Clinical trials: Pregnancy in Diabetic
CKD Stage 4
Could Ketoanalogue-supplemented Low Protein Diet Defer Dialysis in Advanced Diabetic Kidney Disease? (K-DDD)
This is a prospective single center open label randomized controlled trial aiming to assess the effectiveness and safety of a low protein diet (0.6 g/kg-day, mainly vegetarian) supplemented with ketoanalogues of essential…
- Trial name
- K-DDD (NCT03415074)
- Testing
- Protein restriction
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Anemia Working Group Romania
Type 2 Diabetes Mellitus, Diabetic Nephropathy
Study for the Effectiveness of Intensive Therapy Aiming at a Remission of Diabetic Nephropathy
Study for the effectiveness of intensive therapy aiming at the remission of diabetic nephropathy
- Trial name
- NCT00253786
- Testing
- Intensive multifactorial therapy, Standard therapy
- Where
- Japan
- Volunteers
- 312 people
- Sponsor
- Okayama University
Diabetic Kidney Disease, Hyperuricemia
Uric Acid Lowering Trial in Youth Onset T2D
Adolescents and young adults with youth-onset type 2 diabetes (T2D) are disproportionally impacted by hyperuricemia compared to non-diabetic peers and youth with type 1 diabetes (T1D).
- Conditions
- Diabetic Kidney Disease, Hyperuricemia, Diabetes, Diabetes Mellitus, Type 2
- Trial name
- ULTRA-T2D (NCT03899883)
- Testing
- Pegloticase 8 MG/ML [Krystexxa]
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Melatonin, Diabetic Nephropathy
Efficacy of Melatonin in the Treatment of Diabetic Nephropathy Compared With Folic Acid
The current study aims to investigate and compare the anti-inflammatory effects of melatonin versus folic acid in patients with diabetic nephropathy.
- Conditions
- Melatonin, Diabetic Nephropathy, Folic Acid
- Trial name
- NCT07825961
- Testing
- Conventional diabetic treatment, Folic acid, Melatonin
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Chronic Kidney Disease, Insulin Resistance
Study of Vitamin D3 Supplementation in Patients With Chronic Kidney Disease
The purpose of this study is to evaluate the impact of vitamin D3 supplementation on the insulin resistance in non-diabetic patients with chronic kidney disease (CKD) stages 3-4, vitamin D deficiency/insufficiency and elevated…
- Conditions
- Chronic Kidney Disease, Insulin Resistance, Vitamin D Deficiency
- Trial name
- VitaD-CKD1 (NCT00893451)
- Testing
- cholecalciferol (TillVal-D)
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Sahlgrenska University Hospital
Chronic Kidney Disease, Diabetes
PRevention of End Stage Kidney Disease by Darbepoetin Alfa In Chronic Kidney Disease Patients With nondiabeTic Kidney Disease
The purpose of this study is to ask whether treating non-diabetic chronic kidney disease (CKD) patients with GFR 8-20mL/min/1.73m2 by darbepoetin Alfa targeting Hb between 11.0 and 13.0g/dL preserves renal function better than…
- Trial name
- PREDICT (NCT01581073)
- Testing
- Darbepoetin alfa
- Where
- Japan
- Volunteers
- 476 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Gestational Diabetes
Remote Monitoring of Diabetes in Pregnancy: a Feasibility Study
When women with diabetes become pregnant it is particularly important to control blood sugar levels to prevent complications. Women are advised to test their blood glucose levels seven times a day and to attend antenatal and…
- Trial name
- Tele-Mum (NCT01630759)
- Testing
- Telemonitoring, Control
- Where
- 2 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Ulster
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Evaluating the Effectiveness of a Smart Screening and Tiered Management Tool for Diabetic Kidney Disease in Primary Care: A Cluster Randomized Trial
This is a cluster-randomized controlled trial aiming to evaluate the effectiveness of an intelligent standardized screening and risk-stratified management tool for diabetic kidney disease (DKD) among adults with type 2 diabetes…
- Trial name
- SMART-DKD (NCT07707518)
- Testing
- Intervention Name Clinical decision support system for diabetic kidney disease (DKD-CDSS), Routine guideline-based diabetes management
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Kidney Disease, Diabetic Nephropathy
Using the Drug Spironolactone to Test If It Reduces Protein Leakage From the Kidney
The purpose of this study is to determine which combination of the tablets ramipril, irbesartan or spironolactone is best to lower protein leakage from the kidney.
- Conditions
- Kidney Disease, Diabetic Nephropathy, Glomerulonephritis, Proteinuria
- Trial name
- NCT00106561
- Testing
- Spironolactone, Irbesartan
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Melbourne Health
Diabetes, Gestational, Diabetes, Type 2
Glycemic Control Using Insulin Levemir Versus Insulin NPH for Diabetes in Pregnancy
The aim of this study is to compare glycemic control in pregnant women treated with insulin Detemir and pregnant women treated with NPH insulin.
