Clinical trials: Pregnancy in Diabetic
Diabetic Nephropathy
Lactoferrin Supplementation in Diabetic Nephropathy
Multiple pathways and mediators, including oxidative stress, inflammation, and the over-activity of the renin-angiotensin-aldosterone system are involved in the development of albuminuria and progression of diabetic nephropathy…
- Trial name
- NCT07764991
- Testing
- Lactoferrin, Antidiabetic
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
IgA Nephropathy, Focal Segmental Glomerulosclerosis
Atrasentan in Patients With Proteinuric Glomerular Diseases
The AFFINITY Study is a phase 2, open-label, basket study to evaluate the efficacy and safety of atrasentan in patients with proteinuric glomerular disease who are at risk of progressive loss of renal function.
- Conditions
- IgA Nephropathy, Focal Segmental Glomerulosclerosis, Alport Syndrome, Diabetic Kidney Disease
- Trial name
- AFFINITY (NCT04573920)
- Testing
- Atrasentan
- Where
- 33 sites in United States, Australia and 4 more
- Volunteers
- 103 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes Mellitus With Diabetic Nephropathy
Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria
NADPH oxidase enzymes (NOX) have been implicated in the development of several diabetic complications including diabetic nephropathy. GKT137831 is the first in class NOX1/4 inhibitor.
- Trial name
- NCT02010242
- Testing
- GKT137831
- Where
- 48 sites in United States, Australia and 4 more
- Volunteers
- 136 people
- Sponsor
- Calliditas Therapeutics AB
Pregnancy, Diabetes Mellitus
Fetal Heart Interventricular Septum in Fetuses of Diabetic Mothers
The investigators asume that the measurement of the fetal heart interventricular septum can serve as a good tool to predict glucose control in pregnant patients with diabetes mellitus.
- Trial name
- NCT01845324
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Chronic Kidney Diseases
Outcome of Glargine Insulin in Renal Impairment Patients With Diabetic Ketoacidosis
The study aims to compare between the use of continuous low dose insulin infusion versus co-administration of low dose continuous insulin infusion and early subcutaneous insulin glargine in diabetic ketoacidosis patients with…
- Trial name
- NCT05219942
- Testing
- Glargine, normal saline
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM)
Research on Gut Microbiota and Metabolomics in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is characterized by high prevalence, multiple pathogenesis, and lack of effective treatment and management strategies.
- Conditions
- Diabetic Nephropathy Type 2, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Disease
- Trial name
- NCT06833541
- Where
- China
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
Obesity, Type 2 Diabetes
Lifestyle Management of CKD in Obese Diabetic Patients
The purpose of this randomized clinical trial is to evaluate the efficacy of 3 different technology-supported approaches to engaging 300 individuals with diabetes and concurrent chronic kidney disease in weight loss, dietary…
- Conditions
- Obesity, Type 2 Diabetes, Chronic Kidney Disease (CKD)
- Trial name
- NCT02276742
- Testing
- Social Cognitive Theory, Monitoring
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- NYU Langone Health
Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment
Gestational Diabetes Mother-infant Cohort
The bi-directional dynamic cohort study is to learn about the effects of prenatal exposure to high blood glucose levels and postnatal nurturing environment factors on delayed language development in children.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Cognitive Impairment, Cohort Study
- Trial name
- NCT06021691
- Testing
- Acquired nurturing environment
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gansu Provincial Maternal and Child Health Care Hospital
Postpartum Period, Pregnancy
Enhancing Care & Outcomes for Patients During the First Postpartum Year
The United States is in the midst of a maternal mortality and morbidity crisis, with more than half of maternal deaths occurring within the first postpartum year.
- Conditions
- Postpartum Period, Pregnancy, Hypertension, Pregnancy Induced
- Trial name
- NCT06615076
- Testing
- Postpartum Visits
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Diabetic Nephropathies
Clinical Study to Evaluate the Possible Efficacy and Safety of Levocetirizine in Patients With Diabetic Kidney Disease
The prevalence of diabetes mellitus is increasing worldwide, and its complications are one of the leading causes of mortality from non-communicable diseases.
- Trial name
- NCT05638880
- Testing
- Valsartan 80 mg, Empagliflozin 10 MG, Levocetirizine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mostafa Bahaa
Diabetes Mellitus in Pregnancy
Efficacy of FGM in Pregestational Diabetes
Diabetes is the most common metabolic disease complicating pregnancy, and the number of women in childbearing age facing this problem is rising worldwide.
