Clinical trials: Pregnancy in Diabetic
Pregestational Diabetes, Type 2 Diabetes
Glucose Control in Type 2 Diabetes in Pregnancy
The goal of this clinical trial is to evaluate the effect of physical activity on glucose control in pregnant patients with pregestational Type 2 diabetes.
- Trial name
- NCT07250698
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Eastern Virginia Medical School
Diabetic Nephropathy, Dyslipidemia
The Non-high-density Lipoprotein Cholesterol (Non-HDL-C) to High-density Lipoprotein Cholesterol (HDL-C) Ratio (NHHR) and Its Association With Occurrence of Diabetic Nephropathy in Patients With Diabetes Mellitus
The study aims to examine the relationship between the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) and CKD in patients with DM.
- Trial name
- NCT07476248
- Volunteers
- 84 people
- Sponsor
- Assiut University
Kidney Diseases, Diabetic Nephropathies
First-In-Human Study of GFB-024 in Healthy Overweight and Obese Participants, and Participants With Type 2 Diabetes
GFB-024 is intended for use in patients with kidney disease such as diabetic nephropathy. This study is the first time GFB-024 has been used in humans.
- Conditions
- Kidney Diseases, Diabetic Nephropathies, Diabetes Complications, Diabetes Mellitus
- Trial name
- NCT04880291
- Testing
- GFB-024
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Goldfinch Bio, Inc.
Diabetes Mellitus, Type 2, Diabetic Nephropathies
Cholesterol Metabolism in Plasma and Interstitial Fluid Among Subjects Undergoing Hemodialysis.
Because the atherosclerosis process partly occur in the intercellular space of the vessel wall, the determination of the constitution of lipoproteins in the interstitial fluid may expand the knowledge about the atherosclerosis…
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Nephropathies, Chronic Kidney Diseases
- Trial name
- NCT03921216
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska University Hospital
Diabetic Nephropathy
Clinical Research of UC-MSCs in the Treatment of Diabetic Nephropathy
Diabetic nephropathy (DN) is one of the most serious complications of diabetes and the leading cause of end-stage chronic kidney disease. DN is a refractory disease with low awareness, high incidence, and high disability.
- Trial name
- UC-MSCs (NCT04562025)
- Testing
- UC-MSCs
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Renmin Hospital of Wuhan University
Chronic Kidney Diseases, Albuminuria
Diabetic Nephropathy in People With Diabetes. Prevalence and Predictive Factors
a prospective, observational, multi-center study with a cohort of 300 patients with Type 2 diabetes and macroalbuminuria. Prospectively we will collect kidney biopsies and analyse the transciptome of the kidney tissue and other…
- Conditions
- Chronic Kidney Diseases, Albuminuria, Diabetic Kidney Disease, Diabetic Nephropathies
- Trial name
- PRIMETIME2 (NCT04916132)
- Testing
- Kidney Biopsy
- Where
- 13 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Herlev Hospital
Type 2 Diabetes Mellitus, Chronic Kidney Diseases
A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus
A Phase 2b, study to measure the effect of Cotadutide at different doses versus placebo or comparator (semaglutide) in participants who have Chronic Kidney Disease with Type 2 Diabetes Mellitus.
- Trial name
- NCT04515849
- Testing
- Cotadutide 100 micrograms, Cotadutide 300 micrograms, Cotadutide 600 micrograms
- Where
- 83 sites in Australia, Canada and 6 more
- Volunteers
- 248 people
- Sponsor
- AstraZeneca
Diabetic Nephropathy, Diabetes Mellitus
Soy Protein in Early Diabetic Nephropathy
Diabetic nephropathy is a frequent cause of end-stage renal disease. Reduction of dietary protein has been used to slow down renal disease progression, but patients are often unwilling to make these dietary changes.
- Trial name
- NCT00067678
- Testing
- soy protein
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Diabetes
Urinary Vitamin C Loss in Diabetic Subjects
Several studies have reported that diabetic subjects have lower plasma vitamin C concentrations than non-diabetic subjects. Although urinary vitamin C loss in diabetic subjects was reported to be increased in two studies, these…
- Trial name
- NCT00071526
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetic Nephropathy, Hypertension
Effect of Green Tea (Epigallocatechin Gallate) on Albuminuria in Patients With Diabetic Nephropathy.
The purpose of this study is to determine the safety and effect of green tea (epigallocatechin gallate) in albuminuria in diabetic patients and nephropathy.
- Trial name
- NCT01923597
- Testing
- Green tea extract
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Campinas, Brazil
Chronic Kidney Disease, Diabetic Kidney Disease
A Trial to Learn More About How BAY2327949 Works and How Safe it is in Patients Whose Kidneys Are Damaged Due to High Blood Sugar Levels or High Blood Pressures, and With a Further Disease of the Heart or the Blood Vessels.
In people with type 2 diabetes (T2D), the body makes insulin, but cannot use it well. This results in high blood sugar levels causing damage to the blood vessels inside the kidneys.
