effect of LY333531 on Protein in the Urine in Patients With Type 2 Diabetes
The purpose of this study are to determine 1) Whether Ly333531 can reduce urinary albumin/creatinine excretion in patients with Type II diabetes and persistent albuminuria 2) Whether LY333531 reduces urinary TGF-B, 3) the safety…
- Trial name
- NCT00044148
- Testing
- LY333531
- Where
- 15 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Chromaderm, Inc.
Gestational Diabetes, Type 2 Diabetes
Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country
The study hypothesis was In women with gestational diabetes and type 2 diabetes in pregnancy metformin treatment compared with insulin will result in better perinatal and maternal outcome and improved treatment acceptability with…
- Conditions
- Gestational Diabetes, Type 2 Diabetes, Pregnancy
- Trial name
- migdm&t2dm (NCT01855763)
- Testing
- Metformin, Insulin
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Invasive Infection, Diabetic Foot
Invasive Group B Streptococcus Disease Burden and Its Antimicrobial Resistance in Malaysia Among Non-pregnant Adults.
Group B Streptococcus (GBS) infection is a potential aetiology of meningitis and septicemia in neonates, pregnant women and non-pregnant adults.
- Conditions
- Invasive Infection, Diabetic Foot, Immunocompromised Patients, Group B Streptococcal Infections
- Trial name
- NCT05726006
- Testing
- No Intervention in This study
- Where
- Malaysia
- Volunteers
- 133 people
- Sponsor
- Universiti Putra Malaysia
Diabetic Nephropathies
Niclosamide Role in Diabetic Nephropathy
This study is randomized, controlled, parallel, prospective clinical study will be conducted on 60 patients diagnosed with type 2 diabetes mellitus at least five years ago.
- Trial name
- NCT04317430
- Testing
- Niclosamide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension
No-worry Baby Project
The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Thyroid Disease Pregnancy, Obesity
- Trial name
- NCT03922087
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,216 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Low Carbohydrate Diet in Diabetic Kidney Disease
The current population of type 2 diabetes mellitus (T2DM) worldwide is over 200 million and Malaysia contributes to 1.2% of that number.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Obesity
- Trial name
- NCT04931030
- Testing
- Dietary advice
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- Universiti Teknologi Mara
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Renal Oxygenation, Oxygen Consumption and Hemodynamic Kinetics in Type 2 DIabetes: an Ertugliflozin Study.
Current study will render insight in to the role of renal hypoxia in the diabetic kidney and is able to associate its finding with measurements of renal perfusion and glomerular filtration rate.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Diabetic Nephropathy, Renal Hypoxia
- Trial name
- ROCKIES (NCT04027530)
- Testing
- Ertugliflozin 15 mg
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
ESRD
Pioglitazone, Body Composition,Insulin Sensitivity and Protein Metabolism in ESRD
Non diabetic patients on renal replacement therapy are prone to changes in body composition with an increase in visceral fat and muscle wasting all favoured by the insulin resistant state.
- Trial name
- NCT01253928
- Testing
- Pioglitazone
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Type 2 Diabetes Mellitus, Inflammation, Chronic Low-Grade
Lifestyle Intervention and Its Effects on Inflammatory Cytokines and Oxidative Stress Markers in Diabetic Chronic Kidney Disease Patients: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of a 12-week structured lifestyle intervention-including supervised aerobic exercise and a calorie-restricted diet-on inflammatory cytokines and oxidative stress…
- Conditions
- Type 2 Diabetes Mellitus, Inflammation, Chronic Low-Grade, Chronic Kidney Disease, Stage 3 Chronic Kidney Disease
- Trial name
- Lifestyle Inte (NCT07119892)
- Testing
- Lifestyle Modification (Exercise + Diet)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sinai University
Gestational Diabetes, Diabetes, Gestational
Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a significant clinical and public health burden, affecting over 400,000 pregnant women in the United States each year.
- Conditions
- Gestational Diabetes, Diabetes, Gestational, Pregnancy in Diabetes
- Trial name
- MATCh-GDM (NCT03029702)
- Testing
- Insulin, Glyburide, Metformin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Maisa N. Feghali, MD
Chronic Kidney Disease, Pre Diabetes
What is the Role of Triglyceride-glucose Index as a Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients?
The aim of this study is to evaluate the role of the triglyceride-glucose (TyG) index as a predictive marker for insulin resistance in pre-diabetic patients with chronic kidney disease (CKD), and to investigate its potential…
- Trial name
- NCT07279922
- Testing
- Triglyceride-glucose index
- Volunteers
- 60 people
- Sponsor
- Assiut University
Kidney Disease
Effects of High Dietary Fiber Supplementation in Diabetic Chronic Kidney Disease
Loss of kidney function results in accumulation in the blood of molecules that are either excreted or metabolized by the kidney. Collectively, these molecules are termed Uremic Retention Molecules (URMs) or toxins.
- Trial name
- NCT01838330
- Testing
- psyllium
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Utah
Type 1 Diabetes, Pregnancy in Diabetic
Telemedicine in Pregnant Women With Type 1 Diabetes Mellitus
Hypothesize that co-managing pregnant type 1 diabetics with telemedicine will have at least equivalent outcomes to those managed with standard care.
- Trial name
- NCT04278664
- Volunteers
- 5 people
- Sponsor
- Ana Braescu
Preterm Birth, Hyperglycemia
Blood Glucose in Pregnant Non-diabetic Women During Treatment With Betamethasone for Fetal Lung Maturation
In case of threatening preterm birth, it is standard to recommend treatment with betamethasone to accelerate fetal lung maturation.
- Conditions
- Preterm Birth, Hyperglycemia, Neonatal Hypoglycemia, Threatened Preterm Labor
- Trial name
- NCT06794307
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- University of Aarhus
Pregnancy in Diabetic, Diabetes Mellitus, Type 1
Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound Radiomics
The goal of this observational study is to compare fetal liver ultrasound radiomics between pregnancies complicated by type 1 diabetes and healthy controls.
- Trial name
- NCT06343974
- Where
- 2 sites in Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Diabetes Mellitus, Impaired Renal Function
Platelet Function in Diabetic Patients With and Without Renal Impairment, and the Effects of Lipid Lowering Treatment
The purpose of this study is compare the effects of simvastatin+ezetimibe with those of simvastatin alone on platelet activity, platelet-leukocyte interactions and inflammatory variables in diabetic patients with or without…
- Trial name
- PLAUDIT (NCT01035320)
- Testing
- Ezetimibe
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Karolinska Institutet