- Trial name
- FlashMom (NCT04666818)
- Testing
- Use of Flash Glucose Monitoring
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Catania
Proteinuria
Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus Losartan
Losartan, an angiotensin II receptor blocker, has already been established as a treatment for diabetic nephropathy due to its ability to reduce blood pressure and mitigate the progression of kidney damage.
- Trial name
- NCT06491940
- Testing
- Losartan, Losartan + Hydrochlorothiazide
- Where
- Pakistan
- Volunteers
- 234 people
- Sponsor
- RESnTEC, Institute of Research
Gestational Diabetes Mellitus in Pregnancy
4 vs 7 Points Blood Glucose Monitoring in Gestational Diabetes on Dietary Modification
This study aims to compare between 4 and 7 points blood glucose monitoring in women with gestational diabetes on diet modification.
- Trial name
- NCT04101396
- Testing
- diabetic diet
- Where
- 2 sites in Malaysia
- Volunteers
- 200 people
- Sponsor
- National University of Malaysia
Diabetes, Proteinuria
Use of Mucomyst to Ameliorate Oxidant Stress in Diabetics With Proteinuria
The study will look at the effect of 30 days of treatment of 15 diabetics with proteinuria with N-acetylcysteine ( Mucomyst ) at a dose of 1 gm twice a day by mouth.
- Trial name
- NCT00493727
- Testing
- N-acetylcysteine(Mucomyst)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Nephropathies
A Pilot Study of Fenofibrate to Prevent Kidney Function Loss in Type 1 Diabetes
Diabetic kidney disease remains the leading cause of end-stage kidney disease (ESKD), rising in frequency in parallel with the epidemic of diabetes worldwide.
- Trial name
- PERL-FENO (NCT04929379)
- Testing
- Fenofibrate
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Alessandro Doria
Type 2 Diabetes, Pregnancy in Diabetic
CSII Versus MDI in Pregnant Women With Type 2 Diabetes
The primary objective of the study is to determine if continuous subcutaneous insulin infusion (CSII) can improve glycemic control in women with type 2 diabetes (T2D) who are pregnant.
- Trial name
- NCT05001815
- Testing
- Continuous subcutaneous insulin infusion (CSII), Multiple daily insulin injection (MDI)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Gastric Ultrasonography, Gastric Volume
Gastric Ultrasound in Diabetic and Non-Diabetic Pregnant Women
Perioperative aspiration is particularly concerning in pregnant women due to anatomical changes. To mitigate this risk, pre-anesthetic fasting is recommended, with varying guidelines.
- Conditions
- Gastric Ultrasonography, Gastric Volume, Pulmonary Aspiration, Diabetic Pregnancy
- Trial name
- NCT05959135
- Testing
- Gastric ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Weight Loss, Gestational Diabetes Mellitus in Pregnancy
Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational Diabetes
The goal of this clinical trial is to evaluate the effectiveness of a 6-month lifestyle intervention compared to Metformin in postpartum women who have delivered a singleton, live born infant within the last 12 weeks to 1 year…
- Conditions
- Weight Loss, Gestational Diabetes Mellitus in Pregnancy, Postpartum Care
- Trial name
- GooDMomS2 (NCT06948825)
- Testing
- Metformin Hcl 850Mg Tab, Lifestyle Intervention, Enhanced Lifestyle Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diabetic Nephropathy
Efficacy and Safety of Canagliflozin (TA-7284) in Patients With Diabetic Nephropathy
The purpose of this study is to evaluate the efficacy and safety of Canagliflozin (TA-7284) in Japanese patients with Diabetic Nephropathy, compared with placebo
- Trial name
- NCT03436693
- Testing
- Canagliflozin
- Where
- 26 sites in Japan
- Volunteers
- 308 people
- Sponsor
- Tanabe Pharma Corporation
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Efficacy and Safety of Jinshuibao Capsule on Diabetic Kidney Disease
The purpose of this study is to investigate the therapeutic effect and safety of Jinshuibao Capsule on diabetic kidney disease in T2DM patients.
- Trial name
- NCT03164785
- Testing
- Jinshuibao Capsule
- Where
- China
- Volunteers
- 202 people
- Sponsor
- Second Xiangya Hospital of Central South University