Clinical trials: Pregnancy in Diabetic
Gestational Diabetes, Pregnancy in Diabetics
Texting for Diabetes Success in Pregnancy
Diabetes during pregnancy can be a challenging circumstance requiring extensive patient learning and self-care. The purpose of this study is to develop and pilot test a patient-centered diabetes education and self-care tool using…
- Trial name
- NCT03240289
- Testing
- Texting group
- Volunteers
- 33 people
- Sponsor
- Northwestern University
Pregnant Women, Gestational Diabetes
Physical Acvitiy in Pregnancy
The goal of this observational study is to learn how a physically active lifestyle during pregnancy affects placental development and function.
- Conditions
- Pregnant Women, Gestational Diabetes, Obese But Otherwise Healthy Participants, Overweight (BMI > 25)
- Trial name
- NCT07356180
- Testing
- Pregnancy Physical Activity Questionnaire (PPAQ)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Chronic Kidney Diseases
Dapagliflozin in Non-diabetic Stage IV CKD
This is a phase 2b, prospective, randomized, cross-over, double-blind, placebo-controlled trial primarily aimed at assessing whether the SGLT2 inhibitor dapagliflozin ameliorates hyperfiltration and reduces proteinuria as…
- Trial name
- ADAPT (NCT04794517)
- Testing
- Dapagliflozin 10Mg Tab
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Chronic Kidney Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
This study will evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses (SAD) and multiple ascending doses (MAD) of AZD4248 administered as an oral solution and intravenous (IV)…
- Trial name
- NCT07024823
- Testing
- AZD4248
- Where
- 5 sites in United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Type 1 Diabetes Mellitus With Diabetic Nephropathy
dApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation
The aim of this study is to test the hypothesis that dapagliflozin (SGLT2 inhibitor) and SC0062 (ERA) combination therapy augments nephroprotection and mitigates fluid retention and ketogenesis in people with T1D through…
- Trial name
- ASPIRE-1 (NCT06072326)
- Testing
- Dapagliflozin (Forxiga®), SC0062 strength 10mg, SC0062 and dapagliflozin
- Where
- 5 sites in Denmark, Finland
- Volunteers
- 36 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Chronic Kidney Disease
Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney Disease
The purpose of the study is to evaluate the efficacy and safety of AZD9977 in combination with dapagliflozin compared with dapagliflozin alone and to assess the dose-response relationship, dapagliflozin alone and 3 doses of…
- Trial name
- MIRACLE (NCT04595370)
- Testing
- AZD9977, Dapagliflozin
- Where
- 156 sites in United States, Belgium and 20 more
- Volunteers
- 153 people
- Sponsor
- AstraZeneca
Type 2 Diabetes, Diabetes Type 2
Renal Hemodynamics, Energetics and Insulin Resistance: A Follow-up Study
The current protocol plans to enroll participants with youth-onset Type 2 Diabetes (T2D) as well as obese and lean controls from the Renal-HEIR - Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2…
- Conditions
- Type 2 Diabetes, Diabetes Type 2, Diabetic Nephropathies, Nephropathy
- Trial name
- HEIRitage (NCT05530356)
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Colorado, Denver
Chronic Kidney Diseases, Type2diabetes
EFFECT SGLT2 INHIBITORS ON CONTRAST MEDIUM INDUCED ACUTE KIDNEY INJURY
Chronic kidney disease and type 2 diabetes mellitus patients are with in high-risk patients in coronary arterial diseases and increasing number of coronary angiography and coronary interventional procedures have been performed in…
- Trial name
- NCT06288529
- Where
- Turkey (Türkiye)
- Volunteers
- 975 people
- Sponsor
- University of Health Sciences Balikesir Hospital Eduation and Research
Nervous System, Diabetic Kidney Disease
Mechanisms of Diabetic Kidney Disease in American Indians
Background: An ongoing study is looking at American Indians who have kidney problems caused by type 2 diabetes. Kidney disease due to type 2 diabetes is a major problem in American Indians.
- Conditions
- Nervous System, Diabetic Kidney Disease, Diabetes Mellitus, Type 2
- Trial name
- NCT01878045
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Proteinuric Kidney Disease, Diabetic Nephropathy
Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease
Primary Hypothesis: Aldosterone breakthrough will occur at a far lower frequency during renin inhibition (0-10% over 9 months), alone or in combination with an ARB, compared to conventional ARB therapy (35-45% over 9 months).