- Trial name
- NCT01837680
- Testing
- Insulin
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Gestational Diabetes, Gestational Diabetes Mellitus
Gestational Diabetes: Induction Versus Expectant Management of Labour
The purpose of this study is to determine whether, in Gestational Diabetes Mellitus (GDM) pregnancies, induction of labour at 38-39 weeks of pregnancy is superior to expectant management in terms of maternal and neonatal outcomes.
- Conditions
- Gestational Diabetes, Gestational Diabetes Mellitus, Diabetes Mellitus, Gestational, Pregnancy-Induced Diabetes
- Trial name
- GINEXMAL (NCT01058772)
- Testing
- INDUCTION of LABOUR
- Where
- 9 sites in Israel, Italy and 3 more
- Volunteers
- 425 people
- Sponsor
- IRCCS Burlo Garofolo
Diabetic Kidney Disease, Diabetic Nephropathies
Systemic Immune-Inflammation Index and Platelet Parameters in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a frequent microvascular complication in individuals with type 2 diabetes mellitus (T2DM) and a major cause of chronic kidney failure worldwide.
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Type 2 Diabetes Mellitus, Albuminuria
- Trial name
- NCT07773467
- Volunteers
- 120 people
- Sponsor
- Assiut University
Type 2 Diabetes, Diabetic Nephropathy
Effects of SGLT2 Inhibition Treatment on Different Levels of Albuminuria in Patients With Type 2 Diabetes
Diabetic kidney disease has become the leading cause for ESRD worldwide.Albuminuria is a major risk factor for progression of diabetic nephropathy.
- Trial name
- NCT04127084
- Testing
- SGLT2 Inhibition
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Zhongshan Hospital Xiamen University
Diet Modification, Diabetic Kidney Disease
Effect of the Teleconsultation of Renal Nutrition on Renal Function and Glycemic Control in Patients With DKD
The modern era is characterized by progress, development and social and economic globalization. Currently the electronic technology has applications in a wide variety of work areas. A clear example of this, is telemedicine.
- Conditions
- Diet Modification, Diabetic Kidney Disease, Chronic Kidney Diseases
- Trial name
- NCT03344549
- Testing
- Renal nutrition teleconsultation, Face-to-face consultation of renal nutrition
- Where
- Mexico
- Volunteers
- 53 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Healthy Adult Participants, Diabetic Kidney Disease
Evaluation of MTX-439 in Healthy Adults and Adults With Diabetic Kidney Disease
This is a phase 1 randomized, double-blind, single ascending dose (SAD) and multiple ascending dose (MAD) study to assess the safety, tolerability, and Pharmacokinetics (PK) of single and multiple ascending doses of MTX-439…
- Trial name
- NCT07473323
- Testing
- MTX-439
- Where
- Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Mediar Therapeutics
Diabetic Nephropathy
Minocycline and Proteinuria in Diabetic Nephropathy
Diabetic kidney disease increases the risk of illness and death from heart disease in patients with Type 2 diabetes. Some blood pressure medications called ACE inhibitors and ARBs slow progression of kidney disease, but the dose…
- Trial name
- NCT01779089
- Testing
- Minocycline 100 mg po bid for 6 months
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Intrahepatic Cholestasis of Pregnancy, Gestational Diabetes Mellitus
The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus
ICP is known to cause abnormal bile acid homeostasis and to be associated with an increased risk of diseases of the biliary system in later life. There have been small studies (Dann et al. 2006; Wójcicka-Jagodzińska et al.
- Trial name
- NCT01499524
- Where
- 2 sites in United Kingdom
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis
Study of WAL0921 in Patients With Glomerular Kidney Diseases
This is an adaptive prospective, multi-center, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of WAL0921 in subjects with glomerular kidney disease and…
- Conditions
- Diabetic Nephropathies, Primary Focal Segmental Glomerulosclerosis, Minimal Change Disease, Primary Immunoglobulin A Nephropathy
- Trial name
- NCT06466135
- Testing
- WAL0921
- Where
- 50 sites in United States, Australia and 5 more
- Volunteers
- 96 people
- Sponsor
- Walden Biosciences
Type 1 Diabetic Nephropathy
Resveratol in Diabetic Nephropathy
Background: Food-derived compounds have been shown to have beneficial effects in type 1 diabetes mellitus (T1DM). Among these compounds, resveratrol (3,5,4'-trihydroxystilbene) which is found in grapes, peanuts, cranberries.
- Trial name
- NCT07332819
- Testing
- Resveratol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Albuminuria, Chronic Kidney Diseases
Improving Albuminuria Screening Compliance Using a Smartphone Urinalysis Kit
This study will test the effectiveness of mailed, smartphone urinalysis kits to improve albuminuria screening compliance and detection of albuminuria.
- Conditions
- Albuminuria, Chronic Kidney Diseases, Cardiovascular Diseases, Hypertension
- Trial name
- NCT03470701
- Testing
- Mailed Urinalysis Smartphone Kit
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- Geisinger Clinic