- Trial name
- ASSESS-CKD (NCT04661917)
- Testing
- BAY2327949
- Where
- 36 sites in Austria, Denmark and 5 more
- Sponsor
- Bayer
Hypertension, Diabetic Nephropathy
Antiproteinuric Effect of Valsartan and Lisinopril
Title: Antiproteinuric effect of valsartan, lisinopril and valsartan versus lisinopril in non-diabetic and diabetic renal disease: a randomized (3:3:1), double blind, parallel group, controlled trial, 5 months follow-up.
- Trial name
- NCT00171574
- Testing
- Valsartan, Valsartan plus HCTZ, Lisinopril
- Where
- Switzerland
- Volunteers
- 124 people
- Sponsor
- Novartis
Type 2 Diabetes, Pregnancy in Diabetic
CSII Versus MDI in Pregnant Women With Type 2 Diabetes
The primary objective of the study is to determine if continuous subcutaneous insulin infusion (CSII) can improve glycemic control in women with type 2 diabetes (T2D) who are pregnant.
- Trial name
- NCT05001815
- Testing
- Continuous subcutaneous insulin infusion (CSII), Multiple daily insulin injection (MDI)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Hyperglycemia, Pregnancy
The Extension of HAPO Follow-up Study
The prevalence of diabetes mellitus (DM) and cardiovascular disease (CVD) escalate remarkably worldwide and obesity becomes an epidemic disease.
- Conditions
- Hyperglycemia, Pregnancy, Overnutrition, Maternal Obesity During Childbirth
- Trial name
- NCT05477511
- Where
- Hong Kong
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Sepsis, Acute Renal Failure
Inferior Vena Cava Collapsibility and Distensibility Assessment in Critical Care.
This study will help in determining the impact of assessment of Inferior Vena Cava Collapsibility and Distensibility Index (IVC CI and DI) through Point Of Care Ultra Sound (POCUS), for the fluid management of critically ill…
- Conditions
- Sepsis, Acute Renal Failure, Acute Gastroenteritis, Diabetic Ketoacidosis
- Trial name
- NCT06516692
- Testing
- Inferior Vena Cava Collapsibility/distensibility Index (IVC CI/DI) assessment
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Renal Insufficiency, Chronic, Diabetic Nephropathy Type 2
Safety and Efficacy of Two Year of RAAS Alone or in Combination With Spironolactone Therapy
NephroNet proposes to examine whether combining Spironolactone with maximal RAAS blockade will further reduce urinary protein at one year and whether prolonged therapy (24 months) is able to slow the decline in GFR.
- Trial name
- MRA-ACE (NCT03502031)
- Testing
- Renin-Angiotensin (RAAS) alone, Renin-Angiotensin (RAAS) blockers in combination with Spironolactone
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- James A. Tumlin, MD
Diabetes Mellitus, Type 2, Chronic Kidney Disease
Carotid Doppler Screening for Subclinical Atherosclerosis in Diabetic CKD Patients.
This study is being done at Assiut University to look for early signs of hardening of the arteries (atherosclerosis) in people who have both diabetes and chronic kidney disease (CKD).
- Conditions
- Diabetes Mellitus, Type 2, Chronic Kidney Disease, Atherosclerosis
- Trial name
- DiCKD-CAROTID (NCT07266220)
- Volunteers
- 96 people
- Sponsor
- Abdallah Ali Mohammed
Gestational Diabetes Mellitus in Pregnancy
Can Albumin/C-reactive Protein Ratio be Utilized for Predicting Gestational Diabetes Diagnosis or the Adverse Outcomes
This study provides a comprehensive evaluation of the potential utility of the albumin/high-sensitivity C-reactive protein (hsCRP) ratio in diagnosing gestational diabetes mellitus (GDM) and predicting adverse pregnancy outcomes.
- Trial name
- Alb/hsCRP (NCT06761053)
- Testing
- Intervention/Exposure for the GDM Group (Experimental Arm), Intervention/Exposure for the Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- ALI BAHADIRLI
Diabetic Retinopathy, Chronic Kidney Diseases
Effect of SGLT2 Inhibition on OCT-A Parameters in Diabetic CKD
Diabetes mellitus is a major and growing problem worldwide with many known micro and macrovascular complications. According to International Diabetes Federation, there were 285 million adults diagnosed with diabetes in 2010 and…
- Conditions
- Diabetic Retinopathy, Chronic Kidney Diseases, Diabetes Mellitus
- Trial name
- NCT04215445
- Testing
- Empagliflozin 25 MG, OCT-A
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- National University of Malaysia
Diabetic Nephropathies, Hypertension
Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease
The purpose of the study is to determine whether a diuretic drug called amiloride is capable of increasing renal salt excretion and thereby decrease blood pressure in diabetic patients with kidney disease.
- Trial name
- NCT01918488
- Testing
- Standardized salt diet, Amiloride
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- University of Southern Denmark