- Conditions
- Proteinuric Kidney Disease, Diabetic Nephropathy, Hypertensive Nephrosclerosis, IgA Nephropathy
- Trial name
- NCT01129557
- Testing
- Aliskiren, Valsartan
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Columbia University
Infant of Diabetic Mother, Sacral Agenesis
Screening for Sacral Agenesis in Offspring of Mothers With Diabetes in Pregnancy
Babies born to mothers with pregestational diabetes will be screened with parental consent for sacral agenesis
- Trial name
- NCT05033275
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Missouri-Columbia
Diabetes Mellitus, Diabetes, Gestational
Recent GDM Lifestyle Intervention
Women with a history of gestational diabetes (GDM) have a substantially increased risk of developing type 2 diabetes. In fact, 50-70% of these women will go on to develop type 2 diabetes within the 20 years following their…
- Trial name
- LIFe (NCT01910805)
- Testing
- Lifestyle and Risk Assessment class
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Impaired Glucose Tolerance, Fetal Macrosomia
Treatment of Impaired Glucose Tolerance in Pregnancy
The purpose of this study is to evaluate if treatment (insulin or diet) of pregnant women with impaired glucose tolerance (75-g OGTT with a fasting P-gluc <7.0 mmol/l and 2 h P-gluc >10.0 and <12.2 mmol/l) close to normoglycemia…
- Trial name
- TIP (NCT00625781)
- Testing
- Insulin aspart and Insulin human (isophane)
- Where
- Sweden
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Kidney Failure, Chronic, Eye Diseases
Feasibility Study of Retinal Screening Using the RetinaVue 100 Camera in Outpatient Dialysis Centers
The purpose of this research study is to look at retinal abnormalities in outpatient renal dialysis patients using the FDA approved RetinaVue 100 hand-held (non-mydriatic) camera.
- Conditions
- Kidney Failure, Chronic, Eye Diseases, Diabetic Retinopathy
- Trial name
- NCT02823600
- Testing
- RetinaVue 100 camera
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Kidney Disease
A Study to Test the Effect of Different Doses of Avenciguat (BI 685509) on Kidney Function in People With Chronic Kidney Disease
This study is open to adults who have kidney disease that is not caused by diabetes. The purpose of the study is to find out whether a medicine called avenciguat (BI 685509) improves kidney function.
- Trial name
- NCT04736628
- Testing
- Avenciguat
- Where
- 110 sites in United States, Argentina and 16 more
- Volunteers
- 261 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes, Diabetic Kidney Disease
Renal Mechanism of SGLT2 Inhibition
Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA).
- Trial name
- NCT05507892
- Testing
- canagliflozin, Aminohippurate Sodium Inj 20%
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Colorado, Denver
Intrauterine Growth Restriction
FETAL PULMONARY VEIN AND UMBILICAL ARTERY PULSATILITY INDICES AS PREDICTORS OF FETAL GROWTH RESTRICTION IN DIABETIC AND HYPERTENSIVE PREGNANT WOMEN
Diabetic and hypertensive pregnant women attending at Kasr Alani for antenatal care were subjected to Complete History taking. All the participants were scanned using B mode sonography to determine the fetal biometric parameters…
- Trial name
- NCT06988436
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Cairo University
Gestational Diabetes Mellitus in Pregnancy
Telerehabilitation Exercise: Effects on Maternal Quality of Life, Fetal and Neonatal Health.
Gestational diabetes mellitus (GDM) occurs when blood sugar levels rise during pregnancy, typically between 24-28 weeks, affecting about 2-18% of all pregnancies.
- Trial name
- NCT06480292
- Testing
- telerehabilitation exercise, routine medical care
- Where
- 2 sites in Pakistan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Diabetic Nephropathies
Metabolic Effects of the SGLT-2 Inhibitor Empagliflozin in Patients With Diabetic Nephropathy (MEDiaN)
The MEDiaN study aims to examine the state of fuel metabolism in participants with diabetic nephropathy (DN) before and after the use of the sodium-glucose transport protein 2 inhibitor (SGLT-2i) empagliflozin.
- Trial name
- (MEDiaN) (NCT03933956)
- Testing
- Empagliflozin 10 MG
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Singapore General Hospital
Chronic Kidney Disease, Insulin Resistance
Study of Vitamin D3 Supplementation in Patients With Chronic Kidney Disease
The purpose of this study is to evaluate the impact of vitamin D3 supplementation on the insulin resistance in non-diabetic patients with chronic kidney disease (CKD) stages 3-4, vitamin D deficiency/insufficiency and elevated…
- Conditions
- Chronic Kidney Disease, Insulin Resistance, Vitamin D Deficiency
- Trial name
- VitaD-CKD1 (NCT00893451)
- Testing
- cholecalciferol (TillVal-D)
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Sahlgrenska University Hospital